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Journal of Iron and Steel Research International 2024年第4期31卷 894-908页

作者： Yan-li Xin Zhi-ying gao Bo Tian qing-dong Zhang School of Mechanical Engineering University of Science and Technology BeijingBeijing 100083China

In the high-speed cold tandem rolling process of thin plate,chatter or slip instability gives rise to the deterioration of equipment and product *** instability behavior is closely related to interfacial friction-lubrication con-dition which is generally characterized by the friction ***,with higher and higher speed requirements,the commonly used model of friction coefficient is no longer applicable and accurate.A novel approach is suggested to calculate the speed-dependent friction coefficient,in which the viscosity-pressure-temperature effects of the lubricant,surface roughness states of work rolls and rolled piece are comprehensively involved and the mixed flm lubrication theory is ***,the influences of friction coefficient on the instability of slip and chatter are investigated for a five-stand cold tandem rolling *** one side,the critical friction coefficient for each stand is determined by calculating the corresponding slip factor;on the other hand,the friction coefficient varying with rolling speed is combined with the model of theoretical critical rolling speed presented under constant friction coefficient,so that the speed threshold is ***,the stable and unstable regions corresponding to the rear three stands are individually discussed,and the technical strategies are proposed to suppress both slip and chatter frequently occurring in the actual rolling process.

关键词： Cold tandem rolling:Oil film thickness Speed-dependent friction coefficient-Slip:Chatter

Tribological and Corrosion Properties of the CoCrAlYTaSiC-xCNTs Coatings Deposited by Laser Cladding

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Acta Metallurgica Sinica(English Letters) 2024年第4期37卷 726-738页

作者： hai Zhao Yi Ding Wei gao Bo Yu Jinghui Li Mingya Zhang School of Material Science and Engineering Anhui University of TechnologyMaanshan243002China Maanshan Iron&Steel Co. LtdMaanshan243000China Applied Technology Research Institute Jiujiang Vocational UniversityJiujiang332000China School of Metallurgical Engineering Anhui University of TechnologyMaanshan243002China

The MCrAlY coating has been potential candidate for the parts applied in friction and corrosion conditions, and CNTs (carbon nanotubes) are expected to improve the service performance of coatings owing to high lubrication and low chemical reactivity. In this work, a systematic investigation on the tribological and corrosion properties of CoCrAlYTaSiC-xCNTs coatings deposited by laser melting was analyzed. Results showed that the coatings had good-quality without typical metallurgical defects. The CNTs addition homogenized and refined the microstructure of coating, and also improved the tribological and corrosion properties. As the CNTs content changed from 0 to 4 wt%, the wear rate of coating decreased from 16.23 × 10^(-3) to 7.58 × 10^(-3) mg m^(−1), the jcorr of coating decreased from 4.13 × 10^(-4) to 1.23 × 10^(-4) A cm^(−2), and the Rct values increased from 12.69 to 25.07 Ω cm2.

关键词： MCrAlY coating Laser melting deposition Friction Electrochemical corrosion

DNA Damage-driven Inflammatory Cytokines:Reprogramming of Tumor Immune Microenvironment and Application of Oncotherapy

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Current Medical Science 2024年第2期44卷 261-272页

作者： Meng-jie WANG Yu XIA qing-lei gao Department of Obstetrics and Gynecology National Clinical Research Center for Obstetrics and GynecologyTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Key Laboratory of Cancer Invasion and Metastasis(Ministry of Education) Hubei Key Laboratory of Tumor Invasion and MetastasisTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

DNA damage occurs across tumorigenesis and tumor *** intrinsic DNA damage can not only increase the risk of mutations responsible for tumor generation but also initiate a cellular stress response to orchestrate the tumor immune microenvironment(TIME)and dominate tumor *** evidence documents that multiple signaling pathways,including cyclic GMP-AMP synthase-stimulator of interferon genes(cGAS-STING)and ataxia telangiectasia-mutated protein/ataxia telangiectasia and Rad3-related protein(ATM/ATR),are activated downstream of DNA damage and they are associated with the secretion of diverse *** cytokines possess multifaced functions in the anti-tumor immune ***,it is necessary to deeply interpret the complex TIME reshaped by damaged DNA and tumor-derived cytokines,critical for the development of effective tumor *** manuscript comprehensively reviews the relationship between the DNA damage response and related cytokines in tumors and depicts the dual immunoregulatory roles of these *** also summarize clinical trials targeting signaling pathways and cytokines associated with DNA damage and provide future perspectives on emerging technologies.

关键词： DNA damage tumor immune microenvironment inflammatory cytokines cancer therapy

Progranulin:A promising biomarker and therapeutic target for fibrotic diseases

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3312-3326页

作者： Fan Yang Ming-Han Cheng hai-Feng Pan Jian gao Pediatric Translational Medicine Institute Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghai 200000China Department of Ophthalmology the First Affiliated Hospital of Anhui Medical UniversityHefei 230022China Department of Epidemiology and Biostatistics School of Public HealthAnhui Medical UniversityHefei 230022China Inflammation and Immune Mediated Diseases Laboratory of Anhui Province Hefei 230022China

Progranulin(PGRN),a multifunctional growth factor-like protein expressed by a variety of cell types,serves an important function in the physiologic and pathologic processes of fibrotic diseases,including wound healing and the inflammatory *** was discovered to inhibit proinflammation effect by competing with tumor necrosis factor-alpha(TNF-a)binding to TNF ***,excessive tissue repair in the development of inflammation causes tissue *** investigations have indicated the significance of PGRN in regulating inflammatory ***,multiple studies have shown that PGRN was linked to fibrogenesis,and was considered to monitor the formation of fibrosis in multiple organs,including liver,cardiovascular,lung and *** paper is a comprehensive review summarizing our current knowledge of PGRN,from its discovery to the role in *** is followed by an in-depth look at the characteristics of PGRN,consisting of its structure,basic function and intracellular ***,we will discuss the potential of PGRN in the diagnosis and treatment of fibrosis.

关键词： Progranulin Fibrotic disease Fibrosis Inflammation Biomarker Therapeutic target PGRN/TNFR interaction Signaling pathway

时代思潮中的技术批判理论——安德鲁·芬伯格教授访谈录

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自然辩证法研究 2015年第3期31卷 27-31页

作者：高海青中山大学哲学系广州510275

近年来,芬伯格教授的技术批判理论对技术研究产生了深刻的影响,在技术哲学学术界受到广泛关注。但是学界对芬伯格技术批判理论产生的历史背景、社会背景较少阐述,对其在当今时代思潮中的理论地位较少述及。鉴于此,通过对芬伯格的访谈,... 详细信息

近年来,芬伯格教授的技术批判理论对技术研究产生了深刻的影响,在技术哲学学术界受到广泛关注。但是学界对芬伯格技术批判理论产生的历史背景、社会背景较少阐述,对其在当今时代思潮中的理论地位较少述及。鉴于此,通过对芬伯格的访谈,意在清楚地展示技术批判理论与西方马克思主义、技术现象学、建构主义、后现代主义的关联和不同之处,旨在阐明技术批判理论在时代思潮中的价值。

关键词：时代思潮技术批判理论芬伯格

A survey on dynamic graph processing on GPUs: concepts, terminologies and systems

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Frontiers of Computer Science 2024年第4期18卷 1-23页

作者： Hongru gao Xiaofei LIAO Zhiyuan SHAO Kexin LI Jiajie CHEN hai JIN National Engineering Research Center for Big Data Technology and System/Services Computing Technology and System Lab/Cluster and Grid Computing Lab School of Computer Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China Zhejiang Lab Hangzhou 311121China

Graphs that are used to model real-world entities with vertices and relationships among entities with edges,have proven to be a powerful tool for describing real-world problems in *** most real-world scenarios,entities and their relationships are subject to constant *** that record such changes are called dynamic *** recent years,the widespread application scenarios of dynamic graphs have stimulated extensive research on dynamic graph processing systems that continuously ingest graph updates and produce up-to-date graph analytics *** the scale of dynamic graphs becomes larger,higher performance requirements are demanded to dynamic graph processing *** the massive parallel processing power and high memory bandwidth,GPUs become mainstream vehicles to accelerate dynamic graph processing ***-based dynamic graph processing systems mainly address two challenges:maintaining the graph data when updates occur(i.e.,graph updating)and producing analytics results in time(i.e.,graph computing).In this paper,we survey GPU-based dynamic graph processing systems and review their methods on addressing both graph updating and graph *** comprehensively discuss existing dynamic graph processing systems on GPUs,we first introduce the terminologies of dynamic graph processing and then develop a taxonomy to describe the methods employed for graph updating and graph *** addition,we discuss the challenges and future research directions of dynamic graph processing on GPUs.

关键词： dynamic graphs graph processing graph algorithms GPUs

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退耕还林(草)工程管理模式创新研究

社会科学家 2010年第7期25卷 58-61页

作者：高海清榆林学院管理学院陕西榆林719000

退耕还林(草)工程是一项正外部性的生态工程,属于公共管理范畴,但目前传统的"户退户管"管理模式,使政府直接面对千家万户,运行成本较高,政府风险较大。陕北地区根据自身的实际情况,因地制宜,探索出参与式管理、民营承包管理、科教先导... 详细信息

退耕还林(草)工程是一项正外部性的生态工程,属于公共管理范畴,但目前传统的"户退户管"管理模式,使政府直接面对千家万户,运行成本较高,政府风险较大。陕北地区根据自身的实际情况,因地制宜,探索出参与式管理、民营承包管理、科教先导式的管理等适合的管理模式。这些模式一定程度上调动了农民退耕还林的积极性,推动了退耕还林的可持续发展。

关键词：退耕还林(草)工程管理模式创新

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探索新的哲学思维模式

求是学刊 2005年第5期32卷 47-49页

作者：高清海吉林大学哲学基础理论研究中心

哲学的理论品格决定了哲学不以解决实际问题为目标,而是以为人们提供正确的思维方式为目的。改革开放以来,中国哲学界经历了从作为僵化教条体系的彼岸哲学向现实的生活世界的回归。这一历史性回归为我们这些哲学工作者提供了广阔的理论... 详细信息

哲学的理论品格决定了哲学不以解决实际问题为目标,而是以为人们提供正确的思维方式为目的。改革开放以来,中国哲学界经历了从作为僵化教条体系的彼岸哲学向现实的生活世界的回归。这一历史性回归为我们这些哲学工作者提供了广阔的理论空间和发展契机。

关键词：彼岸哲学生活世界思维方式

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树突状细胞在动脉粥样硬化免疫反应中的作用

中华心血管病杂志 2007年第10期35卷 972-974页

作者：由倍安高海青山东大学齐鲁医院老年病科济南250012

越来越多的证据表明，炎症和免疫反应是各种内在和外在危险因素导致动脉粥样硬化（AS）发生发展的中心环节。而树突状细胞（Dendritic Cell，DC）是一种广泛分布于机体各组织的抗原递呈细胞，它具有不成熟和成熟两种功能状态。一旦不成... 详细信息

越来越多的证据表明，炎症和免疫反应是各种内在和外在危险因素导致动脉粥样硬化（AS）发生发展的中心环节。而树突状细胞（Dendritic Cell，DC）是一种广泛分布于机体各组织的抗原递呈细胞，它具有不成熟和成熟两种功能状态。一旦不成熟的DC捕获抗原以后，就会发展为成熟的DC，从而具有激活T细胞的功能。近来认为DC可能处于AS免疫反应的中心环节。

关键词：致动脉粥样硬化树突状细胞免疫反应抗原递呈细胞激活T细胞危险因素 Cell 成熟

Coordination-driven self-assembly of a molecular 818knot and molecular borromean rings

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Science China Chemistry 2024年第11期67卷 3652-3656页

作者： Xiang gao Dong Liu hai-Ning Zhang Guo-Xin Jin Department of Chemistry Fudan University

We report the facile construction of a molecular 818knot and a molecular Borromean rings assembly through self-assembly directed by Cp*Rh corner units. Two curved ligands of similar size and shape were used in this study. The slight steric differences between the two ligands induce the formation of distinctly different topologies of the assembled products. The structures were confirmed by single-crystal X-ray analysis and nuclear magnetic resonance spectroscopy.

关键词： coordination-driven Cp*Rh 818 knot Borromean rings