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Post-fabrication phase trimming of Mach–Zehnder interferometers by laser annealing of germanium implanted waveguides

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Photonics Research 2017年第6期5卷 97-101页

作者： XIA CHEN MILAN M.MILOSEVIC DAVID J.tHOMSON ALI Z.KHOKHAR YOHANN FRANZ ANtOINE F.J.RUNGE SAKELLARIS MAILIS ANNA C.PEACOCK graham t.reed Optoelectronics Research Centre University of Southampton

We demonstrate a novel high-accuracy post-fabrication trimming technique to fine-tune the phase of integrated Mach–Zehnder interferometers, enabling permanent correction of typical fabrication-based phase errors. the effective index change of the optical mode is 0.19 in our measurement, which is approximately an order of magnitude improvement compared to previous work with similar excess optical loss. Our measurement results suggest that a phase accuracy of 0.078 rad was achievable with active feedback control.

关键词： Post-fabrication phase trimming of Mach Zehnder interferometers by laser annealing of germanium implanted waveguides MZI

Universal silicon ring resonator for error-free transmission links

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Photonics Research 2024年第4期12卷 701-711页

作者： JUNBO ZHU WEIWEI ZHANG KE LI BHARAt PANt MARtIN EBERt XINGZHAO YAN MEHDI BANAKAR DEHN t.tRAN CALLUM G.LIttLEJOHNS FUWAN GAN graham reed DAVID J.tHOMSON Optoelectronics Research Centre University of SouthamptonSouthampton SO171BJUK National Key Laboratory of Materials for Integrated Circuits Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China University of Chinese Academy of Sciences Beijing 100049China Peng Cheng Laboratory ShenzhenChina

We report the design, fabrication, and characterization of a universal silicon PN junction ring resonator for C band error-free communication links operated up to 50 Gb/s with co-designed optical modulation and detection performance. the universal p-n junction ring device shows co-designed detection responsivity up to 0.84 A/W, in conjunction with a modulation efficiency of -4 V·mm and>8 d B optical modulation extinction ratio, enabling C band 50 Gb/s NRZ communication link with a bit error rate≤3×10^(-12).

关键词： Gb/s resonator communication

High-speed silicon photonic electro-optic Kerr modulation

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Photonics Research 2024年第1期12卷 51-60页

作者： JONAtHAN PELtIER WEIWEI ZHANG LEOPOLD VIROt CHRIStIAN LAFFORGUE LUCAS DENIEL DELPHINE MARRIS-MORINI GUY AUBIN FARAH AMAR DENH tRAN XINGZHAO YAN CALLUM G.LIttLEJOHNS CARLOS ALONSO-RAMOS KE LI DAVID J.tHOMSON graham reed LAURENt VIVIEN University Paris-Saclay CNRSCentre for Nanoscience and Nanotechnology(C2N)Palaiseau 91120France University Grenoble Alpes CEALETIGrenoble 38000France Optoelectronics Research Centre Zepler Institute for Photonics and NanoelectronicsFaculty of Engineering and Physical SciencesUniversity of SouthamptonSouthampton SO171BJUK

Silicon-based electro-optic modulators contribute to easing the integration of high-speed and low-power consumption circuits for classical optical communications and data *** the plasma dispersion modulation,an alternative solution in silicon is to exploit the DC Kerr effect,which generates an equivalent linear electro-optical effect enabled by applying a large DC electric *** some theoretical and experimental studies have shown its existence in silicon,limited contributions relative to plasma dispersion have been achieved in high-speed modulation so *** paper presents high-speed optical modulation based on the DC Kerr effect in silicon PIN *** contributions of both plasma dispersion and Kerr effects have been analyzed in different waveguide configurations,and we demonstrated that the Kerr induced modulation is dominant when a high external DC electric field is applied in PIN ***-speed optical modulation response is analyzed,and eye diagrams up to 80 Gbit/s in NRZ format are obtained under a *** of 30 *** work paves the way to exploit the Kerr effect to generate high-speed Pockels-like optical modulation.

关键词： waveguide dispersion effect

Matrix Crack Detection by an Embedded Polarimetric Sensor

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Journal of Materials Science & technology 2006年第2期22卷 220-224页

作者： H. Wang S.L. Ogin A.M. thorne G. t.reed School-of Engineering University of Surrey Guildford Surrey GU2 5XH UK School of Electronic Engineering Information and Mathematics University of Surrey Guildford Surrey GU2 5XH UK

Polarimetric optical fibre sensors have been embedded within the 0° ply and close to the 0/90 interface of transparent cross-ply GFRP coupons. the laminate ply cracks may initiate and propagate across the coupon when the coupons were subjected to an increasing quasi-static load in a servo-hydraulic testing machine. Crack accumulation have been monitored using a long gauge-length extensometer. the response of the strain signal, the optical signal and the load signal to cracks at different positions in the coupon in relation to the extensometer and optical sensor positions have been acquired and compared by means of video images of the crack growth. the relationship between crack growth and sensor response was demonstrated. the displacement induced by a new transverse crack has been predicted and compared with experimental data.

关键词： Matrix cracking Polarimetric sensor Fourier analysis

Risk of hepatitis B virus reactivation in cancer patients undergoing treatment with tyrosine kinase-inhibitors

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World Journal of Gastroenterology 2024年第24期30卷 3052-3058页

作者： Bansi P Savaliya Ramin Shekouhi Fatima Mubarak Harsheen K Manaise Paola Berrios Jimenez Gabrielle Kowkabany reed A Popp Kyle Popp Emmanuel Gabriel Department of Surgery Medical Academy Named after SI Georgievsky of Vernadsky Crimean Federal UniversitySimferopol 295015CrimeaRussia Division of Plastic and Reconstructive Surgery Department of SurgeryUniversity of FloridaGainesvilleFL 32608United States Department of Surgery Aga Khan UniversityKarachi 74800SindhPakistan Department of Surgery Government Medical College and HospitalChandigarh 160030PunjabIndia Department of Surgery University of Puerto Rico School of MedicineSan Juan 00921Puerto Rico Department of Chemical and Biological Engineering University of AlabamaTuscaloosaAL 35487United States Department of Surgery University of Florida College of MedicineGainesvilleFL 32610United States Department of Surgery Florida State UniversityTallahasseeFL 32306United States Department of Surgery Mayo ClinicJacksonvilleFL 32224United States

this editorial commented on an article in the World Journal of Gastroenterology titled“Risks of Reactivation of Hepatitis B Virus in Oncological Patients Using tyrosine Kinase-Inhibitors:Case Report and Literature Analysis”by Colapietro et *** this editorial,we focused on providing a more comprehensive exploration of hepatitis B virus reactivation(HBVr)associated with the usage of tyrosine kinase inhibitors(tKIs).It includes insights into the mechanisms underlying HBV reactivation,the temporal relationship between tKIs and HBV reactivation,and preventive *** aim is to understand the need for nucleos(t)ide analogs(NAt)and serial blood tests for early recognition of reactivation and acute liver injury,along with management *** are considered to be an intermediate(1%-10%)of *** guidelines stipulate that patients receiving therapy with high or moderate risks of reactivation or recent cancer diagnosis must have at least tested hepatitis B surface antigen,anti-hepatitis B core antigen(HBc),and anti-hepatitis B surface ***-HBc screening in highly endemic areas means people with negative tests should be vaccinated against *** or nucleotide analogs(NAs)like entecavir(EtV),tenofovir disoproxil fumarate(tDF),and tenofovir alafenamide(tAF)form the basis of HBV reactivation prophylaxis and treatment during ***,lamivudine,telbivudine,and adefovir are generally discouraged due to their reduced antiviral efficacy and higher risk of fostering drug-resistant viral ***,these less effective NAs may still be utilized in cases where EtV,tDF,and tAF are not feasible treatment options.

关键词： Hepatitis B virus Reactivation Chronic hepatitis B tyrosine-kinase inhibitor Immunomodulators Immunosuppressant Nucleoside analogue Hemato-oncology

Amyloid-beta and tau protein beyond Alzheimer's disease

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Neural Regeneration Research 2024年第6期19卷 1262-1276页

作者： Morteza Abyadeh Vivek Gupta Joao A.Paulo Arezoo Gohari Mahmoudabad Sina Shadfar Shahab Mirshahvaladi Veer Gupta Christine t.O.Nguyen David I.Finkelstein Yuyi You Paul A.Haynes Ghasem H.Salekdeh Stuart L.graham Mehdi Mirzaei ProGene technologies Pty Ltd. 2. Department of Clinical Medicine Faculty of Medicine Health and Human Sciences Macquarie Medical School Macquarie University Department of Cell Biology Harvard Medical School School of Medicine Deakin University Department of Optometry and Vision Sciences School of Health Sciences Faculty of Medicine Dentistry and Health Sciences University of Melbourne the Florey Institute of Neuroscience and Mental Health The University of Melbourne School of Natural Sciences Macquarie University

the aggregation of amyloid-beta peptide and tau protein dysregulation are implicated to play key roles in Alzheimer’s disease pathogenesis and are considered the main pathological hallmarks of this devastating disease. Physiologically, these two proteins are produced and expressed within the normal human body. However, under pathological conditions, abnormal expression, posttranslational modifications, conformational changes, and truncation can make these proteins prone to aggregation, triggering specific disease-related cascades. Recent studies have indicated associations between aberrant behavior of amyloid-beta and tau proteins and various neurological diseases, such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis, as well as retinal neurodegenerative diseases like Glaucoma and age-related macular degeneration. Additionally, these proteins have been linked to cardiovascular disease, cancer, traumatic brain injury, and diabetes, which are all leading causes of morbidity and mortality. In this comprehensive review, we provide an overview of the connections between amyloid-beta and tau proteins and a spectrum of disorders.

关键词： amyloid-beta cancer cardiovascular diseases diabetes neurodegeneration tau traumatic brain injury

MMP-9 deficiency accelerates the progress of periodontitis

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Genes & Diseases 2024年第5期11卷 117-121页

作者： Chun-Yan Wan Yixin Yin Xiaoyan Li Meng Meng Liu graham Goldman Li-An Wu Feng Wang Dao-Shu Luo Zhuo Chen Wen-An Xu Stephen Chen Mary MacDougall Merry L.Lindsey Zhi Chen Shuo Chen Department of Endodontics The Affiliated Hospital of Qingdao UniversitySchool of StomatologyQingdao UniversityQingdaoShandong 266003China Department of Developmental Dentistry School of DentistryThe University of Texas Health Science Center at San AntonioSan AntonioTX 78229USA Oral Implantology Center Jinan Stomatological HospitalJinanShandong 250001China Department of Endodontics School and Hospital of StomatologyCheeloo College of MedicineShandong Key Laboratory of Oral Tissue RegenerationShandong Engineering Laboratory for Dental Materials and Oral Tissue RegenerationShandong UniversityJinanShandong 250012China Department of Pediatric Dentistry School of StomatologyThe Fourth Military Medical UniversityXi’anShaanxi 710032China Laboratory of Clinical Applied Anatomy Department of Human AnatomySchool of Basic Medical SciencesFujian Medical UniversityFuzhouFujian 350108China Key Laboratory for Oral Biomedical Research of Zhejiang Province Affiliated Hospital of StomatologyMedical CollegeZhejiang UniversityHangzhouZhejiang 310027China Department of Stomatology Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China UBC Faculty of Dentistry University of British ColumbiaVancouverBC V6T 1Z3Canada School of Graduate Studies and Research Meharry Medical College and Research BiologistResearch Service Nashville VA Medical CenterNashvilleTN 37208USA State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei-MOSt) Key Laboratory for Oral Biomedicine of Ministry of Education(KLOBM)School and Hospital of StomatologyWuhan UniversityWuhanHubei 430079China

Periodontitis is a chronic inflammatory disease caused by periodontopathic bacteria that affects periodontal support tissues.1 If left untreated,it results in loss of periodontal attachment and alveolar bone *** one-half of adults in the United States older than 30 years have periodontal disease.2 though the disease is initiated by bacterial infection,it activates host defense systems that eventually lead to the degradation of the *** periodontitis,the disease progress involves further production of pro-inflammatory mediators such as cytokines,proteolytic enzymes like matrix metalloproteinases(MMPs),and their inhibitors.

关键词： period eventually untreated

Regulation of proprietary traditional Chinese medicines in Australia

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Chinese Journal of Natural Medicines 2017年第1期15卷 12-14页

作者： David t. graham ISO technical committee 249 (1SO/tC 249) 7-C Shuguang Building 189 Pu 'an Road Shanghai 200021 China

this review article describes the regulation of proprietary Chinese medicines for the Australian market, which may permit many medicines used in traditional Chinese Medicine to have a simplified process of market acce... 详细信息

关键词： Regulation Australia Chinese medicines

Associations between health-related fitness and patient-reported symptoms in newly diagnosed breast cancer patients

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Journal of Sport and Health Science 2024年第6期13卷 851-862页

作者： Ki-Yong An Fernanda Z.Arthuso Myriam Filion Spencer J.Allen Stephanie M.Ntoukas Gordon J.Bell Jessica McNeil Qinggang Wang Margaret L.McNeely Jeff K.Vallance Lin Yang S.Nicole Culos-reed Leanne Dickau John R.Mackey Christine M.Friedenreich Kerry S.Courneya Faculty of Kinesiology Sportand RecreationCollege of Health SciencesUniversity of AlbertaEdmonton T6G 2H9Canada Department of Kinesiology School of Health and Human SciencesUniversity of North Carolina at GreensboroGreensboroNC 27412USA Department of Cancer Epidemiology and Prevention Research Cancer Care AlbertaAlberta Health ServicesCalgary T2S 3C3Canada Faculty of Rehabilitation Medicine University of AlbertaEdmonton T6G 2H9Canada Faculty of Health Disciplines Athabasca UniversityAthabasca T9S 3A3Canada Department of Oncology Cumming School of MedicineUniversity of CalgaryCalgary T2N 4N1Canada Faculty of Kinesiology University of CalgaryCalgary T2N 1N4Canada Faculty of Medicine and Dentistry University of AlbertaEdmonton T6G 2H9Canada

Background:Newly diagnosed breast cancer patients experience symptoms that may affect their quality of life,treatment outcomes,and *** and managing breast cancer-related symptoms soon after diagnosis is *** purpose of this study was to investigate the associations between health-related fitness(HRF)and patient-reported symptoms in newly diagnosed breast cancer ***:this study utilized baseline data from the Alberta Moving Beyond Breast Cancer Cohort Study that were collected within 90 days of *** measures included peak cardiopulmonary fitness(peak volume of oxygen consumption(VO_(2peak))),maximal muscular strength and endurance,flexibility,and body *** measures included depression,sleep quality,and *** multivariable logistic regression was performed for ***:Of 1458 participants,51.5%reported poor sleep quality,26.5%reported significant fatigue,and 10.4%reported moderate *** multivariable-adjusted models,lower relative VO_(2peak)was independently associated with a greater likelihood of all symptom measures,including moderate depression(pty(p=0.009),significant fatigue(p=0.008),any symptom(ptiple symptoms(ptrated threshold associations with all symptom measures such that all 3 lower quartiles exhibited similar elevated risk compared to the highest *** strength of the threshold associations varied by the symptom measure with odds ratios ranging from-1.5 for poor sleep quality to-3.0 for moderate depression and multiple ***,lower relative upper body muscular endurance was also independently associated with fatigue in a dose-response manner(p=0.001),and higher body weight was independently associated with poor sleep quality in an inverted U pattern(p=0.021).Conclusion:Relative VO_(2peak)appears to be a critical HRF component associated with multiple patient-reported symptoms in newly diag

关键词： Breast cancer Fatigue Depression Sleep quality Cardiorespiratory fitness