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Carcinosarcoma of the breast:Facing the challenge of a rare nosologic entity

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World Journal of Clinical Cases 2025年第2期13卷 14-20页

作者： Aikaterini Mastoraki Maria Tsamopoulou Foivos-Konstantinos Stamatis Alexios Strimpakos Ero Mouchtouri Christiana Panagi evgenia Mela Sotiria Mastoraki Aristotelis Kechagias Dimitrios Schizas Department of Surgery National and Kapodistrian University of AthensLaikon General HospitalAthens 11527Greece Department of Surgery National and Kapodistrian University of AthensAthens 11527Greece Department of Medical Oncology Hygeia HospitalAthens 15123Greece Department of Radiology Henry Dunant Hospital CenterAthens 11526Greece Department of Surgery Athens Metropolitan HospitalAthens 15562Greece

Carcinosarcoma(CS),also known as metaplastic breast carcinoma with mesenchymal differentiation,is one of the five distinct subtypes of metaplastic breast *** is considered as a mixed,biphasic neoplasm consisting of a carcinomatous component combined with a malignant nonepithelial element of mesenchymal origin without an intermediate transition *** cellular origin of this neoplasm remains controversial,most researchers declare that neoplastic cells derive from a cellular structure with potential biphasic *** recent research on the therapeutic strategies against CS neoplastic disorders,surgical resection appears the only potentially curative *** CS metastasize by the lymphatic route,axillary assessment with sentinel lymph node biopsy and/or axillary lymph node dissection is always ***,the tumor also presents a hematogenous metastatic pattern including pleural,pulmonary,liver,brain and less commonly bone ***,surgical removal of breast CS does not necessarily ensure patient’s long-term ***,alternative therapies,such as radio-and chemotherapy proved insufficient and 5-year survival rate is ***,there is evidence that following surgery,the combination of radio and chemotherapy is associated with a better prognosis than either treatment *** aim of this review is to evaluate the results of surgical treatment for breast CS with special reference to the extent of its histological *** features,histogenesis,morphological and immunochemical findings are discussed,while the role of current diagnostic and therapeutic management of this aggressive neoplasm is emphasized.

关键词： Carcinosarcoma Breast Diagnostic approach Therapeutic management Prognostic parameters

Functional impacts of non-coding RNA processing on enhancer activity and target gene expression

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Journal of Molecular Cell Biology 2019年第10期11卷 868-879页

作者： evgenia Ntini Annalisa Marsico Max Planck Institute for Molecular Genetics 14195BerlinGermany Free University Berlin 14195BerlinGermany Institute of Computational Biology Helmholtz Zentrum MunchenMunchenGermany

Tight regulation of gene expression is orchestrated by *** recent research advancements,it is becoming clear that enhancers are not solely distal regulatory elements harboring transcription factor binding sites and decorated with specific histone marks,but they rather display sign atures of active transcription,showingdistinct degrees oftranscription unit ***,a substantial fraction of enhancers give rise to different species of non-coding RNA transcripts with an unprecedented range of potential *** this review,we bring together data from recent studies indicating that non-coding RNA transcription from active enhancers,as well as enhancer-produced long non-coding RNA transcripts,may modulate or define the functional regulatory potential ofthe cognate *** addition,we summarize supporting evidence that RNA processing ofthe enhancer-associated long non-coding RNA transcripts may constitute an additional layer of regulation of enhancer activity,which contributes to the control and final outcome of enhancer-targeted gene expression.

关键词： transcription enhancer RNA processing cotranscriptional RNA splicing chromatin long non-coding RNA(IncRNA)

Numerical study on fatigue crack propagation behaviors in lubricated rolling contact

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Chinese Journal of Aeronautics 2021年第9期34卷 24-36页

作者： Haifeng HE Huaiju LIU Caichao ZHU Andrea mura State Key Laboratory of Mechanical Transmissions Chongqing UniversityChongqing 400044China Department of Mechanical and Aerospace Engineering Politecnico di TorinoTorino 10129Italy

The surface-initiated Rolling Contact Fatigue(RCF)including pitting and micro-pitting is one of the key issues affecting the reliability of tribological components such as gears and bearings used in various *** this work,a surface-initiated crack Finite Element(FE)model which considers the effect of lubricant on crack faces was developed to investigate surface-initiated RCF using an automatic crack propagating Python *** lubricating states,initial crack parameters and loading conditions were simulated to analyze the evolution of crack propagation and the Stress Intensity Factors(SIFs).The RCF crack propagation path and life were predicted by employing the Maximum Tangential Stress(MTS)criterion coupled with the Paris’s law.A typical RCF failure is predicted in the numerical *** reveal that the lubricating pressurization dominates the surface-initiated *** addition,the initial crack angle has a significant effect on the RCF crack propagation path and the fatigue life.

关键词： Fatigue crack propagation Finite element Life prediction Lubricating states Rolling Contact Fatigue(RCF) Stress Intensity Factors(SIFs)

Multifunctional 2D materials for antiviral protection and detection

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National Science Review 2022年第5期9卷 8-9页

作者： Daria V.andreeva Kostya S.Novoselov Department of Materials Science and Engineering National University of Singapore Chongqing 2D Materials Institute National Graphene Institute University of Manchester

Two-dimensional (2D) materials [1]with their high surface to volume ratio,flexibility,tunable electronic properties,and most importantly—the large variety of the properties covered by the members of the 2D family—have already found their way to many applications in very different areas of technology[2].One of the most promising areas of applications for 2D crystals remains healthcare [3],where such materials have been considered for drug delivery,

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Analysing light pipe two-side aperture in dense population housing to improve the visual and thermal condition

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Energy and Built Environment 2024年第5期5卷 787-799页

作者： Tika Hanjani ova Candra Dewi Nandy Putra Department of Architecture Faculty of EngineeringUniversitas IndonesiaKampus UIDepok16424Indonesia Applied Heat Transfer Research Group Department of Mechanical EngineeringUniversitas IndonesiaKampus UIDepok16424Indonesia

Daylight is one of the essential criteria for decent ***,in an urban kampung,access to daylight is limited due to the high-density population in urban Kampung *** study aims to improve the visual and thermal conditions by modifying the aperture of the light pipe based on visual daylight distribution,illuminance level,and thermal conditions in multi-storey houses in hot-humid *** pipe was developed experi-mentally through the simulation model to investigate the performance and impact on the visual and thermal conditions like operational temperature and RH in densely populated Kampung Kota without vertical *** to the results,the two-aperture light pipe residential space enhanced the current situation but did not fulfill the *** two aperture light pipe visually improved daylight distribution by 1.05%-31.36%and illumination level by 8.4%-14.8%.We also found that light pipe also impacts thermal conditions with a 10.92%RH reduction while at the same time increasing temperature up to 10.57%.Therefore,it can be concluded that a two-aperture light pipe has the potential to be applied to actual conditions in hot-humid climates.

关键词： Daylight Light pipe two aperture Densely populated urban kampung Housing Hot-humid climates

Finite Volume Evolution galerkin Methods for the Shallow Water Equations with Dry Beds

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Communications in Computational Physics 2011年第7期10卷 371-404页

作者： Andreas Bollermann Sebastian Noelle Maria Lukacova-Medvid’ova IGPM RWTH AachenTemplergraben 5552062 AachenGermany Institut fur Mathematik Universitat MainzStaudingerweg 955099 MainzGermany.

We present a new Finite Volume Evolution galerkin(FVEG)scheme for the solution of the shallow water equations(SWE)with the bottom topography as a source *** new scheme will be based on the FVEG methods presented in(Noelle and Kraft,***.,221(2007)),but adds the possibility to handle dry *** most important aspect is to preserve the positivity of the water *** present a general approach to ensure this for arbitrary finite volume *** main idea is to limit the outgoing fluxes of a cell whenever they would create negative water ***,this corresponds to the absence of fluxes in the presence of *** is then re-established by splitting gravitational and gravity driven parts of the ***,a new entropy fix is introduced that improves the reproduction of sonic rarefaction waves.

关键词： Well-balanced schemes dry boundaries shallow water equations evolution galerkin schemes source terms

Research of Mechanical and Thermal Properties of Composite Material Based on Gypsum and Straw

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Journal of Renewable Materials 2022年第7期10卷 1859-1873页

作者： Nikola Vavřínová Kateřina Stejskalová JiříTeslík Kateřina Kubenková JiříMajer Faculty of Civil Engineering VSB-Technical University of OstravaOstrava70800Czech Republic

This article is focused on the investigation of the mechanical and thermal properties of composite material that could be used for the production of plaster or *** composite material is made of gypsum and reinforcing natural *** article verifies whether this natural reinforcement can improve the investigated properties compared to conventional plasters and gypsum plasterboards made of pure *** this composite material,high-strength plasterboards could then be produced,which meet the higher demands of users than conventional gypsum *** their production,natural waste materials would be used *** part of the development of new building materials,it is necessary to specify essential characteristics for their later use in civil *** wheat straw and three gypsum classes with strengths G2(2 MPa)—gypsum Class I.,G5(5 MPa)—gypsum Class *** G16(16 MPa)—gypsum Class *** used to create the test *** were made with different ratios of the two ingredients,with the percentages of straw being 0%,2.5%,and 5%for each gypsum *** first part of the article describes how the increasing proportion of straw affects the composite’s mechanical properties(flexural strength and compressive strength).The second part of the article focuses on the change of thermal properties(thermal conductivity and specific heat capacity).The last part of the article mentions the verification of the fire properties(single-flame source fire test and gross heat of combustion)of this composite *** research has shown that the increasing proportion of straw reinforcement caused a deterioration in the flexural strength(up to 56.49%in the *** of gypsum Class II.)and compressive strength(up to 80.27%in the *** of gypsum Class III.)and an improvement in the specific heat capacity and thermal conductivity(up to 31.40%in the ***).This composite material is thus not suitable for the production of high-streng

关键词： Composite material gypsum plasterboard crushed straw flexural strength compressive strength thermal conductivity specific heat capacity ignitability gross heat of combustion

Inflammatory priming of mesenchymal stem cells:Focus on growth factors enhancement

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BIOCELL 2022年第9期46卷 2049-2052页

作者： ALEKSANDRA GORNOSTAEVA ELENA andreeva LUDMILA BURAVKova Cell Physiology Laboratory Institute of Biomedical Problems of Russian Academy of SciencesMoscow123007Russia

Multipotent mesenchymal stromal cells(MSCs)are actively involved in reparation and inflammation processes,providing damaged tissue reparation and suppressing immune cell responses in *** effects are mostly due to the production of a wide range of paracrine factors,including growth factors and immunomodulatory *** induce immunosuppressive activity,MSCs are primed by inflammatory cytokines,which results in an increased production of immunomodulatory ***,stimulation of reparative properties is also *** viewpoint manuscript highlights the possibilities of inflammatory priming to increase the production of growth factors by MSCs.

关键词： Multipotent mesenchymal stromal cells Priming Growth factors

Soil erosion: An important indicator for the assessment of land degradation neutrality in Russia

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International Soil and Water Conservation Research 2020年第4期8卷 418-429页

作者： Petr Tsvmbarovich German Kust Mikhail Kumani Valentin Golosov Olga andreeva Institute of Geography RAS Russian Academy of SciencesMoscowRussia Lomonosov Moscow State University MoscowRussia Kursk State University KurskRussia

This review of soil erosion(SE)studies in Russia focuses on two main tasks:(i)ensuring the completeness and reliability of SE data in Russia,a large country(17.1 million km2)with a variety of natural and socio-economic causes of land degradation,(ii)assessing the possibility of including a SE indicator among the indicators of land degradation neutrality(LDN).A wide range of statistical,remote sensing,mathematical modeling *** results of scientific and field studies obtained at different levels were *** is asserted that in Russia the total area of eroded lands and those under erosion risk occupy more than 50%of all agricultural lands,whereas soil fertility of croplands decreased in Soviet time(from 1950s to 1980s)by 30-60%only due to water ***,recent scientific studies indicate a decrease in erosion rate and in the area of eroded land during the last 30-40 years as a result of abandonment of arable land and subsequent overgrown with natural *** climate change resulting in decrease of the depth of soil freezing,flow of spring runoff also adds to the decrease of soil *** SE indicator was suggested as an important complement to three global LDN *** national and subnational level,it can be interpreted through such indices as"Rate of soil loss"(ton ha-1 yr-1)and"Total soil loss"(1000 tons,in certain area during selected time period).At local level the set of indices can be wider and site-specific,including those obtained through remote sensing data by using the classifier of thematic applications of remote sensing technologies;the example was tested at the local site.

关键词： Russian Federation Soil erosion Land degradation neutrality