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Liver tumors invading the hepatocaval confluence:treatment improvements still not completed

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Hepatobiliary & Pancreatic diseases International 2016年第6期15卷 570-571页

作者： Isidoro di carlo Department of Surgical Sciences and Advanced Technologies University of Catania

Also if rarely, hepatocellular carcinoma, cholangiocarcinoma, and metastatic carcinoma can invade the retrohepatic portion of the inferior vena cava （IVC）, because of the proximity of this vessel to the liver.

关键词： IVC Liver tumors invading the hepatocaval confluence

Particle focusing by 3D inertial microfluidics

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Microsystems & Nanoengineering 2017年第1期3卷 204-211页

作者： Petra Paiè Francesca Bragheri dino di carlo Roberto Osellame Istituto di Fotonica e Nanotecnologie(IFN)-CNR and dipartimento di Fisica-Politecnico di Milano Piazza Leonardo da Vinci 3220133 MilanItaly Department of Bioengineering Department of Mechanical EngineeringCalifornia NanoSystems Instituteand Jonsson Comprehensive Cancer CenterUniversity of California-Los Angeles420 Westwood Plaza5121 Engineering VLos AngelesCA 90095USA

Three-dimensional(3D)particle focusing in microfluidics is a fundamental capability with a wide range of applications,such as on-chip flow cytometry,where high-throughput analysis at the single-cell level is ***,3D focusing is achieved mainly in devices with complex layouts,additional sheath fluids,and complex pumping *** this work,we present a compact microfluidic device capable of 3D particle focusing at high flow rates and with a small footprint,without the requirement of external fields or lateral sheath flows,but using only a single-inlet,single-outlet microfluidic sequence of straight channels and tightly curving vertical *** device exploits inertial fluidic effects that occur in a laminar regime at sufficiently high flow rates,manipulating the particle positions by the combination of inertial lift forces and Dean drag *** device is fabricated by femtosecond laser irradiation followed by chemical etching,which is a simple two-step process enabling the creation of 3D microfluidic networks in fused silica glass *** use of tightly curving three-dimensional microfluidic loops produces strong Dean drag forces along the whole loop but also induces an asymmetric Dean flow decay in the subsequent straight channel,thus producing rapid cross-sectional mixing flows that assist with 3D particle *** use of out-of-plane loops favors a compact parallelization of multiple focusing channels,allowing one to process large amounts of *** addition,the low fluidic resistance of the channel network is compatible with vacuum driven *** resulting device is quite interesting for high-throughput on-chip flow cytometry.

关键词： 3D fluidic network 3D particle focusing Dean flow inertial microfluidics

Stem cell-based 3D brain organoids for mimicking, investigating, and challenging Alzheimer's diseases

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Neural Regeneration Research 2022年第2期17卷 330-332页

作者： Federica Cordella carlo Brighi Alessandro Soloperto Silvia di Angelantonio Center for Life Nanoscience Istituto Italiano di TecnologiaRomeItaly Department of Physiology and Pharmacology Sapienza UniversityRomeItaly

Alzheimer's disease(AD) is a progressive and irreversible neurodegene rative disorder that causes a decline of cognitive functions and a deterioration of behavioral and social performances. According to current estima... 详细信息

关键词： Alzheimer diseases irreversible

Single-cell sorting based on secreted products for functionally defined cell therapies

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Microsystems & Nanoengineering 2022年第4期8卷 17-34页

作者： Hiromi Miwa Robert dimatteo Joseph de Rutte Rajesh Ghosh dino di carlo Department of Bioengineering University of California-Los AngelesLos AngelesCA 90095USA Department of Chemical and Biomolecular Engineering University of California-Los AngelesLos AngelesCA 90095USA Partillion Bioscience Los AngelesCA 90095USA Department of Mechanical and Aerospace Engineering University of California-Los AngelesLos AngelesCA 90095USA California NanoSystems Institute(CNSI) University of California-Los AngelesLos AngelesCA 90095USA

Cell therapies have emerged as a promising new class of“living”therapeutics over the last decade and have been particularly successful for treating hematological ***,cellular therapeutics are being developed with the aim of treating almost any disease,from solid tumors and autoimmune disorders to fibrosis,neurodegenerative disorders and even aging ***,their therapeutic potential has remained limited due to the fundamental differences in how molecular and cellular therapies *** the structure of a molecular therapeutic is directly linked to biological function,cells with the same genetic blueprint can have vastly different functional properties(e.g.,secretion,proliferation,cell killing,migration).Although there exists a vast array of analytical and preparative separation approaches for molecules,the functional differences among cells are exacerbated by a lack of functional potency-based sorting *** this context,we describe the need for next-generation single-cell profiling microtechnologies that allow the direct evaluation and sorting of single cells based on functional properties,with a focus on secreted molecules,which are critical for the in vivo efficacy of current cell *** first define three critical processes for single-cell secretion-based profiling technology:(1)partitioning individual cells into uniform compartments;(2)accumulating secretions and labeling via reporter molecules;and(3)measuring the signal associated with the reporter and,if sorting,triggering a sorting event based on these reporter *** summarize recent academic and commercial technologies for functional single-cell analysis in addition to sorting and industrial applications of these *** approaches fall into three categories:microchamber,microfluidic droplet,and lab-on-a-particle ***,we outline a number of unmet needs in terms of the discovery,design and manufacturing of cellular therapeutics a

关键词： therapies sorting realization

Benefits of minimally invasive surgery in the treatment of gastric cancer

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World Journal of Gastroenterology 2022年第30期28卷 4227-4230页

作者： Simone Sibio Francesca La Rovere Sara di carlo Department of Surgery P.Valdoni Unit of Oncologic and Minimally Invasive SurgerySapienza University of RomeUmberto I University HospitalRome 00161Italy Minimally Invasive Surgery Unit Department of SurgeryTor Vergata UniversityRome 00133Italy

We read with great interest the article that retrospectively analyzed 814 patients with primary gastric cancer,who underwent minimally invasive R0 gastrectomy between 2009 and 2014 by grouping them in laparoscopic vs robotic *** results of the study highlighted that age,American Society of Anesthesiologists status,gastrectomy type and pathological T and N status were the main prognostic factors of minimally invasive gastrectomy and showed how the robotic approach may improve long-term outcomes of advanced gastric *** to most of the current literature,robotic surgery is associated with a statistically longer operating time when compared to open and laparoscopic surgery;however,looking at the adequacy of resection,defined by negative surgical margins and number of lymph nodes removed,it seems that robotic surgery gives better results in terms of the 5-year overall survival and recurrencefree *** robotic approach to gastric cancer surgery aims to overcome the difficulties and technical limitations of laparoscopy in major *** threedimensional vision,articulation of the instruments and good ergonomics for the surgeon allow for accurate and precise movements which facilitate the complex steps of surgery such as lymph node dissection,esophagus-jejunal anastomosis packaging and reproducing the technical accuracy of open *** the literature,as well as the analyzed study,offers us countless data regarding the short-term oncological results of robotic surgery in the treatment of gastric cancer,satisfactory data on long-term follow-up are lacking,so future studies are necessary.

关键词： Gastric cancer Robotic gastrectomy Laparoscopy D2 lymphadenectomy Long-term outcomes Morbidity

Pancreatic cancer stem cells:Perspectives on potential therapeutic approaches of pancreatic ductal adenocarcinoma

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World Journal of Stem Cells 2018年第11期10卷 172-182页

作者： Claudia di carlo Jessica Brandi Daniela Cecconi Department of Biotechnology Proteomics and Mass Spectrometry Laboratory University of Verona

Pancreatic ductal adenocarcinoma is one of the most aggressive solid tumours of the pancreas, characterised by a fve-year survival rate less than 8%. Recent reports that pancreatic cancer stem cells （PCSCs） contribute to the tumorigenesis, progression, and chemoresistance of pancreatic cancer have prompted the investigation of new therapeutic approaches able to directly target PCSCs. In the present paper the non-cancer related drugs that have been proposed to target CSCs that could potentially combat pancreatic cancer are revi-ewed and evaluated. The role of some pathways and deregulated proteins in PCSCs as new therapeutic tar-gets are also discussed with a focus on selected speci-fic inhibitors. Finally, advances in the development of nanoparticles for targeting PCSCs and site-specifc drug delivery are highlighted, and their limitations considered.

关键词： Pancreatic cancer stem cells Pancreatic cancer Therapeutic approaches Pancreas Treatment

Legacy of neuropsychiatric symptoms associated with past COVID-19 infection:A cause of concern

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World Journal of Psychiatry 2022年第6期12卷 773-778页

作者： Domenico De Berardis Francesco di carlo Massimo di Giannantonio Mauro Pettorruso Mental Health NHSASL 4 TeramoTeramo 64100Italy Neurosciences and Imaging and Clinical Sciences University"G.D'Annunzio"Chieti 66100Italy

Although primarily affecting the respiratory system,growing attention is being paid to the neuropsychiatric consequences of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)*** and sub-acute neuropsychiatric manifestations of coronavirus disease 2019(COVID-19)disease and their mechanisms are better studied and understood currently than they had been when the pandemic began;however,many months or years will be necessary to fully comprehend how significant the consequences of such complications will *** this editorial,we discuss the possible long-term sequelae of the COVID-19 pandemic,deriving our considerations on experiences drawn from past coronaviruses’outbreaks,such as the SARS and the middle east respiratory syndrome,and from the knowledge of the mechanisms of neurotropism and invasiveness of *** the global spread of COVID-19 and the vast number of people affected,to date amounting to many millions,the matter of this pandemic’s neuropsychiatric legacy appears *** health monitoring strategies and early interventions seem to be necessary to manage the possible emergence of a severe wave of neuropsychiatric distress among the survivors.

关键词： COVID-19 Neuropsychiatric symptoms Neuropsychiatric sequelae Mental health Post-traumatic stress disorder Depression

Current highlights on solid pseudopapillary neoplasm of the pancreas

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World Journal of Hepatology 2022年第1期14卷 300-303页

作者： Simone Sibio Sara di carlo Department of Surgery Pietro Valdoni Sapienza University of RomeUmberto I HospitalRome 00161Italy Minimally Invasive Surgery Unit Tor Vergata HospitalTor Vergata University of RomeRome 00133Italy

Solid pseudopapillary neoplasm of the pancreas is a low-grade malignant tumor that predominantly affects young women in their third and fourth *** and risk factors are *** symptoms are aspecific and most commonly due to mass *** is made by computed tomography scan or magnetic resonance imaging and histological characterization is obtained by endoscopic ultrasound-guided fine needle ***,these lesions are composed by both solid and pseudopapillary structures with necrotic and hemorrhagic ***,the biological behavior is aggressive with tumor recurrence and distant ***,curative R0 surgical resection is the best option able to provide long term survival even in advanced *** disease is the main predictor of poor *** and radiotherapy regimens are not well ***,they could be effective in reducing tumor size as neoadjuvant treatment or disease control in palliative *** complete surgical resection provides a cure rate of>95%,considering young age of the patients and morbidity associated to pancreatic surgery,further studies are needed to better investigate risk factors and responsiveness to hormones in order to allow early diagnosis and follow up strategies that could avoid unnecessary surgery in less aggressive disease.

关键词： Pseudopapillary neoplasm Pancreatic tumor Pancreaticoduodenectomy distal pancreatectomy Pancreas Surgery

Numerical investigation of the dynamics of a rigidspherical particle in a vortical cross-slot flow atmoderate inertia

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Microsystems & Nanoengineering 2023年第4期9卷 181-195页

作者： Konstantinos Kechagidis Benjamin Owen Lionel Guillou Henry Tse dino di carlo Timm Krüger School of Engineering Institute for Multiscale ThermofluidsUniversity of EdinburghW Mains RdEdinburgh EH93JW ScotlandUK Cytovale Inc.Executive Park Blvd.San Fransisco CA 90095 CAUSA Department of Bioengineering University of CaliforniaWestwood PlazaLos Angeles 610101 CAUSA

The study of flow and particle dynamics in microfluidic cross-slot channels is of high relevance for lab-on-a-chipapplications. In this work, we investigate the dynamics of a rigid spherical particle in a cross-slot junction for a channelheight-to-width ratio of 0.6 and at a Reynolds number of 120 for which a steady vortex exists in the junction *** an in-house immersed-boundary-lattice-Boltzmann code, we analyse the effect of the entry position of theparticle in the junction and the particle size on the dynamics and trajectory shape of the particle. We find that thedynamics of the particle depend strongly on its lateral entry position in the junction and weakly on its vertical entryposition;particles that enter close to the centre show trajectory oscillations. Larger particles have longer residencetimes in the junction and tend to oscillate less due to their confinement. Our work contributes to the understanding ofparticle dynamics in intersecting flows and enables the design of optimised geometries for cytometry and particlemanipulation.

关键词： particle dynamics spherical