Biodegradable magnesium fixation screw for barrier membranes used in guided bone regeneration

作     者：Zeljka Peric Kacarevic Patrick Rider Akiva Elad Drazen Tadic Daniel Rothamel Gerrit Sauer Fabien Bornert Peter Windisch David Botond Hangyasi Balint Molnar Till Kammerer Bernhard Hesse Emely Bortel Marco Bartosch Frank Witte 

作者机构：Department of Anatomy HistologyEmbryologyPathology Anatomy and Pathology HistologyFaculty of Dental Medicine and HealthUniversity of OsijekOsijek31000Croatia Department of ProsthodonticsGeriatric Dentistry and Craniomandibular DisordersCharite-Universitatsmedizin BerlinAßmannshauser Straße 4–614197BerlinGermany Botiss Biomaterials AGUllsteinstrasse 10812109BerlinGermany CMF SurgeryJohannes BLA HospitalMonchengladbachGermany Dental ClinicUniversity of StrasbourgFrance Department of PeriodontologySemmelweis UniversityBudapestHungary Xploraytion GmbHBismarkstrasse 11BerlinGermany University Hospital MunichDepartment of Dermatology and AllergyFrauenlobstr.9-1180337MunichGermany Biotrics Bioimplants AGUllsteinstrasse 10812109BerlinGermany 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2022年第7卷第8期

页      面：15-30页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 1003[医学-口腔医学] 0805[工学-材料科学与工程（可授工学、理学学位）] 10[医学] 

主　　题：Magnesium Biodegradable Implant GBR Bone healing Soft tissue healing 

摘      要：An ideal fixation system for guided bone(GBR)regeneration in oral surgery must fulfil several criteria that includes the provision of adequate mechanical fixation,complete resorption when no longer needed,complete replacement by bone,as well as be biocompatible and have a good clinical *** the first time,a biodegradable magnesium fixation screw made of the magnesium alloy WZM211 with a MgF2 coating has been designed and tested to fulfill these *** mechanical fixation was shown for the magnesium fixation screw in several benchtop tests that directly compared the magnesium fixation screw with an equivalent polymeric resorbable *** demonstrated slightly superior mechanical properties of the magnesium device in comparison to the polymeric device even after 4 weeks of *** of the magnesium fixation screw was demonstrated in several in vitro and in vivo *** of the magnesium screw was investigated in in vitro and in vivo tests,where it was found that the screw is resorbed slowly and completely after 52 weeks,providing adequate fixation in the early critical healing ***,the magnesium fixation screw demonstrates all of the key properties required for an ideal fixation screw of membranes used in guided bone regeneration(GBR)surgeries.