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How dopamine tunes parvalbumin interneurons in the hippocampus:new experimental observations in Alzheimer's disease

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Neural Regeneration Research 2025年第5期20卷 1405-1406页

作者： Livia La Barbera Paraskevi Krashia annalisa Nobili Department of Medicine and Surgery UniversitàCampus Bio-Medico di RomaViaÁlvaro del PortilloRomeItaly Department of Experimental Neurosciences IRCCS Santa Lucia FoundationVia del Fosso di FioranoRomeItaly Department of Science and Technology for Sustainable Development and One Health UniversitàCampus Bio-Medico di RomaViaÁlvaro del PortilloRomeItaly

Despite decades of dedicated resea rch,Alzheimer's disease (AD) is an age-related and progressive neurodegenerative disorder for which the mechanisms of onset are sti unc *** is cha racterized by featured histological alterations including amyloid-beta (AB) plaque deposition,accumulation of neurofibrillary to ngles of hyperphosphorylated-tau,and neuronal loss,accompanied by progressive cognitive decline and behavioral changes.

关键词： Alzheimer alterations dopamine

Homocysteinemia and Depression in Community-Dwelling Older Adults: The Cohort Longitudinal Study “InveCeAb” (Brain Aging in Abbiategrasso)

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Health 2024年第1期16卷 22-36页

作者： Mauro Colombo annalisa Davin Elena Rolandi Michele Rossi Riccardo Ferrari Erica Spina Antonio Guaita Golgi Cenci Foundation Abbiategrasso Italy

Depression is a major health problem, especially for elderly people. According to the “homocysteine hypothesis of depression”, high homocysteine levels may cause depression of mood via cerebrovascular diseases. Whilst biologically plausible, such hypothesis needs yet confirmation. We aimed at: 1) studying the relationships between homocysteinemia (HCY) and depression in a community-dwelling cohort of people aged 70 to 75 years at baseline;2) investigating plasma levels of HCY and 3) comparing these levels between males and females, in the same population. We exploited the data from four waves (2010, 2012, 2014 and 2018) of the longitudinal study “InveCeAb”, with specific regard towards mood assessment, by Geriatric Depression Scale (GDS) scoring, and diagnosis of clinically relevant or subthreshold depression. HCY plasma levels were measured in the waves 2012, 2014 and 2018. Sample attrition was due mainly to death or overall worsening. No statistically significant differences were found in plasma homocysteine levels in each wave, according to depressive symptoms. No correlations were found between plasma HCY levels in each wave with their corresponding GDS scores, even after adjustment for folate and cobalamin blood concentrations. Dichotomized levels of HCY (≤15 vs >15 μM/l) were not associated with dichotomized GDS scores (≤4 vs higher), clinically relevant and subthreshold depression diagnosis and any antidepressive use, in any wave. First (2012) HCY levels increased with participants’ increasing age, cross-sectionally. Listwise HCY concentrations decreased along the 3 waves. HCY levels were always higher in males than in females. Our results may challenge the “homocysteine hypothesis” of depression, whilst supporting the role of high homocysteinemia as a marker of overall bad health.

关键词： Homocysteinemia Depression Aging Cohort

Functional impacts of non-coding RNA processing on enhancer activity and target gene expression

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Journal of Molecular Cell Biology 2019年第10期11卷 868-879页

作者： Evgenia Ntini annalisa Marsico Max Planck Institute for Molecular Genetics 14195BerlinGermany Free University Berlin 14195BerlinGermany Institute of Computational Biology Helmholtz Zentrum MunchenMunchenGermany

Tight regulation of gene expression is orchestrated by *** recent research advancements,it is becoming clear that enhancers are not solely distal regulatory elements harboring transcription factor binding sites and decorated with specific histone marks,but they rather display sign atures of active transcription,showingdistinct degrees oftranscription unit ***,a substantial fraction of enhancers give rise to different species of non-coding RNA transcripts with an unprecedented range of potential *** this review,we bring together data from recent studies indicating that non-coding RNA transcription from active enhancers,as well as enhancer-produced long non-coding RNA transcripts,may modulate or define the functional regulatory potential ofthe cognate *** addition,we summarize supporting evidence that RNA processing ofthe enhancer-associated long non-coding RNA transcripts may constitute an additional layer of regulation of enhancer activity,which contributes to the control and final outcome of enhancer-targeted gene expression.

关键词： transcription enhancer RNA processing cotranscriptional RNA splicing chromatin long non-coding RNA(IncRNA)

On the Numerical Solution to a Nonlinear Wave Equation Associated with the First Painlev Equation:an Operator-Splitting Approach

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Chinese Annals of Mathematics,Series B 2013年第2期34卷 237-254页

作者： Roland GLOWINSKI annalisa QUAINI Department of Mathematics University of Houston4800 Calhoun RdHouston(TX) 77204USA Laboratoire Jacques-Louis Lions Universit Pierre et Marie Curie4Place Jussieu75252 Paris CEDEX 05France

The main goal of this article is to discuss the numerical solution to a nonlinear wave equation associated with the first of the celebrated Painlevd transcendent ordinary differential equations. In order to solve numerically the above equation, whose solutions blow up in finite time, the authors advocate a numerical methodology based on the Strang＇s symmetrized operator-splitting scheme. With this approach, one can decouple nonlinearity and differential operators, leading to the alternate solution at every time step of the equation as follows：（i） The first Painlevd ordinary differential equation, （ii） a linear wave equation with a constant coefficient. Assuming that the space dimension is two, the authors consider a fully discrete variant of the above scheme, where the space-time discretization of the linear wave equation sub-steps is achieved via a Galerkin/finite element space approximation combined with a second order accurate centered time discretization scheme. To handle the nonlinear sub-steps, a second order accurate centered explicit time discretization scheme with adaptively variable time step is used, in order to follow accurately the fast dynamic of the solution before it blows up. The results of numerical experiments are presented for different coefficients and boundary conditions. They show that the above methodology is robust and describes fairly accurately the evolution of a rather ＂violent＂ phenomenon.

关键词： Painlevd equation Nonlinear wave equation Blow-up solution Operator-SDlitting

Histone deacetylase inhibitors for treatment of hepatocellular carcinoma

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Acta Pharmacologica Sinica 2005年第9期26卷 1025-1033页

作者： Danila CORADINI annalisa SPERANZA UO Tumor Biology and Experimental Therapy Department of Experimental Oncology Istituto Nazionale per lo Studio e la Cura dei Tumori 20133 Milan Italy UO Tumor Biology and Experimental Therapy Department of Experimental Oncology Istituto Nazionale per lo Studio e la Cura dei Tumori 20133 Milan Italy

Hepatocellular carcinoma(HCC)is one of the most common cancers in the *** resection has been considered the optimal treatment approach,but onlya small proportion of patients are suitable candidates for surgery,and the relapserate is *** to prevent recurrence,including chemoemboliza-tionbefore and adjuvant therapy after surgery,have proven to have a limited benefit;liver transplantation is successful in treating limited-stage HCC because only aminority of patients qualify for ***,new therapeutic strat-egies are urgently *** in addition to the classical genetic mecha-nisms of deletion or inactivating point mutations,epigenetic alterations,such ashyperacetylation of the chromatin-associated histones(responsible for genesilencing),are believed to be involved in the development and progression ofHCC,novel compounds endowed with a histone deacetylase(HDAC)inhibitoryactivity are an attractive therapeutic *** particular,pre-clinical resultsobtained using HA-But,an HDAC inhibitor in which butyric acid residues areesterified to a hyaluronic acid backbone and characterized by a high affinity forthe membrane receptor CD44,indicated that this class of compounds may repre-sent a promising approach for hepatocellular carcinoma treatment.

关键词： hepatocellular carcinoma histone deace-tylase inhibitors cancer therapy

The FAIR Funding Model:Providing a Framework for Research Funders to Drive the Transition toward FAIR Data Management and Stewardship Practices

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Data Intelligence 2020年第1期2卷 171-180,314页

作者： Margreet Bloemers annalisa Montesanti The Netherlands Organization for Health Research and Development(ZonMw) 2509 AEThe HagueThe Netherlands Health Research Board(HRB) Dublin 2DO2 H638Ireland

A growing number of research funding organizations(RFOs)are taking responsibility to increase the scientific and social impact of research *** reusable research data are recognized as relevant output for gaining *** are therefore promoting FAIR research data management and stewardship(RDM)in their research funding ***,the implementation of FAIR RDM still faces important obstacles and *** solve these,stakeholders work together to develop innovative tools and *** we elaborate on the role of RFOs in developing a FAIR funding model to support the FAIR RDM in the funding cycle,integrated with research community specific guidance,criteria and metadata,and enabling automatic assessments of progress and output from *** model facilitates to create research data with a high level of FAIRness that are meaningful for a research *** fully benefit from the model,RFOs,research institutions and service providers need to implement machine actionability in their FAIR RDM tools and *** many stakeholders still need to get familiar with“human actionable”FAIR data practices,the introduction of the model will be stepwise,with an active role of the RFOs in driving FAIR RDM processes as effectively as possible.

关键词： FAIR funder Data stewardship Data management plan(DMP) Policy Tools

Targeting endothelial cell metabolism： new therapeutic prospects？

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Frontiers in Biology 2015年第2期10卷 125-140页

作者： annalisa Zecchin Laboratory of Angiogenesis and Neurovascular Link Vesalius Research Center VIB Leuven Belgium Laboratory of Angiogenesis and Neurovaseular Link Department of Oncology KU Leuven Leuven Belgium

Endothelial cells （ECs） line blood vessels and function as a vital conduit for oxygen and nutrients, but can also form vascular niches for various types of stem cells. While mostly quiescent throughout adult life, ECs can rapidly switch to a highly active state, and start to sprout in order to form new blood vessels. ECs can also become dysfunctional, as occurs in diabetes and atherosclerosis. Recent studies have demonstrated a key role for EC metabolism in the regulation of angiogenesis, and showed that EC metabolism is even capable of overriding genetic signals. In this review, we will review the basic principles of EC metabolism and focus on the metabolic alterations that accompany EC dysfunction in diabetes and vessel overgrowth in cancer. We will also highlight how EC metabolism influences EC behavior by modulating post-translational modification and epigenetic changes, and illustrate how dietary supplementation of metabolites can change EC responses. Finally, we will discuss the potential of targeting EC metabolism as a novel therapeutic strategy.

关键词： angiogenesis metabolism endothelial cell dysfunction anti-angiogenic therapy

Interplay between the glass and the gel transition

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Science China(Physics,Mechanics & Astronomy) 2019年第10期62卷 45-50页

作者： annalisa Fierro Antonio de Candia Antonio Coniglio CNR-SPIN c/o Complesso di Monte S.AngeloNapoli 80126Italy Dipartimento di Fisica"Pancini" Universita di Napoli"FedericoⅡ"Complesso di Monte S.AngeloNapoli 80126Italy

By changing the control parameters, many physical systems reach a slow dynamics regime followed by an arrested or a quasiarrested state. Examples, among others, are gels and glasses. In this paper, we discuss some experimental and theoretical results in polymer and colloidal systems, where gel and glass transitions interfere, and use models from Mode Coupling Theory（MCT）to illustrate the rich phenomenology observed. The continuous and the discontinuous transition lines, found in the MCT models,are considered suitable to describe respectively the gel and the glass transitions, so we suggest that the interplay between gel and glass may be interpreted in terms of the F13 MCT model, clarifying also the origin of logarithmic decays often observed in such systems. In particular, the theoretical predictions of the MCT in the F13 model are compared with Molecular Dynamics simulations in model systems for chemical gels and charged colloids.

关键词： glass gel and sol colloid

Diagnosis of cirrhosis and portal hypertension:imaging,non-invasive markers of fibrosis and liver biopsy

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Gastroenterology Report 2017年第2期5卷 79-89,I0001页

作者： Bogdan Procopet annalisa Berzigotti University of Medicine and Pharmacy‘Iuliu Hatieganu’ 3rd Medical Clinic and Hepatology DepartmentRegional Institute of Gastroenterology and Hepatology‘O Fodor’Cluj-NapocaRomania Swiss Liver Center HepatologyUniversity Clinic for Visceral Surgery and MedicineInselspitalUniversity of BernBernSwitzerland

The concept of‘cirrhosis’is evolving and it is now clear that compensated and decompensated cirrhosis are completely different in terms of ***,the term‘advanced chronic liver disease(ACLD)’better reflects the continuum of histological changes occurring in the liver,which continue to progress even after cirrhosis has developed,and might regress after removing the etiological factor causing the liver *** compensated ACLD,portal hypertension marks the progression to a stage with higher risk of clinical complication and requires an appropriate evaluation and *** tests to diagnose cirrhosis(liver biopsy)and portal hypertension(hepatic venous pressure gradient measurement and endoscopy)remain of crucial importance in several difficult clinical scenarios,but their need can be reduced by using different non-invasive tests in standard *** non-invasive tests,the accepted use,major limitations and major benefits of serum markers of fibrosis,elastography and imaging methods are summarized in the present review.

关键词： compensated advanced chronic liver disease hepatic venous pressure gradient elastography ultrasound