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Muscle strength deficits are associated with low bone mineral density in young pediatric cancer survivors:The iBoneFIT project

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Journal of Sport and Health Science 2024年第3期13卷 419-427页

作者： Andres Marmol-Perez Jose J.Gil-Cosano Esther Ubago-Guisado francisco J.Llorente-Cantarero Juan francisco Pascual-Gázquez Kirsten K.Ness Vicente martinez-Vizcaino Jonatan R.Ruiz Luis Gracia-Marco Department of Physical Education and Sports Faculty of Sport SciencesSport and Health University Research Institute(iMUDS)University of GranadaGranada 18011Spain Department of Epidemiology and Cancer Control St.Jude Children's Research HospitalMemphisTN 38105USA Department of Communication and Education Loyola University AndalusiaSeville 41704Spain Biosanitary Research Institute ibs.GranadaGranada 18012Spain Maimonides Biomedical Research Institute of Cordoba(IMIBIC) Cordoba 14004Spain CIBEROBN Biomedical Research Networking Center for Physiopathology of Obesity and NutritionCarlos III Health InstituteMadrid 28029Spain Department of Specific Didactics Faculty of EducationUniversity of CordobaCordoba 14071Spain Pediatric and adolescent hematology and oncology service Pediatrics and Pediatric Surgery Clinical Management UnitVirgen de las Nieves University HospitalGranada 18014Spain Health and Social Research Center Universidad de Castilla-La ManchaCuenca 13001Spain

Background Pediatric cancer survivors are at increased risk of muscle weakness and low areal bone mineral density(aBMD).However,the prevalence of muscle strength deficits is not well documented,and the associations of muscle strength with aBMD are unknown in this population.Therefore,this study aimed to investigate the prevalence of upper-and lower-body muscle strength deficits and to examine the associations of upper-and lower-body muscle strength with age-,sex,and race-specific aBMD Z-scores at the total body,total hip,femoral neck,and lumbar spine.Methods This cross-sectional study included 116 pediatric cancer survivors(12.1±3.3 years old,mean±SD;42.2%female).Upper-and lower-body muscle strength were assessed by handgrip and standing long jump test,respectively.Dual‑energy X‑ray absorptiometry was used to measure aBMD(g/cm2).Associations between muscle strength and aBMD were evaluated in multivariable linear regression models.Logistic regression was used to evaluate the contribution of muscle strength(1-decile lower)to the odds of having low aBMD(Z-score≤1.0).All analyses were adjusted for time from treatment completion,radiotherapy exposure,and body mass index.Results More than one-half of survivors were within the 2 lowest deciles for upper-(56.9%)and lower-body muscle strength(60.0%)in comparison to age-and sex-specific reference values.Muscle strength deficits were associated with lower aBMD Z-scores at all sites(B=0.133–0.258,p=0.001–0.032).Each 1-decile lower in upper-body muscle strength was associated with 30%–95%higher odds of having low aBMD Z-scores at all sites.Each 1-decile lower in lower-body muscle strength was associated with 35%–70%higher odds of having low aBMD Z-scores at total body,total hip,and femoral neck.Conclusion Muscle strength deficits are prevalent in young pediatric cancer survivors,and such deficits are associated with lower aBMD Z-scores at all sites.These results suggest that interventions designed to improve muscle strength in this vulnerable population may have the added ben

关键词： Bone health Childhood cancer DXA Lean mass Resistance training

Unilateral rNurr1-V5 transgene expression in nigral dopaminergic neurons mitigates bilateral neuropathology and behavioral deficits in parkinsonian rats withα-synucleinopathy

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Neural Regeneration Research 2024年第9期19卷 2057-2067页

作者： Bismark Gatica-Garcia Michael J.Bannon Irma Alicia Martínez-Dávila Luis O.Soto-Rojas David Reyes-Corona Lourdes Escobedo Minerva Maldonado-Berny ME Gutierrez-Castillo Armando J.Espadas-Alvarez Manuel A.Fernandez-Parrilla Juan U.Mascotte-Cruz CP Rodríguez-Oviedo Irais E.Valenzuela-Arzeta Claudia Luna-Herrera francisco E.Lopez-Salas Jaime Santoyo-Salazar Daniel martinez-Fong Departamento de Fisiología Biofísica y NeurocienciasCentro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Department of Pharmacology Wayne State University School of MedicineDetroitMIUSA Laboratorio de Patogénesis Molecular Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico Red de Medicina para la Educación y Desarrollo y la Investigación Científica de Iztacala(Red MEDICI) Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico Nanoparticle Therapy Institute AguascalientesMéxico Departamento de Biociencias e Ingeniería Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y DesarrolloInstituto Politécnico NacionalCiudad de MéxicoMéxico Escuela Nacional de Medicina y Homeopatía Instituto Politécnico NacionalCiudad de MéxicoMéxico Departamento de Fisiología Escuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalCiudad de MéxicoMéxico Departamento de Biología Molecular y Biotecnología Instituto de Investigaciones BiomédicasUniversidad Nacional Autónoma de MéxicoCiudad de MéxicoMéxico Departamento de Física Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Programa de Nanociencias y Nanotecnología Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico

Parkinsonism by unilateral,intranigralβ-sitosterolβ-D-glucoside administration in rats is distinguished in that theα-synuclein insult begins unilaterally but spreads bilaterally and increases in severity over time,thus replicating several clinical features of Parkinson’s disease,a typicalα-synucleinopathy.As Nurr1 repressesα-synuclein,we evaluated whether unilateral transfected of rNurr1-V5 transgene via neurotensin-polyplex to the substantia nigra on day 30 after unilateralβ-sitosterolβ-D-glucoside lesion could affect bilateral neuropathology and sensorimotor deficits on day 30 post-transfection.This study found that rNurr1-V5 expression but not that of the green fluorescent protein(the negative control)reducedβ-sitosterolβ-D-glucoside-induced neuropathology.Accordingly,a bilateral increase in tyrosine hydroxylase-positive cells and arborization occurred in the substantia nigra and increased tyrosine hydroxylase-positive ramifications in the striatum.In addition,tyrosine hydroxylase-positive cells displayed less senescence markerβ-galactosidase and more neuron-cytoskeleton markerβIII-tubulin and brain-derived neurotrophic factor.A significant decrease in activated microglia(positive to ionized calcium-binding adaptor molecule 1)and neurotoxic astrocytes(positive to glial fibrillary acidic protein and complement component 3)and increased neurotrophic astrocytes(positive to glial fibrillary acidic protein and S100 calcium-binding protein A10)also occurred in the substantia nigra.These effects followed the bilateral reduction inα-synuclein aggregates in the nigrostriatal system,improving sensorimotor behavior.Our results show that unilateral rNurr1-V5 transgene expression in nigral dopaminergic neurons mitigates bilateral neurodegeneration(senescence and loss of neuron-cytoskeleton and tyrosine hydroxylase-positive cells),neuroinflammation(activated microglia,neurotoxic astrocytes),α-synuclein aggregation,and sensorimotor deficits.Increased neurotrophic astrocytes and brain-derived neurotrophic factor can mediate t

关键词： A1 astrocytes A2 astrocytes gene therapy microglia motor deficits nanoparticles neurodegeneration neuroinflammation senescence α-synuclein aggregates

Emerging patterns in the construction of Sejima’s,Sanaa’s and Nishizawa’s domestic spaces,from 1987 to 2010

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Frontiers of Architectural Research 2022年第3期11卷 375-401页

作者： Pedro Garcia martinez francisco Javier Maroto Ramos Universidad Politecnica de Cartagena Escuela Tecnica Superior de Arquitectura y Tecnologfa de EdificationCartagena30201Spain Universidad Politecnica de Madrid Escuela Tecnica Superior de Arquitectura de MadridMadrid28040Spain

Sejima and Nishizawa have developed their work without explicitly referencing a theoretical discourse.However,they have stated that their housing projects describe their"architectural biography."This study presents the hypothesis that systermic theories had infu-enced their housing projects at a spatial and constructive Level.With the aim of testing it,the research produces four lines of results.Firstly,we observe that the word system is prominently current in a signifcant sample of their published texts.We describe how architects like Tomi-naga,Ito,Taki,and Shinohara,who infuenced Sejima when she was still a student,discussed this concept inspired by Christopher Alexander's texts.The second line brings together all the couple's single-family housing projects published between 1987 and 2010 for the first time in a single document,as well as an original graphic-constructive reconstruction of the most outstanding ones.Thirdly,we unveil the emergence of four constructive patterns by applying these theories to the graphic material developed.Finally,we summarize the results in dia-grams,showing the frequency,intensity,and continuity of the identified patterns in the four phases throughout the studied period.Verifying the hypothesis facilitates further research relate their domestic work and their other types of projects.

关键词： Architecture House Pattern Sejima Nishizawa SANAA

Decoupled Photovoltaic Power Ramp-rate Calculation Method for Perturb and Observe Algorithms

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Journal of Modern Power Systems and Clean Energy 2022年第4期10卷 932-940页

作者： Jose Miguel Riquelme-Dominguez francisco M.Gonzalez-Longatt Sergio martinez Electrical Engineering Department Escuela Tecnica Superior de Ingenieros IndustrialesUniversidad Politecnica de Madrid28006 MadridSpain Department of Electrical Engineering Information Technology and CyberneticsUniversity of South-Eastern Norway3918 PorsgrunnNorway

As photovoltaic energy increasingly penetrates in power systems,transmission system operators have started to request its participation in providing ancillary services.One of the demanded services is the power ramp-rate control(PRRC),which attempts to limit the power ramps produced by intermittent irradiance conditions.In order to achieve the desired objective,solutions based on storage systems or modifying the maximum power point tracking(MPPT)in perturb and observe(P&O)algorithms are commonly adopted.The starting point in PRRC is the determination of the instantaneous power ramprate,and different methods have been proposed in the literature for its calculation.However,the accuracy and computational speed of existing procedures can be improved,which may be critical in situations with rapid irradiance fluctuations.In this paper,a decoupled photovoltaic power ramp-rate calculation method is presented,in which the effect of variable irradiance and the P&O algorithm are computed separately.The proposed method has been theoretically demonstrated and tested through simulation and experimental tests.Simulation results show that it can improve the previous methods in terms of accuracy and computation time.Experimental validation with hardware-inthe-loop demonstrates the suitability of the proposed method for real-time applications,even in presence of noisy measurements.

关键词： Hardware-in-the-loop maximum power point tracking perturb and observe photovoltaic power ramp-rate control ramp-rate calculation method

Water Manipulation through Curvature Energy on Humidity Microparticles

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Electrical Science & Engineering 2022年第1期4卷 21-29页

作者： francisco Bulnes Isaias martinez Isai M.martinez IINAMEI International Advanced Research in Mathematics and EngineeringC.A.ChalcoMexico

The electric field created in a curvature energy sensor on air microparticles is used to obtain a temperature-humidity map G:M→SO(2)∪F,by stereo-radially of the sensor design to detect and measure the temperature and humidity of certain local region of the environment space.Likewise,considering the curvature energy as the deviation of any field interaction,even the obstruction to its proper flow,is designed and created a humidity-resistor sensor to the control and optimization of humidity in a space with different gradients of humidity,pressure and temperature in a radial detection and measuring.Then the sensing problem is a problem of free boundary conditions where is satisfied an energy functional of norm ||ξ||_(2),to curvature functions κ,that satisfy in the temperature and humidity function ξ,the change limit condition ξ|_(∂Ω)≤2πξ(r).This carries to that the temperature-humidity sensor must be designed on a length gauge to measure the changes of humidity and temperature in the space.

关键词： Curvature energy Humidity Mean energy curvature Spectral curvature Stereo-radially Water particles

Senescent mesenchymal stem/stromal cells in pre-metastatic bone marrow of untreated advanced breast cancer patients

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Oncology Research 2023年第3期31卷 361-374页

作者： francisco RAÚL BORZONE MARÍA BELÉN GIORELLO LEANDRO MARCELO martinez MARÍA CECILIA SANMARTIN LEONARDO FELDMAN FEDERICO DIMASE EMILIO BATAGELJ GUSTAVO YANNARELLI NORMA ALEJANDRA CHASSEING Laboratorio de Inmunohematología Instituto de Biología y Medicina Experimental(IBYME)Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)Buenos AiresArgentina Division of Hematology and Medical Oncology Department of MedicineWeill Cornell Medical CollegeNew YorkUSA Laboratorio de Regulación Génica y Células Madre Instituto de Medicina TraslacionalTrasplante y Bioingeniería(IMeTTyB)Universidad Favaloro-CONICETBuenos AiresArgentina Facultad de Ciencias de la Salud Universidad Nacional del Centro de la Provincia de Buenos Aires(UNCPB)TandilBuenos AiresArgentina Servicio de Hematología Hospital Militar CentralBuenos AiresArgentina Servicio de Oncología Hospital Militar CentralBuenos AiresArgentina

Breast cancer is the predominant form of carcinoma among women worldwide,with 70%of advanced patients developing bone metastases,with a high mortality rate.In this sense,the bone marrow(BM)mesenchymal stem/stromal cells(MSCs)are critical for BM/bone homeostasis,and failures in their functionality,transform the BM into a premetastatic niche(PMN).We previously found that BM-MSCs from advanced breast cancer patients(BCPs,infiltrative ductal carcinoma,stage III-B)have an abnormal profile.This work aims to study some of the metabolic and molecular mechanisms underlying MSCs shift from a normal to an abnormal profile in this group of patients.A comparative analysis was undertaken,which included self-renewal capacity,morphology,proliferation capacity,cell cycle,reactive oxygen species(ROS)levels,and senescence-associatedβ‑galactosidase(SA‑β‑gal)staining of BMderived MSCs isolated from 14 BCPs and 9 healthy volunteers(HVs).Additionally,the expression and activity of the telomerase subunit TERT,as well as telomere length,were measured.Expression levels of pluripotency,osteogenic,and osteoclastogenic genes(OCT-4,SOX-2,M-CAM,RUNX-2,BMP-2,CCL-2,M-CSF,and IL-6)were also determined.The results showed that MSCs from BCPs had reduced,self-renewal and proliferation capacity.These cells also exhibited inhibited cell cycle progression and phenotypic changes,such as an enlarged and flattened appearance.Additionally,there was an increase in ROS and senescence levels and a decrease in the functional capacity of TERT to preserve telomere length.We also found an increase in pro-inflammatory/pro-osteoclastogenic gene expression and a decrease in pluripotency gene expression.We conclude that these changes could be responsible for the abnormal functional profile that MSCs show in this group of patients.

关键词： Mesenchymal stem/stromal cells Senescence Breast cancer Bone marrow Pre-metastatic niche Bone metastasis

Determining the need for a thoracoscopic approach to treat a giant hiatal hernia when abdominal access is poor

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World Journal of Gastrointestinal Surgery 2023年第12期15卷 2739-2746页

作者： francisco Javier Pérez Lara Rogelio Zubizarreta Jimenez Tatiana Prieto-Puga Arjona Pilar Gutierrez Delgado Juan Manuel Hernández Carmona Jose Manuel Hernández Gonzalez Maria Pitarch martinez Department of Surgery Hopital de AntequeraAntequera 29200Spain DOXA MicrofluidicsRincon de la Victoria 29730Spain Department of Surgery HRU Carlos HayaUnidad Cirugia Hepatobiliopancreat&TrasplantesMalaga 29200Spain

BACKGROUND Giant hernias present a significant challenge for digestive surgeons.The approach taken(laparoscopic vs thoracoscopic)depends largely on the preferences and skills of each surgeon,although in most cases today the laparoscopic approach is preferred.AIM To determine whether patients presenting inadequate laparoscopic access to the intrathoracic hernial sac obtain poorer postoperative results than those with no such problem,in order to assess the need for a thoracoscopic approach.METHODS For the retrospective series of patients treated in our hospital for hiatal hernia(n=112),we calculated the laparoscopic field of view and the working area accessible to surgical instruments,by means of preoperative imaging tests,to assess the likely outcome for cases inaccessible to laparoscopy.RESULTS Patients with giant hiatal hernias for whom a preoperative calculation suggested that the laparoscopic route would not access all areas of the intrathoracic sac presented higher rates of perioperative complications and recurrence during follow-up than those for whom laparoscopy was unimpeded.The difference was statistically significant.Moreover,the insertion of mesh did not improve results for the non-accessible group.CONCLUSION For patients with giant hiatal hernias,it is essential to conduct a preoperative evaluation of the angle of vision and the working area for surgery.When parts of the intrathoracic sac are inaccessible laparoscopically,the thoracoscopic approach should be considered.

关键词： Hiatal hernia Abdominal surgery Laparoscopy Thoracoscopy surgery

Multi-objective optimization design of bridge piers with hybrid heuristic algorithms

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2012年第6期13卷 420-432页

作者： francisco J. martinez-MARTIN Fernando GONZALEZ-VIDOSA Antonio HOSPITALER Víctor YEPES Department of Geotechnical Engineering Universitat Politècnica de València 46022 Valencia Spain Department of Construction Engineering ICITECH Universitat Politècnica de València 46022 Valencia Spain

This paper describes one approach to the design of reinforced concrete (RC) bridge piers, using a three-hybrid multi- objective simulated annealing (SA) algorithm with a neighborhood move based on the mutation operator from the genetic algorithms (GAs), namely MOSAMO1, MOSAMO2 and MOSAMO3. The procedure is applied to three objective functions: the economic cost, the reinforcing steel congestion and the embedded CO 2 emissions. Additional results for a random walk and a descent local search multi-objective algorithm are presented. The evaluation of solutions follows the Spanish Code for structural concrete. The methodology was applied to a typical bridge pier of 23.97 m in height. This example involved 110 design variables. Results indicate that algorithm MOSAMO2 outperforms other algorithms regarding the definition of Pareto fronts. Further, the proposed procedure will help structural engineers to enhance their bridge pier designs.

关键词： Bridge piers Concrete structures Multi-objective optimization Simulated annealing (SA) Structural design

Hospital without dyspnea： rationale and design of a multidisciplinary intervention

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Journal of Geriatric Cardiology 2016年第7期13卷 625-631页

作者： Lourdes Vicent Juan Manuel Nunez Olarte Luis Puente-Maestu Esther Artajona francisco Fernandez-Aviles Manuel martinez-Selles Department of Cardiology Gregorio Maranon General Hospital Madrid Spain Department of Palliative Care Gregorio Maranon General Hospital Madrid Spain Department of Respirology Gregorio Maranon General Hospital Madrid Spain European University of Madrid Madrid Spain Complutense University of Madrid Madrid Spain

呼吸困难是普通、停用的症状呼吸并且心疾病，它在发生正在成长。在医院承认期间，呼吸急促下面诊断、下面对待，尽管有为控制症状可得到的治疗。我们开发了指导到医药职员在处理呼吸困难支持这些药理学和非药理学工具的应用程序的定制... 详细信息

呼吸困难是普通、停用的症状呼吸并且心疾病，它在发生正在成长。在医院承认期间，呼吸急促下面诊断、下面对待，尽管有为控制症状可得到的治疗。我们开发了指导到医药职员在处理呼吸困难支持这些药理学和非药理学工具的应用程序的定制的实现策略。主要目的是不收到呼吸困难的足够的消除的病人的率到减少。这是四阶段的伪试验性的研究。干预在将在心病学和呼吸的药部门被教的二次教学谈话在于。内容将被辩解的照顾专家准备，基于为呼吸困难和病人需要的管理的可得到的工具。在就医的病人的呼吸困难的代表性的研究将在干预前后被执行在诊所由于变化在呼吸困难紧张查明改进。最后阶段为根据我们的经验基于的呼吸困难管理在一致协议的创造在于。这研究的结果被期望价值大并且在不久的将来可以改变临床的实践并且支持一变化为呼吸困难照顾更好。

关键词：长期的肺的疾病呼吸困难心失败辩解的照顾