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A Reduced Basis Approach for Some Weakly Stochastic Multiscale Problems

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Chinese Annals of Mathematics,Series B 2012年第5期33卷 657-672页

作者： Claude LE BRIS florian THOMINES CERMICS Ecole Nationale des Ponts et Chaussees6 et 8 Avenue Blaise PascalCite DescartesChamps-sur-Marne77455 Marne-La-Vallée Cedex 2France INRIA Rocquencourt MICMAC teamprojectDomaine de VoluceauBP10578153 Le Chesnay CedexFrance. INRIA Rocquencourt MICMAC team-projectDomaine de VoluceauBP10578153 Le Chesnay CedexFrance Laboratoire Navier Ecole Nationale des Ponts et Chaussees6 et 8 Avenue Blaise PascalCite DescartesChamps-Sur-Marne77455 Marne-La-Vallée Cedex 2France.

In this paper,a multiscale problem arising in material science is *** problem involves a random coefficient which is assumed to be a perturbation of a deterministic coefficient,in a sense made precisely in the body of the *** homogenized limit is then computed by using a perturbation *** computation requires repeatedly solving a corrector-like equation for various configurations of the *** this purpose,the reduced basis approach is employed and adapted to the specific *** authors perform numerical tests that demonstrate the efficiency of the approach.

关键词： Reduced basis Stochastic homogenization Perturbation approach

Zeckendorf representations with at most two terms to x-coordinates of Pell equations

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Science China Mathematics 2020年第4期63卷 627-642页

作者： Carlos A.Gómez florian Luca Departamento de Matematicas Universidad del ValleCali 25360Colombia school of Mathematics University of the WitwatersrandWits 2050South Africa Max Planck Institute for Mathematics Bonn 53111Germany Department of Mathematics Faculty of SciencesUniversity of OstravaOstrava 70103Czech Republic

In this paper,we find all positive squarefree integers d satisfying that the Pell equation X^2-d Y^2=±1 has at least two positive integer solutions(X,Y)and(X′,Y′)such that both X and X′have Zeckendorf representati... 详细信息

关键词： Pell equation Fibonacci numbers lower bounds for linear forms in logarithms reduction method

Strategies to prevent and detect intraoperative spinal cord ischemia during complex aortic surgery:from drainages and biomarkers

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Neural Regeneration Research 2021年第4期16卷 678-679页

作者： Alexander Gombert florian Simon Department of Vascular Surgery University Hospital RWTH Aachen AachenGermany Department of Vascular and Endovascular Surgery Heinrich-Heine-University of DüsseldorfDüsseldorfGermany

Spinal cord ischemia(SCI),a frequent complication following open and endovascular thoracoabdominal aortic aneurysm(TAAA)repair,is a feared complication with relevant impact on a patient's quality of *** the early days of open TAAA repair,more than one third of the patients suffered from ***,due to improved preventive measures and the option of staged endovascular TAAA repair,10%of all patients are affected by spinal cord problems after TAAA repair(Rocha et al.,2020).

关键词： ischemia aortic SCI

An Optimised Surface Structure for Passive, Unidirectional Fluid Transport Bioinspired by True Bugs

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Journal of Bionic Engineering 2021年第2期18卷 375-386页

作者： Sebastian Lifka florian Hischen Johannes Heitz Werner Baumgartner Institute of Biomedical Mechatronics Johannes Kepler University LinzAltenberger Straße 694040 LinzAustria Institute of Applied Physics Johannes Kepler University LinzAltenberger Straße 694040 LinzAustria

Some true bug species use droplet-shaped,open-capillary structures for passive,unidirectional fluid transport on their body surface in order to spread a defensive fluid to protect themselves against *** this paper we investigated if the shape of the structures found on bugs(bug-structure)could be optimised with regard to better performance in unidirectional fluid ***,to use this kind of surface structure in technical applications where fluid surface interaction occurs,it is necessary to adapt the structure geometry to the contact angle between fluid and *** on the principal of operation of the droplet-shaped structures,we optimised the structure shape for better performance in targeted fluid flow and increase in flexibility in design of the structure *** adapt the structure geometry and the structure spacing to the contact angle,we implemented an equilibrium simulation of the,the structure surrounding,*** order to verify the functionality of the optimised structure,we designed and manufactured a *** testing this prototype with pure water used as fluid,the functionality of the optimised structure and the simulation could be *** kind of structure may be used on technical surfaces where targeted fluid transport is needed,*** of condensate in order to prevent the surface from mold growth,microfluidics,lab-on-a-chip applications and on microneedles for efficient drug/vaccine coating.

关键词： biomimetics true bugs liquid-surface interaction passive unidirectional fluid transport microfluidics lab-on-a-chip

Helicobacter pylori vaccination:Is there a path to protection?

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World Journal of Gastroenterology 2014年第34期20卷 11939-11949页

作者： florian Anderl Markus Gerhard Institute for Medical Microbiology Immunology and HygieneTechnische Universit?t MünchenMunich 81675Germany

Helicobacter pylori (H. pylori) is a pathogenic, extracellular bacterium that colonizes the stomach in approximately 50% of the world population. It strongly interacts with the gastric epithelium and mostly causes asymptomatic gastritis. The colonization of H. pylori leads to ulcer development in around 20% of infected patients and may progress to gastric cancer or mucosa-associated lymphoid tissue lymphoma in 1%. Thus, H. pylori is the major cause of gastric cancer worldwide. It has been classified as a class I carcinogen by the World Health Organization. Since its discovery in the early eighties by Warren and Marshall, research has been focused on the investigation of H. pylori biology, host-pathogen interaction, prevention and treatment. Although H. pylori induces a strong humoral and local cellular immune response, the pathogen is not cleared and establishes a chronic infection after encounters in childhood. The ability to colonize the stomach is mediated by several virulence factors that change the host environment, promote adhesion to the epithelium, influence the gastric inflammation and induce immune evasion. H. pylori can be eradicated by antibiotic treatment in combination with a proton-pump inhibitor, but efficacy is decreasing. Current therapies are expensive, have side effects and contribute to increasing antibiotic resistance, underlining the need for novel therapeutics.

关键词： Helicobacter pylori Vaccination Immune response Dendritic cells T-cells

Numerical Visualization of Grease Flow in a Gearbox

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Chinese Journal of Mechanical Engineering 2023年第2期36卷 220-233页

作者： Hua Liu florian Dangl Thomas Lohner Karsten Stahl school of Engineering&Design Department of Mechanical EngineeringTechnical University of MunichGear Research Center(FZG)BoltzmannstraBe1585748 Garching near MunichGermany

Lubricating greases are widely used in *** gear drives and gearboxes with difficult sealing *** efficiency and heat balance of grease-lubricated gearboxes depend strongly on the lubrication mechanisms channeling and circulating,for which the grease flow is *** computational fluid dynamics opens up the possibility to visualize and understand the grease flow in gearboxes in more *** this study,a single-stage gearbox lubricated with an NLGI 1-2 grease was modeled by the finite-volume method to numerically investigate the fluid *** show that the rotating gears influence the grease sump only locally around the *** a low grease fill volume,the rotation of the gears is widely separated from the grease *** a high grease fill volume,a pronounced geargrease interaction results in a circulating grease flow around the *** simulated grease distributions show good accordance with high-speed camera recordings.

关键词： Lubrication Grease Transmission Gearbox Computational fluid dynamics

Unexpected encounter of the parasitic kind

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World Journal of Stem Cells 2019年第11期11卷 904-919页

作者： Holly Matthews florian Noulin Centre for Applied Entomology and Parasitology School of Life Sciences Keele University

Both parasitology and stem cell research are important disciplines in their own *** are a real threat to human health causing a broad spectrum of diseases and significant annual rates morbidity and mortality *** cell research,on the other hand,focuses on the potential for regenerative medicine for a range of diseases including cancer and regenerative *** these two topics might appear distant,there are some“unexpected encounters”.In this review,we summarise the various links between parasites and stem ***,we discuss how parasites’own stem cells represent interesting models of regeneration that can be translated to human stem cell ***,we explore the interactions between parasites and host stem cells during the course of ***,we investigate from a clinical perspective,how stem cell regeneration can be exploited to help circumvent the damage induced by parasitic infection and its potential to serve as treatment options for parasitic diseases in the ***,we discuss the importance of screening for pathogens during organ transplantation by presenting some clinical cases of parasitic infection following stem cell therapy.

关键词： Stem cells Parasites Transplantation Therapeutic Host pathogen interactions

Battery package design optimization for small electric aircraft

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Chinese Journal of Aeronautics 2020年第11期33卷 2864-2876页

作者： Mingkai WANG Shuguang ZHANG Johannes DIEPOLDER florian HOLZAPFEL Institute of Aircraft Airworthiness Engineering School of Transportation Science and EngineeringBeihang UniversityBeijing 100083China Institute of Flight System Dynamics Department of Mechanical EngineeringTechnical University of MunichGarching D-85748Germany

The increasing gross weight of electric Unmanned Aerial Vehicle(UAV) poses a challenge in practical applications. The range and endurance of the electric UAV are limited by the fixed mass of the battery package. In this work, a design optimization method for the battery package topology of small electric UAV is proposed to enhance the performance. To improve the accuracy of the method, the dynamic battery model and simplified electric component models are *** models are utilized by the trajectory optimization method, which takes the dynamic characteristic into consideration to calculate the aircraft performance. The direct optimal control method is used for solving the trajectory optimization problem, and this method is tested on a small blended-wing-body electric aircraft. The test result shows that the range and energy-consumption are mainly influenced by the parallel topology of the battery package, while the flight time in climb phase is more sensitive to the series topology. It is deduced that the range-and energy-optimal design points can be considered concurrently in design optimization. The work proves the feasibility of integrating the trajectory optimization and battery package design.

关键词： Battery pack Design optimization Electric power system Trajectory optimization Unmanned Aerial Vehicle(UAV)

Single-lens dynamic z-scanning for simultaneous in situ position detection and laser processing focus control

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Light(Science & Applications) 2023年第12期12卷 2655-2667页

作者： Xiaohan Du Camilo florian Craig B.Arnold Department of Mechanical and Aerospace Engineering Princeton UniversityPrincetonNJ 08544USA Department of Systems Engineering City University of Hong KongHong KongChina Institut für Werkstofftechnik Universität Kassel34125 KasselGermany Princeton Materials Institute Princeton UniversityPrincetonNJ 08544USA

Existing auto-focusing methods in laser processing typically include two independent modules,one for surface detection and another for z-axis *** latter is mostly implemented by mechanical z stage motion,which is up to three orders of magnitude slower than the lateral processing *** alleviate this processing bottleneck,we developed a single-lens approach,using only one high-speed z-scanning optical element,to accomplish both in situ surface detection and focus control quasi-simultaneously in a dual-beam *** probing beam scans the surface along the z-axis continuously,and its reflection is detected by a set of confocal *** on the temporal response of the detected signal,we have developed and experimentally demonstrated a dynamic surface detection method at 140-350 kHz,with a controlled detection range,high repeatability,and minimum linearity error of 1.10%.Sequentially,by synchronizing at a corresponding oscillation phase of the z-scanning lens,the fabrication beam is directed to the probed z position for precise focus ***,our approach provides instantaneous surface tracking by collecting position information and executing focal control both at 140-350 kHz,which significantly accelerates the axial alignment process and offers great potential for enhancing the speed of advanced manufacturing processes in three-dimensional space.

关键词： dynamic beam simultaneous