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Investigating the Role of Symbiosis-Regulated CAZymes in the Ectomycorrhizal Interaction between Laccaria bicolor and Populus

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Investigating the Role of Symbiosis-Regulated CAZymes in the...

The Impact of the Essential Fatty Acids (EFA) in Human Health

多彩菌物美丽中国——中国菌物学会2019年学术年会

作者： ZHANG F LABOUREL A CHAMPION C HAON M MACHADO E ANASONTZIS G KEMPPAINEN M PARDO A DAGUERRE Y DEVEAU A VENEAULT-FOURREY C KOHLER A rosso MN HENRISSAT B BERRIN JG MARTIN F UMR 1136 INRA-Université de Lorraine ’Interactions Arbres/Microorganismes’ Laboratoire d’Excellence ARBRE Centre INRA-Lorraine State Key Laboratory of Grassland Agro-Ecosystems Institute of Innovation Ecology Lanzhou University UMR 1163 INRA-Biodiversité et Biotechnologie Fongiques Polytech Marseille Faculté des Sciences de Luminy Laboratorio de Micología Molecular Departamento de Ciencia y TecnologíaUniversidad Nacional de Quilmes CNRS UMR 7257 & Architecture et Fonction des Macromolécules Biologiques Aix-Marseille Université Beijing Advanced Innovation Center for Tree Breeding by Molecular Design Beijing Forestry University

In forest soils, ectomycorrhizal fungi establish a mutualistic symbiosis with tree roots. The mutualistic fungi trade host photoassimilates against soil nitrogen and phosphorus. Differentiation of symbiotic roots induces extensive cell wall architectural modifications in the host apoplastic space. The origin of enzymes involved in these cell wall modifications has been the subject of debate for several *** ectomycorrhizal basidiomycete Laccaria bicolor has a restricted set of carbohydrate-active enzymes(CAZymes) degrading plant cell wall polysaccharides. We speculate that several of the symbiosis-induced CAZymes are involved in the remodeling of the host apoplastic space. Here, we characterize the sole GH5 endoglucanase with a cellulose-binding motif(CBM1) domain(LbGH5) identified in the genome of L. *** showed that the LbGH5 gene is induced five-fold in ectomycorrhizal roots using qPCR and RNA-Seq;RNAi mutants with a decreased expression of LbGH5 have a lower ability to form ectomycorrhizal roots;the purified recombinant LbGH5 displayed enzymatic activity as endoglucanase;In situ localization of LbGH5 in ectomycorrhizal roots demonstrated that the enzyme accumulates in hyphal cell walls forming the mantle and Hartig net. In addition, the other highly induced polygalacturonase-LbGH28 was characterized. LbGH28 gene is upregulated five-fold in ectomycorrhizal roots by qPCR. The knock-down RNAi mutants are failed to form Hartig net in ectomycorrhizal roots. However, the overexpression of LbGH28 in *** is ability to induce more lateral roots and ectomycorrhiza comparing with wild type. We purified recombinant LbGH28 which showing polygalacturonase activity in vitro. LbGH28 is also secreted in cell wall of Hartig net and mantle by indirect immunofluorescence and immunogold *** together, these data suggest that ectomycorrhizal fungi secreted apoplastic effectors to remodeling plant cell wall for mycorrhizal formation.

关键词： Laccaria bicolor pectinase carbohydrate-active enzymes cell wall-modifying enzymes apoplastic effector endoglucanase polygalacturonase

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Open Journal of Endocrine and Metabolic Diseases 2015年第7期5卷 98-104页

作者： Alberto Krayyem Arbex Vagner Rosa Bizarro Julio Cesar Salles Santos Lis Marina Mesquita Araújo Ana Luísa Conceicao de Jesus Minelli Salles Alves Fernandes Marcela Miranda Salles Denise rosso Tenório Wanderley Rocha Aline Marcadenti Division of Endocrinology Faculdade IPEMED de Ciências Médicas (IPEMED) Rio de Janeiro Brazil Visiting Scientist of the Harvard School of Public Health Harvard University Boston USA Postgraduate Studies Program in Cardiology Instituto de Cardiologia/Fundacao Universitária de Cardiologia do Rio Grande do Sul (IC/FUC) Porto Alegre Brazil Department of Nutrition Universidade Federal de Ciências da Saúde de Porto Alegre (UFSCPA) Porto AlegreBrazil

Linoleic (LA) and α-linolenic acids (ALA) are considered essential fatty acids (EFA) because they are not produced by the human body. This way, EFAs sources must come from the diet. The primary dietary source of n-3 fatty acids is ALA, found in seeds and seed oils. Other important sources are fish oils such as tuna, salmon and herring. Currently, numerous studies suggest possible benefits of essential fatty acids in human health, such as in cardiovascular, cognitive and eye health, and also during pregnancy and childhood. This paper also discusses the impact of fatty acids in human metabolism, and the available evidence regarding its risks. It addresses the relevant debate regarding a general ban of trans fatty acids (TFA) from the world food market, because of the cardiovascular risks associated with its consumption.

关键词： Fatty Acids Linoleic Acid Alpha-Linolenic Acid Cardiovascular Health Trans Fatty Acids

根据表观扩散系数预测梗死面积的增长:无需静脉注射对比剂评价半暗带

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国际医学放射学杂志 2009年第2期32卷 180-181页

作者： C.rosso N.Hevia-Montiel S.Deltour *** D.Dormont S. Crozier 高欣 AP-HP-Urgences Cérébro-Vasculaires Laboratoire de Neurosciences Cognitives et Imagerie Cérébraleand APHP-Service de NeuroradiologieUniversité Pierre et Marie Curie

目的通过对急性脑卒中病人的MR扩散加权成像（DWI）进行后处理得到表观扩散系数图（ADC图）来比较预测的和最终梗死的病变体积，证实预测的梗死面积的增长可反映因血管是否再通而处于危险状态的半暗带。方法法国立法规定基于病人医疗... 详细信息

目的通过对急性脑卒中病人的MR扩散加权成像（DWI）进行后处理得到表观扩散系数图（ADC图）来比较预测的和最终梗死的病变体积，证实预测的梗死面积的增长可反映因血管是否再通而处于危险状态的半暗带。方法法国立法规定基于病人医疗文件的此类研究无需通知病人并得到其同意，但病人和（或）其亲属也被告知可拒绝参加此研究。

关键词：表观扩散系数梗死面积半暗带静脉注射预测对比剂 MR扩散加权成像 ADC图

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Prevalence of Low Levels of Vitamin D in Type 2 Diabetes at the City of Mangueirinha, Paraná, Southern Brazil

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Open Journal of Endocrine and Metabolic Diseases 2016年第1期6卷 8-12页

作者： Paulo Sérgio Chiamolera Cristiano Alvariza Amaral Monica Cristina de Oliveira Russo Gilberto de Oliveira Netto Ricardo Augusto Fernandes Ricardo Teles de Andrade José Luiz Gonçalves Buscariolli Denise rosso Tenório Wanderley Rocha Alberto Krayyem Arbex Division of Endocrinology IPEMED Medical School Sao Paulo Brazil Visiting Scholar Harvard T. H. Chan School of Public Health Harvard University Boston USA

Background: Diabetes mellitus is a worldwide epidemic. In 2002 there were 173 million diabetic adults worldwide, and these numbers are expected to reach up to 300 million people by 2030. Meanwhile, vitamin D deficiency has its worldwide prevalence directly influenced by factors as solar radiation, skin color, latitude and seasons, cultural habits of populations such as clothing and food, and these factors are important to explain the different prevalences of vitamin D deficiency in the world. Methods: A prospective cross-sectional cohort study was conducted with patients in the outpatient clinic of the Health Unit of the city of Mangueirinha, Paraná, Southern Brazil. Fifty-four type 2 diabetic patients were evaluated (38 women and 16 men), aged 55.8 ± 12.6 years. The following variables were evaluated: age, ethnicity, presence of type 2 diabetes (DM2), hypertension, dyslipidemia, weight, BMI, WC, blood pressure, blood glucose, glycated hemoglobin, ionized calcium, PTH, 25-OH Vit, total cholesterol, HDL, LDL, urea, creatinine, uric acid and red cell/hematocrit. Results: mean BMI was 30.2 ± 4.4 kg/m2, indicating class 1 obesity in this population. Fasting glucose levels were approximately 169.8 ± 74.5 mg/dL. The 25-OH vitamin D values for this population were 23.4 ± 8.3 ng/mL, and 13% of them showed 25-OH vitamin D levels above 30 mg/dL. Fifty percent of those patients had vitamin D levels lower than 30 mg/dL, and 37% had less than 20 mg/dL. Conclusions: this study suggests that vitamin D is associated with low levels of vitamin D in type 2 diabetic patients. Supplementation of vitamin D should be considered in diabetic patients, when levels under 30 mg/mL are found.

关键词： 25 OH Vitamin D Type 2 Diabetes Mellitus Cardiovascular Risk

单体位乳腺断层融合技术独立检出乳腺癌的效能:Malm乳腺断层融合筛查试验的人群普查结果

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国际医学放射学杂志 2016年第2期 205-206页

作者： K.Lng I.Andersson A.rosso A.Tingberg P.Timberg S.Zackrisson 郑丽 Department of Diagnostic Radiology Translational Medicine Malm Lund University

摘要目的评估单体位数字化乳腺断层融合技术(DBT)在乳腺癌筛查中的检出效能。方法 Malm觟乳腺断层融合筛查试验是一项基于人群的前瞻性非干预性研究,计划在符合筛查试验要求的40～74岁女性群体中,随机抽取15 000例纳入该研究。本文就此... 详细信息

摘要目的评估单体位数字化乳腺断层融合技术(DBT)在乳腺癌筛查中的检出效能。方法 Malm觟乳腺断层融合筛查试验是一项基于人群的前瞻性非干预性研究,计划在符合筛查试验要求的40～74岁女性群体中,随机抽取15 000例纳入该研究。本文就此研究的前半部分内容进行探析(n=7 500)。

关键词：乳腺癌 DBT 乳腺肿瘤 Malm 筛查试验检出体位融合技术断层地质构造

Clinical and Technological Dependence Characteristics on a Series of Brazilian Cases with Infantile Onset Pompe Disease in Enzyme Replacement Therapy

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Open Journal of Clinical Diagnostics 2019年第1期9卷 16-32页

作者： Paula De Almeida Thomazinho Eliana Pelissari Regina Celia Beltrao Duarte Carolina Fishinger Moura De Souza Heloise Helena Siqueira Borges Maria Da Gloria Cruvinel Horta Liane De rosso Giuliani Ana Maria Martins Lilian Stewart Dafne Dain Gandelman Horovitz Juan Clinton Llerena Motor Physical Therapy Unit Fernandes Figueira National Institute/FIOCRUZRio de JaneiroBrazil Clinical Medical Unit Dr.Jeser Amarante Faria Children’s HospitalJoinvilleBrazil Pediatric Neurology Unit Santa Casa de Misericordia do Para FoundationBelemBrazil Sciences Medical Genetics Unit Service of Information on Inborn Errors of MetabolismHospital de Clínicas de Porto AlegrePorto AlegreBrazil Clinical Medical Unit University of Cuiaba UNICCuiabaBrazil Santa Casa de Belo Horizonte Belo HorizonteBrazil Genetics Unit Federal University of Mato Grosso do SulCampo GrandeBrazil Inborn Errors of Metabolism and Genetics Unit Federal University of São PauloUNIFESPSão PauloBrazil Pediatric Intensive Care Unit State Institute of Cardiology of Rio de JaneiroIECACRio de JaneiroBrazil 1 Medical Genetics Unit Fernandes Figueira National Institute of WomenChildren and Adolescent Health/FIOCRUZRio de JaneiroBrasil

Pompe disease (PD) is a rare inborn error of metabolism due to an abnormal acid alpha-glucosidase (GAA) activity that comprises glycogen breakdown mainly in the lysosomes. Since the introduction of enzyme replacement therapy (ERT), with recombinant human GAA for the early onset PD patient, a relevant field of clinical research due to the benefits regarding survival rate has been widely documented worldwide. Objective: To describe the clinical characteristics and the ERT effects in a series of Brazilian patients with infantile onset PD (IOPD) under ERT. Methods: Brazilian patients diagnosed with IOPD under ERT were recruited through their physicians participating in the International Pompe Disease Registry from 2009 to 2017. Data were collected by an online survey. Results: 10 IOPD patients were identified through the survey with a death rate of 30% and technology dependency rate reported as 80% (motor, respiratory or nutritional fields) of the patients. After the third year of ERT, motor disabilities were lost in 50% of ambulated patients. The overall characteristics were similar to international studies. Conclusion: Despite ERT benefits in cardiac involvement, motor disabilities seem to be much more compromised in IOPD patients, with high technology dependence, especially after three years of age.

关键词： Motor Development Child Disability Glycogen Storage Disease Type II Enzyme Replacement Therapy

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纳米地球科学:从电子运动到岩石层板块

世界地震译丛 2002年第5期33卷 69-73页

作者： S.K.Lower M.F.Hochella.Jr J.F.Banfield K.M.rosso 李娟中国地震局分析预报中心

纳米尺度科学的研究者们在1 nm(纳米)到100 nm 空间范围内探索自然运作规律。尽管地球科学家们以探索大尺度、复杂的过程而自豪,但几乎所有地质现象的本源都来源于纳米尺度的现象。据保守估计,地球近表面由10^(30) nm^2的非生物和生物... 详细信息

纳米尺度科学的研究者们在1 nm(纳米)到100 nm 空间范围内探索自然运作规律。尽管地球科学家们以探索大尺度、复杂的过程而自豪,但几乎所有地质现象的本源都来源于纳米尺度的现象。据保守估计,地球近表面由10^(30) nm^2的非生物和生物表面构成(Hochella and White,1990;Whitman,

关键词：纳米地球科学电子运动岩石层板块弹性模量

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Diabetes, Obesity and the Nutrition Transition in the Mercosur

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Open Journal of Endocrine and Metabolic Diseases 2016年第1期6卷 28-37页

作者： Tatiane Andreazza Lucchese Amanda Maia Breis Karine Rucker Vagner Rosa Bizarro Lis Marina Mesquita Araújo Alessandre Gomes Mikele Torino Paletti Ana Luísa Conceição de Jesus Marcella Garcez Duarte Denise rosso Tenório Wanderley Rocha Alberto Krayyem Arbex Division of Endocrinology IPEMED Medical School (IPEMED) Sao Paulo Brazil Brazilian Association of Nutrology (ABRAN) Catanduva Sao Paulo Brazil Visiting Scholar Harvard T. H. Chan School of Public Health Harvard University Boston USA

Diabetes and obesity are major health hazards in Latin America nowadays. Their prevalence has steadily increased since the eighties. Today, more than 50% of the population are overweight, 15% has obesity and 6% to 15% has diabetes. The nutrition transition is a long-term process that brings chronic metabolic diseases as an undesired consequence, whilst ultra processed foods become increasingly part of daily food choices. These changes bring impacts in all fields of daily life, especially in the economic and legal fields—the “Right to Health”—and regarding autonomy of the individual and their choices, when confronted with an ideal of health and well-being. Governments and citizens struggle to propose new pathways and find effective solutions to control both epidemics and solve these issues. This article poses the evolution of diabetes and obesity in the Mercosur, seeking a better understanding of these chronic, non-communicable diseases, and looking for concrete, effective solutions towards health in South America.

关键词： Obesity Diabetes Mercosur Nutrition Transition Right to Health South America

非酒精性脂肪性肝病中脂肪组织胰岛素抵抗与肝巨噬细胞的相互作用

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临床肝胆病杂志 2020年第3期36卷 531-531页

作者：赵优优高普均 rosso C KAZANKOV K YOUNES R 吉林大学第一医院感染病中心肝病科不详

【据《J Hepatol》2019年11月报道】题:非酒精性脂肪性肝病中脂肪组织胰岛素抵抗与肝巨噬细胞的相互作用(作者rosso C等)非酒精性脂肪性肝病(NAFLD)和脂肪性肝炎(NASH)的发病机制可能是由于紊乱的代谢环境与肝脏炎症和纤维化的局部介质... 详细信息

【据《J Hepatol》2019年11月报道】题:非酒精性脂肪性肝病中脂肪组织胰岛素抵抗与肝巨噬细胞的相互作用(作者rosso C等)非酒精性脂肪性肝病(NAFLD)和脂肪性肝炎(NASH)的发病机制可能是由于紊乱的代谢环境与肝脏炎症和纤维化的局部介质之间的相互作用。该研究旨在阐明巨噬细胞活化、靶器官/组织胰岛素抵抗(IR)与肝损伤之间的相互作用。

关键词：非酒精性脂肪性肝病肝巨噬细胞巨噬细胞活化脂肪组织肝脏炎症靶器官肝损伤纤维化

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