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自制小枕在清理新生儿呼吸道中的应用研究

临床和实验医学杂志 2010年第15期9卷 1133-1135页

作者：朱艳梅罗丹林艳玲张彩霞罗美香深圳市宝安区石岩人民医院广东深圳518108

目的探讨自制小枕在新生儿呼吸道清理中的应用观察,寻求快速、彻底、操作简单、安全性更高的清理新生儿呼吸道地方法。方法通过自制小枕对我院2008年1月至2009年11月对我院收治的顺产或剖宫产的胎儿600例,随机分为自制小枕治疗组(实验组... 详细信息

目的探讨自制小枕在新生儿呼吸道清理中的应用观察,寻求快速、彻底、操作简单、安全性更高的清理新生儿呼吸道地方法。方法通过自制小枕对我院2008年1月至2009年11月对我院收治的顺产或剖宫产的胎儿600例,随机分为自制小枕治疗组(实验组)300例,另外300例采用常规治疗(对照组),两组进行疗效分析与评价。结果实验组操作时间、吸引次数、出院时间、并发症情况,及新生儿发生窒息的血气及AG改变情况优于对照组(P<0.05)。结论自制小枕在新生儿呼吸道清理中操作简单、经济实用、清理彻底,有效地降低了新生儿窒息和吸入性肺炎的发生率,值得临床大力推广。

关键词：新生儿呼吸道清理自制小枕应用

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诊断为乳腺癌后的孕产史与死亡率

世界核心医学期刊文摘（妇产科学分册） 2005年第9期1卷 32-32页

作者： Whiteman M.K. Hillis s.D. Curtis K.M. 张丽娟 Centers for D is. Contr. and Prev. Mailstop K-34 4770 Buford Highway NE Atlanta GA 30341 -3724 United States Dr.

OBJECTIVE: To assess whether reproductive factors are associated with mortal it y after breast cancer diagnosis. METHODs: We followed up 4,299 U.s. women enroll ed between 1980 and 1982 at ages 20-54 years as incident breast cancer cases in a population-based, case-control study, the Cancer and steroid Hormone study. Vital status through 1997 for these cases was obtained by linking Cancer and st eroid Hormone study data to surveillance, Epidemiology, and End Results files. W e estimated hazard ratios (HRs) and 95%confidence intervals (cis) for death ass ociated with selected reproductive factors using proportional hazards models. RE sULTs: During a median follow-up of 14.5 years, 1,847 deaths occurred. Women ag ed 20-45 years whose last birth occurred 12 months or less (age-adjusted HR = 1.62, 95%CI 1.10-2.37) and 13-48 months before breast cancer diagnosis (age- adjusted HR = 1.35, 95%CI 1.05-1.75) were at an increased risk for death compa red with nulliparous women. After adjusting for additional factors including tum or stage, women whose last birth occurred 12 months or less before diagnosis rem ained at an increased risk for death (HR = 1.51, 95%CI 1.02-2.23). Fifteen-ye ar survival was 38%, 51%, and 60%among women aged 20-45 years whose last bir th was 12 months or less, 13-48 months, and more than 48 months before diagnosi s, respectively, compared with 65%among nulliparous women. Mortality risk was n ot associated with age at first birth, parity, or breast-feeding duration among women aged 20-45 years or among women aged 46-54 years. CONCLUsION: A recent birth may be an adverse prognostic indicator among women diagnosed with breast c ancer at ages 20-45 years.

关键词：孕产史比例危险率模型最终结局未产妇类固醇激素最后一次研究中心母乳喂养研究机构生存状态

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阴道镜对诊断宫颈病变的临床分析

实用医技杂志 2005年第9B期12卷 2622-2624页

作者：单莉高巧莲张恩娣龙泳陕西省妇幼保健院陕西西安710003 第四军医大学陕西西安710032

目的:探讨阴道镜检查对宫颈病变的诊断的临床价值。方法:研究对象为2003年1月1日至2004年12月31日陕西省妇幼保健院妇产科诊治的3 541例患者,对其宫颈阴道镜检查结果及镜下定位活组织病理检查结果进行分析。结果:经病理确诊为宫颈上皮... 详细信息

目的:探讨阴道镜检查对宫颈病变的诊断的临床价值。方法:研究对象为2003年1月1日至2004年12月31日陕西省妇幼保健院妇产科诊治的3 541例患者,对其宫颈阴道镜检查结果及镜下定位活组织病理检查结果进行分析。结果:经病理确诊为宫颈上皮内瘤样病变(CIN)的患者287例,其中CINⅠ228例,CINⅡ29例,CINⅢ(包括宫颈原位癌cis)30例;宫颈浸润癌87例,慢性宫颈炎1 899例,亚临床人乳头状病毒感染(sPI)147例,宫颈息肉461例,子宫内膜异位症12例,平滑肌瘤14例。结论:阴道镜检查对早期发现宫颈癌,宫颈癌前病变、亚临床人乳头状病毒感染(sPI)有重要价值。对CIN诊断的敏感性和阴性预测值高。统一阴道镜评分标准的意义重大。

关键词：阴道镜宫颈病变诊断

Down-regulation of fra a 1.02 in strawberry fruits causes transcriptomic and metabolic changes compatible with an altered defense response

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Horticulture Research 2021年第1期8卷 777-789页

作者： Begona Orozco-Navarrete Jina song Ana Casanal Rosangela sozzani Victor Flors Jose F.sanchez-sevilla Johanna Trinkl Thomas Hoffmann Catharina Merchante Wilfried schwab Victoriano Valpuesta Laboratorio de Bioquimica y Biotecnologia Vegetal Instituto de Hortofruticultura Subtropical y Mediterranea(IHSM)Universidad de Malaga-Consejo Superior de Investigaciones CientificasDepartamento de Biologia Molecular y BioquimicaFacultad de CienciasUMAMalagaSpain Department of Plant and Microbial Biology North Carolina State UniversityRaleighNCUSA Metabolic Integration and Cell signalling Group Plant Physiology SectionDepartment of Ciencias Agrarias y del Medio NaturalUniversitat Jaume ICastelloSpain Departamento de Genomica y Biotecnologia IFAPAMalagaSpain Biotechnology of Natural Products Technische Universität MünchenLiesel-Beckmann-Str.185354 FreisingGermany

The strawberry fra a 1 proteins belong to the class 10 Pathogenesis-Related(PR-10)*** strawberry,a large number of members have been identified,but only a limited number is expressed in the *** this organ,fra a 1.01 and fra a 1.02 are the most abundant fra proteins in the green and red fruits,respectively,however,their function remains *** know the function of fra a 1.02 we have generated transgenic lines that silence this gene,and performed metabolomics,RNA-seq,and hormonal *** studies associated fra a 1.02 to strawberry fruit color,but the analysis of anthocyanins in the ripe fruits showed no diminution in their content in the silenced *** ontology(GO)analysis of the genes differentially expressed indicated that oxidation/reduction was the most represented biological *** state was not apparently altered since no changes were found in ascorbic acid and glutathione(GsH)reduced/oxidized ratio,but GsH content was reduced in the silenced *** addition,a number of glutathione-s-transferases(GsT)were down-regulated as result of fra a *** highly represented GO category was transport which included a number of ABC and MATE *** the regulatory genes differentially expressed WRKY33.1 and WRKY33.2 were down-regulated,which had previously been assigned a role in strawberry plant defense.A reduced expression of the VQ23 gene and a diminished content of the hormones JA,sA,and IAA were also *** data might indicate that fra a 1.02 participates in the defense against pathogens in the ripe strawberry fruits.

关键词： straw content fruits

缺血性卒中开始时使用降脂类药物与死亡率降低相关

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世界核心医学期刊文摘（神经病学分册） 2005年第11期1卷 57-57页

作者： Elkind M.s.V. Flint A.C. sciacca R.R. sacco R.L. 刘凯 Dr.Neurological Institute 710 West 168th Street New York NY 10032 United States

Background: 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins), the most frequently used lipid-lowering agents (LLAs) have neuroprotective effects in rodent models of ischemic stroke. The authors hypothesized that patients with ischemic stroke taking LLAs would have better outcomes than patients not taking LLAs. Methods: The Northern Manhattan study is a population-based study designed to determine stroke incidence and prognosis in a multiethnic, urban population. Northern Manhattan residents age 40 years or older diagnosed with their first ischemic stroke were eligible. Patients or their proxies were interviewed regarding medications being taken at home before stroke onset. The NIH stroke scale was used to assess stroke severity, categorized as mild (≤5), moderate (6 to 13), or severe (≥14), and the Barthel Index at 6 months to assess functional outcome. Clinical worsening in hospital was recorded by trial neurologists. Odds ratios and 95%cis for association of LLA use and stroke severity, mortality, and functional outcome were calculated using logistic regression. Results: Of 650 patients, 57 (8.8%) were taking LLAs. The majority (90.9%) of LLA users were taking a statin. Clinical worsening in hospital occurred less frequently among patients taking LLAs at stroke onset (6.3%vs 18.2%; p=0.04). Ninety day mortality was lower in those taking LLAs (1.8%vs 10.6%, p=0.03). The proportion of patients with severe stroke among those taking LLAs was not lower (10.7%vs 16.8%, p=0.39). Conclusion: Patients taking lipid-lowering agents (LLAs) at the time of an ischemic stroke may have lower poststroke mortality and a lower risk of worsening during hospitalization. Prospective studies are warranted to determine whether LLAs, and statins in particular, have neuroprotective properties or other beneficial effects in acute ischemic stroke.

关键词：缺血性卒中降脂类药物卒中发作神经保护作用他汀类药物城市人群神经科医师还原酶抑制剂比值比可信区间

富含油酸和亚油酸的油类对提高牛奶中共轭亚油酸含量的影响

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饲料与畜牧（新饲料） 2008年第7期 61-61页

作者：张艳玲 D.P.Bu J.Q.Wang T.R.Dhiman s.J.Liu

选择40头荷斯坦奶牛,测定富含油酸和亚油酸的油类对提高牛奶中C18：2cis-9,trans-11共轭亚油酸和C18：1trans-11（VA）含量的影响。采用完全随机分组法,试验为期9周,最后6周为测定期。对照组的基础中日粮含粗饲料59%,试验组在此基础上... 详细信息

选择40头荷斯坦奶牛,测定富含油酸和亚油酸的油类对提高牛奶中C18：2cis-9,trans-11共轭亚油酸和C18：1trans-11（VA）含量的影响。采用完全随机分组法,试验为期9周,最后6周为测定期。对照组的基础中日粮含粗饲料59%,试验组在此基础上分别添加4%的大豆油（sO）、4%的亚麻油（FO）以及2%的大豆油＋2％的亚麻油（sFO）。

关键词：共轭亚油酸油酸含量牛奶油类荷斯坦奶牛大豆油试验组亚麻油

活性炭固载磷钨酸催化合成异丁醛缩顺-2-丁烯-1,4-二醇

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山东化工 2003年第1期32卷 1-2,16页

作者：彭安顺张成霞付广云临沂师范学院化学与环境科学系山东临沂276005 华北油田井下工艺研究所河北任丘062552

研究了用活性炭固载磷钨酸催化合成异丁醛缩顺 -2 -丁烯 -1,4-二醇。考察了催化剂固载量、醇醛物质的量比、带水剂用量等因素对缩合反应的影响。其优化条件为 :顺 -2 -丁烯 -1,4-二醇、异丁醛、催化剂、带水剂的量分别为 1mol、1.0 5mol... 详细信息

研究了用活性炭固载磷钨酸催化合成异丁醛缩顺 -2 -丁烯 -1,4-二醇。考察了催化剂固载量、醇醛物质的量比、带水剂用量等因素对缩合反应的影响。其优化条件为 :顺 -2 -丁烯 -1,4-二醇、异丁醛、催化剂、带水剂的量分别为 1mol、1.0 5mol、7.0 g、10 0mL ,反应在回流温度下进行 ,时间约 3h ,收率达 86.4%。

关键词：活性炭固载磷钨酸催化合成异丁醛缩顺-2-丁烯-1,4-二醇

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乳腺原位癌的诊断与治疗(附8例报告)

临床和实验医学杂志 2006年第11期5卷 1689-1690页

作者：伍建春王先明李戎郭良峰朱国献深圳市第二人民医院普外科广东深圳518035

目的探讨乳腺原位癌的临床特征和诊断治疗。方法对8例乳腺原位癌的临床资料进行回顾性分析。结果8例乳腺原位癌术前检查5例钼靶摄片有多个密聚钙化点,3例有单孔乳头血性溢液,4例有局部腺体增厚,均在术中快速病理检查明确诊断。4例行乳... 详细信息

目的探讨乳腺原位癌的临床特征和诊断治疗。方法对8例乳腺原位癌的临床资料进行回顾性分析。结果8例乳腺原位癌术前检查5例钼靶摄片有多个密聚钙化点,3例有单孔乳头血性溢液,4例有局部腺体增厚,均在术中快速病理检查明确诊断。4例行乳房切除术,4例行保乳手术。结论随着现代乳腺疾病检查技术的改进与普及,乳腺原位癌的诊断水平必将大幅度提高;保乳手术是治疗乳腺原位癌的趋势;术后一般无须辅助治疗。

关键词：乳腺肿瘤原位癌诊断治疗

提示多发性硬化的临床孤立性综合征:灰质和白质的动态变化——2年的MRI随访研究

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国际医学放射学杂志 2016年第3期 305-305页

作者： M.A.Rocca P.Preziosa s.Mesaros E.Pagani J.Dackovic T.stosic-Opincal 翁艺菲 Neuroimaging Research Unit Institute of Experimental NeurologyDivision of NeuroscienceSan Raffaele Scientific InstituteVita-Salute San Raffaele University

摘要目的研究临床孤立综合征(cis)的病人局域脑灰质和白质萎缩,白质微结构组织损伤和改变模式,能在疾病发生后2年内提示多发性硬化。材料与方法研究经过伦理委员会批准,并征得病人知情同意后进行。在疾病发生2个月内对37例cis病人进行... 详细信息

摘要目的研究临床孤立综合征(cis)的病人局域脑灰质和白质萎缩,白质微结构组织损伤和改变模式,能在疾病发生后2年内提示多发性硬化。材料与方法研究经过伦理委员会批准,并征得病人知情同意后进行。在疾病发生2个月内对37例cis病人进行神经病学评估、常规MRI检查及扩散张量成像,并在之后的第3、12及24个月进行随访。同

关键词：多发性硬化白质髓质脑灰质 MRI