The therapeutic potential of MSC-EVs as a bioactive material for wound healing
作者机构：School of Material Science and Engineering&Henan Key Laboratory of Advanced Magnesium Alloy&Key Laboratory of materials processing and mold technology(Ministry of Education)Zhengzhou University100 Science RoadZhengzhou 450001PR China Department of ProsthodonticsGeriatric Dentistry and Craniomandibular DisordersCharite–Universitatsmedizin BerlinAssmannshauser Strasse 4–6Germany
出 版 物：《Engineered Regeneration》 (再生工程（英文）)
年 卷 期：2021年第2卷第1期
页 面：182-194页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：funded by the Key Projects of the Joint Fund of the National Natural Science Foundation of China(U1804251) National Key Research and Development Program of China(2017YFB0702500,2018YFC1106703 and 2016YFC1102403) Innovation and Entrepreneurship Program for College Students(2021cxcy564)
主 题：Exosomes Wound healing Mesenchymal stem cells Bioactive particles
摘 要：In clinical trials,cell therapy,especially mesenchymal stem cells(MSC),contributed to wound treatment options in an innovative ***,there are some limitations of MSC during the application process,including strict maintenance requirements and unpredictable *** order to expand the scope of application and reduce the restrictions related to direct use of SMC,the mechanisms of stem cells need to be *** latest research found that the effect of cell therapy is achieved mainly through paracrine effects,and the major bioactive vesicles which responsible for the paracrine effects is *** is a kind of extracellular membrane vesicle,which secreted from various cells and contain proteins,lipids and nucleic acids,to coordinate intercellular *** this review,the main cells type and cytokines relevant to every healing stage has been discussed,and the research about MSC-derived exosomes that has therapeutic effects has been *** last,the potential application of exosomes as a bioactive material in the treatment of wound healing and related challenges as well as its possible solutions are discussed to reveal highly effective therapeutic strategies.
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