Nephrotoxicity in cancer treatment:An overview

作     者：Maria Luísa Cordeiro Santos Breno Bittencourt de Brito Filipe Antonio FranÇa da Silva Anelise Costa dos Santos Botelho Fabrício Freire de Melo 

作者机构：Instituto Multidisciplinar em SaúdeUniversidade Federal da BahiaVitória da Conquista 45029094BahiaBrazil 

出 版 物：《World Journal of Clinical Oncology》 (世界临床肿瘤学杂志（英文版）)

年 卷 期：2020年第11卷第4期

页      面：190-204页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Acute kidney injury Cancer Chemotherapy Conventional cytotoxic agents Molecularly targeted agents Nephrotoxicity 

摘      要：Anticancer drug nephrotoxicity is an important and increasing adverse drug event that limits the efficacy of cancer *** kidney is an important elimination pathway for many antineoplastic drugs and their metabolites,which occurs by glomerular filtration and tubular *** agents,both conventional cytotoxic agents and molecularly targeted agents,can affect any segment of the nephron including its microvasculature,leading to many clinical manifestations such as proteinuria,hypertension,electrolyte disturbances,glomerulopathy,acute and chronic interstitial nephritis,acute kidney injury and at times chronic kidney *** clinician should be alert to recognize several factors that may maximize renal dysfunction and contribute to the increased incidence of nephrotoxicity associated with these drugs,such as intravascular volume depletion,the associated use of nonchemotherapeutic nephrotoxic drugs(analgesics,antibiotics,proton pump inhibitors,and bonetargeted therapies),radiographic ionic contrast media or radiation therapy,urinary tract obstruction,and intrinsic renal *** of patients at higher risk for nephrotoxicity may allow the prevention or at least reduction in the development and severity of this adverse ***,the aim of this brief review is to provide currently available evidences on oncologic drug-related nephrotoxicity.