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Activation of endogenous neurogenesis and angiogenesis by basic fibroblast growth factor-chitosan gel in an adult rat model of ischemic stroke

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Neural Regeneration Research 2024年第2期19卷 409-415页

作者： Hongmei Duan Shulun Li Peng Hao Fei Hao Wen Zhao Yudan Gao Hui Qiao yiming gu Yang Lv Xinjie Bao Kin Chiu Kwok-Fai So Zhaoyang Yang Xiaoguang Li Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Beijing Key Laboratory for Biomaterials and Neural Regeneration School of Engineering MedicineBeihang UniversityBeijingChina Department of Epidemiology and Statistics School of Public Health and ManagementNingxia Medical UniversityYinchuanNingxia Hui Autonomous RegionChina Department of Physical Education Capital University of Economics and BusinessmBeijingChina Department of Neurosurgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Psychology State Key Lab of Brain and Cognitive SciencesThe University of Hong KongHong Kong Special Administration RegionChina guangdong-Hongkong-Macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhouGuangdong ProvinceChina Bioland Laboratory(guangzhou Regenerative Medicine and Health guangdong Laboratory) GuangzhouGuangdong ProvinceChina Department of Ophthalmology and State Key Laboratory of Brain and Cognitive Sciences The University of Hong KongHong Kong Special Administration RegionChina Center for Brain Science and Brain-Inspired Intelligence Guangdong-Hong Kong-Macao Greater Bay AreaGuangzhouGuangdong ProvinceChina Co-innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Biomedical Engineering School of Biological Science and Medical EngineeringBeihang UniversityBeijingChina

Attempts have been made to use cell transplantation and biomaterials to promote cell proliferation,differentiation,migration,and survival,as well as angiogenesis,in the context of brain ***,whether bioactive materials can repair the damage caused by ischemic stroke by activating endogenous neurogenesis and angiogenesis is still *** this study,we applied chitosan gel loaded with basic fibroblast growth factor to the stroke cavity 7 days after ischemic stroke in *** gel slowly released basic fibroblast growth factor,which improved the local microenvironment,activated endogenous neural stem/progenitor cells,and recruited these cells to migrate toward the penumbra and stroke cavity and subsequently differentiate into neurons,while enhancing angiogenesis in the penumbra and stroke cavity and ultimately leading to partial functional *** study revealed the mechanism by which bioactive materials repair ischemic strokes,thus providing a new strategy for the clinical application of bioactive materials in the treatment of ischemic stroke.

关键词： adult endogenous neurogenesis angiogenesis basic fibroblast growth factor-chitosan gel chitosan functional recovery ischemic stroke neural stem cell newborn neuron

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上海失能老人社区照护服务质量提升路径研究

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运筹与模糊学 2024年第2期14卷 832-846页

作者：顾一鸣上海工程技术大学管理学院上海

随着信息技术的不断发展和社会的迅速发展,失能老人的生活服务质量正在不断得到提高,但是相应的问题也随之出现,失能老人的身体问题也在不断的开始出现并且开始增多,而社区作为失能老人的居住单位,具有直接的照护作用,如何发挥社区照护... 详细信息

随着信息技术的不断发展和社会的迅速发展,失能老人的生活服务质量正在不断得到提高,但是相应的问题也随之出现,失能老人的身体问题也在不断的开始出现并且开始增多,而社区作为失能老人的居住单位,具有直接的照护作用,如何发挥社区照护服务,提升失能老人的社区照护服务质量成为了当前的显著问题。为解决该问题,文章以上海市为范例,对失能老人的社区照护服务质量作为创新研究视角,依托福利多元理论、马斯洛需求层次理论等理论依据,结合问卷调查,探究上海市的失能老人对现阶段社区照护服务的满意度进行研究,并结合结构方程,去探究影响上海市的失能老人对现阶段社区照护服务质量的影响因素。研究结果发现,需要增强政府领导力、加强政策保证进而去提高上海市医养结合社区医疗服务质量。

关键词：失能老人社区照护服务质量

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2D VARIABLE FACTOR LEARNING CONTROLLER AND ITS APPLICATION IN PNEUMATIC SERVO SYSTEM

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Chinese Journal of Mechanical Engineering 1998年第4期11卷 24-29页

作者： Lu, Lu gu, yiming Shi, Weixiang Xi'an Jiaotong Univ Xi'an China

A new learning control law is presented which can obtain learning gain matrices from a recursive identifier along the learning axis. The system convergence is proved when disturbances exist in the system. Finally it i... 详细信息

关键词： Learning control Convergence Pneumatic servo system

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紧急宫颈环扎术后延长孕周的影响因素

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中华围产医学杂志 2024年第8期27卷 662-667页

作者：朱伟英艾玲严琴芳马蔷项生群顾一鸣嘉兴市妇幼保健院(温州医科大学嘉兴市妇女儿童医院)产科嘉兴314000

目的探讨紧急宫颈环扎术后延长孕周的影响因素。方法回顾性纳入2019年1月1日至2022年9月1日于嘉兴市妇幼保健院诊断宫颈机能不全并于孕12~26周行紧急宫颈环扎术的单胎妊娠孕妇88例,28周后分娩者作为环扎成功组(n=77),<28周分娩/流产者... 详细信息

目的探讨紧急宫颈环扎术后延长孕周的影响因素。方法回顾性纳入2019年1月1日至2022年9月1日于嘉兴市妇幼保健院诊断宫颈机能不全并于孕12~26周行紧急宫颈环扎术的单胎妊娠孕妇88例,28周后分娩者作为环扎成功组(n=77),<28周分娩/流产者作为环扎失败组(n=11)。采用两独立样本t检验或Mann-Whitney U检验进行组间比较,采用单因素分析和多个回归方程筛选术后延长孕周的影响因素。结果紧急宫颈环扎术环扎成功率(≥28周分娩率)为87.5%(77/88),其中孕28~31周+6分娩者6例(6/77,7.8%),孕32~33周+6分娩者2例(2/77,2.6%),孕34~36周+6分娩者16例(16/77,20.8%),≥37周分娩者53例(53/77,68.8%)。多个回归方程分析结果显示早孕期流产3次(β=-5.1,95%CI:-9.5~-0.7)、早孕期流产5次(β=-11.8,95%CI:-22.1~-1.6)、产次2次(β=-6.9,95%CI:-12.9~0.9)、环扎孕周(β=-0.6,95%CI:-1.0~-0.3)、环扎术前宫颈外口扩张<15 mm(β=-12.1,95%CI:-22.5~-1.8)和环扎术前宫颈外口扩张≥15 mm(β=-11.0,95%CI:-21.4~-0.71)是环扎术后延长孕周的影响因素;校正孕妇年龄及宫颈环扎术前体重后,早孕期流产5次(β=-18.1,95%CI:-28.3~-7.8)、环扎孕周(β=-0.6,95%CI:-1.0~-0.3)和环扎术前宫颈外口扩张≥15 mm(β=-11.4,95%CI:-21.2~-1.6)是环扎术后延长孕周的影响因素(P值均<0.05)。结论早孕期流产次数、环扎孕周及环扎术前宫颈外口扩张≥15 mm是影响紧急宫颈环扎术后延长孕周的因素。

关键词：紧急宫颈环扎术延长孕周影响因素

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Low-cost preferential different amine grafted silica spheres adsorbents for DAC CO_(2)removal

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Journal of Energy Chemistry 2022年第12期75卷 494-503,I0013页

作者： Salman Qadir Hongjiu Su Defu Li yiming gu Shengsheng Zhao Sheng Wang Shudong Wang Dalian Institute of Chemical Physics Chinese Academy of SciencesDalian 116023LiaoningChina University of Chinese Academy of Sciences Beijing 100049China

DAC CO_(2)capture is gaining wide attention as one of the most difficult carbon approaches to tackle climate *** this work,different pore-size silica spheres were grafted using different amine groups such as APTES,APTMS,and ***,all samples based on the wet and dry grafting method were used for CO_(2)adsorption isotherm at room temperature and pressure(298 K and 1 bar).The sample based on the wet grafting(Silica-APTES-W)sample shows the highest CO_(2)uptake 1.67 mmol/***,the adsorption isotherm of the Silica-APTES-W sample was showed a high capacity of CO_(2)1.2 mmol/g at 25℃,which describes the strong physical interaction between CO_(2)and *** isosteric adsorption of Silica-APTES-W also confirmed that the physical adsorption was dominant because of low adsorption heat ranging from 23 to 37 k J/***,the fixed bed experiment was conducted with 2000 ppm CO_(2)that obtains the optimal working capacity 4.5 m L/g with the lowest regeneration temperature 90℃.It was shown that Silica-APTES-W sample was superior performance for DAC CO_(2)capture in practical applications.

关键词： CO_(2)capture Direct air capture Silica spheres APTES APTMS Diamine

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中药调控小胶质细胞极化改善抑郁症研究进展

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中华中医药学刊 2024年第6期42卷 107-112,I0018页

作者：顾一鸣马巧琳吕转高静苏凯奇罗萌冯晓东河南中医药大学河南郑州450046 河南中医药大学第三附属医院河南郑州450000 河南中医药大学第一附属医院河南郑州450099

抑郁症是危害人类健康生活的常见精神类疾病,其发病机制尚未明确。目前认为神经炎症假说与抑郁症病理生理关系密切。该假说提出,在抑郁症病程中,持续的刺激过度激活小胶质细胞(Microglia, MG)的M1极化表型,通过分泌大量促炎因子,造成脑... 详细信息

抑郁症是危害人类健康生活的常见精神类疾病,其发病机制尚未明确。目前认为神经炎症假说与抑郁症病理生理关系密切。该假说提出,在抑郁症病程中,持续的刺激过度激活小胶质细胞(Microglia, MG)的M1极化表型,通过分泌大量促炎因子,造成脑部病理损伤,加重抑郁的病理发展。因而通过调控MG极化表型,可能是改善抑郁症的一种有效干预策略。临床会应用抗炎药物改善患者抑郁情绪,虽然有一定的疗效,但存在适用范围窄、不良反应明显等局限性。中药具有多靶点、多途径的特点,其药性内容丰富且复杂。近年来,研究发现诸多中药通过修复线粒体功能障碍、促进脑源性神经营养因子(Brain-derived neurotrophic factor, BDNF)、调节蛋白表达、调节神经炎症反应等机制发挥了抗抑郁作用。因此,以MG为治疗靶点,对中药和复方减轻神经炎症改善抑郁症的文献研究进行梳理和探讨,期望为临床治疗抑郁症提供新的治疗思路。

关键词：抑郁症小胶质细胞极化中药作用机制

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Byzantine Robust Federated Learning Scheme Based on Backdoor Triggers

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Computers, Materials & Continua 2024年第5期79卷 2813-2831页

作者： Zheng Yang Ke gu yiming Zuo School of Computer and Communication Engineering Changsha University of Science and TechnologyChangsha410114China

Federated learning is widely used to solve the problem of data decentralization and can provide privacy protectionfor data owners. However, since multiple participants are required in federated learning, this allows attackers tocompromise. Byzantine attacks pose great threats to federated learning. Byzantine attackers upload maliciouslycreated local models to the server to affect the prediction performance and training speed of the global model. Todefend against Byzantine attacks, we propose a Byzantine robust federated learning scheme based on backdoortriggers. In our scheme, backdoor triggers are embedded into benign data samples, and then malicious localmodels can be identified by the server according to its validation dataset. Furthermore, we calculate the adjustmentfactors of local models according to the parameters of their final layers, which are used to defend against datapoisoning-based Byzantine attacks. To further enhance the robustness of our scheme, each localmodel is weightedand aggregated according to the number of times it is identified as malicious. Relevant experimental data showthat our scheme is effective against Byzantine attacks in both independent identically distributed (IID) and nonindependentidentically distributed (non-IID) scenarios.

关键词： Federated learning Byzantine attacks backdoor triggers

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DEEP GROUND STATES RELATED TO Fe IN GaAs_(1-x)P_(x) ALLOY SYSTEM

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Chinese Physics Letters 1987年第9期4卷 405-408页

作者： gu yiming HUANG Mingzhu WANG Keling University of Science and Technology of China Hefei

A theory suggested by Vogl et *** extended to the iron-doped GaAs_(1-x)P_(x) alloy *** deep ground states(including acceptor(Fe/Fe)levels,donor(Fe/Fe)levels,local charges and spin densities)are predicted for different composition *** calculated results show good agreement with the relevant experimental data and reveal their variation trends.

关键词： alloy

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THE DEEP LEVELS IN GaSb/AlSb(00l)SUPERLATTICES

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Chinese Physics Letters 1987年第6期4卷 253-256页

作者： HUANG Mingzhu gu yiming REN Shangyuan Department of Physics University of Science and Technology of ChinaHefei

The electronic states,especially the deep levels of the defects in GaSb/AlSb(001)superlattices have been *** band gap becomes larger and the donor binding energy becomes deeper with the decrease of the quantum well **... 详细信息

关键词： GaSb AlSb donor

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Effect of Steam Explosion Technology Main Parameters on Moso Bamboo and Poplar Fiber

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Journal of Renewable Materials 2021年第3期9卷 585-597页

作者： Biqing Shu Qin Ren Lu Hong Zhongping Xiao Xiaoning Lu Wenya Wang Junbao Yu Naiqiang Fu yiming gu Jinjun Zheng The College of Materials Science and Engineering Nanjing Forestry UniversityNanjing210037China College of Civil Engineering Yangzhou Polytechnic InstituteYangzhou225127China

One of the large-scale industrial applications of Moso bamboo and poplar in China is the production of standardized *** making fiberboard,a steam blasting pretreatment without the addition of traditional adhesives has become increasingly popular because of its environmental friendliness and wide *** this study,the steam explosion pretreatment of Moso bamboo and poplar was *** steam explosion pressure and holding time were varied to determine the influence of these factors on fiber quality by investigating the morphology of the fiber,the mass ratio of the unexploded specimen at the end face,the chemical composition,and the tensile *** following conclusions were drawn:As the steam burst pressure and holding time increased,more cellulose and hemicellulose degradation occurred(the degradation of hemicellulose was greater than that of cellulose),the lignin content rose,and the fiber bundle strength *** degradation of bamboo cellulose was slightly higher than that of poplar,and the degradation of poplar hemicellulose was significantly faster than that of ***,increasing the steam explosion pressure and pressure holding time could not effectively increase the lignin *** is recommended to use a steam blasting pressure of 2.5 MPa or 3.0 MPa and a holding time of 180 s to perform steam blasting on bamboo and poplar specimens.

关键词： Fiber binderless fiberboard steam explosion moso bamboo poplar

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