A comparative study of the osteogenic performance between the hierarchical micro/submicro-textured 3D-printed Ti6Al4V surface and the SLA surface

作     者：Jinkai Zhanga Jiaqiang Liu Chengtao Wang Fengshan Chen Xudong Wang Kaili Lin 

作者机构：Department of OrthodonticsSchool&Hospital of StomatologyTongji UniversityShanghai Engineering Research Center of Tooth Restoration and RegenerationShanghai200072China Department of Oral&Cranio-Maxillofacial SurgeryShanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of Stomatology&Shanghai Research Institute of StomatologyShanghai200011China School of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai200240China 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2020年第5卷第1期

页      面：9-16页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 0710[理学-生物学] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0802[工学-机械工程] 0836[工学-生物工程] 080201[工学-机械制造及其自动化] 

基　　金：This study was supported by the Natural Science Foundation of China(No.81871490,81670958,81670973) Science and Technology Commission of Shanghai Municipality(No.17510710800,19441902900) Two-hundred Talent in Shanghai Jiao Tong University School of Medicine(No.20191819) Program of Shanghai Academic/Technology Research Leader(No.19XD1434500) Ninth People's Hospital affiliated to Shanghai Jiao Tong University,School of Medicine"Multi-Disciplinary Team"Clinical Research Project(No.201701013)。 

主　　题：3D printing Ti6Al4V Surface modification Osteogenesis SLA 

摘      要：Three-dimensional(3D)printed titanium and its alloys have broad application prospect in the field of biomedical implant materials,although the biological performance of the original surface should be improved.Learning from the development experience of conventional titanium implants,to construct a hierarchical hybrid topological surface is the future direction of efforts.Since the original 3D-printed(3D hereafter)Ti6Al4V surface inherently has micron-scale features,in the present study,we introduced submicron-scale pits on the original surface by acid etching to obtain a hierarchical micro/submicro-textured surface.The characteristic and biological performance of the 3D-printed and acid-etched(3DA hereafter)surface were evaluated in vitro and in vivo,compared with the conventional sandblasted,large-grit,acid-etched(SLA hereafter)surface.Our results suggested the adhesion,proliferation and osteogenic differentiation of bone marrow derived mesenchymal stromal cells(BMSCs),as well as the in vivo osseointegration on 3DA surfaces were significantly improved.However,the overall osteogenic performance of the 3DA surface was not as good as the conventional SLA surface.