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Asian Pacific Journal of Tropical Biomedicine 2023年第9期13卷 393-402页

作者： Wei Feng Zheng-Yong Cao fu-min guan Hong Chen Laboratory Department Maternal and Child Health Hospital of Qijiang DistrictChongqing401429China Otolaryngology Department People’s Hospital of Qijiang DistrictChongqing401420China Pharmacy Department People’s Hospital of Qijiang DistrictChongqing401420China Science and Education Department People’s Hospital of Qijiang DistrictChongqing401420China

Objective:To explore the regulatory mechanism of transient receptor potential melastatin-7(TRPM7)in high glucose-induced renal tubular epithelial cell ***:The expression of TRPM7 in the serum of diabetic nephropathy patients and high glucose-induced HK-2 cells was detected by ***,the TRPM7 interference vector was constructed,and the downstream high mobility group box 1(HMGB1)/Toll-like receptor 4(TLR4)signaling pathway proteins were ***,in addition to interference with TRPM7 expression,overexpression of HMGB1 in high glucose-induced HK-2 cells was *** activity,apoptosis,oxidative stress levels,and inflammation levels were determined by CCK8,TUNEL,Western blotting,immunofluorescence and related ***:TRPM7 expression was upregulated in the serum of diabetic nephropathy patients and high glucose-induced HK-2 *** with TRPM7 reduced cell damage,epithelial-mesenchymal transition,oxidative stress,and inflammatory response in high glucose-induced HK-2 cells via inhibiting the HMGB1/TLR4 signaling ***,the effects induced by TRPM7 silencing were abrogated by HMGB1 ***:Decreased TRPM7 alleviates high glucose-induced renal tubular epithelial cell injury by inhibiting the HMGB1/TLR4 signaling *** animal experiments and clinical trials are warranted to verify its effect.

关键词： Diabetic nephropathy TRPM7 HMGB1/TLR4 High glucose Renal tubular epithelial cell

Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PERK as a potential target for intervention

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Neural Regeneration Research 2025年第5期20卷 1455-1466页

作者： Ju Zheng Yixin Li Ting Zhang Yanlin fu Peiyan Long Xiao Gao Zhengwei Wang Zhizhong guan Xiaolan Qi Wei Hong Yan Xiao Key Laboratory of Endemic and Ethnic Diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina Guizhou Center for Disease Control and Prevention GuiyangGuizhou ProvinceChina Department of Histology and Embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Collaborative Innovation Center for Prevention and Control of Endemic and Ethnic Regional Diseases Co-constructed by the Province and ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion *** occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains *** this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion *** found that prolongation of oxygen-glucose deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced ***,inhibition of ER stress using inhibitors or by si RNA knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating *** autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion *** from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PERK

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羧甲基β-1,3-葡聚糖在护肤品中的功能

日用化学品科学 2000年第5期23卷 4-6页

作者：傅冠民上海轻工业高等专科学校食化系上海200433

介绍了羧甲基 β-1 ,3 -葡聚糖的免疫活性作用以及在护肤品中的主要功能。能增加皮肤的保湿性并能减弱表面活性剂对皮肤的损伤 ;能提高角质层的更新速度 ;能改善皮肤的紧密度 ;能防止皮肤因紫外线照射引起的氧化效力。并论述了该添加剂... 详细信息

介绍了羧甲基 β-1 ,3 -葡聚糖的免疫活性作用以及在护肤品中的主要功能。能增加皮肤的保湿性并能减弱表面活性剂对皮肤的损伤 ;能提高角质层的更新速度 ;能改善皮肤的紧密度 ;能防止皮肤因紫外线照射引起的氧化效力。并论述了该添加剂在护肤品中的应用前景。

关键词：化妆品原料羧甲基葡聚糖保湿性护肤品

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驱蚊功能性香精的调配

上海应用技术学院学报（自然科学版） 2005年第3期5卷 214-217页

作者：傅冠民俞苓上海应用技术学院生物与食品工程系上海200235

从组成日化香精的香原料中筛选出具有较好驱蚊效果的植物精油和单体香料,运用调香技术将其调配成各种香型的香精并从中再筛选出既有愉快的香气又有很好驱蚊功效的香精。此香精以植物精油为主成分,属植物源驱避剂,符合绿色环保要求,可添... 详细信息

从组成日化香精的香原料中筛选出具有较好驱蚊效果的植物精油和单体香料,运用调香技术将其调配成各种香型的香精并从中再筛选出既有愉快的香气又有很好驱蚊功效的香精。此香精以植物精油为主成分,属植物源驱避剂,符合绿色环保要求,可添加到多种日化产品中。

关键词：蚊虫驱避剂功能性香精精油筛选调配

Reversing anther thermotolerance by manipulating the cis-elements in the promoter of a high-temperature upregulated gene Casein Kinase I in upland cotton

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Science China Life Sciences 2025年

作者： Yanlong Li Yinuo fu Yaoyao Li Rui Zhang Jing Yang Huanhuan Ma Ling min Xianlong Zhang National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural University

High temperature (HT) stress causes male sterility,leading to reduced upland cotton ***,we identified a key gene,Casein Kinase I (GhCKI),that negatively regulates male fertility in upland cotton under ***,conventional genetic manipulations of GhCKI would result in male sterility,hindering its utilization in breeding ***,we engineered quantitative variation for anther thermotolerance-related traits in upland cotton by creating weak promoter alleles of GhCKI genes,using CRISPR/Cas9 and CRISPR/Cpf1genome ***,we screened and identified two new upland cotton plant lines exhibiting a HT-tolerant phenotype with edited GhCKI promoters,and characterized their corresponding heat-tolerant allelic *** research revealed that the primary reason for the HT tolerance of the GhCKI promoter editing mutants is that the trans-acting factors GhMYB73 and GhMYB4,which positively regulate GhCKI expression under HT,failed to bind and activate the expression of ***,our study not only provides a rapid strategy to generate new beneficial alleles but also offers novel germplasm resources and molecular insights for crop HT tolerance breeding.

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De novo synthesis of atropisomeric benzofurans via Cu/SPDO complex catalyzed asymmetric formal [3 + 2] annulation

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Science China Chemistry 2025年第1期 174-180页

作者： Fan-Xiao Meng Xing-Yu Wang Ka Lu Ju-Song Yang fu-min Zhang Ai-Jun Ma Bao Du Yong-Qiang Tu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University School of Chemistry and Chemical Engineering Shanghai Jiao Tong University School of Biotechnology and Health Sciences Wuyi University

Herein, the de novo synthesis of atropisomeric benzofurans through the Cu/spirocyclic-pyrrolidine-oxazoline(SPDO) complex catalyze asymmetric formal [3 + 2] cycloaddition between quinones and ynamides is explored, producing a range of structurally diverse axially chiral benzofurans in satisfactory yields with good to excellent enantioselectivities. furthermore, density functional theory calculations were applied to explain the possible reaction mechanism.

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Primary parenchymal squamous cell carcinoma of the kidney:A case report

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World Journal of Clinical Cases 2025年第4期13卷 34-40页

作者： Zhi-Hui Zheng Bo Shao Chao-min Xu Ke Wang Jia-Zhu Wen Li-Kang Luo Jia-Cheng guan Department of Ultrasound The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Radiology Shulan(Quzhou)HospitalQuzhou 324000Zhejiang ProvinceChina Department of Radiology The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Pathology The Second people’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina

BACKGROUND Primary squamous cell carcinoma(SCC)of the renal parenchyma is extremely rare,with only nine cases *** SUMMARY This study reports a 51-year-old man with primary SCC of the renal *** patient was admitted with recurrent dull pain and discomfort in the right lumbar region,which had worsened over 2 weeks,accompanied by painful gross *** antigen(SCCA)levels were elevated,and imaging revealed a renal mass with associated *** patient underwent laparoscopic unilateral nephrectomy and lymph node *** pathology confirmed highly differentiated SCC with necrosis in the right renal parenchyma,with negative renal pelvis and *** pathological stage was *** months after surgery,the tumor recurred with involvement of the liver,right psoas major muscle,and inferior vena *** patient refused chemotherapy and succumbed to the disease 6 months postoperatively due to disease *** We report a case of primary SCC of the renal parenchyma,a rare renal *** clinical symptoms,laboratory tests,and imaging findings are nonspecific,making accurate and timely diagnosis *** to the literature,for patients with renal calculi accompanied by a renal mass,elevated serum SCCA levels,and magnetic resonance imaging showing cystic or cystic-solid masses within the kidney with pseudocapsules and heterogeneous mild enhancement,the possibility of this disease should be considered.

关键词： Renal tumor Renal parenchyma Squamous cell carcinoma Renal calculi Computed tomography Case report

续断对兔膝骨关节炎模型滑膜中白介素-1β、骨桥蛋白和血管内皮生长因子影响的实验研究

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中国卫生检验杂志 2016年第20期26卷 2922-2924页

作者：童静玲朱让腾罗利飞徐强汪官富管敏昌台州恩泽医疗中心(集团)路桥医院中药房浙江台州318050 台州恩泽医疗中心(集团)路桥医院骨科浙江台州318050 台州恩泽医疗中心(集团)路桥医院检验科浙江台州318050 台州恩泽医疗中心(集团)路桥医院科教科浙江台州318050 台州恩泽医疗中心(集团)路桥医院儿科浙江台州318050

目的探讨续断对兔膝骨关节炎(KOA)模型滑膜中白介素-1β(IL-1β)、骨桥蛋白(OPN)和血管内皮生长因子(VEGF)的影响。方法采用分层随机化的方法将动物分为5组,正常组、对照组、续断组低剂量、中剂量、高剂量组,每组各15只。对5组滑膜IL-1... 详细信息

目的探讨续断对兔膝骨关节炎(KOA)模型滑膜中白介素-1β(IL-1β)、骨桥蛋白(OPN)和血管内皮生长因子(VEGF)的影响。方法采用分层随机化的方法将动物分为5组,正常组、对照组、续断组低剂量、中剂量、高剂量组,每组各15只。对5组滑膜IL-1β、OPN和VEGF水平进行检测。结果治疗第8周5组滑膜IL-1β、OPN和VEGF浓度差异有统计学意义(F值分别为780.61、1 291.03、206.77,P<0.01);5组两两比较,对照组滑膜IL-1β、OPN和VEGF浓度显著高于低剂量组,而中剂量组显著低于低剂量组、高剂量组;正常组显著低于高剂量组,差异均有统计学意义(P<0.05)。治疗第8周续断组不同剂量与滑膜OPN和VEGF水平相关性研究显示,续断组滑膜IL-1β、OPN和VEGF水平与续断剂量均呈正相关(r值分别为0.98、0.99、0.90,P<0.01)。结论续断可降低KOA滑膜IL-1β、OPN和VEGF水平。

关键词：膝骨关节炎滑膜白介素-1β 骨桥蛋白血管内皮生长因子

8周运动预适应增强脂肪干细胞治疗心肌梗死大鼠的效果

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中国组织工程研究 2025年第7期29卷 1363-1370页

作者：娄国张敏付常喜江苏经贸职业技术学院江苏省南京市211168 南京旅游职业学院江苏省南京市211100 徐州工程学院体育学院江苏省徐州市221008

背景:干细胞移植是心肌梗死的崭新疗法,然而梗死区域极其恶劣的微环境造成干细胞存活率低下并导致远期疗效甚微。运动预适应是一种通过运动诱导机体产生内源性保护效应的方式,可作为心脏康复预防与治疗的新策略。目的:评估运动预适应是... 详细信息

背景:干细胞移植是心肌梗死的崭新疗法,然而梗死区域极其恶劣的微环境造成干细胞存活率低下并导致远期疗效甚微。运动预适应是一种通过运动诱导机体产生内源性保护效应的方式,可作为心脏康复预防与治疗的新策略。目的:评估运动预适应是否能够增强大鼠心肌梗死后脂肪干细胞移植的心脏保护效应,探讨血管生成在其中的作用机制。方法:6周龄雄性SD大鼠随机分为对照组、造模组、干细胞组以及干细胞运动组。利用冠状动脉闭塞术制作急性心肌梗死模型,对照组同期行假手术;干细胞运动组于造模前进行8周有氧运动,造模后30 min进行脂肪干细胞移植;干细胞组仅进行脂肪干细胞移植。干细胞移植后1 d和7 d,利用免疫印迹法测定心肌总Akt(t-Akt)、磷酸化Akt(p-Akt)、血管内皮生长因子(VEGF)、总内皮型一氧化氮合酶(t-eNOS)和磷酸化内皮型一氧化氮合酶(p-eNOS)蛋白表达量,计算p-Akt/t-Akt和p-eNOS/t-eNOS比值;4周后利用彩色多普勒超声诊断系统检测心脏结构与功能以及心肌血流量,TTC染色法检测心肌梗死面积,Masson染色法检测心肌间质胶原沉积,免疫荧光染色法测定心肌毛细血管密度,TUNEL染色法评估心肌细胞凋亡。结果与结论:(1)干细胞移植后4周:与对照组比较,造模组左心室缩短分数、左心室射血分数、心肌毛细血管密度和心肌血流量下降(P0.05);与造模组比较,干细胞组上述指标均无显著性变化(P>0.05),干细胞运动组磷酸化p-Akt蛋白表达量以及p-Akt/t-Akt比值上调(P0.05),干细胞运动组p-Akt、VEGF、p-eNOS蛋白表达量以及p-Akt/t-Akt、p-eNOS/t-eNOS比值升高(P<0.05)。结果表明:运动预适应可增强脂肪干细胞对心肌梗死大鼠心脏重塑的治疗效果,其机制与促进心肌血管生成并增加血流灌注有关。

关键词：干细胞脂肪干细胞运动预适应心肌梗死血管生成心脏重塑血流灌注

The Characterization of Graphs with No 2-connected Spanning Subgraph of V_(8)as a minor

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Acta Mathematicae Applicatae Sinica 2022年第4期38卷 902-915页

作者： Xiao-min ZHOU Xia-xia guan Cheng-fu QIN Wei-hua YANG Department of Mathematics Taiyuan University of TechnologyTaiyuan 030000China School of Mathematical Sciences Xiamen UniversityXiamen 361005China School of Mathematics Science Guangxi Teachers Education UniversityNanning 530001China

It is difficult to characterize graphs which contain no a 2-connected graph as a minor in graph *** V_(8)be a graph constructed from an 8-cycle by connecting the antipodal *** are thirteen 2-connected spanning subgraphs of V_(8).In particular,one of them is obtained from the Petersen graph by deleting two vertices and it is also a hard problem to characterize Petersen-minor-free *** this paper,we characterize internally 4-connected graphs which contain a 2-connected spanning subgraph of V_(8)as a forbidden minor.

关键词： V_(8) internally 4-connected graph minor-free 2-connected subgraph