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Journal of Magnesium and Alloys 2024年第1期12卷 394-404页

作者： Lokesh Choudhary Parama Chakraborty Banerjee R.K.Singh Raman Derrek E.Lobo Christopher D.Easton Mainak Majumder frank witte Jörg F.Löffler Department of Mechanical and Aerospace Engineering Monash UniversityClayton CampusMelbourneVIC 3800Australia Department of Chemical and Biological Engineering Monash UniversityClayton CampusMelbourneVIC 3800Australia Nanoscale Science and Engineering Laboratory(NSEL) Bldg 37Monash UniversityClayton CampusMelbourneVIC 3800Australia CSIRO Materials Science and Engineering Bayview AvenueClaytonVIC 3168Australia Julius Wolff Institute and Berlin Brandenburg Center for Regenerative Therapies Charité–Universitätsmedizin BerlinAugustenburger Platz 113353 BerlinGermany Laboratory of Metal Physics and Technology Department of MaterialsETH Zurich8093 ZurichSwitzerland

Biodegradable implants are critical for regenerative orthopaedic procedures,but they may suffer from too fast corrosion in human-body *** necessitates the synthesis of a suitable coating that may improve the corrosion resistance of these implants without compromising their mechanical *** this study,an AZ91 magnesium alloy,as a representative for a biodegradable Mg implant material,was modified with a thin reduced graphene oxide(RGO)-calcium carbonate(CaCO_(3))composite *** analytical and in-vitro electrochemical characterization reveals that this coating significantly improves the corrosion resistance and mechanical integrity,and thus has the potential to greatly extend the related application field.

关键词： Graphene coating Biodegradable implant Hydroxyapatite Corrosion Magnesium alloy

The therapeutic potential of MSC-EVs as a bioactive material for wound healing

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Engineered Regeneration 2021年第1期2卷 182-194页

作者： Yachen Hou Jingan Li Shaokang Guan frank witte School of Material Science and Engineering&Henan Key Laboratory of Advanced Magnesium Alloy&Key Laboratory of materials processing and mold technology(Ministry of Education) Zhengzhou University100 Science RoadZhengzhou 450001PR China Department of Prosthodontics Geriatric Dentistry and Craniomandibular DisordersCharite–Universitatsmedizin BerlinAssmannshauser Strasse 4–6Germany

In clinical trials,cell therapy,especially mesenchymal stem cells(MSC),contributed to wound treatment options in an innovative ***,there are some limitations of MSC during the application process,including strict maintenance requirements and unpredictable *** order to expand the scope of application and reduce the restrictions related to direct use of SMC,the mechanisms of stem cells need to be *** latest research found that the effect of cell therapy is achieved mainly through paracrine effects,and the major bioactive vesicles which responsible for the paracrine effects is *** is a kind of extracellular membrane vesicle,which secreted from various cells and contain proteins,lipids and nucleic acids,to coordinate intercellular *** this review,the main cells type and cytokines relevant to every healing stage has been discussed,and the research about MSC-derived exosomes that has therapeutic effects has been *** last,the potential application of exosomes as a bioactive material in the treatment of wound healing and related challenges as well as its possible solutions are discussed to reveal highly effective therapeutic strategies.

关键词： Exosomes Wound healing Mesenchymal stem cells Bioactive particles

Global collaboration on Biomaterials is starting with Binational WorkshopseSino-German Workshop on Biomaterials in Beijing 2016

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Bioactive Materials 2017年第1期2卷 51-52页

作者： frank witte Mike Barbeck Yufeng Zheng Julius Wolff Institute and Center for Musculoskeletal Surgery Berlin-Brandenburg Center for Regenerative TherapiesCharité-Universitätsmedizin BerlinAugustenburger Platz 113353 BerlinGermany Botiss GmbH Ullsteinstrasse 10812109 BerlinGermany Department of Materials Science and Engineering College of EngineeringPeking UniversityBeijing 100871China

Bioactive Materials is reporting about international events which may promote biomaterial research beyond national *** this regard,both countries,Germany and China have become global players in the field of health economy in the last decades.A sino-german platform for life sciences has already been founded in the field of health economy that enables for more cooperative projects between both research and economy from both ***,many different research projects have already been conducted between both ***,cooperation between researchers,clinicians and industry of different disciplines and fields is especially essential for the progress in biomaterial research and related ***,material scientists,biologists and physicians amongst many others are participating in this research field and are ambitious to find mutual solutions for the regeneration of various *** collaborative research and the markets for biomedical products become more and more global and,thus,programs to sustained established cooperative research are desirable.

关键词： sustained starting mutual

Exploring the degradation behavior of MgXAg alloys by in vitro electrochemical methods

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Bioactive Materials 2022年第1期7卷 441-452页

作者： Yuqiuhan Zhang Tycho Zimmermann Wolf-Dieter Mueller frank witte Florian Beuer Andreas Schwitalla Charit´e-Universit¨atsmedizin Berlin corporate member of Freie Universit¨at Berlin and Humboldt-Universit¨at zu BerlinDental Materials and Biomaterial ResearchDepartment of ProsthodonticsGeriatric Dentistry and Craniomandibular DisordersAßmannshauser Str.4-614197BerlinGermany

Magnesium as biodegradable biomaterial could serve as bone augmentation material in implant *** knowledge about the predictability of the biodegradation process is essential as this process needs to go hand in hand with the formation of new bone to gradually replace the augmentation ***,this work aimed to assess if the electrochemistry(EC)measurements of the corrosion process correlate with the surface features at various time points during the surface degradation,in order to describe the degradation process of Mg and Mg alloys more reliably,under the assumption that differences in EC behavior can be detected and related to specific patterns on the *** this test setup,a special optical chamber was used for electrochemical measurements on Mg and Mg-alloys(Mg2Ag,Mg4Ag,and Mg6Ag).Specimens were investigated using different circulating cell culture solutions as electrolytes,these were minimum essential medium(MEM),Hank’s Balanced Salt Solution(HBSS),and MEM+(MEM with added sodium hydrogen carbonate)at 37℃.Open circuit potential measurements(OCP)over 30 min followed by cyclic polarization were *** electrochemistry data,including OCP,exchange current density and corrosion potential,were compared with visible changes at the surface during these treatments over *** results show that the addition of silver(Ag)leads to a“standardization”of the degradation regardless of the selected test *** is currently difficult to correlate the visible microscopic changes with the data taken from the ***,further investigations are necessary.

关键词： Biodegradable magnesium Magnesium silver alloys Electrochemistry Hydrogen evolution

Open-porous magnesium-based scaffolds withstand in vitro corrosion under cyclic loading:A mechanistic study

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Bioactive Materials 2023年第1期19卷 406-417页

作者： Roxane Bonithon Colin Lupton Marta Roldo Joseph Nicholas Dunlop Gordon William Blunn frank witte Gianluca Tozzi Zeiss Global Centre School of Mechanical and Design EngineeringUniversity of PortsmouthAnglesea RoadPO13DJPortsmouthUnited Kingdom School of Pharmacy and Biomedical Sciences University of PortsmouthWhite Swan RoadPO12DTPortsmouthUnited Kingdom School of the Environment Geography&GeosciencesUniversity of PortsmouthBurnaby RoadPO13QLPortsmouthUnited Kingdom Department of Prosthodontics Geriatric Dentistry and Craniomandibular DisordersCharite-Universitätsmedizin BerlinAßmannshauser Straße 4-614197BerlinGermany Biotrics Bioimplants AG Ullsteinstr.10812109BerlinGermany

The successful application of magnesium(Mg)alloys as biodegradable bone substitutes for critical-sized defects may be comprised by their high degradation rate resulting in a loss of mechanical *** study investigates the degradation pattern of an open-porous fluoride-coated Mg-based scaffold immersed in circulating Hanks’Balanced Salt Solution(HBSS)with and without in situ cyclic compression(30 N/1 Hz).The changes in morphological and mechanical properties have been studied by combining in situ high-resolution X-ray computed tomography mechanics and digital volume *** in situ cyclic compression induced acceleration of the corrosion rate,probably due to local disruption of the coating layer where fatigue microcracks were formed,no critical failures in the overall scaffold were observed,indicating that the mechanical integrity of the Mg scaffolds was *** changes,due to the accumulation of corrosion debris between the scaffold fibres,resulted in a significant increase(p<0.05)in the material volume fraction from 0.52±0.07 to 0.47±0.03 after 14 days of ***,despite an increase in fibre material loss,the accumulated corrosion products appear to have led to an increase in Young’s modulus after 14 days as well as lower third principal strain(εp3)accumulation(-91000±6361μεand-60093±2414μεafter 2 and 14 days,respectively).Therefore,this innovative Mg scaffold design and composition provide a bone replacement,capable of sustaining mechanical loads in situ during the postoperative phase allowing new bone formation to be initially supported as the scaffold resorbs.

关键词： Magnesium alloys Bone regeneration In vitro corrosion X-ray computed tomography(XCT) Digital volume correlation(DVC)

Preliminary study of microstructure, mechanical properties and corrosion resistance of antibacterial Ti-15Zr-xCu alloy for dental application

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Journal of Materials Science & Technology 2020年第15期47卷 31-43页

作者： Sharafadeen Kunle Kolawole Wang Hai Shuyuan Zhang Ziqing Sun Muhammad Ali Siddiqui Ihsan Ullah Wei Song frank witte Ke Yang School of Materials Science and Engineering University of Science and Technology of ChinaHefei230026China Institute of Metal Research Chinese Academy of SciencesShenyang110016China Department of Prosthodontics Geriatric Dentistry and Craniomandibular DisordersAssmannshauser Strane 4-614197BerlinGermany Federal Polytechnic OffaP.M.B.420OffaKwara StateNigeria

Ti-15 Zr-xCu(3≤x≤7,wt.%) novel antibacterial and antibiofilm alloys with competitive mechanical properties,biological responses and corrosion resistance were designed and *** heat treatment on Ti-15 Zr-7 Cu(TZC-7 A),after holding for 2 h at slightly above their beta transus temperature(BTT) ensured their tensile strength(UTS),yield strength(YS) and hardness(HRV) were improved by31.2%,20% and 12.3% respectively compared to the control without Cu,Ti-15 Zr(T-15 ZA).Although the3 wt.% Cu alloy displayed the highest elongation(26%),the TZC-7 A alloy also possessed a good *** of evenly dispersed Ti2 Cu and Zr2 Cu Cu-rich intermetallic phases formed as interwoven and alternating lamellae within the α+β matrix as a result of Cu addition,as revealed by X-ray diffraction(XRD),scanning electron microscopy(SEM) and transmission electron microscopy(TEM).These greatly contributed to their strengthening and bactericidal *** 98% antibacterial effect against *** and *** have been imparted,coupled with excellent biofilm *** polarization curves showed that the TZC-7 A alloy possessed higher corrosion resistance than commercially pure titanium,cp-Ti;contact angle test revealed enhanced hydrophilicity;while confocal laser scanning microscopy(CLSM) and cell counting kit(CCK-8) assays also displayed drastically lowered bacterial adhesion rate with comparatively no *** attachment on all alloys was similar but the best spread was obtained on TZC-7 A after 24 *** developed alloy has good potential as an antibacterial implant material with combination of optimized properties.

关键词： Ti-Zr alloy Cu addition Antibacterial Mechanical properties Intermetallic phases

Immunomodulatory biomaterials against bacterial infections:Progress,challenges,and future perspectives

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The Innovation 2023年第6期4卷 101-114页

作者： Shutao Zhang Hongtao Yang Minqi Wang Diego Mantovani Ke Yang frank witte Lili Tan Bing Yue Xinhua Qu Department of Bone and Joint Surgery Department of OrthopedicsRenji HospitalShanghai Jiaotong University School of MedicineShanghai 200001China School of Engineering Medicine Beihang UniversityBejjing 100191China Laboratory for Biomaterials and Bioengineering Canada Research Chair 1 in Biomaterials and Bioengineering for the Innovation in SurgeryDepartment of Min-Met-MaterialsEngineeringResearch Center of CHU de QuebecDivision of Regenerative MedicineL aval UniversityQuebec CityQC G1V 0A6Canada Institute of Metal Research Chinese Academy of SciencesShenyang 110016China Department of Prosthodontics Geriatic Dentistry and Craniomandibular DisordersCharite Medical UniversityAssmannshauser Strasse 4-614197 BerlinGermany

Bacterial infectious diseases are one of the leading causes of death *** with the use of multiple antibiotic treatment strategies,4.95 million people died from drug-resistant bacterial infections in *** 2050,the number of deaths will reach 10 milion *** increasing mortality may be partly due to bacterial heterogeneity in the infection microenvironment,such as drug-resistant bacteria,biofilms,persister cells,intracellular bacteria,and small colony *** addition,the complexity of the immune microenvironment at different stages of infection makes biomaterials with direct antimicrobial activity unsatisfactory for the longterm treatment of chronic bacterial *** increasing mortality may be partly attributed to the biomaterials failing to modulate the active antimicrobial action of immune ***,there is an urgent need for effective alternatives to treat bacterial ***,the development of immunomodulatory antimicrobial biomaterials has recently received considerable interest;however,a comprehensive review of their research progress is *** this review,we focus mainly on the research progress and future perspectives of immunomodulatory antimicrobial biomaterials used at different stages of ***,we describe the characteristics of the immune microenvironment in the acute and chronic phases of bacterial ***,we highlight the immunomodulatory strategies for antimicrobial biomaterials at different stages of infection and their corresponding advantages and ***,we discuss biomaterial-mediated bacterial vaccines'potential applications and challenges for activating innate and adaptive immune *** review will serve as a reference for future studies to develop next-generation immunomodulatory biomaterials and accelerate their translation into clinical practice.

关键词： infections biomaterials modulator

Biodegradable magnesium barrier membrane used for guided bone regeneration in dental surgery

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Bioactive Materials 2022年第8期7卷 152-168页

作者： Patrick Rider Zeljka Peric Kacarevic Akiva Elad Drazen Tadic Daniel Rothamel Gerrit Sauer Fabien Bornert Peter Windisch David Botond Hangyasi Balint Molnar Emely Bortel Bernhard Hesse frank witte Department of Prosthodontics Geriatric Dentistry and Craniomandibular DisordersCharite-Universitatsmedizin BerlinAßmannshauser Straße 4-614197BerlinGermany Botiss Biomaterials AG Ullsteinstrasse 10812109BerlinGermany Department of Anatomy Histology EmbryologyPathology Anatomy and Pathology HistologyFaculty of Dental Medicine and HealthUniversity of OsijekOsijek31000Croatia CMF Surgery Johannes BLA HospitalMonchengladbachGermany Dental Clinic University of StrasbourgFrance Department of Periodontology Semmelweis UniversityBudapestHungary Xploraytion GmbH Bismarkstrasse 11BerlinGermany Biotrics Bioimplants AG Ullsteinstrasse 10812109BerlinGermany

Barrier membranes are commonly used as part of the dental surgical technique guided bone regeneration(GBR)and are often made of resorbable collagen or non-resorbable materials such as *** collagen membranes do not provide sufficient mechanical protection of the covered bone defect,titanium reinforced membranes and non-resorbable membranes need to be removed in a second ***,biodegradable GBR membranes made of pure magnesium might be an *** this study a biodegradable pure magnesium(99.95%)membrane has been proven to have all of the necessary requirements for an optimal regenerative outcome from both a mechanical and biological *** implantation,the magnesium membrane separates the regenerating bone from the overlying,faster proliferating soft *** the initial healing period,the membrane maintained a barrier function and space provision,whilst retaining the positioning of the bone graft material within the defect *** the magnesium metal corroded,it formed a salty corrosion layer and local gas cavities,both of which extended the functional lifespan of the membrane barrier *** the resorption of the magnesium metal and magnesium salts,it was observed that the membrane became surrounded and then replaced by new *** the membrane had completely resorbed,only healthy tissue *** in vivo performance study demonstrated that the magnesium membrane has a comparable healing response and tissue regeneration to that of a resorbable collagen ***,the magnesium membrane demonstrated all of the ideal qualities for a barrier membrane used in GBR treatment.

关键词： Magnesium Biodegradable Implant GBR Bone healing Soft tissue healing

Biodegradable magnesium fixation screw for barrier membranes used in guided bone regeneration

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Bioactive Materials 2022年第8期7卷 15-30页

作者： Zeljka Peric Kacarevic Patrick Rider Akiva Elad Drazen Tadic Daniel Rothamel Gerrit Sauer Fabien Bornert Peter Windisch David Botond Hangyasi Balint Molnar Till Kammerer Bernhard Hesse Emely Bortel Marco Bartosch frank witte Department of Anatomy Histology EmbryologyPathology Anatomy and Pathology HistologyFaculty of Dental Medicine and HealthUniversity of OsijekOsijek31000Croatia Department of Prosthodontics Geriatric Dentistry and Craniomandibular DisordersCharite-Universitatsmedizin BerlinAßmannshauser Straße 4–614197BerlinGermany Botiss Biomaterials AG Ullsteinstrasse 10812109BerlinGermany CMF Surgery Johannes BLA HospitalMonchengladbachGermany Dental Clinic University of StrasbourgFrance Department of Periodontology Semmelweis UniversityBudapestHungary Xploraytion GmbH Bismarkstrasse 11BerlinGermany University Hospital Munich Department of Dermatology and AllergyFrauenlobstr.9-1180337MunichGermany Biotrics Bioimplants AG Ullsteinstrasse 10812109BerlinGermany

An ideal fixation system for guided bone(GBR)regeneration in oral surgery must fulfil several criteria that includes the provision of adequate mechanical fixation,complete resorption when no longer needed,complete replacement by bone,as well as be biocompatible and have a good clinical *** the first time,a biodegradable magnesium fixation screw made of the magnesium alloy WZM211 with a MgF2 coating has been designed and tested to fulfill these *** mechanical fixation was shown for the magnesium fixation screw in several benchtop tests that directly compared the magnesium fixation screw with an equivalent polymeric resorbable *** demonstrated slightly superior mechanical properties of the magnesium device in comparison to the polymeric device even after 4 weeks of *** of the magnesium fixation screw was demonstrated in several in vitro and in vivo *** of the magnesium screw was investigated in in vitro and in vivo tests,where it was found that the screw is resorbed slowly and completely after 52 weeks,providing adequate fixation in the early critical healing ***,the magnesium fixation screw demonstrates all of the key properties required for an ideal fixation screw of membranes used in guided bone regeneration(GBR)surgeries.

关键词： Magnesium Biodegradable Implant GBR Bone healing Soft tissue healing