EFFECT　OF　CHRONIC　ACE　INHIBITIONONGLUCOSE　TOLERANCE　AND　INSULIN　SENSITIVITY　IN　HYPERTENSIVE　TYPE　2　DIABETIC　PATIENTS

作     者：尹卫东 G.Seghieri C.Boni,G,Sanna R.Anichinl G.Bartolomei E.Ferrannini 

作者机构：Correspondingauthor.DepartmentofBiochemistryHengyangMedicalCollegeHunan421001 MetabolismUnitoftheC.N.R.InstituteofClinicalPhysiologyUniversityofPisaandtheSecondMedicalDivisionoftheGeneralHospitalPistoiaItaly 

出 版 物：《Chinese Medical Sciences Journal》 (中国医学科学杂志（英文版）)

年 卷 期：1994年第9卷第1期

页      面：29-33页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：glucose tolerance test hypertension ACE inhibition 

摘      要：We studied 14 moderately overweight Typo 2 diabetic patients with essential hypertension in stable metabolic control after a run-in period , and again after 3 months of antihypertensive treatment with the angiotensin-converting enzyme (ACF) inhibitor captopril. Glucose tolerance was tested with a 75g oral glucose load (OGTT) and insulin sensitivity was measured by the insulin suppression test (IST) while dietary and drug treatment of the hyperglycemia was maintained constant. In the whole group. mean blood pressure (MBP) fell progressively over 3months from a baseline value of 123± 3 mmHg (1 mmHg= 0. 133 kpa) to a final value of 115± 2 mmHg(P0. 005). After treatment, fasting plasma glucose, insulin, free fatty acid (FFA). potassium, and glycosylated hemoglobin concentrations were unchanged from baseline. There were no significant differences in glucose tolerance and insulin sensitivity between pre- and post-trearment values. Neither endogenous (oral glucose) nor exogenous (IST) insulin caused any change in plasma potassium concentration. This resistance to the hypokalemic action of insulin was not affected by captopril.