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Aerosol jet printing of surface acoustic wave microfluidic devices

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Microsystems & Nanoengineering 2024年第1期10卷 231-242页

作者： Joseph rich Brian Cole Teng Li Brandon Lu Hanyu Fu Brittany N.Smith Jianping Xia Shujie Yang Ruoyu Zhong James L.Doherty Kanji Kaneko Hiroaki Suzuki Zhenhua Tian Aaron D.Franklin Tony Jun Huang Department of Biomedical engineering Duke UniversityDurhamNC 27708USA Department of electrical and Computer engineering Duke UniversityDurhamNC 27708USA Department of Mechanical engineering Virginia Polytechnic Institute and State UniversityBlacksburgVA 24061USA Thomas Lord Department of Mechanical engineering and Materials Science Duke UniversityDurhamNC 27708USA Deptartment of Precision Mechanics Faculty of Science and EngineeringChuo UniversityTokyo 112-8551Japan Department of Chemistry Duke UniversityDurhamNC 27708USA

The addition of surface acoustic wave(SAW)technologies to microfluidics has greatly advanced lab-on-a-chip applications due to their unique and powerful attributes,including high-precision manipulation,versatility,integrability,biocompatibility,contactless nature,and rapid ***,the development of SAW microfluidic devices is limited by complex and time-consuming micro/nanofabrication techniques and access to cleanroom facilities for multistep photolithography and vacuum-based *** simplify the fabrication of SAW microfluidic devices with customizable dimensions and functions,we utilized the additive manufacturing technique of aerosol jet *** successfully fabricated customized SAW microfluidic devices of varying materials,including silver nanowires,graphene,and poly(3,4-ethylenedioxythiophene)polystyrene sulfonate(PeDOT:PSS).To characterize and compare the acoustic actuation performance of these aerosol jet printed SAW microfluidic devices with their cleanroom-fabricated counterparts,the wave displacements and resonant frequencies of the different fabricated devices were directly measured through scanning laser Doppler ***,to exhibit the capability of the aerosol jet printed devices for lab-on-a-chip applications,we successfully conducted acoustic streaming and particle concentration ***,we demonstrated a novel solution-based,direct-write,single-step,cleanroom-free additive manufacturing technique to rapidly develop SAW microfluidic devices that shows viability for applications in the fields of biology,chemistry,engineering,and medicine.

关键词： printing wave fluid

High-yield and rapid isolation of extracellular vesicles by flocculation via orbital acoustic trapping:FLOAT

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Microsystems & Nanoengineering 2024年第1期10卷 313-323页

作者： Joseph Rufo Peiran Zhang Zeyu Wang Yuyang Gu Kaichun Yang Joseph rich Chuyi Chen Ruoyu Zhong Ke Jin Ye He Jianping Xia Ke Li Jiarong Wu Yingshi Ouyang Yoel Sadovsky Luke P.Lee Tony Jun Huang Department of Mechanical engineering and Materials Science Duke UniversityDurhamNCUSA Department of Biomedical engineering Duke UniversityDurhamNCUSA Department of Obstetrics Gynecologyand Reproductive SciencesMagee-Womens Research InstituteUniversity of PittsburghPittsburghPAUSA Department of Microbiology and Molecular Genetics School of MedicineUniversity of PittsburghPittsburghPAUSA Renal Division and Division of engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMAUSA Department of Bioengineering Department of Electrical Engineering and Computer ScienceUniversity of CaliforniaBerkeleyBerkeleyCAUSA Department of Biophysics Institute of Quantum BiophysicsSungkyunkwan UniversitySuwonKorea

extracellular vesicles(eVs)have been identified as promising biomarkers for the noninvasive diagnosis of various ***,challenges in separating eVs from soluble proteins have resulted in variable eV recovery rates and low ***,we report a high-yield(>90%)and rapid(eV isolation method called FLocculation via Orbital Acoustic Trapping(FLOAT).The FLOAT approach utilizes an acoustofluidic droplet centrifuge to rotate and controllably heat liquid *** adding a thermoresponsive polymer flocculant,nanoparticles as small as 20 nm can be rapidly and selectively concentrated at the center of the *** demonstrate the ability of FLOAT to separate urinary eVs from the highly abundant Tamm-Horsfall protein,addressing a significant obstacle in the development of eV-based liquid *** to its high-yield nature,FLOAT reduces biofluid starting volume requirements by a factor of 100(from 20 mL to 200µL),demonstrating its promising potential in point-of-care diagnostics.

关键词： trapping utilize separating

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美联储难逃美国大选的聚光灯

商业周刊（中文版） 2024年第3期 26-27页

作者： rich Miller 融汐(译) 不详

美联储不希望受到美国大选波及,但此时鲍威尔的任何决定都毫无疑问,美联储主席杰罗姆·鲍威尔(Jerome Powell),并不希望该机构被卷人一场可能极具争议的总统大选。但他发现那几乎是不可能的。在哥伦比亚广播公司2月4日播出的《60分钟》... 详细信息

美联储不希望受到美国大选波及,但此时鲍威尔的任何决定都毫无疑问,美联储主席杰罗姆·鲍威尔(Jerome Powell),并不希望该机构被卷人一场可能极具争议的总统大选。但他发现那几乎是不可能的。在哥伦比亚广播公司2月4日播出的《60分钟》节目中,鲍威尔接受了一次罕见的采访。他在节目中坚称,在决定何时因应通胀消退而降低利率时,美联储不会把政治因素考虑在内。他说:“我们不会考虑这一点。”

关键词：美国大选总统大选鲍威尔美联储聚光灯杰罗姆降低利率通胀

Phase separation of S-RNase promotes self-incompatibility in Petunia hybrida

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Journal of Integrative Plant Biology 2024年第5期66卷 986-1006页

作者： Huayang Tian Hongkui Zhang Huaqiu Huang Yu'e Zhang Yongbiao Xue The State Key Laboratory of Plant Cell and Chromosome engineering Institute of Genetics and Developmental Biologythe Chinese Academy of SciencesBeijing 100101China University of the Chinese Academy of Sciences Beijing 100049China Beiing Institute of Genomics Chinese Academy of SciencesNational Center for BioinformationBeijing 100101China

Self-incompatibility(SI)is an intraspecific reproductive barrier widely present in *** SI system with the broadest occurrence in angiosperms is based on an S-RNase linked to a cluster of multiple S-locus F-box(SLF)genes found in the Solanaceae,Plantaginaceae,Rosaceae,and *** studies reveal that non-self S-RNase is degraded by the Skip Cullin F-box(SCF)SLF-mediated ubiquitin–proteasome system in a collaborative manner in Petunia,but how self-RNase functions largely remains ***,we show that S-RNases form S-RNase condensates(SRCs)in the self-pollen tube cytoplasm through phase separation and the disruption of SRC formation breaks SI in self-incompatible Petunia *** further find that the pistil SI factors of a small asparagine-rich protein HT-B and thioredoxin h together with a reduced state of the pollen tube all promote the expansion of SRCs,which then sequester several actin-binding proteins,including the actin polymerization factor PhABRACL,the actin polymerization activity of which is reduced by S-RNase in ***,we find that S-RNase variants lacking condensation ability fail to recruit PhABRACL and are unable to induce actin foci formation required for pollen tube growth *** together,our results demonstrate that phase separation of S-RNase promotes SI response in ***,revealing a new mode of S-RNase action.

关键词： self-incompatibility S-RNase phase separation

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实践中的独立性论题:如何理解群体认知成功

逻辑学研究 2024年第3期17卷 102-128页

作者：帕翠夏·里奇刘海林拜罗伊特大学哲学系中山大学逻辑与认知研究所中山大学哲学系

社会认识论的一个重要经验是由两部分内容构成的“独立性论题”:群体可能是非理性的,尽管其每一成员都是理性的;群体也可能是理性的,尽管其成员都是非理性的。我们强烈建议将合作合理化方面的研究视为一个范例,进而对现实世界中涉及论... 详细信息

社会认识论的一个重要经验是由两部分内容构成的“独立性论题”:群体可能是非理性的,尽管其每一成员都是理性的;群体也可能是理性的,尽管其成员都是非理性的。我们强烈建议将合作合理化方面的研究视为一个范例,进而对现实世界中涉及论题中第二部分内容的分析提出质疑。我们集中讨论了这类分析的一个突出例子:信息层叠,并论证说明它可以富有成效地概念重构为认知合作的一个实例。这一新视角为改进对这一重要情景的解释和理解指明了方向。

关键词：社会认识论概念重构群体认知独立性提出质疑合理化集中讨论非理性

A national longitudinal cohort study of factors contributing to UK medical students’mental ill-health symptoms

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General Psychiatry 2023年第2期36卷 92-105页

作者： Asta Medisauskaite Milou e W M Silkens Antonia rich Medical School UCLLondonUK Department of Health Services Research and Management City University of LondonLondonUK

Background The mental health of current medical students is predictive of their mental health as future *** prevalence of anxiety,depression and burnout is high among medical students,but less is known about the occurrence of other mental ill-health symptoms,such as eating or personality disorders,and factors contributing to mental ***(1)To explore the prevalence of various mental ill-health symptoms in medical students and(2)to investigate what medical school factors and students’attitudes contribute to these mental ill-health *** Between November 2020 and May 2021,medical students from nine geographically spread medical schools in the UK participated by completing online questionnaires at two points in time,approximately 3 months *** Of the 792 participants who filled in the questionnaire at baseline,over half experienced medium to high somatic symptoms(50.8%;402)and drank alcohol at hazardous levels(62.4%;494).Adjusted longitudinal data analysis of 407 students who completed the follow-up questionnaire demonstrated that less supportive educational climates that were more competitive and less centralised around the students,lower feelings of belongingness,greater stigma towards mental ill-health and lower intentions to seek help for mental ill-health,all contributed to students’mental ill-health *** Medical students experience a high prevalence of various mental ill-health *** study suggests that medical school factors and students’attitudes towards mental ill-health are significantly associated with students’mental health.

关键词： filled doctor competitive

Regeneration of copper catalysts mediated by molybdenum-based oxides

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Journal of energy Chemistry 2024年第8期95卷 618-625,I0013页

作者： Changyu Ding Xiaoli Pan Isla e.Gow Xia Wu Hongchen Cao Zhounan Yu Xiaoyan Liu Xiaofeng Yang Qinggang Liu Yanqiang Huang CAS Key Laboratory of Science and Technology on Applied Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina University of Chinese Academy of Sciences Beijing 100049China Cardiff Catalysis Institute School of ChemistryTranslational Research HubCardiff UniversityCardiff CF244HQUnited Kingdom College of Chemistry Chemical Engineering and Resource UtilizationNortheast Forestry UniversityHarbin 150040HeilongjiangChina

Cu catalysts,known for their unparalleled catalytic capabilities due to their unique electronic structure,have faced inherent challenges in maintaining long-term effectiveness under harsh hydrogenation ***,we demonstrate a molybdenum-mediated redispersion behavior of Cu under hightemperature oxidation *** oxidized Cu nanoparticles with rich metal-support interfaces tend to dissolve into the MoO_(3)support upon heating to 600℃,which facilitates the subsequent regeneration in a reducing atmosphere.A similar redispersion phenomenon is observed for Cu nanoparticles supported on Zn O-modified MoO_(3).The modification of ZnO significantly improves the performance of the Cu catalyst for CO_(2)hydrogenation to methanol,with the high activity being well maintained after four repeated oxidation-reduction *** situ spectroscopic and theoretical analyses suggest that the interaction involved in the formation of the copper molybdate-like compound is the driving force for the redispersion of *** method is applicable to various Mo-based oxide supports,offering a practical strategy for the regeneration of sintered Cu particles in hydrogenation applications.

关键词： Cu-based catalysts Aggregation Regeneration Oxidation CO_(2)hydrogenation

Introducing electrolytic electrochemical polymerization for constructing protective layers on Ni-rich cathodes of Li-ion batteries

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Rare Metals 2024年第6期43卷 2536-2545页

作者： Lin-Tao Dou Bei Li Hao-Long Nie Dong-Dong Xiao Chao-Qun Shang Xiao-Min Wang Zhan-Hui Zhang Katerina e.Aifantis Pu Hu School of Materials Science and engineering Wuhan Institute of TechnologyWuhan 430205China Huairou Division Institute of PhysicsChinese Academy of SciencesBeijing 101400China Department of Mechanical and Aerospace engineering University of FloridaGainesvilleFL 32603USA

LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)(NCM811)is the most promising cathode for high-energy Li-ion batteries,despite its poor cycling stability that originates from the reactions that occur with the ***,to solve this interfacial issue,a facile electrolytic electrochemical polymerization process was introduced in this paper,and a uniform conductive electrolyte interface(polyaniline)was successfully constructed on the surface of the NCM811 porous electrode(PANI-NCM),which facilitated the charge transfer during charge/*** side reactions at the interface between the cathode and the electrolyte are suppressed,and thereby,the cycling performance and rate capability are considerably ***-NCM delivers an initial capacity of 157.2 mAh·g^(-1)as well as excellent cyclability(capacity retention of 88%after 500 cycles at 2C),whereas the capacity of the bare NCM811 has dropped to 31.3 mAh·g^(-1).In addition,polypyrrole and polythiophene also can be formed through electrolytic electrochemical polymerization process,which provides a practicable tactic to modify the interfacial stability of cathodes for high-energy Li-ion batteries.

关键词： Lithium-ion battery Ni-rich cathode In-situ polymerization Conductive polymer electrochemical performance

Acoustofluidics for simultaneous nanopartide-based drug loading and exosome encapsulation

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Microsystems & Nanoengineering 2022年第2期8卷 149-159页

作者： Zeyu Wang Joseph rich Nanjing Hao Yuyang Gu Chuyi Chen Shujie Yang Peiran Zhang Tony Jun Huang Department of Mechanical engineering and Materials Science Duke UniversityDurhamNC 27708USA Department of Biomedical engineering Duke UniversityDurhamNC 27708USA

Nanocarrier and exosome encapsulation has been found to significantly increase the efficacy of targeted drug delivery while also minimizing unwanted side ***,the development of exosome-encapsulated drug nanocarriers is limited by low drug loading efficiencies and/or complex,time-consuming drug loading ***,we have developed an acoustofluidic device that simultaneously performs both drug loading and exosome *** synergistically leveraging the acoustic radiation force,acoustic microstreaming,and shear stresses in a rotating droplet,the concentration,and fusion of exosomes,drugs,and porous silica nanoparticles is *** final product consists of drug-loaded silica nanocarriers that are encased within an exosomal *** drug loading efficiency is significantly improved,with nearly 30%of the free drug(e.g.,doxorubicin)molecules loaded into the ***,this acoustofluidic drug loading system circumvents the need for complex chemical modification,allowing drug loading and encapsulation to be completed within a matter of *** exosome-encapsulated nanocarriers exhibit excellent efficiency in intracellular transport and are capable of significantly inhibiting tumor cell *** utilizing physical forces to rapidly generate hybrid nanocarriers,this acoustofluidic drug loading platform wields the potential to significantly impact innovation in both drug delivery research and applications.

关键词： exosome loading simultaneous