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Thrombolysis in acute stroke under dual antiplatelet therapy: perspectives arising from translational studies

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Neural Regeneration Research 2021年第1期16卷 113-114页

作者： franziska Lieschke Yi Zheng Christian Foerch Klaus van Leyen Neuroprotection Research Laboratory Massachusetts General HospitalHarvard Medical SchoolCharlestownMAUSA Department of Neurology University Hospital FrankfurtGoethe-UniversityFrankfurt am MainGermany

We have recently established a mouse model of focal stroke under dual antiplatelet therapy(DAPT)to study tissue plasminogen activator(tPA)-associated hemorrhagic *** purpose of this short perspective is to discuss the rationale for establishing the model,highlighting its relevance for addressing unresolved clinical *** conversion of the ischemic stroke remains one of the major liabilities of thrombolytic therapy with tPA,contributing to unfavorable outcomes and failed *** was recognized early on,and the resulting restrictions on tPA usage have led to only a minor percentage of stroke patients receiving any kind of drug treatment to limit ischemic injury.

关键词： DAPT hemorrhagic establishing

Multi-LED package design,fabrication and thermal analysis

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Journal of Semiconductors 2013年第5期34卷 54-58页

作者： R.H.Poelma S.Tarashioon H.W.van Zeijl S.Goldbach J.L.J.zijl G.Q.Zhang Delft University of Technology DelftThe Netherlands Philips Lighting EindhovenThe Netherlands Fico/Besi DuivenThe Netherlands

An ultra-thin multi-LED package is designed, manufactured and its thermal performance is character- ized. The objective of this study is to develop an efficient thermal modelling approach for this system which can be used for optimization of the thermal-performance of future ultra-thin designs. A high-resolution thermal imaging camera and thermocouples were used to measure the temperature distribution of the multi-LED package and the LED-die temperature for different operating powers. Finally, we compare the thermal measurements with the finite element simulation results. It is concluded that the modelling approach can assist in the thermal optimization of future multi-LED package designs.

关键词： LED packaging optics molding high-resolution thermal imaging thermal modeling and measure-ments

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红细胞抗体的持续存在性

国外医学（输血及血液学分册） 2001年第6期24卷 533-534页

作者： Henk Schonewille Hans L.Haak Annette M.van zijl 孙国栋李荣国高晖邯郸市中心血站 056001

由于输血、妊娠、组织移植使个体暴露于外来抗原而产生同种抗体,为了检测受血者血清中具有临床意义的同种抗体,输注前须进行红细胞配合性试验.对于不同人和不同抗体而言,抗体持续存在性的血清检测水平也是不同的.抗体免疫球蛋白的类型... 详细信息

由于输血、妊娠、组织移植使个体暴露于外来抗原而产生同种抗体,为了检测受血者血清中具有临床意义的同种抗体,输注前须进行红细胞配合性试验.对于不同人和不同抗体而言,抗体持续存在性的血清检测水平也是不同的.抗体免疫球蛋白的类型、数量及筛选方法的敏感性是影响输血前检测的主要因素.抗体一旦被检出,病人和医生应意识到必须避免不配合输血(特别是当病人在不同医院治疗时,医院应出具这一结果),选择缺乏相应抗原的血液输注.对于曾经检出的具有临床意义的同种抗体,即便现在检测是阴性,也应寻找配合性输血以避免迟发性溶血性输血反应(DHTR)的发生.人们至今还未统计出DHTR的发生率和死亡率,这与诊断标准和所涉及的抗体有关.DHTR常常因其反应的温和性和自限性而被忽略,然而也有一些DHTR导致贫血需要输血.本文回顾调查了有临床意义的红细胞同种抗体经历20年周期的持续存在性.

关键词：红细胞抗体持续存在性红细胞配合性试验输血血液检验

Enhanced π-π Interactions Between a C_(60) Fullerene and a Buckle Bend on a Double-Walled Carbon Nanotube

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Nano Research 2010年第2期3卷 92-97页

作者： Sandeep Gorantla Stanislav Avdoshenko Felix Börrnert Alicja Bachmatiuk Maria Dimitrakopoulou franziska Schäffel Ronny Schönfelder Jürgen Thomas Thomas Gemming Jamie HWarner Gianaurelio Cuniberti Jürgen Eckert Bernd Büchner Mark H.Rümmeli IFW Dresden P.O.Box 270116D-01171 DresdenGermany Institute for Materials Science and Max Bergmann Center of Biomaterials Dresden University of TechnologyDresden 01062Germany Department of Materials University of OxfordParks Rd.Oxford OX13PHUnited Kingdom

In situ low-voltage aberration corrected transmission electron microscopy(TEM)observations of the dynamic entrapment of a C_(60) molecule in the saddle of a bent double-walled carbon nanotube is *** fullerene interaction is non-covalent,suggesting that enhancedπ-πinteractions(van der Waals forces)are *** molecular dynamics calculations confirm that the increased interaction area associated with a buckle is sufficient to trap a ***,they show hopping behavior in agreement with our experimental *** findings further our understanding of carbon nanostructure interactions,which are important in the rapidly developing field of low-voltage aberration corrected TEM and nano-carbon device fabrication.

关键词： Carbon nanotubes fullerenes low-voltage transmission electron microscopy molecule trap

再生微粉配制细砂改善ECC力学性能研究(英文)

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青岛理工大学学报 2009年第4期30卷 119-122页

作者：高嵩崔永清李秋义 G.P.A.Gvanzijl 青岛理工大学土木工程学院青岛266033 青岛市国土资源和房屋管理局青岛266000 Civil Engineering Department Stellenbosch University

作为一种纤维增强水泥基复合材料,ECC的力学性能受到很多因素影响。因而可以通过很多手段对其力学性能进行改良,对水泥砂浆基材进行改性是提升ECC力学性能的一个重要手段,而改良细骨料级配是容易被忽视的有效措施。本试验利用废弃混凝... 详细信息

作为一种纤维增强水泥基复合材料,ECC的力学性能受到很多因素影响。因而可以通过很多手段对其力学性能进行改良,对水泥砂浆基材进行改性是提升ECC力学性能的一个重要手段,而改良细骨料级配是容易被忽视的有效措施。本试验利用废弃混凝土再生微粉与普通砂制备均匀级配细砂,用该细砂配制的ECC砂浆,与普通砂(过1.25mm筛)配制的ECC砂浆进行力学性能比较。结果表明:均匀级配细砂ECC砂浆的直拉、抗弯性能均比普通砂ECC砂浆有明显提高。研究有助于拓展再生超细骨料的应用领域.

关键词：再生微粉 ECC 级配力学性能

DPHL:A DIA Pan-human Protein Mass Spectrometry Library for Robust Biomarker Discovery

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Genomics, Proteomics & Bioinformatics 2020年第2期18卷 104-119页

作者： Tiansheng Zhu Yi Zhu Yue Xuan Huanhuan Gao Xue Cai Sander R.Piersma Thang V.Pham Tim Schelfhorst Richard R.G.D.Haas Irene V.Bijnsdorp Rui Sun Liang Yue Guan Ruan Qiushi Zhang Mo Hu Yue Zhou Winan J.van Houdt Tessa Y.S.Le Large Jacqueline Cloos Anna Wojtuszkiewicz Danijela Koppers-Lalic franziska Bottger Chantal Scheepbouwer Ruud H.Brakenhoff Geert J.L.H.van Leenders Jan N.M.Ijzermans John W.M.Martens Renske D.M.Steenbergen Nicole C.Grieken Sathiyamoorthy Selvarajan Sangeeta Mantoo Sze S.Lee Serene J.Y.Yeow Syed M.F.Alkaff Nan Xiang Yaoting Sun Xiao Yi Shaozheng Dai Wei Liu Tian Lu Zhicheng Wu Xiao Liang Man Wang Yingkuan Shao Xi Zheng Kailun Xu Qin Yang Yifan Meng Cong Lu Jiang Zhu Jin'e Zheng Bo Wang Sai Lou Yibei Dai Chao Xu Chenhuan Yu Huazhong Ying Tony K.Lim Jianmin Wu Xiaofei Gao Zhongzhi Luan Xiaodong Teng Peng Wu Shi'ang Huang Zhihua Tao Narayanan G.Iyer Shuigeng Zhou Wenguang Shao Henry Lam Ding Ma Jiafu Ji Oi L.Kon Shu Zheng Ruedi Aebersold Connie R.Jimenez Tiannan Guo Zhejiang Provincial Laboratory of Life Sciences and Biomedicine Westlake UniversityHangzhou 310024China Key Laboratory of Structural Biology of Zhejiang Province School of Life SciencesWestlake UniversityHangzhou 310024China Institute of Basic Medical Sciences Westlake Institute for Advanced StudyHangzhou 310024China School of Computer Science Shanghai Key Laboratory of Intelligent Information ProcessingFudan UniversityShanghai 200433China Thermo Fisher Scientific(BREMEN)GmbH Bremen 28195Germany OncoProteomics Laboratory Department of Medical OncologyVU University Medical CenterVU UniversityAmsterdam 1011The Netherlands Amsterdam UMC Vrije Universiteit AmsterdamUrologyCancer Center AmsterdamAmsterdam 1011The Netherlands Thermo Fisher Scientific Shanghai 201206China The Netherlands Cancer Institute Surgical OncologyAmsterdam 1011The Netherlands Amsterdam UMC Vrije Universiteit AmsterdamSurgeryCancer Center AmsterdamAmsterdam 1011The Netherlands Amsterdam UMC Vrije Universiteit AmsterdamPediatric Oncology/HematologyCancer Center AmsterdamAmsterdam 1011The Netherlands Amsterdam UMC Vrije Universiteit AmsterdamHematologyCancer Center AmsterdamAmsterdam 1011The Netherlands Amsterdam UMC Vrije Universiteit AmsterdamMedical OncologyCancer Center AmsterdamAmsterdam 1011The Netherlands Amsterdam UMC Vrije Universiteit AmsterdamNeurosurgeryCancer Center AmsterdamAmsterdam 1011The Netherlands Amsterdam UMC Vrije Universiteit AmsterdamPathologyCancer Center AmsterdamAmsterdam 1011The Netherlands Amsterdam UMC Vrije Universiteit AmsterdamOtolaryngology/Head and Neck SurgeryCancer Center AmsterdamAmsterdam 1011The Netherlands Erasmus MC University Medical Center PathologyRotterdam 1016LVThe Netherlands Erasmus MC University Medical Center SurgeryRotterdam 1016LVThe Netherlands Erasmus MC University Medical Center Medical OncologyRotterdam 1016LVThe Netherlands Department of Anatomical Pathology Singapore General HospitalSingapore 169608Singapore Division of Medical Scie

To address the increasing need for detecting and validating protein biomarkers in clinical specimens,mass spectrometry(MS)-based targeted proteomic techniques,including the selected reaction monitoring(SRM),parallel reaction monitoring(PRM),and massively parallel dataindependent acquisition(DIA),have been *** optimal performance,they require the fragment ion spectra of targeted peptides as prior *** this report,we describe a MS pipeline and spectral resource to support targeted proteomics studies for human tissue *** build the spectral resource,we integrated common open-source MS computational tools to assemble a freely accessible computational workflow based on *** then applied the workflow to generate DPHL,a comprehensive DIA pan-human library,from 1096 data-dependent acquisition(DDA)MS raw files for 16 types of cancer *** extensive spectral resource was then applied to a proteomic study of 17 prostate cancer(PCa)***,PRM validation was applied to a larger study of 57 PCa patients and the differential expression of three proteins in prostate tumor was *** a second application,the DPHL spectral resource was applied to a study consisting of plasma samples from 19 diffuse large B cell lymphoma(DLBCL)patients and 18 healthy control *** expressed proteins between DLBCL patients and healthy control subjects were detected by DIA-MS and confirmed by *** data demonstrate that the DPHL supports DIA and PRM MS pipelines for robust protein biomarker *** is freely accessible at https://***/page/***?id=IPX0001400000.

关键词： Data-independent acquisition Parallel reaction monitoring Spectral library Prostate cancer Diffuse large B cell lymphoma