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Effects of combined chemical design(Cu addition) and topographical modification(sla) of Ti-Cu/sla for promoting osteogenic, angiogenic and antibacterial activities

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Journal of Materials Science & Technology 2020年第12期47卷 202-215页

作者： Rui Liu Yulong Tang Hui Liu Lilan Zeng Zheng Ma Jun Li Ying Zhao Ling Ren Ke Yang Institute of Metal Research Chinese Academy of SciencesShenyang 110016China Institute of Molecular Medicine State Key Laboratory of Oncogenes and Related GenesShanghai Institute of CancerRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200011China Department of Stomatology General Hospital of Shenyang Military CommandShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaHefei 230026China Center for Human Tissues and Organs Degeneration Shenzhen Institute of Advanced TechnologyChinese Academy of ScienceShenzhen 518055China

Cu has been proved to possess various beneficial biological activities, while sandblasting and acid etching(sla) is widely used to modify the commercial dental implant in order to improve osseointegration. Based on the above, a novel antimicrobial dental implant material, Ti-Cu alloy, was treated with sla, to combine chemical design(Cu addition) and topographical modification(sla). In this work, the effects of sla treated Ti-Cu alloys(Ti-Cu/sla) on osteogenesis, angiogenesis and antibacterial properties were evaluated from both in vitro and in vivo tests, and Ti/sla and Ti-Cu(without sla) were served as control groups. Benefiting by the combined effects of chemical design(Cu addition) and micro-submicron hybrid structures(sla),Ti-Cu/sla had significantly improved inhibitory effects on oral anaerobic bacteria(P. gingivalis and ***) and could induce upregulation of osteogenic-related and angiogenic-related genes expression in vitro. More importantly, in vivo studies also demonstrated that Ti-Cu/sla implants had wonderful biological performance. In the osseointegration model, Ti-Cu/sla implant promoted osseointegration via increasing peri-implant bone formation and presenting good bone-binding, compared to Ti/sla and Ti-Cu implants. Additionally, in the peri-implantitis model, Ti-Cu/sla effectively resisted the bone resorption resulted from bacterial infection and meanwhile promoted osseointegration. All these results suggest that the novel multiple functional Ti-Cu/sla implant with rapid osseointegration and bone resorption inhibition abilities has the potential application in the future dental implantation.

关键词： Ti-Cu sla Peri-implantitis Osseointegration

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A Privacy-Based sla Violation Detection Model for the Security of Cloud Computing

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China Communications 2017年第9期14卷 155-165页

作者： Shengli Zhou Lifa Wu Canghong Jin Army Engineering University Information Department of Zhejiang Police College Zhejiang University City College

A Service Level Agreement(sla) is a legal contract between any two parties to ensure an adequate Quality of Service(Qo S). Most research on slas has concentrated on protecting the user data through encryption. However, these methods can not supervise a cloud service provider(CSP) directly. In order to address this problem, we propose a privacy-based sla violation detection model for cloud computing based on Markov decision process theory. This model can recognize and regulate CSP's actions based on specific requirements of various users. Additionally, the model could make effective evaluation to the credibility of CSP, and can monitor events that user privacy is violated. Experiments and analysis indicate that the violation detection model can achieve good results in both the algorithm's convergence and prediction effect.

关键词： security and privacy markovchain cloud computing reputation manage-ment sla

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Novel sla-DR Alleles of Three Chinese Pig Strains and the Related Function in Human T Cell Response

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Cellular & Molecular Immunology 2004年第3期1卷 212-218页

作者： FuxiangChen JinXie YunZhou NingliLi Kuang-YenChou ShanghaiInstituteoflmmunology.ShanghaiSecondMedicalUniversity Shanghai200025.China

To elucidate the structures of sla-DR(swine leukocyte antigen DR)genes of three Chinese pig strains (Gz,Bm and Yn),the sla-DRA and sla-DRB cDNA were amplified by RT-PCR and subjected to determine the *** whole structures of sla-DRA alleles are identical among three strains,consisting of 759 nucleotides including an open reading frame(ORF),and are shared with those reported from NIH minipigs sla-DRA^c and sla-DRA^*** same length of the ORF-containing sla-DRB genes of three Chinese pig strains was also *** are composed of 801 nucleotides encoding a xenogeneic antigen molecule of 266 amino acid *** nucleotide sequences of the sla-DRB genes,however,are different when compared either among the three strains or with the published data of sla-DRB sequences,which allowed our novel sla-DRB alleles receiving their accession numbers AY102479,AY102480 and AY102481 from the *** study further reveals that the phylogenic homologies of MHC DR or DR-like genes in structures of nucleotides and deduced amino acids between Chinese pigs(sla)and human(HLA-DRB1*0901)are better than those between pigs and mice (H-2~b Eβ).High similarities were also found for DRα-DRβ heterodimers between Chinese pigs and human in terms of amino acids sequences critical for binding with human CD4 coreceptor molecule,which are better than those between sla-DR and H-2 I-E molecules.A functional test indicated that,by cotransfection with Bm-DRA and Bm-DRB genes,the Bm-DR molecule-expressed L929 cells could stimulate human T cells quite well in a xenogeneic reaction in presence of human *** & Molecular Immunology.2004;1 (3):212-218.

关键词： MHC-DR sla Chinese pig strain CD4 coreceptor xenotransplantation

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A comparative study of the osteogenic performance between the hierarchical micro/submicro-textured 3D-printed Ti6Al4V surface and the sla surface

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Bioactive Materials 2020年第1期5卷 9-16页

作者： Jinkai Zhanga Jiaqiang Liu Chengtao Wang Fengshan Chen Xudong Wang Kaili Lin Department of Orthodontics School&Hospital of StomatologyTongji UniversityShanghai Engineering Research Center of Tooth Restoration and RegenerationShanghai200072China Department of Oral&Cranio-Maxillofacial Surgery Shanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of Stomatology&Shanghai Research Institute of StomatologyShanghai200011China School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai200240China

Three-dimensional(3D)printed titanium and its alloys have broad application prospect in the field of biomedical implant materials,although the biological performance of the original surface should be *** from the development experience of conventional titanium implants,to construct a hierarchical hybrid topological surface is the future direction of *** the original 3D-printed(3D hereafter)Ti6Al4V surface inherently has micron-scale features,in the present study,we introduced submicron-scale pits on the original surface by acid etching to obtain a hierarchical micro/submicro-textured *** characteristic and biological performance of the 3D-printed and acid-etched(3DA hereafter)surface were evaluated in vitro and in vivo,compared with the conventional sandblasted,large-grit,acid-etched(sla hereafter)*** results suggested the adhesion,proliferation and osteogenic differentiation of bone marrow derived mesenchymal stromal cells(BMSCs),as well as the in vivo osseointegration on 3DA surfaces were significantly ***,the overall osteogenic performance of the 3DA surface was not as good as the conventional sla surface.

关键词： 3D printing Ti6Al4V Surface modification Osteogenesis sla

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A method of dealing polygon’s self-intersection contour in sla

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Journal of Harbin Institute of Technology(New Series) 2007年第2期14卷 163-165页

作者：高永强莫健华董树槐 State Key Lab of Mould Technology Huazhong University of Science and Technology

The contour of the slices of sla parts is composed of a great deal of small lines. When offsetting the contour to compensate for the radius of laser spot, many self-intersection contours come into being, which decrease the precision of formed parts. A new lemma to judge the local self-intersection contour and the global self-intersection contour separately is put forward, according to which self-intersection contour can be removed reliably. Meanwhile, a new beam offsetting algorithm for sla parts is described, which brings about good resuits in the practical manufacturing process.

关键词： sla oolwon laser soot comoensation self-intersection

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Study on Possible Associations Between sla-types and Reproductive Hormone Levels in Sows

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Agricultural Sciences in China 2001年第1期 130-133页

作者： JI Hai-feng LIU Yan GAO Hui MO Yu-zhong ZHANG Chun-ying Institute of Animal and Veterinary Sciences Beijing Academy of Agriculture and Forestry SciencesBeijing 100089

The levels of plasma luteinizing hormone(LHt)、estrogen(E_(2))and progesterone(P_(4))were determined in one hundred and ninety-eight sla-typed sows of Chinese lean-type dam-line(DVI).During the lactation,the levels of LH、E_(2)and P_(4)were Iow,which had no significant differences in different sla-typed sows.E_(2)reached its peak at breeding *** and P_(4)reached their peaks at 15th day of *** with other sla-typed sows,type-D had higher levels of E_(2)and P_(4)at breeding day,higher levels of P_(4)during early pregnancy,which favored the oestrus,breeding and pregnancy of sows.

关键词： Sow sla Hormone

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sla表面处理TiCu合金的抗菌性能研究

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表面技术 2019年第7期48卷 278-284页

作者：刘蕊任玲杨柯东北大学沈阳110819 中国科学院金属研究所沈阳110016

目的对TiCu合金进行sla表面粗糙化处理,探究具有粗糙表面的TiCu合金的抗菌性能。方法用喷砂+酸蚀(sla)的方法对TiCu合金表面进行粗糙化处理(sla-TiCu),并与经过相同处理的sla-Ti进行对比研究。采用金黄色葡萄球菌作为实验菌株,通过平板... 详细信息

目的对TiCu合金进行sla表面粗糙化处理,探究具有粗糙表面的TiCu合金的抗菌性能。方法用喷砂+酸蚀(sla)的方法对TiCu合金表面进行粗糙化处理(sla-TiCu),并与经过相同处理的sla-Ti进行对比研究。采用金黄色葡萄球菌作为实验菌株,通过平板菌落计数法计算杀菌率,采用活/死细菌染色实验观察表面细菌的粘附分布及生物被膜的形成情况,在透射电镜下观察细菌微观结构的变化,探究sla-TiCu的抗菌作用及对细菌微观结构的影响。结果sla表面处理使TiCu合金具有微米-亚微米的复合双层孔洞结构表面,sla-TiCu具有优异的抗菌性能,对表面粘附细菌的抗菌率为100%。染色结果表明,sla-TiCu表面粘附的细菌中大量的是死细菌,没有形成生物被膜,而sla-Ti表面已经形成细菌生物被膜。透射电镜观察表明,sla-TiCu作用后的细菌出现了明显的细胞膜溶解现象,破损的细菌体内部出现透明和半透明的区域,细胞壁和细胞膜破损,细胞内的细胞质流出,在破损的细菌周围可以看到高电子密度的颗粒和沉淀。结论sla处理的TiCu合金具有优异的抗菌性能,更能有效发挥合金中Cu的杀菌作用,能够高效杀死表面粘附的细菌,从而抑制表面生物被膜的形成。因此,具有优异抗菌性能的sla-TiCu具有极大潜力应用于牙种植体制造。

关键词： sla TiCu合金钛抗菌表面粗糙化牙种植体

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sla的分型与检测

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遗传 2004年第2期26卷 211-214页

作者：李华罗怀容张亚平邱祥聘叶春中国科学院昆明动物研究所细胞与分子进化重点实验室昆明650223 四川农业大学动物科技学院四川雅安625014

传统的强调抗原多态性的sla分型方法主要是血清学、细胞学和生物化学的方法,随着分子生物学技术发展,各具特点的sla分型技术不断涌现,如PCR RFLP法、PCR SSCP法、微卫星(MS)法、DNA序列的测定等,基于强调sla的抗原多态性的分型和强调抗... 详细信息

传统的强调抗原多态性的sla分型方法主要是血清学、细胞学和生物化学的方法,随着分子生物学技术发展,各具特点的sla分型技术不断涌现,如PCR RFLP法、PCR SSCP法、微卫星(MS)法、DNA序列的测定等,基于强调sla的抗原多态性的分型和强调抗原保守性的功能学上的新分型技术(如sla超型和超基序)进行了详细探讨,比较了各类方法的优缺点,指明了未来sla分型的发展趋势。此外还指出了现行参考教材血清学sla单倍型的编写错误以及重点强调了sla DQB基因的准确分型技术必须借鉴于克隆测序。

关键词： sla 抗原多态性分子生物学技术血清学主要组织相容性复合物

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slaⅠ类基因最新命名进展

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遗传 2006年第5期28卷 606-610页

作者：李波李华李学伟于辉李彬佛山科学技术学院动科系南海528231 四川农业大学动物科技学院雅安625014

介绍了国际动物遗传学会(ISAG)sla命名委员会2004年制定的依据基因测序及进化树分析的slaⅠ类基因系统命名法,详细叙述了对slaⅠ类基因座、等位基因组、等位基因及单倍型的命名规则,其中概括介绍了命名新等位基因对基因序列的具体要求。... 详细信息

介绍了国际动物遗传学会(ISAG)sla命名委员会2004年制定的依据基因测序及进化树分析的slaⅠ类基因系统命名法,详细叙述了对slaⅠ类基因座、等位基因组、等位基因及单倍型的命名规则,其中概括介绍了命名新等位基因对基因序列的具体要求。slaⅠ类基因系统命名法对于人类移植免疫学、猪免疫遗传及抗病育种具有重要意义。

关键词： sla Ⅰ 序列命名

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sla 3D打印技术在熔模铸造中的应用

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特种铸造及有色合金 2018年第4期38卷 379-381页

作者：司马建高陈军李亚东苏州大学化学化工与材料科学学部帝斯曼迪索特种化学(上海)有限公司

论述了sla 3D打印在熔模铸造领域中的应用以及具体的工艺过程,重点研究了薄壁铸件胀壳的问题,并结合实例提供了解决方案。运用该技术生产的铸件具有尺寸精度高、表面光洁、工艺较环保等优点,可大幅度缩减样件开发周期和研发成本,显著提... 详细信息

论述了sla 3D打印在熔模铸造领域中的应用以及具体的工艺过程,重点研究了薄壁铸件胀壳的问题,并结合实例提供了解决方案。运用该技术生产的铸件具有尺寸精度高、表面光洁、工艺较环保等优点,可大幅度缩减样件开发周期和研发成本,显著提升企业竞争力。

关键词： sla 3D打印熔模铸造胀壳

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