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Journal of Materials Science & Technology 2019年第2期35卷 336-343页

作者： Jinkai Zhang Wenhui Zhou Hui Wang Kaili Lin Fengshan Chen Department of Orthodontics School & Hospital of Stomatology Tongji University Shanghai Engineering Research Center of Tooth Restoration and Regeneration Department of Oral & Cranio-Maxillofacial Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai Key Laboratory of Stomatology Shanghai Research Institute of Stomatology

Three-dimensional-printed(3 D-P) titanium implants display many advantages, such as design flexibility,higher efficiency, the capability to easily construct complex or customized structures, etc., and is believed to potentially replace traditional implants. However, the biological performance of the 3 D-P titanium surface has not been investigated systematically. Herein, we analyzed the surface characteristics of 3 D-P Ti6 Al4 V implants and evaluated the biological responses of bone marrow derived mesenchymal stromal cells(BMSCs) to the 3 D-P surface in vitro. Moreover, after implantation into the rat femoral condyle for3 and 6 weeks, the osseointegration performance was evaluated. The results showed the 3 D-P Ti6 Al4 V implant presented distinct fluctuant macroscale rough surface and relatively better hydrophilicity which enhanced the adhesion, proliferation, osteogenic differentiation and angiogenetic factor expression of BMSCs. Moreover, the in vivo osseointegration performance was also better than that of the control group at the early stage. The present study suggested the 3 D-P titanium alloy is a promising candidate to be used as implant material.

关键词： Three-dimensional printing Titanium alloy BMSCs Osteogenesis Osseointegration

A comparative study of the osteogenic performance between the hierarchical micro/submicro-textured 3D-printed Ti6Al4V surface and the SLA surface

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Bioactive Materials 2020年第1期5卷 9-16页

作者： Jinkai Zhanga Jiaqiang Liu chengtao Wang Fengshan Chen Xudong Wang Kaili Lin Department of Orthodontics School&Hospital of StomatologyTongji UniversityShanghai Engineering Research Center of Tooth Restoration and RegenerationShanghai200072China Department of Oral&Cranio-Maxillofacial Surgery Shanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of Stomatology&Shanghai Research Institute of StomatologyShanghai200011China School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai200240China

Three-dimensional(3D)printed titanium and its alloys have broad application prospect in the field of biomedical implant materials,although the biological performance of the original surface should be improved.Learning from the development experience of conventional titanium implants,to construct a hierarchical hybrid topological surface is the future direction of efforts.Since the original 3D-printed(3D hereafter)Ti6Al4V surface inherently has micron-scale features,in the present study,we introduced submicron-scale pits on the original surface by acid etching to obtain a hierarchical micro/submicro-textured surface.The characteristic and biological performance of the 3D-printed and acid-etched(3DA hereafter)surface were evaluated in vitro and in vivo,compared with the conventional sandblasted,large-grit,acid-etched(SLA hereafter)surface.Our results suggested the adhesion,proliferation and osteogenic differentiation of bone marrow derived mesenchymal stromal cells(BMSCs),as well as the in vivo osseointegration on 3DA surfaces were significantly improved.However,the overall osteogenic performance of the 3DA surface was not as good as the conventional SLA surface.

关键词： 3D printing Ti6Al4V Surface modification Osteogenesis SLA

Analysis of Porosity and Preheating Temperature on the Decomposition and Combustion Characteristics within 5 N Ammonium Dinitramide(ADN)-based Monopropellant Thruster

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Journal of Thermal Science 2020年第1期29卷 81-89页

作者： ZHANG Tao WANG fengshan chen Jun Beijing Institute of Control Engineering Beijing 100190China Beijing Engineering Research Center of Efficient and Green Aerospace Propulsion Technology Beijing 100190China

In this study,the effects of porosity of the fore-catalytic bed and after-catalytic bed and preheat temperature on the decomposition and combustion characteristics of a 5N ammonium dinitramide(ADN)-based thruster were numerically investigated in terms of the distribution of components,temperature,and pressure.The results indicated that the porosity of the fore-catalytic bed and preheating temperature significantly affected the decomposition and combustion characteristics.The porosity of the fore-catalytic bed was optimized,and the thrust performance was demonstrated to improve with increasing of porosity of the after-catalytic bed and pre-heating temperature.The results were favorable for the investigation of decomposition and combustion characteristics and could also be beneficial to the design and manufacture of different types of ADN-based thrusters.

关键词： porosity preheating temperature decomposition and combustion characteristics ammonium dinitramide monopropellant

The functions and applications of A7R in anti-angiogenic therapy, imaging and drug delivery systems

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Asian Journal of Pharmaceutical Sciences 2019年第6期14卷 595-608页

作者： Lu Lu Hongyuan chen Dake Hao Xinke Zhang fengshan Wang Key Laboratory of Chemical Biology(Ministry of Education) Institute of Biochemical and Biotechnological DrugSchool of Pharmaceutical SciencesShandong UniversityJinan 250012China Department of General Surgery Shandong University Affiliated Shandong Provincial HospitalJinan 250021China Department of Surgery UC Davis Health Medical CenterSacramento 95817USA Key Laboratory of Chemical Biology(Ministry of Education) Department of PharmacologySchool of Pharmaceutical SciencesShandong UniversityJinan 250012China

Vascular endothelial growth factor receptor 2(VEGFR-2)and neuropilin-1(NRP-1)are two prominent antiangiogenic targets.They are highly expressed on vascular endothelial cells and some tumor cells.Therefore,targeting VEGFR-2 and NRP-1 may be a potential antiangiogenic and antitumor strategy.A7R,a peptide with sequence of Ala-Thr-Trp-Leu-Pro-Pro-Arg that was found by phage display of peptide libraries,can preferentially target VEGFR-2 and NRP-1 and destroy the binding between vascular endothelial growth factor 165(VEGF165)and VEGFR-2 or NRP-1.This peptide is a new potent inhibitor of tumor angiogenesis and a targeting ligand for cancer therapy.This review describes the discovery,function and mechanism of the action of A7R,and further introduces the applications of A7R in antitumor angiogenic treatments,tumor angiogenesis imaging and targeted drug delivery systems.In this review,strategies to deliver different drugs by A7R-modified liposomes and nanoparticles are highlighted.A7R,a new dual targeting ligand of VEGFR-2 and NRP-1,is expected to have efficient therapeutic or targeting roles in tumor drug delivery.

关键词： A7R Vascular endothelial growth factor receptor 2 Neuropilin-1 Antiangiogenesis Tumor angiogenesis imaging Drug delivery

Orthodontic camouflage versus orthognathic surgery: A comparative analysis of long-term stability and satisfaction in moderate skeletal Class III

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Open Journal of Stomatology 2013年第1期3卷 89-93页

作者： Xueyan Xiong Yaxin Yu Fengshan Chen Department of Emergency Medicine First Hospital Jilin University Changchun China Laboratory of Oral Biomedical Science and Translational medicine School & Hospital of Stomatology Tongji University Shanghai China

Objective: The purpose of this study was to compare long-term stability and satisfaction between orthodontic camouflage and orthognathic surgery in treatment of moderate skeletal Class III adults. Materials and Methods: A total of 25 adults females who had been treated with orthodontic camouflage for Class III malocclusions were recalled at least 3 years post-treatment to evaluate stability and satisfaction with treatment outcomes. The data were compared with similar data for long-term outcomes in 21 patients with the same Class III problems who had bimaxillary surgical correction. Results: In the camouflage patients, small mean changes in skeletal landmark positions occurred over the long term, although the changes were generally much smaller than in the surgery patients. Dental changes in the surgery group were more severe than those in the camouflage group. The camouflage patients reported fewer functional or temporomandibular joint problems than did the surgery patients. Both groups reported similar levels of overall satisfaction with treatment. Conclusion: The results suggest that both camouflage and surgical treatment in moderate skeletal Class III adults can achieve satisfactory outcomes and provide long-term stability. If patients do not readily accept surgery because of potential surgical complications or financial difficulties, camouflage treatment may be an effective alternative treatment.

关键词： Moderate Skeletal Class III Adults Orthodontic Camouflage Orthognathic Surgery

Influences of agricultural phenology dynamic on land surface biophysical process and climate feedback

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Journal of Geographical Sciences 2017年第9期27卷 1085-1099页

作者： LIU fengshan chen Ying SHI Wenjiao ZHANG Shuai TAO Fulu GE Quansheng Key Laboratory of Land Surface Pattern and Simulation Institute of Geographic Sciences and Natural Re- sources Research CAS Beijing 100101 China Fujian Agriculture and Forestry University Fuzhou 350002 China College of Resources and Environment University of Chinese Academy of Sciences Beijing 100049 China

Response and feedback of land surface research priorities in the field of geoscience. The process to climate change is one of the current study paid more attention to the impacts of global change on land surface process, but the feedback of land surface process to climate change has been poorly understood. It is becoming more and more meaningful under the framework of Earth system science to understand systematically the relationships between agricultural phenology dynamic and biophysical process, as well as the feedback on climate. In this paper, we summarized the research progress in this field, including the fact of agricultural phenology change, parameterization of phenology dynamic in land surface progress model, the influence of agricultural phenology dynamic on biophysical process, as well as its feedback on climate. The results showed that the agriculture phenophase, represented by the key phenological phases such as sowing, flowering and maturity, had shifted significantly due to the impacts of climate change and agronomic management. The digital expressions of land surface dynamic process, as well as the biophysical process and atmospheric process, were improved by coupling phenology dynamic in land surface model. The agricultural phenology dynamic had influenced net radiation, latent heat, sensible heat, albedo, temperature, precipitation, circulation, playing an important role in the surface energy partitioning and climate feedback. Considering the importance of agricultural phenology dynamic in land surface biophysical process and climate feedback, the following research priorities should be stressed：（1） the interactions between climate change and land surface phenology dynamic; （2） the relations between agricultural phenology dynamic and land surface reflectivity at different spectrums; （3） the contributions of crop physiology characteristic changes to land surface biophysical process; （4） the regional differences of climate feedbacks from phenology dynamic in different climate zones. This review i

关键词： agricultural phenology land surface biophysical process land surface process model climate feedback

Super-resolution quantification of nanoscale damage to mitochondria in live cells

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Nano Research 2020年第8期13卷 2149-2155页

作者： Xintian Shao Qixin chen Lianting Hu Zhiqi Tian Liuyi Liu Fei Liu fengshan Wang Peixue Ling Zong-Wan Mao Jiajie Diao Shandong Academy of Pharmaceutical Sciences Key Laboratory of BiopharmaceuticalsEngineering Laboratory of Polysaccharide DrugsNational-Local Joint Engineering Laboratory of Polysaccharide DrugsJinan250101China Department of Cancer Biology University of Cincinnati College of MedicineCincinnatiOH45267USA School of Pharmaceutical Sciences Cheeloo College of MedicineShandong UniversityJinan250012China Xintian Shao Qixin Chenand Lianting Hu contributed equally to this work.Shandong First Medical University&Shandong Academy of Medical SciencesJinan250062China Xintian Shao Qixin Chenand Lianting Hu contributed equally to this work.School of Information ManagementWuhan UniversityWuhan430072China MOE Key Laboratory of Bioinorganic and Synthetic Chemistry School of ChemistrySun Yat-Sen UniversityGuangzhou510275China

Mitochondrial damage,characterized by altered morphological distribution and the damage of cristae,is closely associated with mitochondrial disease.However,imaging methods for capturing mitochondrial morphology at the nanoscale level in live samples remain unavailable,which seriously hinders the accurate evaluation and diagnosis of mitochondrial-related diseases.In response,we propose a super-resolution quantification strategy based on structured illumination microscopy(SIM)for the rapid,accurate evaluation of mitochondrial morphology.Using the strategy,we accurately captured the morphological distribution of mitochondria at the nanoscale level in a way generally applicable to checking various cell processes and identifying patients with mitochondrial disease who exhibit the SLC25A46 mutation.We also used algorithm-assisted super-resolution imaging to quantitatively analyze damage to mitochondrial cristae,which supports a novel drug screening strategy—high-resolution drug screening—for investigating drugs’pharmacodynamics on organelles in living cells.In short,our strategy improves the accurate examination of changes in mitochondrial morphology in living cells and indicates new ways in which SIM-imaging can assist in diagnosing mitochondrial disease at the single-cell level.

关键词： mitochondria structured illumination microscopy quantification analyze morphology cristae

Profiles of and correlation between objective and subjective outcome assessments following open-door laminoplasty for cervical spondylotic myelopathy

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Chinese Medical Journal 2014年第14期127卷 2659-2663页

作者： Zhou Feifei Zhang Yilong Sun Yu Zhang fengshan Pan Shengfa Diao Yinze chen Xin Zhao Yanbin Peking Univ Hosp 3 Dept Orthoped Beijing 100191 Peoples R China

Background Open-door laminoplasty is widely used in the treatment of cervical spondylotic myelopathy （CSM）. This study aimed to investigate the profiles of and correlation between objective and subjective short-term outcome assessments after open-door laminoplasty for CSM. Methods We retrospectively analyzed surgical outcomes in 129 consecutive CSM patients who underwent open-door laminoplasty in Peking University Third Hospital from February 2008 to November 2011. Both objective and subjective assessments were evaluated before surgery, 3 months after surgery, and 1 year after surgery. We then analyzed the profiles of and correlation between objective and subjective short-term outcomes. Results The Modified Japanese Orthopaedic Association （mJOA） score was significantly improved at 3 months （P〈0.01） and 1 year （P〈0.01） after surgery. Bivariate Logistic regression showed that sensory improvement contributed more to the recovery rate than motor function improvement at 3 months after surgery, while motor function contributed more to the recovery rate at 1 year after surgery. On the subjective assessment （the short form （SF）-36）, there was no significant improvement at 3 months after surgery （P〉0.05）, while physical function （PF）, role-physical （RP）, and social function （SF） were notably improved at 1 year after surgery （P〈0.01）. Improved mJOA score correlated with improvements in PF, RP, bodily pain, general health （GH）, vitality （VT）, and SF （P〈0.05） at 3 months after surgery; PF, GH, VT, and SF were associated with improved mJOA scores at 1 year after surgery. Conclusions Patients benefit from surgery by postoperative restitution of neurological function with early recovery of sensory function, followed by a gradual transition to motor function improvement. At the early stage of recovery, improvement in the mJOA score essentially correlated with improvements in the physical domains of the SF-36, while at the later stage, mJOA score improvement was associated with improvements in both mental and physical domains of

关键词： cervical verberae spinal cord diseases patient outcome assessment

The relevance study of effective information between near infrared spectroscopy and chondroitin sulfate in ethanol precipitation process

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Journal of Innovative Optical Health Sciences 2014年第6期7卷 63-69页

作者： Lian Li Baoyang Ding Qi Yang Shang chen Huaying Ren Jinfeng Wang Hengchang Zang fengshan Wang Lixuan Zang School of Pharmaceutical Sciences and National Glycoengineering Research Center Shandong University No.44 Wenhuaxi Road Jinan 250012P.R.China School of Chemistry and Chemical Engineering Shandong University No.27 Shandanan Road Jinan 250010P.R.China

Near infrared spectroscopy(NIRS)is based on molecular overtone and combination vibrations.It is difficult to assign specific features under complicated system.So it is necessary to find the relevance between NIRS and target compound.For this purpose,the chondroitin sulfate(CS)ethanol precipitation process was selected as the research model,and 90 samples of 5 different batches were collected and the content of CS was determined by modifed carbazole method.The relevance between NIRS and CS was studied throughout optical pathlength,pretreat ment methods and variables selection methods.In conclusion,the first derivative with Savitzky--Golay(SG)smoothing was selected as the best pretreatment,and the best spectral region was selected using interval partial least squares(iPLS)method under 1 mm optical cell.A multivariate cali-bration model was established using PLS algorithm for determining the content of CS,and the root mean square error of prediction(RMSEP)is 3.934gL-1.This method will have great potential in process analytical technology in the future.

关键词： Chondroitin sulfate near infrared spectroscopy variable selection pathlength

Identification and Analysis of SSRs Derived from Protein-coding Genes in Grape

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Agricultural Science & Technology 2017年第9期18卷 1579-1584页

作者： Pengfei WANG Ling SU Xilong JIANG Yingchun chen fengshan REN Yongmei WANG Shandong Engineering Research Center for Grape Cultivation and Deep-processing Shandong Academy of Grape

SSR(Simple Sequence Repeats), also known as microsatellites or STRs(short tandem repeats), are a type of PCRbased markers. So far, the version of grape genome has been updated constantly, but SSRs derived from protein-coding genes in grape have not yet been identified. In this study, 4 337 SSR-containing genes were found among 29 971 protein-coding genes in grape(Vitis vinifera L.), and 5 384 SSRs were found. There were 96 types of repeat motifs in SSRs derived from protein-coding genes in grape, and the most frequently occurring repeat motif was A/T. Among various repeat motifs in dinucleotide SSRs, the most frequently occurring repeat motif was AG/CT. Moreover, many genes exhibited codon usage bias, which was affected by the mutation pressure. GO annotation, KEGG annotation and domain analysis of these genes were performed.Several genes were found to be closely related to the synthesis and metabolism of secondary metabolites, synthesis of flavones or anthocyanins, development and morphology of plant organs, and tolerance to biotic or abiotic stresses, including transcription factors in MYB, Hsf, NBS and TPC families. This study laid a solid foundation for the development of SSR markers and research of QTLs controlling complex agronomic traits in grape.

关键词：蛋白编码基因 SSR标记标记鉴定葡萄简单重复序列短串联重复序列非生物胁迫次生代谢产物