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Chinese Medical Sciences Journal 1994年第1期9卷 29-33页

作者：尹卫东 g.Seghieri C.Boni,g,Sanna R.Anichinl g.bartolomei E.Ferrannini Correspondingauthor.DepartmentofBiochemistry HengyangMedicalCollegeHunan421001 MetabolismUnitoftheC.N.R.InstituteofClinicalPhysiology UniversityofPisaandtheSecondMedicalDivisionoftheGeneralHospitalPistoiaItaly

We studied 14 moderately overweight Typo 2 diabetic patients with essential hypertension in stable metabolic control after a run-in period , and again after 3 months of antihypertensive treatment with the angiotensin-converting enzyme (ACF) inhibitor captopril. glucose tolerance was tested with a 75g oral glucose load (OgTT) and insulin sensitivity was measured by the insulin suppression test (IST) while dietary and drug treatment of the hyperglycemia was maintained constant. In the whole group. mean blood pressure (MBP) fell progressively over 3months from a baseline value of 123± 3 mmHg (1 mmHg= 0. 133 kpa) to a final value of 115± 2 mmHg(Pg plasma glucose, insulin, free fatty acid (FFA). potassium, and glycosylated hemoglobin concentrations were unchanged from baseline. There were no significant differences in glucose tolerance and insulin sensitivity between pre- and post-trearment values. Neither endogenous (oral glucose) nor exogenous (IST) insulin caused any change in plasma potassium concentration. This resistance to the hypokalemic action of insulin was not affected by captopril.

关键词： glucose tolerance test hypertension ACE inhibition

Unveiling Citizens’ Perceptions, Attitudes, and Behaviors towards Air Quality: Insights from a Survey in the Po Basin Area

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Open Journal of Air Pollution 2023年第4期12卷 103-120页

作者： Marco Ottolenghi Michele bartolomei Duccio Tosi Niccolò Maria Todaro ART-ER S.cons.p.a. Bologna Italy Institute of Management Sant’Anna School of Advanced Studies Pisa Italy

Air pollution has far-reaching environmental and social consequences, requiring the active participation of individual citizens in improving air quality by means of emission-reducing behaviors. This research examines the relationship between citizens’ knowledge, perceptions of air quality, attitudes towards policy measures, and intentions to adopt environmentally-friendly behaviors to combat air pollution. A comprehensive survey is conducted among a representative sample from seven regions in the Po basin area: Emilia-Romagna, Friuli-Venezia giulia, Lombardy, Piedmont, Province of Trento, Valle d’Aosta, and Veneto. The survey aims at profiling participants based on their level of information, perceptions of air pollution, and attitudes towards emission-reducing behaviors. Cluster analysis identifies meaningful differences among citizen groups in terms of their awareness and intentions to engage in specific behaviors. Four distinct clusters emerge, each characterized by varying levels of willingness to embrace pro-environmental behaviors and support air quality improvement initiatives. By examining these profiles, the study uncovers patterns in citizens’ awareness, concerns, and acceptance of environmentally-friendly practices. The findings offer valuable insights for policymakers to develop targeted interventions, policies, and communication strategies.

关键词： Air Quality Air Pollution Cluster Analysis Sustainable Development

Emerging personalized virtual brain models: next-generation resection neurosurgery for drug-resistant epilepsy?

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Acta Epileptologica 2023年第3期6卷 185-187页

作者： Qiao Wang guangyuan Jin Tao Yu Fabrice bartolomei Liankun Ren Department of Neurology Xuanwu HospitalClinical Center for EpilepsyCapital Medical UniversityBeijing 100053China National Center for Neurological Disorders Beijing 100070China Department of Functional Neurosurgery Beijing Institute of Functional NeurosurgeryXuanwu HospitalClinical Center for EpilepsyCapital Medical UniversityBeijing 100053China APHM Epileptology and Clinical Neurophysiology DepartmentTimone HospitalMarseille 13005France Aix-Marseille Université Institut National de la Santéet de la Recherche MédicaleInstitut de Neurosciences des Systèmes(INS)UMR1106Marseille 13005France Chinese Institute for Brain Research Beijing 102206China Department of Neurology Xuanwu HospitalCapital Medical UniversityNO.45 Changchun StreetXicheng DistrictBeijing 100053China

Recently,a novel workflow known as the virtual epileptic patient(VEP)has been proposed by a research team from Aix Marseille Universitéin their papers published in Lancet Neurology,Science Translational Medicine and *** method involves creating an individualized virtual brain model based on computational modelling,which can facilitate clinical decision-making by estimating the epileptogenic zone and performing the virtual ***,we summarize brief workflow,strengths,and limitations of VEP,as well as its performance in a retrospective study of 53 patients with drug-resistant focal epilepsy who underwent stereoelectroencephalography.A large-scale clinical trial(NCT03643016)is underway to further assess VEP,which is expected to enroll 356 patients *** supporting evidence accumulates,the clinical application of VEP has the potential to improve clinical practice,leading to better outcomes and qualities of life of patients.

关键词： Drug-resistant focal epilepsy Personalized virtual brain models Machine learning Epileptogenic zone networks Stereoelectroencephalography Virtual surgery

Analysis of human skin tissue by a skin-meter: A preliminary study

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Open Journal of Molecular and Integrative Physiology 2012年第4期2卷 107-111页

作者： Sergio Mazzulla Annarita Carino Antonino Miano Fiorenzo Mignini giovanni bartolomei guglielmo Martino Department of Cellular Biology University of Calabria Cosenza Italy Department of Chemistry University of Calabria Cosenza Italy Department of Public Healthy and Experimental Medicine University of Camerino Camerino Italy

The aim of this study is to evaluate the skin elasticity in individuals who practise spinning. Mechanical eva- luations were conducted, under environmental and physical established conditions, during a physical training period. A total of 12 volunteers aged 35 ± 5 years were enrolled in this study, (60 min) before (control) and (60 min) after practicing spinning. Skin elasticity and area were measured by a Skin Meter and analysed with the Skin Meter software 1.3. In subjects who practiced spinning, the data shown a sig-nificant effect: on elasticity, evaluated as the ratio of final retraction (UA) and final distension (UF), on viscoelasticity express as the ratio delayed distension (UV) and immediate distension (UE);and on measurements of skin area vs control subjects. Skin Meter can be useful for a non-invasive screening of skin condition with also a potential extension in subjects with skin pathologies or to monitor skin oxidative stress in sportive subjects.

关键词： Skin Meter Elasticity Skin Parameters Spinning

癫痫网络的定义：立体脑电图和信号分析的贡献

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癫痫杂志 2018年第2期4卷 135-149页

作者： bartolomei F Lagarde S Wendling F 郑舒畅秦兵

致痫网络定义为癫痫放电产生和传播过程中累及的脑区。基于颅内电极电生理数据的分析,文章综述介绍了致痫网络的历史、方法和概念。在癫痫术前评估中,确定产生癫痫发作的脑区(如致痫区)是最重要的目标。较药物难治性局灶性癫痫传统的、... 详细信息

致痫网络定义为癫痫放电产生和传播过程中累及的脑区。基于颅内电极电生理数据的分析,文章综述介绍了致痫网络的历史、方法和概念。在癫痫术前评估中,确定产生癫痫发作的脑区(如致痫区)是最重要的目标。较药物难治性局灶性癫痫传统的、局限性的视觉分析方法而言,致痫网络作为一个模型已逐渐得到公认。该模型能更好地描述发作动态演变的复杂性、更真实地描述大脑致痫性的异常分布。致痫网络概念在历史上与立体脑电图(SEEg)方法学的发展及随后脑电信号定量分析相关。SEEg有明确的发作期、发作前及发作间期放电模式,可以用信号分析方法对上述模式进行分析,如高频振荡定量分析或分析功能连接的改变。我们可以在皮层和皮层下脑区癫痫发生和传播的过程中,依据SEEg数据分析得到大脑连接的显著变化,这些变化与不同的发作症状学模式相关。发作间期特征就是致痫网络产生异常电活动(发作间期棘波)及功能连接的改变。致痫网络大尺度建模新方法的引入为更好地预测手术预后提供了新方法。就明确致痫性脑区的分布而言,致痫网络的概念是一个关键的要素,这对癫痫手术尤为重要。

关键词：立体脑电图信号处理脑网络局灶性癫痫功能连接

EFFICACY AND SAFETY OF BIMATO- PROST IN PATIENTS WITH UNCON- TROLLED gLAUCOMA ON MAXIMAL TOLERABLE MEDICAL THERAPY

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国际眼科杂志 2003年第1期3卷 18-19页

作者： M.Vetrugno C.Sborgia E.Balestrazzi C.Bianchi A.Caporossi M.Nardi A.Rapisarda g.Tassinari L.Zeppa M.bartolomei S.di Staso P.Frezzotti g.Laffi L.Marino Department of Ophthalmology University of Bari Department of Ophthalmol-ogy University of L'Aquila Department of Ophthalmology University of Siena Department of Ophthalmology University of Pisa Ophthalmic Hospital Siracusa Ophthalmic Hospital Bologna Ophthalmic Center Milano Ophthalmic Center Benevento Italy

Purpose: to evaluate the efficacy and safety of bimatoprost as alternative to filtration surgery in patients with uncontrolled glaucoma on maximal tolerable medical therapy (MTMT). Methods: 83 consecutive patients (83 eyes), recruited from the waiting lists for glaucoma surgery of 8 ophthalmic centers. All the patients were scheduled for surgery because of inefficacy of the MTMT, and/or a progressive deterioration of the visual field.

关键词： IOP TROLLED gLAUCOMA ON MAXIMAL TOLERABLE MEDICAL THERAPY PROST IN PATIENTS WITH UNCON EFFICACY AND SAFETY OF BIMATO

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高频脑电振荡:临床研究综述

癫痫杂志 2018年第6期4卷 545-557页

作者： Birgit Frauscher Fabrice bartolomei Katsuhiro Kobayashi 陆璐张乐慕洁

现代脑电图(EEg)技术的进步增强了对经典伯杰频段外,包含重要信息的脑电信号的识别。在癫痫领域,近十年的相关研究主要集中在发作间期>80 Hz的高频振荡(High frequency oscillations, HFOs)。HFOs大型临床应用始于癫痫手术术前的评估,... 详细信息

现代脑电图(EEg)技术的进步增强了对经典伯杰频段外,包含重要信息的脑电信号的识别。在癫痫领域,近十年的相关研究主要集中在发作间期>80 Hz的高频振荡(High frequency oscillations, HFOs)。HFOs大型临床应用始于癫痫手术术前的评估,近来也开始用于评估癫痫严重程度和监测抗癫痫疗效。该综述总结了HFOs在癫痫临床应用的证据,重点介绍了最新的进展。近期大量文献强调了HFOs与术后癫痫预后关系,一篇近期的Meta分析证实术后癫痫未发作患者HFOs切除率高于术后发作患者,利用术后EEg中的残留HFOs比术前HFOs率对癫痫手术预后预测更准确。文章深入讨论了区分生理性和癫痫性HFOs的尝试,这可能进一步加强HFOs的特异度。如睡眠结构分析表明,在痫灶内外对HFOs的偶联有差异。同时,越来越多的证据表明,HFOs可用于对评估疾病活动度和利用非侵入性EEg和脑磁图(MEg)等检查中评估治疗效果。鉴于儿童EEg中HFOs比例高,这一技术在患儿中有良好的前景。在婴儿痉挛症中经促肾上腺皮质激素治疗后HFOs比例下降。在Rolandic区棘波时出现HFOs与发作频率相关。耗时的人工评估是过去HFOs临床应用的障碍,目前这一问题可由可靠的计算机算法解决。过去十年,HFOs研究有了长足进展,利用非侵入性手段检测HFOs已在大量患者中得到应用。期待未来有多中心、大样本量研究获取长程监测资料,为这一领域提供更多信息。

关键词：头皮脑电图生物标记手术预后癫痫发作睡眠

Radinimmunotherapy of brain tumor

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中国神经肿瘤杂志 2006年第2期4卷 114-114页

作者： Paganelli g.bartolomei M grana C Ferrari M Rocca P Chinol M Division of Nuclear Medicine European Institute of Oncology Milano Italy

人内侧颞叶癫痫的大规模表达研究:内嗅皮质神经传递和补体系统失调的证据

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世界核心医学期刊文摘(神经病学分册) 2006年第8期 39-40页

作者： Jamali S. bartolomei F. Robaglia-Schlupp A. P. Szepetowski 赵天智 Inserm U491 'Genetics of Human Epilepsies' Group Faculté de Mé decine de la Timone 27 Boulevard J Moulin 13385 Marseille Cedex 5 France Dr.

Human mesial temporal lobe epilepsies (MTLE)are the most frequent form of partial epilepsies and display frequent pharmacoresistance. The molecular alterations underlying human MTLE remain poorly understood. A two- step transcriptional analysis consisting in cDNA microarray experiments followed by quantitative RT- PCR validations was performed. Because the entorhinal cortex (EC) plays an important role in the pathophysiology of the MTLE and usually discloses no detectable or little cell loss, resected EC and each corresponding lateral temporal neocortex (LTC) of MTLE patients were used as the source of disease- associated and control RNAs, respectively. Six genes encoding (i) a serotonin receptor (HTR2A) and a neuropeptide Y receptor type I (NPYIR), (ii) a protein (FHL2) associating with the KCNEI (minK) potassium channel subunit and with presenilin- 2 and (iii) three immune system- related proteins (C3, HLA- DR- γ and CD99), were found consistently downregulated or upregulated in the EC of MTLE patients as compared with non- epileptic autopsy controls. Quantitative western blot analyses confirmed decreased expression of NPYIR in all eight MTLE patients tested. Immunohistochemistry experiments revealed the existence of a perivascular infiltration of C3 positive leucocytes and/or detected membrane attack complexes on a subset of neurons, within the EC of nine out of eleven MTLE patients. To summarize, a large- scale microarray expression study on the EC of MTLE patients led to the identification of six candidate genes for human MTLE pathophysiology. Altered expression of NPYIR and C3 was also demonstrated at the protein level. Overall, our data indicate that local dysregulation of the neurotransmission and complement systems in the EC is a frequent event in human MTLE.

关键词：内侧颞叶癫痫内嗅皮质神经传递神经活动补体系统表达研究

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论癫痫症状学

癫痫杂志 2022年第2期8卷 174-183页

作者： Aileen Mcgonigal Fabrice bartolomei Patrick Chauvel 姚晨(译) 王圆庆(译) 黎思娴(译) 蔡晓东(译) 胡湘蜀(审) 不详

癫痫的主要症状负担即癫痫发作的临床表现。癫痫症状学产生的神经机制,尤其是复杂行为的神经机制,仍知之甚少。在将癫痫视为网络而非局灶性障碍的框架中,我们可以将症状学视为由一组相互关联的结构动态产生的,这些结构之间按一定规律相... 详细信息

癫痫的主要症状负担即癫痫发作的临床表现。癫痫症状学产生的神经机制,尤其是复杂行为的神经机制,仍知之甚少。在将癫痫视为网络而非局灶性障碍的框架中,我们可以将症状学视为由一组相互关联的结构动态产生的,这些结构之间按一定规律相互作用,而不仅是简单的解剖定位,从而产生相应的临床表现。这需要我们如何看待致痫区的范式转变,包括从术前评估的角度。症状学是一个关键的数据来源,尽管它在研究中的应用面临着重大的方法学挑战,包括观察者的偏倚和症状学归类的差异。更好地理解症状学分类和病理生理学相关性与癫痫分类系统有关。神经机制以及不同症状学模式的解剖相关知识的进步有助于提高癫痫网络的知识,并可能有助于治疗创新。

关键词：行为癫痫神经网络癫痫分类症状学