Carcinosarcoma of the breast:Facing the challenge of a rare nosologic entity

作     者：Aikaterini Mastoraki Maria Tsamopoulou Foivos-Konstantinos Stamatis Alexios Strimpakos Ero Mouchtouri Christiana Panagi Evgenia Mela Sotiria Mastoraki Aristotelis Kechagias Dimitrios Schizas 

作者机构：Department of SurgeryNational and Kapodistrian University of AthensLaikon General HospitalAthens 11527Greece Department of SurgeryNational and Kapodistrian University of AthensAthens 11527Greece Department of Medical OncologyHygeia HospitalAthens 15123Greece Department of RadiologyHenry Dunant Hospital CenterAthens 11526Greece Department of SurgeryAthens Metropolitan HospitalAthens 15562Greece 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志（英文）)

年 卷 期：2025年第13卷第2期

页      面：14-20页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Carcinosarcoma Breast Diagnostic approach Therapeutic management Prognostic parameters 

摘      要：Carcinosarcoma(CS),also known as metaplastic breast carcinoma with mesenchymal differentiation,is one of the five distinct subtypes of metaplastic breast *** is considered as a mixed,biphasic neoplasm consisting of a carcinomatous component combined with a malignant nonepithelial element of mesenchymal origin without an intermediate transition *** cellular origin of this neoplasm remains controversial,most researchers declare that neoplastic cells derive from a cellular structure with potential biphasic *** recent research on the therapeutic strategies against CS neoplastic disorders,surgical resection appears the only potentially curative *** CS metastasize by the lymphatic route,axillary assessment with sentinel lymph node biopsy and/or axillary lymph node dissection is always ***,the tumor also presents a hematogenous metastatic pattern including pleural,pulmonary,liver,brain and less commonly bone ***,surgical removal of breast CS does not necessarily ensure patient’s long-term ***,alternative therapies,such as radio-and chemotherapy proved insufficient and 5-year survival rate is ***,there is evidence that following surgery,the combination of radio and chemotherapy is associated with a better prognosis than either treatment *** aim of this review is to evaluate the results of surgical treatment for breast CS with special reference to the extent of its histological *** features,histogenesis,morphological and immunochemical findings are discussed,while the role of current diagnostic and therapeutic management of this aggressive neoplasm is emphasized.