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Cross-sectional study to determine viral hepatitis knowledge in different urban populations in Brazil

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World Journal of Hepatology 2018年第11期10卷 867-876页

作者： Helena Medina Cruz Jakeline Ribeiro Barbosa Jeová Keny Baima Colares Antonio Henrique Almeida de Moraes Neto Maria de Fátima Leal Alencar Francisco Inácio Bastos Jurema Corrêa da Mota filipe Aníbal Carvalho-Costa Claudia Alexandra Pontes Ivantes Lia Laura Lewis-Ximenez Livia Melo Villar Laboratory of Viral HepatitisOswaldo Cruz Institute Fiocruz Rio de Janeiro 21040360 Brazi Postgraduate Program in Pathology Federal University of Ceará Fortaleza Ceará 60020181 Brazil Postgraduate Program in Medical Sciences University of Fortaleza Ceará 60430160 Brazil Laboratory of Innovations in Therapies Teaching and Bioproducts Oswaldo Cruz Institute Fiocruz Rio de Janeiro 21040360 Brazil Institute of Communication and Scientifc Information and Technology for Health Oswaldo Cruz Foundation Rio de Janeiro 21040900 Brazil Laboratory of Epidemiology and Molecular Systematics Oswaldo Cruz Institute Fiocruz Rio de Janeiro 21040900 Brazil Orientation and Counselling Centre Curitiba Paraná 80810070 Brazil

AIM To evaluate viral hepatitis knowledge among individuals from different resource areas and health conditions to identify possible *** A cross-sectional, descriptive study was carried out among 447 individuals from five distinct populations in Brazil: Southeast Viral Hepatitis Ambulatory(n = 100), South(n = 89) and Northeast(n = 114) Health Center, Southeast(n = 77) and Northeast(n = 67) low resource areas. All individuals answered a questionnaire assessing sociodemographic characteristics and viral hepatitis awareness. The perception was scored based on the average number of correct answers of all participants and categorized as "low"(0-28 correct answers) or "desirable"(29-46 correct answers). Associations between sociodemographic characteristics and perception were also *** A low level of knowledge was observed in individuals from Northeast Health Center, Northeast and Southeast low resource areas while desirable knowledge was observed in individuals from Viral Hepatitis Ambulatory and South Health Center. According to sociodemographic characteristics, desirable scores were more common among those with secondary education(47.1%), those who declared themselves as white(46.3%), and those who lived in houses with three individuals(25.5%). Multivariate analysis showed an association between viral hepatitis perception and type of population. CONCLUSION The results demonstrated high level of knowledge among study participants from health clinics from the Southeast region of Brazil and the importance of education programs in increasing the level of knowledge in low resource areas.

关键词： Viral hepatitis Knowledge Perception Urban population Brazil

Clinical applications of the jugal lipectomy technique:case reports

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Plastic and Aesthetic Research 2018年第3期5卷 27-35页

作者： Bárbara do Amaral Antunes Alan Robert Moreira Schmitt Michel Abrao Neto filipe Jaeguer Maria da Graea Naclério-Homem Matheus Furtado de Carvalho Dental School Federal University of Juiz de ForaGovernador Valadares 35010-177Brazil Department of Oral and Maxillofacial Surgery University of the State of Rio de JaneiroRio de Janeiro 20551-030Brazil Department of Oral and Maxillofacial Surgery President Tancredo de Almeida Neves UniversitySao Joao Del Rei 36301-182Brazil Department of Oral and Maxillofacial Surgery Pontifical Catholic University of Minas GeraisBelo Horizonte 30535-901Brazil Department of Oral and Maxillofacial Surgery Federal University of Sao PauloSao Paulo 05508-000Brazil Department of Oral and Maxillofacial Surgery Federal University of Juiz de ForaGovernador Valadares 35010-177Brazil

The adipose body of cheek is the tissue located in the buccal space. In the past, the partial removal of this tissue, called jugal lipectomy, was indicated to fill defects resulting from buccosinusal communications and/or maxillary resections. Recently, such technique became popular in facial aesthetics as it gives patients the feel of a more delicate face, in which the zygomatic bone appears to be more prominent due to the reduction in the volume of the cheeks. However, many professionals are unaware of how to establish the correct diagnosis of facial volume alterations, as well as in performing and treating the complications that may arise from jugal lipectomy. The aim of this paper is to present three clinical cases with different applications of jugal lipectomy, discussing some relevant aspects of surgical planning that involve the request for imaging exams and a previous study of this tissue's anatomical features.

关键词： Face lipectomy adipose tissue aesthetics

Molecular docking of DS-3032B,a mouse double minute 2 enzyme antagonist with potential for oncology treatment development

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World Journal of Clinical Oncology 2022年第6期13卷 496-504页

作者： Vítor Hugo Sales da Mota Fabrício Freire de Melo Breno Bittencourt de Brito filipe Antônio França da Silva Kádima Nayara Teixeira Campus Toledo Universidade Federal do ParanáToledo 85.919-899ParanáBrazil Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

BACKGROUND It is known that p53 suppression is an important marker of poor prognosis of cancers,especially in solid tumors of the breast,lung,stomach,and esophagus;liposarcomas,glioblastomas,and *** p53 has mouse double minute 2(MDM2)as its primary negative regulator,this molecular docking study seeks to answer the following hypotheses:Is the interaction between DS-3032B and MDM2 stable enough for this drug to be considered as a promising neoplastic inhibitor?AIM To analyze,in silico,the chemical bonds between the antagonist DS-3032B and its binding site in *** For molecular docking simulations,the file containing structures of MDM2(receptor)and the drug DS-3032B(ligand)were *** three-dimensional structure of MDM2 was obtained from Protein Data Bank,and the one for DS-3032B was obtained from PubChem *** location and dimensions of the Grid box was determined using AutoDock Tools *** this case,the dimensions of the Grid encompassed the entire *** ligand DS-3032B interacts with the MDM2 receptor in a physiological environment with pH 7.4;thus,to simulate more reliably,its interaction was made with the calculation for the prediction of its protonation state using the MarvinSketch®*** ligands,with and without the protonation,were prepared for molecular docking using the AutoDock Tools *** software detects the torsion points of the drug and calculates the angle of the *** docking simulations were performed using the tools of the AutoDock platform connected to the Vina *** analyses of the amino acid residues involved in the interactions between the receptor and the ligand as well as the twists of the ligand,atoms involved in the interactions,and type,strength,and length of the interactions were performed using the PyMol software(***/2)and Discovery Studio from BIOVIA®.RESULTS The global alignment indicated crystal structure 5SWK was more suitable for docking simulati

关键词： DS-3032B Mouse double minute 2 antagonist Molecular docking Tumor suppressor p53

Scalp Melanoma Treated with Ipilimumab in Elderly Patient： A Complete Response to Treatment--Case Report

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Journal of Pharmacy and Pharmacology 2017年第1期5卷 1-4页

作者： Juliana Ramos Chaves filipe Rocha da Silva Lucas Ivanilson Guedes Henriques Silva Thiago Farias Camara Luis Eduardo Wemeck de Carvalho Jonathan Souza Sarraf Oncologica Brasil--Education and Research Belem-PA 66053-000 Brazil Mecicine Faculty Universidade do Estado do Para Belem-PA 66087-670 Brazil Medicine Faculty Centro Universitario do Estado do Para Belem-PA 66613-903 Brazil Medicine Faculty Universidade Federal do Para Belem-PA 66075-110 Brazil

Melanoma is a malignant neoplasm that affects the melanocytes. Its treatment is based on cancer staging. In immunotherapy, it can be pointed out the ipilimumab, used in the systemic therapy for unresectable and/or metastatic melanoma in the first or the second line treatment with increased survival. However, limiting toxicity and the low complete response discourage its use in the elderly patients. The aim of this study is to report the case of an 83-year-old man, white, with scalp melanoma measuring 3.5 cm in its major axis. After two resections was verified that the deep margin was involved, making the lesions unresectable. The evaluation of distant metastasis, by skull, chest and abdomen CT-scan （computed tomography-scan）, was performed and did not detect the presence of any metastatic loci. The patient underwent the first cycle of chemotherapy with DTIC （dacarbazine） protocol. After the first cycle, the medication was discontinued due to significant myelotoxicity and Grade 3 thrombocytopenia. Underwent second line treatment with ipilimumab by four cycles. After this, the patient follow with complete local response, asymptomatic, with no signs of local recurrence or distant metastasis site, and no limiting toxicity during and after a year of treatment with ipilimumab. Thus, it is possible to suggest that the use of ipilimumab isolatedly as a second line treatment may have a good response even in elderly patients.

关键词： Scalp melanoma ipilimumab elderly patients.

Immunotherapy – new perspective in lung cancer

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World Journal of Clinical Oncology 2020年第5期11卷 250-259页

作者： Fillipe Dantas Pinheiro Adriano Fernandes Teixeira Breno Bittencourt de Brito filipe Antonio Franca da Silva Maria Luísa Cordeiro Santos Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

Lung carcinoma is associated with a high mortality worldwide,being the leading cause of cancer *** is mainly classified into squamous non-small cell lung cancer(NSCLC),non-squamous NSCLC,and small cell lung ***,such malignancy has been increasingly subdivided into histological and molecular subtypes to guide *** can be used in adjuvant and palliative *** immunotherapy,it has been widely tested in both first or subsequent palliative *** this sense,drugs such as pembrolizumab,nivolumab,atezolizumab,ipilimumab,avelumab,and durvalumab have been assessed in large *** of these trials have also studied these medicines in adjuvant and in maintenance *** recent years,advances in immunotherapy have raised the hope that the unfavorable prognosis observed in several affected individuals can be *** has increased the overall survival in squamous NSCLC,non-squamous NSCLC,and small cell lung ***,it has added to the oncology practice some side effects that are unusual in standard chemotherapy and require special clinical *** order to show how immunotherapy is being applied in the treatment of lung carcinoma,we reviewed the main studies in adjuvant and palliative *** is the better scheme?What is the better combination?What is the better dose?When should we use immunotherapy?Does programmed cell death ligand 1 expression significantly interfere in immunotherapy efficiency?Some of these questions have already been answered,while others require more investigations.

关键词： Lung cancer Treatment Immunotherapy Squamous non-small cell lung cancer Non-squamous non-small cell lung cancer Small cell lung cancer

Adipocyte Derived Mesenchymal Stromal Cell and Platelet Lysate: Ideal Cell and Supplement for the Treatment of Immune-Inflammatory Diseases?

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CellBio 2016年第2期5卷 15-25页

作者： Felipe Rodrigues Annelise Pezzi Álvaro Laureano Vanessa Valim Bruna Zambonato Alice Dahmer Letícia Baggio filipe Sehn Ianaê Wilke Maria Aparecida L. da Silva Bruna Amorin Cellular Therapy Center Hospital de Clínicas de Porto Alegre Porto Alegre Brazil Laboratory of Cell Culture and Molecular Analysis of Human Cells Hospital de Clínicas de Porto Alegre Porto Alegre Brazil Laboratory of Cell Culture and Molecular Analysis of Human Cells Hospital de Clínicas de Porto Alegre Porto Alegre Brazil Post-graduation in Medicine: Medical Sciences Federal University of Rio Grande do Sul Porto Alegre Brazil

Background: Mesenchymal stromal cells (MSC) are being tested for the treatment of immune diseases. MSC are present in several adult tissues which milieu may influence MSC behavior particularly under inflammatory conditions. Additionally, culture conditions also can modify cell function or state of activation. Methods: To address the influence of the MSC source on its characteristics, we studied a xenofree, platelet lysate supplemented MSC from dental pulp, adipose tissue and bone marrow, co-cultured with isolated T cells and PBMC subset, and studied the effect of culture animal or human supplements immunomodulatory effect. Results: All three sources were efficient in inhibiting T cells. Among all MSC sources, as also described by others, adipose MSC was capable to significantly induce Treg phenotype and decrease T CD8+. Furthermore, comparing fetal bovine serum and platelet lysate, results demonstrate that platelet lysate alone is capable to induce immunomodulatory phenotype. Additional studies have to be made to elucidate the PL immunomodulatory effect.

关键词： Mesenchymal Stromal Cells Dental Pulp Adipose Tissue Bone Marrow T Cells Immunomodulatory Effect

SC Hemoglobinopathy(HbSC) with Osteoarticular Complications:Case Report

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Health 2017年第7期9卷 1075-1080页

作者： filipe Bezerra Macedo Jucier Goncalves Júnior Fabiana Gouveia Guimaraes Raphael Cisne Tomaz Débora Valentim Monte Alto Paula Pessoa Pinheiro Jácia Maria Neves Coelho Department of Pediatric Hospital Maternidade Sao Vicente de Paulo(HMSVP)BarbalhaBrazil School of Medicine Federal University of Cariri(UFCA)BarbalhaBrazil Residence in Pediatrics Federal University of Cariri(UFCA)BarbalhaBrazil

Background: Among hemoglobinopathies, the most prevalent in our population are hemoglobins S and C, which are capable of producing disease when homozygous. In cases of double heterozygotes with sickle hemoglobin C (SC), the disease is less expressive in its clinical condition and rarer. Case report: Patient has a previous hospitalization with pain in the joints in knee and hip and several febrile peaks. Upon physical examination, the patient had difficulty in walking, without edema, pedal and tibial posterior pulses present, with no signs of compartment syndrome. Complementary exams revealed anemia, leukocytosis and lymphopenia. The hemoglobin electrophoresis showed the SC Hemoglobinopathy. The treatment with antibiotic therapy according to the protocol (Oxacillin and Ceftriaxone) was restarted and submitted to joint drainage in affected limb. Conclusion: Osteomyelitis and septic arthritis in patients in the pediatric age group should be considered as serious infections that deserve hospitalization and more expressive treatment.

关键词： SC Hemoglobinopathy Paediatrics Case Report

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藏身于山林葡萄牙NaMora住宅

室内设计与装修 2022年第8期 20-25页

作者：〔葡萄牙〕filipe Pina 〔葡萄牙〕David Bilo 悠扬(编译) 不详

NaMora住宅所在地位于葡萄牙埃什特雷拉山脚下,靠近Goncalo教区,是一片面积大约为18hm^(2)的农业用地,周围环绕着茂密的松林,当地人称之为“莫拉”(Mora)。由于其农业性质,多年来这片土地的自然状态一直被保护得很好。NaMora住宅坐落在... 详细信息

NaMora住宅所在地位于葡萄牙埃什特雷拉山脚下,靠近Goncalo教区,是一片面积大约为18hm^(2)的农业用地,周围环绕着茂密的松林,当地人称之为“莫拉”(Mora)。由于其农业性质,多年来这片土地的自然状态一直被保护得很好。NaMora住宅坐落在一个小山谷的天然遮蔽处,场地内伫立着一座建于20世纪中期的石头农舍。出于对旧建筑的尊重,建筑师filipePina和DavidBilo决定保留原有农舍,在旁边重新建造2座混凝土建筑,作为业主的生活区域。农舍的石头墙面与朴素的混凝土建筑平衡共存,完美地融入以台地为特色的环境之中。

关键词：混凝土建筑住宅农业用地 20世纪中期农舍建筑师葡萄牙墙面

Ultrashort pulse capability at the L2I high intensity laser facility

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High Power Laser Science and Engineering 2017年第1期5卷 7-11页

作者： Gonqalo Figueira Joana Alves Joao M.Dias Marta Fajardo Nuno Gomes Victor Hariton Tayyab Imran Celso P.Joao Jayanath Koliyadu Swen Kunzel Nelson C.Lopes Hugo Pires filipe Ruao Gareth Williams GoLP/Instituto de Plasmas e Fusao Nuclear lnstituto Superior TecnieoUniversidade de LisboaLisbonPortugal Faculdade de Ciências e Tecnologia Universidade Nova de LisboaCaparicaPortugal Department of Physics&Astronomy College of ScienceKing Saud UniversityRiyadhSaudi Arabia

The Laboratory for Intense Lasers(L2I) is a research centre in optics and lasers dedicated to experimental research in high intensity laser science and technology and laser plasma interaction. Currently the laboratory is undergoing an upgrade with the goal of increasing the versatility of the laser systems available to the users, as well as increasing the pulse repetition rate. In this paper we review the current status of the laser research and development programme of this facility, namely the upgraded capability and the recent progress towards the installation of an ultrashort, diode-pumped OPCPA laser system.

关键词： diode-pumped solid-state laser and applications femtosecond laser and applications frequency conversion laser amplifiers nonlinear optics