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Identific tion of quantitative trait loci and associated candidate genes for pregnancy success in Angus–Brahman crossbred heifers

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Journal of Animal Science and Biotechnology 2024年第1期15卷 162-170页

作者： Quinn A.Hoorn gabriel A.Zayas eduardo E.Rodriguez Laura M.Jensen Raluca G.Mateescu Peter J.Hansen Department of Animal Sciences Donald Henry Barron Reproductive and Perinatal Biology Research Programand the Genetics InstituteUniversity of FloridaGainesvilleFLUSA School of Applied Systems Biology La Trobe UniversityBundooraVIC 3083Australia

Background In beef cattle, more than 50% of the energy input to produce a unit of beef is consumed by the female that produced the calf. Development of genomic tools to identify females with high genetic merit for reproductive function could increase the profitability and sustainability of beef *** Genome-wide association studies(GWAS) were performed using a single-step genomic best linear unbiased prediction approach on pregnancy outcome traits from a population of Angus–Brahman crossbred heifers. Furthermore, a validation GWAS was performed using data from another farm. Heifers were genotyped with the Bovine GGP F250 array that contains 221,077 SNPs. In the discovery population, heifers were bred in winter breeding seasons involving a single round of timed artificial insemination(AI) followed by natural mating for 3 months. Two phenotypes were analyzed: pregnancy outcome to first-service AI(PAI;n = 1,481) and pregnancy status at the end of the breeding season(PEBS;n = 1,725). The heritability was estimated as 0.149 and 0.122 for PAI and PEBS, respectively. In the PAI model, one quantitative trait locus(QTL), located between 52.3 and 52.5 Mb on BTA7, explained about 3% of the genetic variation, in a region containing a cluster of γ-protocadherin genes and SLC25A2. Other QTLs explaining between 0.5% and 1% of the genetic variation were found on BTA12 and 25. In the PEBS model, a large QTL on BTA7 was synonymous with the QTL for PAI, with minor QTLs located on BTA5, 9, 10, 11, 19, and 20. The validation population for pregnancy status at the end of the breeding season were Angus–Brahman crossbred heifers bred by natural mating. In concordance with the discovery population, the large QTL on BTA7 and QTLs on BTA10 and 12 were *** In summary, QTLs and candidate SNPs identified were associated with pregnancy outcomes in beef heifers, including a large QTL associated with a group of protocadherin genes. Confirmation of these associations

关键词： Beef cattle Fertility GWAS QTL

Exploring the genetic control of sweat gland characteristics in beef cattle for enhanced heat tolerance

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Journal of Animal Science and Biotechnology 2024年第5期15卷 1820-1831页

作者： Aakilah S.Hernandez gabriel A.Zayas eduardo E.Rodriguez Kaitlyn M.Sarlo Davila Fahad Rafiq Andrea N.Nunez Cristiane Goncalves Titto Raluca G.Mateescu Department of Animal Science North Carolina State UniversityRaleighNCUSA Department of Animal Sciences University of FloridaGainesvilleFLUSA. Ruminant Diseases and Immunology Research Unit National Animal Disease CentersUnited States Department of Agriculture1920 Dayton AvenueAmesIA 50010USA. Department of Animal Science Iowa StateAmesIAUSA School of Animal Sciences and Food Engineering University of Sao PauloAv Duque de Caxias Norte 225PirassunungaSao Paulo 13635‑900Brazil

Background Thermal stress in subtropical regions is a major limiting factor in beef cattle production systems with around$369 million being lost annually due to reduced *** stress causes numerous physiological and behavioral disturbances including reduced feed intake and decreased production *** utilize various physiological mechanisms such as sweating to regulate internal *** in these traits can help identify genetic variants that control sweat gland properties and subsequently allow for genetic selection of cattle with greater *** This study used 2,401 Brangus cattle from two commercial ranches in *** phenotypes that contribute to an animal's ability to manage heat stress were calculated from skin biopsies and included sweat gland area,sweat gland depth,and sweat gland *** animals were genotyped with the Bovine GGP F250K,and BLUPF90 software was used to estimate genetic parameters and for Genome Wide Association *** Sweat gland phenotypes heritability ranged from 0.17 to 0.42 indicating a moderate amount of the phenotypic variation is due to genetics,allowing producers the ability to select for favorable sweat gland properties.A weighted single-step GWAS using sliding 10 kb windows identified multiple quantitative trait loci(QTLs)explaining a significant amount of genetic *** located on BTA7 and BTA12 explained over 1.0%of genetic variance and overlap the ADGRV1 and CCDC168 genes,*** variants identified in this study are implicated in processes related to immune function and cellular proliferation which could be relevant to heat *** of Origin Alleles(BOA)were predicted using local ancestry in admixed populations(LAMP-LD),allowing for identification of markers'origin from either Brahman or Angus ancestry.A BOA GWAS was performed to identify regions inherited from particular ancestral breeds that might have a significant impact on sweat gland pheno

关键词： GWAS Heritability Skin Thermotolerance

Rifaximin on epigenetics and autophagy in animal model of hepatocellular carcinoma secondary to metabolic-dysfunction associated steatotic liver disease

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World Journal of Hepatology 2024年第1期16卷 75-90页

作者： Matheus Truccolo Michalczuk Larisse Longo Melina Belén Keingeski Bruno de Souza Basso gabriel Tayguara Silveira Guerreiro Jessica T Ferrari Joséeduardo Vargas Cláudia P Oliveira Carolina Uribe-Cruz Carlos Thadeu Schmidt Cerski eduardo Filippi-Chiela Mário ReisÁlvares-da-Silva Division of Gastroenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Graduate Program in Gastroenterology and Hepatology Universidade Federal do Rio Grande do SulPorto Alegre 90035-003Rio Grande do SulBrazil Experimental Laboratory of Hepatology and Gastroenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Laboratory of Inflammatory and Neoplastic Cells Universidade Federal do ParanáParaná81530900Brazil Department of Gastroenterology(LIM07) Faculdade de Medicina da Universidade de São PauloSão Paulo 01246903Brazil Facultad de Ciencias de la Salud Universidad Católica de las MisionesPosadasMisiones 3300Argentina Unit of Surgical Pathology Hospital de Clinicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Center of Biotechnology Universidade Federal do Rio Grande do SulPorto Alegre 90035-003Rio Grande do SulBrazil Department of Morphological Sciences Universidade Federal do Rio Grande do SulPorto Alegre 90.050-170Rio Grande do SulBrazil Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq)ResearcherBrasília 71.605-001Brazil

BACKGROUND Prevalence of hepatocellular carcinoma(HCC)is increasing,especially in patients with metabolic dysfunctionassociated steatotic liver disease(MASLD).AIM To investigate rifaximin(RIF)effects on epigenetic/autophagy markers in *** Adult Sprague-Dawley rats were randomly assigned(n=8,each)and treated from 5-16 wk:Control[standard diet,water plus gavage with vehicle(Veh)],HCC[high-fat choline deficient diet(HFCD),diethylnitrosamine(DEN)in drinking water and Veh gavage],and RIF[HFCD,DEN and RIF(50 mg/kg/d)gavage].Gene expression of epigenetic/autophagy markers and circulating miRNAs were *** All HCC and RIF animals developed metabolic-dysfunction associated steatohepatitis fibrosis,and cirrhosis,but three RIF-group did not develop *** animals who developed HCC with those who did not,miR-122,miR-34a,tubulin alpha-1c(Tuba-1c),metalloproteinases-2(Mmp2),and metalloproteinases-9(Mmp9)were significantly higher in the *** opposite occurred with Becn1,coactivator associated arginine methyltransferase-1(Carm1),enhancer of zeste homolog-2(Ezh2),autophagy-related factor LC3A/B(Map1 Lc3b),and p62/sequestosome-1(p62/SQSTM1)-*** with controls,Map1 Lc3b,Becn1 and Ezh2 were lower in HCC and RIF-groups(P0.05).miR-122 was higher in HCC,and miR-34a in RIF compared to controls(P0.05).CONCLUSION RIF might have a possible beneficial effect on preventing/delaying liver carcinogenesis throu

关键词： Animal model Autophagy Epigenetic Hepatocellular carcinoma Metabolic dysfunction-associated steatotic liver disease Rifaximin

From liver to hormones:The endocrine consequences of cirrhosis

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World Journal of Gastroenterology 2024年第9期30卷 1073-1095页

作者： Juan eduardo Quiroz-Aldave Elman Rolando Gamarra-Osorio María del Carmen Durand-Vásquez Luciana del Pilar Rafael-Robles Jhean gabriel Gonzáles-Yovera María Alejandra Quispe-Flores Luis Alberto Concepción-Urteaga Alejandro Román-González José Paz-Ibarra Marcio José Concepción-Zavaleta Non-communicable Diseases Endocrinology Research LineHospital de Apoyo ChepénChepén 13871Peru Department of Endocrinology Hospital Víctor Lazarte EchegarayTrujillo 13006Peru Department of Endocrinology Clínica Javier PradoLima 15046Peru Department of Gastroenterology Hospital Nacional Guillermo Almenara IrigoyénLima 15018Peru Department of Endocrinology Hospital de Emergencias GrauLima 15001Peru Internal Medicine Hospital Regional Docente de TrujilloTrujillo 13011Peru Department of Endocrinology Hospital Universitario de San Vicente FundaciónMedellin 050010Colombia Internal Medicine Universidad de AntioquiaMedellín 050010Colombia School of Medicine Universidad Nacional Mayor de San MarcosLima 15081Peru Department of Endocrinology Hospital Nacional Edgardo Rebagliati MartinsLima 15072Peru Carrera de Medicina Humana Universidad Científica del SurLima 15067Peru

Hepatocrinology explores the intricate relationship between liver function and the endocrine *** liver diseases such as liver cirrhosis can cause endocrine disorders due to toxin accumulation and protein synthesis *** its importance,assessing endocrine issues in cirrhotic patients is frequently *** article provides a comprehensive review of the epidemiology,pathophysiology,diagnosis,and treatment of endocrine disturbances in liver *** review was conducted using the PubMed/Medline,EMBASE,and Scielo databases,encompassing 172 *** cirrhosis is associated with endocrine disturbances,including diabetes,hypoglycemia,sarcopenia,thyroid dysfunction,hypogonadotropic hypogonadism,bone disease,adrenal insufficiency,growth hormone dysfunction,and secondary *** optimal tools for diagnosing diabetes and detecting hypoglycemia are the oral glucose tolerance test and continuous glucose monitoring system,*** can be assessed through imaging and functional tests,while other endocrine disorders are evaluated using hormonal assays and imaging *** options include metformin,glucagon-like peptide-1 analogs,sodium-glucose co-transporter-2 inhibitors,and insulin,which are effective and safe for diabetes *** standards are followed for managing hypoglycemia,and hormone replacement therapy is often necessary for other endocrine *** transplantation can address some of these problems.

关键词： Diabetes mellitus Hypoglycemia Thyroid diseases Hypogonadism Metabolic bone diseases Liver cirrhosis

Optimizing Nitrogen Use Efficiency for No-Till Corn Production by Improving Root Growth and Capturing NO_(3)-N in Subsoil

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Pedosphere 2016年第4期26卷 474-485页

作者： eduardo F. CAIRES Renato ZARDO FILHO gabriel BARTH Helio A. W. JORIS Department of Soil Science and Agricultural Engineering State University of Ponta Grossa Ponta Grossa 84030-900 Green Circle Growers 51051 US FIighway 20 Oberlin OH 44074 ABC Foundation Research and Agricultural Development Castro 84165-700

Subsoil acidity restricts root growth and reduces crop yields in many parts of the world. More than half of the fertilizer nitrogen(N) applied in crop production is currently lost to the environment. This study aimed to investigate the effect of gypsum application on the efficiency of N fertilizer in no-till corn(Zea mays L.) production in southern Brazil. A field experiment examined the effects of surface-applied gypsum(0, 5, 10, and 15 Mg ha^(-1)) and top-dressed ammonium nitrate(NH_4NO_3)(60, 120, and 180 kg N ha^(-1)) on corn root length, N uptake, and grain yield. A greenhouse experiment was conducted using undisturbed soil columns collected from the field experiment site to evaluate NO_3-N leaching, N uptake, and root length with surface-applied gypsum(0 and 10 Mg ha^(-1)) and top-dressed NH_4NO_3(0 and 180 kg N ha^(-1)). Amelioration of subsoil acidity due to gypsum application increased corn root growth,N uptake, grain yield, and N use efficiency. Applying gypsum to the soil surface increased corn grain yield by 19%–38% and partial factor productivity of N(PFPN) by 27%–38%, depending on the N application rate. Results of the undisturbed soil column greenhouse experiment showed that improvement of N use efficiency by gypsum application was due to the higher N uptake from NO_3-N in the subsoil as a result of increased corn root length. Our results suggest that ameliorating subsoil acidity with gypsum in a no-till corn system could increase N use efficiency, improve grain yield, and reduce environmental risks due to NO_3-N leaching.

关键词： ammonium nitrate grain yield N uptake nitrate leaching partial factor productivity of nitrogen soil acidity

3′-UTR of the SARS-CoV-2 genome as a possible source of piRNAs

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Genes & Diseases 2023年第3期10卷 668-670页

作者： María Teresa Hernández-Huerta Laura Pérez-Campos Mayoral Carlos Alberto Matias-Cervantes Carlos romero Díaz Eli Cruz Parada eduardo Pérez-Campos Mayoral Rafael Baltiérrez-Hoyos Margarito Martínez Cruz gabriel Mayoral Andrade eduardo Pérez-Campos CONACyT Faculty of Medicine and SurgeryAutonomous University“Benito Juárez”of Oaxaca(UABJO)Oaxaca 68020Mexico Research Center Faculty of Medicine UNAM-UABJOAutonomous University“Benito Juárez”of Oaxaca(UABJO)Oaxaca 8020Mexico National Technology of Mexico/IT Oaxaca Oaxaca de JuárezOaxaca 68030Mexico

SARS-CoV-2 is the causal agent of the COVID-19 pandemic. This is a single-stranded RNA beta-coronavirus that is comprised of a 5′ and 3′-untranslated region (UTR) in its non-coding RNA (ncRNA) region. The P-element-induced wimpy testis (PIWI)-interacting RNAs (piRNAs) are ncRNA sequences that bind to transposons and interfere with the translation of new genes. Here, we search for short sequences in the non-coding regions, corresponding to 28 nucleotides (nt). These start from a uracil and have a conserved region of at least 10 nt of homology with the previously reported piRNAs. The aim of this work was to identify piRNA-like sequences in the 3′-UTR of SARS-CoV-2 from the reported Wuhan Patient's genome sequence (GenBank: MN908947.3).

关键词： piRNA sequences piRNAs

Foliar application of rare earth elements on soybean(Glycine max(L)):Effects on biometrics and characterization of phytotoxicity

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Journal of Rare Earths 2020年第10期38卷 1131-1139,I0005页

作者： eduardo S.Rodrigues gabriel S.Montanha Joao P.R.Marques eduardo de Almeida Lauren N.M.Yabuki Amauri A.Menegario Hudson W.Pereira de Carvalho Laboratory of Nuclear Instrumentation(LIN) Center for Nuclear Energy in Agriculture(CENA)University of Sao Paulo(USP)PiracicabaSP13416-000Brazil Environmental Studies Center Sao Paulo State University(UNESP)Rio ClaroSP13506-900Brazil

This study aims at investigating the effects of foliar application of aqueous solutions of La3+and Ce3+nitrates on soybean plants(Glycine max).First,we observe that Triton HW 1000 surfactant at 0.01 vol%reduces droplets contact angle and increases their drying *** greenhouse conditions,the foliar treatments do not affect chlorophyll content,plant height,number of leaves,number of pods,number of seeds per pod,and average seed ***,the treatments induce phytotoxicity since foliar injuries appear after the *** X-ray fluorescence spectroscopy combined to scanning electron microscopy shows that the leaf lesions are positively correlated to accumulation of Ce and La on the leaf surface and also promote structural alteration to the epidermal cells.X-ray absorption near edge structure shows that the La and Ce nitrates are partially bio transformed into oxides by the leaves which might explain the harmful effects.

关键词： Leaf fertilization Rare earth elements Soybean X-ray fluorescence spectroscopy X-ray absorption spectroscopy

Identification of quantitative trait loci and associated candidate genes for pregnancy success in Angus–Brahman crossbred heifers

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Qualification and validation test methodology of the open-source CubeSat FloripaSat-I

畜牧与生物技术杂志(英文版) 2024年第1期

作者： Quinn A.Hoorn gabriel A.Zayas eduardo E.Rodriguez Laura M.Jensen Raluca G.Mateescu Peter J.Hansen

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Journal of Systems Engineering and Electronics 2020年第6期31卷 1230-1244页

作者： MARCELINO gabriel Mariano FILHO Edemar Morsch MARTINEZ Sara Vega DE MATTOS AndréMartins Pio SEMAN Laio Oriel SLONGO Leonardo Kessler BEZERRA eduardo Augusto Department of Electrical Engineering Federal University of Santa CatarinaFlorianópolis 88040-900Brazil SENAI Institute of Innovation in Embedded Systems Florianópolis 88054-700Brazil School of Sea Science and TechnologyUniversity of Vale do ItajaíItajaí88302-901Brazil

The FloripaSat-I project consists of an initiative from the Federal University of Santa Catarina(UFSC),in Brazil,to train students to design,test and integrate innovative space *** group just developed its first open-source CubeSat,the FloripaSat-I,which aims to empower students to develop space systems through a practical approach,where they have full control of the design and test of a real *** project has already gone through all the stages of a CubeSat mission prior to the launching and operation stages.A prototype of the satellite,as well the engineering models 1 and 2(EM-I and EM-II)were *** expertise provided by the engineering models allows the development of a functional flight model(FM).This paper presents the validation and qualification tests that pass various FloripaSat-I models,from the engineering model to the flight *** stages of the project are described,the tests performed in each phase,as well as the lessons ***,this paper serves as a guidance for other university teams that want to test their own CubeSats,as well as teams that want to use the open-source hardware and software left as heritage by this project.

关键词： embedded system nanosatellite cubesats test methodology