The functions and applications of A7R in anti-angiogenic therapy, imaging and drug delivery systems

作     者：Lu Lu Hongyuan Chen Dake Hao Xinke Zhang Fengshan Wang 

作者机构：Key Laboratory of Chemical Biology(Ministry of Education)Institute of Biochemical and Biotechnological DrugSchool of Pharmaceutical SciencesShandong UniversityJinan 250012China Department of General SurgeryShandong University Affiliated Shandong Provincial HospitalJinan 250021China Department of SurgeryUC Davis Health Medical CenterSacramento 95817USA Key Laboratory of Chemical Biology(Ministry of Education)Department of PharmacologySchool of Pharmaceutical SciencesShandong UniversityJinan 250012China 

出 版 物：《Asian Journal of Pharmaceutical Sciences》 (亚洲药物制剂科学（英文）)

年 卷 期：2019年第14卷第6期

页      面：595-608页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：funded by National Natural Science Foundation of China(No.81302686) Primary Research&Developement Plan of Shandong Province(No.2016GSF201083) 

主　　题：A7R Vascular endothelial growth factor receptor 2 Neuropilin-1 Antiangiogenesis Tumor angiogenesis imaging Drug delivery 

摘      要：Vascular endothelial growth factor receptor 2(VEGFR-2)and neuropilin-1(NRP-1)are two prominent antiangiogenic targets.They are highly expressed on vascular endothelial cells and some tumor cells.Therefore,targeting VEGFR-2 and NRP-1 may be a potential antiangiogenic and antitumor strategy.A7R,a peptide with sequence of Ala-Thr-Trp-Leu-Pro-Pro-Arg that was found by phage display of peptide libraries,can preferentially target VEGFR-2 and NRP-1 and destroy the binding between vascular endothelial growth factor 165(VEGF165)and VEGFR-2 or NRP-1.This peptide is a new potent inhibitor of tumor angiogenesis and a targeting ligand for cancer therapy.This review describes the discovery,function and mechanism of the action of A7R,and further introduces the applications of A7R in antitumor angiogenic treatments,tumor angiogenesis imaging and targeted drug delivery systems.In this review,strategies to deliver different drugs by A7R-modified liposomes and nanoparticles are highlighted.A7R,a new dual targeting ligand of VEGFR-2 and NRP-1,is expected to have efficient therapeutic or targeting roles in tumor drug delivery.