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犯罪制图：理解犯罪热点

Ir（Ⅲ） Complexes as Potential Theranostic Photodynamic Therapy Agents

刑事法学 2012年第10期 65-73页

作者： John E.Eck Spencer Chainey James g.cameron Michael Leitner Ronald E.Wilson

理解犯罪热点需要具备一定的理论基础，需要相关犯罪理论的指导。理解犯罪热点具有多种方法和技术。在介绍各种方法和技术并指出各自优缺点的基础上，指出犯罪制图技术在理解犯罪热点上的显著重要性。识别犯罪热点需要借助一定的空间分... 详细信息

理解犯罪热点需要具备一定的理论基础，需要相关犯罪理论的指导。理解犯罪热点具有多种方法和技术。在介绍各种方法和技术并指出各自优缺点的基础上，指出犯罪制图技术在理解犯罪热点上的显著重要性。识别犯罪热点需要借助一定的空间分析工具，各种空间分析工具具有自身特定的优缺点及不同的用途。为防止出现主观性和随意性，犯罪热点分析应考虑多种因素，以科学的方法实施。

关键词：犯罪热点理论基础方法和技术犯罪制图空间分析工具

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Ir（Ⅲ） Complexes as Potential Theranostic Photodynamic The...

中国化学会第十六届全国光化学学术讨论会（2019）

作者： W.Sun B.Liu L.Wang C.Wang S.Moran H.Yin M.Hetu Collin g.cameron K.Colón Sherri A.McFarland Department of Chemistry and Biochemistry North Dakota State University Department of Chemistry Acadia University Department of Chemistry and Biochemistry University of North Carolina at Greensboro

Ir（Ⅲ） complexes with high quantum yields for triplet excited-state formation, long triplet lifetimes, and bright luminescence are potential theranostic photodynamic therapy（PDT） reagents. More importantly, the triplet excited-state characteristics of these complexes are readily tuned via alternation of the ligands However, most of the currently studied Ir（Ⅲ） complex photosensitizers mainly absorb in the UV and blue spectral region, which is not suitable for potential clinical applications. To red-shift the ground-state absorption and meanwhile to retain the desired triplet excited-state characteristics, we synthesized severa series of cationic or neutral Ir（Ⅲ） complexes that have strong absorption in the visible to the red spectra region and are emissive in the red/NIR region. Their photophysical properties and in vitro/in vivo theranostic PDT effects were systematically evaluated. Alternation of the different types of ligands dramatically impacted the natures and energies of the lowest singlet and triplet excited states of these complexes. Many of the complexes can efficiently generate singlet oxygen in solutions and other reactive oxygen species in vitro, and exhibited strong PDT effects upon visible or red light activation. One of the complexes showed the largest phototherapeutic index（＞1600） for the reported Ir（Ⅲ） complexes toward the SKMEL28 cells upon white light activation. These complexes also produce strong intracellular luminescence which highlights their potential as theranostic PDT agents.

关键词： Iridium(Ⅲ) complex photodynamic therapy photophysics singlet oxygen reactive oxygen species

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犯罪制图:理解犯罪热点(上)

预防青少年犯罪研究 2012年第4期 65-73页

作者：郑滋椀金诚 John E.Eck Spencer Chainey James g.cameron Michael Leitner Ronald E.Wilson 浙江警察学院杭州310053

理解犯罪热点需要具备一定的理论基础,需要相关犯罪理论的指导。理解犯罪热点具有多种方法和技术。在介绍各种方法和技术并指出各自优缺点的基础上,指出犯罪制图技术在理解犯罪热点上的显著重要性。识别犯罪热点需要借助一定的空间分析... 详细信息

理解犯罪热点需要具备一定的理论基础,需要相关犯罪理论的指导。理解犯罪热点具有多种方法和技术。在介绍各种方法和技术并指出各自优缺点的基础上,指出犯罪制图技术在理解犯罪热点上的显著重要性。识别犯罪热点需要借助一定的空间分析工具,各种空间分析工具具有自身特定的优缺点及不同的用途。为防止出现主观性和随意性,犯罪热点分析应考虑多种因素,以科学的方法实施。

关键词：犯罪热点理论基础方法和技术犯罪制图空间分析工具

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犯罪制图:理解犯罪热点(中)

预防青少年犯罪研究 2012年第5期 67-77页

作者：郑滋椀金诚 John E.Eck Spencer Chainey James g.cameron Michael Leitner Ronald E.Wilson 浙江警察学院杭州310053

关键词：犯罪热点理论基础方法和技术犯罪制图空间分析工具

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犯罪制图:理解犯罪热点(下)

预防青少年犯罪研究 2012年第6期 63-80,57页

作者：郑滋椀金诚 John E.Eck Spencer Chainey James g.cameron Michael Leitner Ronald E.Wilson 浙江警察学院杭州310053

关键词：犯罪热点理论基础方法技术犯罪制图空间分析工具

Circulation Pattern Controls of Summer Temperature Anomalies in Southern Africa

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Advances in Atmospheric Sciences 2024年第2期41卷 341-354页

作者： Chibuike Chiedozie IBEBUCHI cameron C.LEE Department of geography Kent State UniversityKentOhio 44242USA ClimRISE Lab Kent State UniversityKentOhio 44242USA

This study investigates the relationship between circulation patterns and austral summer temperature anomalies in southern Africa. The results show that the formation of continental lows tends to increase the thickness of the lower atmosphere. Further, the distinct variabilities of high and low pressure under the circulation types, influence air mass advection from the adjacent oceans, as well as atmospheric stability over land. Stronger anticyclonic circulation at the western branch of the Mascarene high-pressure system enhances the low-level cold air advection by southeast winds,decreases the thickness, and lowers the temperature over a majority of the land in southern Africa. Conversely, a weaker Mascarene High, coupled with enhanced cyclonic activity in the southwest Indian Ocean increases low-level warm air advection and increases temperature anomalies over vast regions in southern Africa. The ridging of a closed South Atlantic anticyclone at the southern coast of southern Africa results in colder temperatures near the tip of southern Africa due to enhanced low-level cold air advection by southeast winds. However, when the ridge is weak and westerly winds dominate the southern coast of southern Africa, these areas experience temperature increases. The northward track of the Southern Hemisphere mid-latitude cyclone, which can be linked to the negative Southern Annular Mode, reduces the temperature in the southwestern part of southern Africa. Also, during the analysis period, El Ni?o was associated with temperature increases over the central parts of southern Africa;while the positive Indian Ocean dipole was linked to a temperature increase over the northeastern, northwestern, and southwestern parts of southern Africa.

关键词： temperature circulation types Subtropical Indian Ocean dipole Southern Annular Mode El Ni?o Indian Ocean dipole Mascarene High South Atlantic anticyclone

靶向CXCR4特异性造影剂用于骨肉瘤成像的研究

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靶向CXCR4特异性造影剂用于骨肉瘤成像的研究

Optimizing oncolytic virus design:a“Swiss army knife”approach to create a systemically delivered therapeutic

2010’全国肿瘤分子标志及应用学术研讨会暨第五届中国中青年肿瘤专家论坛

作者：裘秀春马琼陈翔单乐群 Wei Wang Arlin g.cameron Michel E.Mawad 范清宇 Shi Ke 第四军医大学唐都医院骨肿瘤研究所贝勒医学院放射医学系

目的:对靶标特异的(CXCR4)、非损伤的多模式造影剂进行评价,并将该造影剂用于骨肉瘤异体移植模型中病变的检测。方法:体外培养的骨肉瘤细胞与近红外标记的CXCR4造影剂共孵育,共聚焦显微镜检测造影剂与肿瘤细胞的结合。尾静

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Signal Transduction and Targeted Therapy 2024年第5期9卷 1791-1792页

作者： Carolina S.Ilkow John cameron Bell Ottawa Hospital Research Institute 501 Smyth RoadOttawaONK1H 8L6Canada

In a recent paper published in Nature Biotechnology,Chen et al.1 describe a multiplex oncolytic virus platform that coupled with adoptive T cell therapy could solve the problem of repeat,systemic delivery of virus based *** is widely accepted that multi-targeted therapeutic approaches attacking several facets of cancer biology are necessary to effectively deal with the tumor heterogeneity that exists within and between patients.

关键词： therapeutic al. targeted

An electropenetrography waveform library for the probing and ingestion behaviors of Culex tarsalis on human hands

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Insect Science 2024年第4期31卷 1165-1186页

作者： Anastasia M.W.Cooper Samuel B.Jameson Victoria Pickens cameron Osborne Elaine A.Backus Kristopher Silver Dana N.Mitzel Department of Entomology Kansas State UniversityManhattanKansasUSA Department of Tropical Medicine Tulane University School of Public Health and Tropical MedicineNew OrleansLos AngelesUSA USDA Agricultural Research Service San Joaquin Valley Agricultural Sciences CenterParlierCaliforniaUSA National Bio and Agro-Defense Facility USDA Agricultural Research ServiceManhattanKansasUSA

Culex tarsalis Coquillett(Diptera:Culicidae)mosquitoes are capable of vectoring numerous pathogens affecting public and animal ***,the probing behaviors of mosquitoes are poorly understood because they occur in opaque ***(EPg)has the potential to elucidate these behaviors by recording the electrical signals generated during *** used an AC–DC EPg with variable input resistors(Ri levels)to construct a waveform library for *** feeding on human *** events associated with mosquito probing were used to characterize waveforms at four Ri levels and with two electrical current *** optimal settings for EPg recordings of *** probing on human hands was an Ri level of 10^(7)Ohms using an applied signal of 150 millivolts alternating *** for *** included those previously observed and associated with probing behaviors in Aedes aegypti L.(Diptera:Culicidae):waveform families J(surface salivation),K(stylet penetration through the skin),L(types 1 and 2,search for a blood vessel/ingestion site),M(types 1 and 2,ingestion),N(type 1,an unknown behavior which may be a resting and digestion phase),and W(withdrawal).However,we also observed variations in the waveforms not described in ***,which we named types L3,M3,M4,and *** investigation enhances our understanding of mosquito probing *** also provides a new tool for the automated calculation of peak *** work will facilitate future pathogen acquisition and transmission studies and help identify new pest and disease management targets.

关键词： AC-DC blood feeders electrical penetration graph EPg human hands mosquitoes waveform library