Targeting endothelial cell metabolism： new therapeutic prospects？

作     者：Annalisa Zecchin 

作者机构：Laboratory of Angiogenesis and Neurovascular Link Vesalius Research Center VIB Leuven Belgium Laboratory of Angiogenesis and Neurovaseular Link Department of Oncology KU Leuven Leuven Belgium 

出 版 物：《Frontiers in Biology》 (生物学前沿（英文版）)

年 卷 期：2015年第10卷第2期

页      面：125-140页

核心收录：

学科分类：0710[理学-生物学] 12[管理学] 120203[管理学-旅游管理] 1202[管理学-工商管理] 07[理学] 071003[理学-生理学] 

基　　金：supported by an Erasmus Mundus Western Balkans (ERAWEB) scholarship supported by a Federal Government Belgium long-term structural Methusalem funding by the Flemish Government the Research Foundation Flanders (FWO) the Foundation Leducq Transatlantic Network (ARTEMIS) Foundation against cancer European Research Council (ERC) Advanced Research the AXA Research Fund 

主　　题：angiogenesis metabolism endothelial cell dysfunction anti-angiogenic therapy 

摘      要：Endothelial cells （ECs） line blood vessels and function as a vital conduit for oxygen and nutrients, but can also form vascular niches for various types of stem cells. While mostly quiescent throughout adult life, ECs can rapidly switch to a highly active state, and start to sprout in order to form new blood vessels. ECs can also become dysfunctional, as occurs in diabetes and atherosclerosis. Recent studies have demonstrated a key role for EC metabolism in the regulation of angiogenesis, and showed that EC metabolism is even capable of overriding genetic signals. In this review, we will review the basic principles of EC metabolism and focus on the metabolic alterations that accompany EC dysfunction in diabetes and vessel overgrowth in cancer. We will also highlight how EC metabolism influences EC behavior by modulating post-translational modification and epigenetic changes, and illustrate how dietary supplementation of metabolites can change EC responses. Finally, we will discuss the potential of targeting EC metabolism as a novel therapeutic strategy.