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Anisometropia magnitude and visual deficits in previously untreated anisometropic amblyopia

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International Journal of Ophthalmology(English edition) 2013年第5期6卷 606-610页

作者： Bin-Bin Chen feng-wei song Zhao-Hui Sun Yi Yang Eye Center the Second Affiliated HospitalSchool of MedicineZhejiang University Department of Ophthalmology the First Affiliated Hospital of Huzhou Teachers College

AIM:To assess the quantitative association between anisometropia magnitude(AM) and the losses of resolution and contrast sensitivity;and to exemplify how the function of fusion and stereopsis vary with AM in previously untreated anisometropic amblyopia. METHODS:A total of 57 patients with previously untreated anisometropic amblyopia without strabismus(range:8-35 years),were measured refractive error,best corrected visual acuity(BCVA),fusion and stereopsis,and 48 patients have completed contrast sensitivity function *** was determined by dioptric vector addition model,and the amblyopia depth was determined by the difference of BCVA in logMAR units between the amblyopic and fellow ***:AM was significantly correlated with both amblyopia depth(Pearson R=0.728,P<0.001) and the inter-ocular difference of the area under the log contrast sensitivity function(AULCSF)(R=0.505,P<0.001).Depth of amblyopia and the inter-ocular difference of AULCSF was also significantly correlated(R=0.761,P<0.001).The more severity of amblyopia,the poorer levels of contrast *** pure anisometropes with AM was less than 3.0D retain fusion and some stereopsis,but when AM were more than 3.0D,especially for the anisometropes whose AM was more than 6.0D,fusion and stereopsis function were seriously ***:In the patients with previously untreated anisometropic amblyopia,higher degree of anisometropia is significantly associated with deeper amblyopia,worse contrast sensitivity,fusion and stereopsis functions.

关键词： anisometropia amblyopia area under the log contrast senility function fusion stereopsis

Novel mutation c.980_983delATTA compound with c.986C>A mutation of the FRMD7 gene in a Chinese family with X-linked idiopathic congenital nystagmus

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第6期14卷 479-486页

作者： feng-wei song Bin-bin CHEN Zhao-hui SUN Li-ping WU Su-juan ZHAO Qi MIAO Xia-jing TANG Eye Center the Second Affiliated HospitalSchool of MedicineZhejiang University Department of Ophthalmology the First Affiliated Hospital of Huzhou Teachers College Department of Otolaryngology-Head and Neck Surgery the First Affiliated HospitalWenzhou Medical College

Objective:To screen mutations in FERM domain-containing protein 7(FRMD7) gene in two Chinese families with X-linked idiopathic congenital nystagmus(XLICN).Methods:Common ophthalmic data and peripheral blood of two Chinese XLICN families(families A and B) were collected after informed *** DNA was prepared from the peripheral blood of members of the two families and from 100 normal *** in the FRMD7 gene were determined by directly sequencing polymerase chain reaction(PCR) ***:We identified a novel mutation c.980_983delATTA compound with c.986C>A mutation in the 11th exon of FRMD7 in family B,and a previously reported splicing mutation c.782G>C(p.R261G) in family *** mutations were detected in patients and female carriers,while they were absent in other relatives or in the 100 normal ***:Our results expand the spectrum of FRMD7 mutations in association with XLICN,and further confirm that the mutations of FRMD7 are the underlying molecular mechanism for XLICN.

关键词： Mutation Idiopathic congenital nystagmus FERM domain-containing protein 7(FRMD7)

Halogen Inhalation-Induced Lung Injury and Acute Respiratory Distress Syndrome

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Chinese Medical Journal 2018年第10期131卷 1214-1219页

作者： Ting Zhou wei-feng song You Shang Shang-Long Yao Sadis Matalon Department of Anesthesiology and Perioperative Medicine University of Alabama at Birmingham Birmingham AL 35294 USA Department of Critical Care Medicine Institute of Anesthesiology and Critical Care Medicine Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei 430022 China

Objective：Exposure to halogens,such as chlorine or bromine,results in environmental and occupational hazard to the lung and other *** is highly toxic by inhalation,leading to dyspnea,hypoxemia,airway obstruction,pneumonitis,pulmonary edema,and acute respiratory distress syndrome （ARDS）.Although bromine is less reactive and oxidative than chlorine,inhalation also results in bronchospasm,airway hyperresponsiveness,ARDS,and even *** halogens have been shown to damage the systemic circulation and result in cardiac injury as *** is no specific antidote for these injuries since the mechanisms are largely *** Sources：This review was based on articles published in PubMed databases up to January,2018,with the following keywords：＂chlorine,＂＂bromine,＂＂lung injury,＂ and ＂ARDS.＂Study Selection：The original articles and reviews including the topics were the primary ***：Based on animal studies,it is found that inhaled chlorine will form chlorine-derived oxidative products that mediate postexposure toxicity;thus,potential treatments will target the oxidative stress and inflammation induced by ***,cAMP-elevating agents,anti-inflammatory agents,nitric oxide-modulating agents,and high-molecular-weight hyaluronan have shown promising effects in treating acute chlorine *** free heme level is involved in acute lung injury caused by bromine ***,a heme-scavenging protein,when administered postexposure,decreases lung injury and improves ***：At present,there is an urgent need for additional research to develop specific therapies that target the basic mechanisms by which halogens damage the lungs and systemic organs.

关键词： Acute Lung Injury Acute Respiratory Distress Syndrome Bromine Chlorine

A POLAROGRAPHIC CATALYTIC WAVE OF OXYGEN INDUCED BY DIPHENYLAMINE COMPOUNDS

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Chinese Chemical Letters 1992年第1期3卷 67-68页

作者： Jun feng song wei GUO Yin Hua HU Department of Chemistry,Northwest University,Xi’an 710069

It is reported in this paper a polarographic catalytic double wave of oxygen reduction caused by diphenylamine compounds(diphs).The electrochemical process of the wave includes the polarographic generation of the supe... 详细信息

关键词： A POLAROGRAPHIC CATALYTIC WAVE OF OXYGEN INDUCED BY DIPHENYLAMINE COMPOUNDS

Left ventricular reconstruction with no-patch technique：early and late clinical outcomes

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Chinese Medical Journal 2010年第23期123卷 3412-3416页

作者： HU Sheng-shou FAN Hong-guang ZHENG Zhe feng wei WANG wei song Yun-hu WANG Li-qing YUAN Xin ZHANG Shi-ju Department of Cardiovascular Surgery Research Center for Cardiovascular Regenerative Medicine Fu Wai Hospital Peking Union Medical College and Chinese Academy of Medical Sciences Beijing 100037 China

Background Few studies have evaluated late clinical outcome of no-patch technique in patients with large left ventricular aneurysms. The objectives of this study were to evaluate a no-patch surgical technique to reconstruct the left ventricle in patients with left ventricular aneurysm and to assess early and late clinical *** In 1995, we began using a no-patch technique in patients with dyskinetic left ventricular aneurysms. A total of 145 patients underwent left ventricular reconstruction with this technique and were followed up for （59±29） months （range,1-127 months）. Risk factors for early mortality were analyzed by bivariate analyses. Cox＇s proportional hazards model was used to calculate risk factors for all-cause mortality and hospital readmission. Kaplan-Meier methodology was used to analyze late *** One week after operation, left ventricular end-diastolic diameter had decreased from （61±8） mm to （55±8）mm, and geometry of the left ventricle was restored to a more normal conical shape. Early mortality was 3% and late mortality 11%. Over a 5-year follow-up period, hospital readmission was 28%. One-, 5-, and 10-year survival estimates were 95% （95% confidence interval （CI） 91%-99%）, 86% （95% CI 78%-94%）, and 74% （95% CI 60%-88%）.Readmission-free survival at 1 and 5 years after operation was 87% （95% CI81%-93%） and 60% （95% CI50%-70%）,*** The no-patch technique for left ventricular reconstruction is an effective and simple procedure that can achieve satisfactory early and late clinical outcomes in patients with left ventricular aneurysms.

关键词： left ventricular reconstruction no-patch technique follow-up clinical outcome

Association Rule Mining and Its Application

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The Journal of China Universities of Posts and Telecommunications 2001年第4期8卷 13-17页

作者： DUAN Yun feng, LI Jian wei, song Jun de, SHU Hua ying (Beijng University of Posts and Telecommunications, Beijing 100876, P.R. China) Beijng University of Posts and Telecommunications Beijing 100876 P.R. China

Several algorithms in data mining technique have been studied recently, among which association is one of the most important techniques. In this paper, we introduce theory of association rule in data mining, and analyze the characteristics of postal EMS service. We create a data warehouse model for EMS services and give the procedure of applying association rule mining based on it. In the end, we give an example of the whole mining procedure. This EMS Data warehouse model and association rule mining technique have been applied in a practical Postal CRM System.

关键词： association rule mining data mining data warehouse data mart fact table frequency item set EMS post

南极菲尔德斯半岛地区土壤原生动物生态学研究

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水生生物学报 2000年第6期24卷 610-615页

作者：冯伟松余育和中国科学院水生生物研究所武汉430072

作者于 1 994年 1 2月至 1 995年 2月设置 1 3个采样站 ,对南极菲尔德斯半岛地区土壤原生动物进行了研究。共观察到原生动物 37种 ,其中 :鞭毛虫 1 1种 ,肉足虫 9种 ,纤毛虫 1 7种 ;优势种为梨波豆虫 ,球波豆虫 ,小滴虫 ,聚滴虫 ,跳侧滴... 详细信息

作者于 1 994年 1 2月至 1 995年 2月设置 1 3个采样站 ,对南极菲尔德斯半岛地区土壤原生动物进行了研究。共观察到原生动物 37种 ,其中 :鞭毛虫 1 1种 ,肉足虫 9种 ,纤毛虫 1 7种 ;优势种为梨波豆虫 ,球波豆虫 ,小滴虫 ,聚滴虫 ,跳侧滴虫 ,磷壳虫和钩刺斜管虫 ;原生动物密度在采样站间的变化范围在 33- 577个 /g干土之间 ,格鲁玻科湖岸边土壤站最低 ,而阿德雷岛苔藓下土壤站最高 ,回归分析表明 :土壤原生动物密度与土壤含水量呈显著性直线相关。

关键词：南极土壤原生动物生态学菲尔德斯半岛

Identification of a novel frameshift mutation in PITX2 gene in a Chinese family with Axenfeld-Rieger syndrome

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2014年第1期15卷 43-50页

作者： Hou-fa YIN Xiao-yun FANG Chong-fei JIN Jin-fu YIN Jin-yu LI Su-juan ZHAO Qi MIAO feng-wei song Eye Center the Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 China Zhejiang Provincial Key Lab of Ophthalmology Hangzhou 310009 China

Objective： Axenfeld-Rieger syndrome （ARS） is phenotypically and genetically heterogeneous. In this study we identified the underlying genetic defect in a Chinese family with ARS. Methods： A detailed family history and clinical data were recorded. The ocular phenotype was documented using slit-lamp photography and systemic anomalies were also documented where available. The genomic DNA was extracted from peripheral blood leukocytes. All coding exons and intron-exon junctions of paired-like homeodomain transcription factor 2 （PITX2） gene and the forkhead box C1 （FOXC1） gene were amplified by polymerase chain reaction （PCR） and screened for mutation by direct DNA sequencing. Variations detected in exon 5 of PITX2 were further evaluated with cloning sequencing. The exon 5 of PITX2 was also sequenced in 100 healthy controls, unrelated to the family, for comparison. Structural models of the wild type and mutant homeodomain of PITX2 were investigated by SWISS-MODEL. Results： Affected individuals exhibited variable ocular phenotypes, whereas the systemic anomalies were similar. After direct sequencing and cloning sequencing, a heterozygous deletion/insertion mutation c. 198_201delinsTTTCT （p.M661fs＊133） was revealed in exon 5 of PITX2. This mutation co-segregated with all affected individuals in the family and was not found either in unaffected family members or in 100 unrelated controls. Conclusions： We detected a novel frameshift mutation p.M661fs＊133 in PITX2 in a Chinese family with ARS. Although PITX2 mutations and polymorphisms have been re- ported from various ethnic groups, we report for the first time the identification of a novel deletion/insertion mutation that causes frameshift mutation in the homeodomain of PITX2 protein.

关键词： Axenfeld-Rieger syndrome PITX2 gene FOXC1 gene Frameshift mutation Homeodomain

急性共同性内斜视双眼复视患者压贴三棱镜矫正前后视觉相关生活质量及双眼视功能分析

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国际眼科杂志 2017年第11期17卷 2183-2186页

作者：王茜宋峰伟中国浙江省湖州市中心医院眼科 313000 湖州师范学院附属第一医院眼科中国浙江省湖州市313000

目的:评估急性共同性内斜视(acute-onset comitant esotropia,ACE)双眼复视患者行压贴三棱镜矫正前后视觉相关生活质量及双眼视功能。方法:回顾性病例研究。收集2014-03/2017-03于湖州市中心医院因双眼复视就诊并诊断为ACE的患者16例,采... 详细信息

目的:评估急性共同性内斜视(acute-onset comitant esotropia,ACE)双眼复视患者行压贴三棱镜矫正前后视觉相关生活质量及双眼视功能。方法:回顾性病例研究。收集2014-03/2017-03于湖州市中心医院因双眼复视就诊并诊断为ACE的患者16例,采用25项美国国家眼科研究所视觉功能问卷调查(25-item National Eye Institute Visual Function Questionnaire,NEI-VFQ-25)中文版评估三棱镜矫正前后患者的视觉相关生活质量。同时记录ACE双眼复视患者三棱镜矫正前及矫正后1mo的Worth 4点灯检查、立体视检查等临床资料。数据采用配对样本t检验、卡方检验及Fisher确切概率法进行分析。结果:(1)患者行压贴三棱镜矫正后1mo的视觉相关生活质量,包括一般健康状态、总体视觉情况、精神健康状态、社会角色限制、社交功能、近距离工作、远距离工作、独立性和驾驶等方面评分较矫正前均明显提高,差异均有统计学意义(P0.05)。(2)患者行压贴三棱镜矫正前后的远距离融合功能和近立体视功能差异均有统计学意义(P<0.05)。结论:压贴三棱镜能够改善ACE双眼复视患者的视觉相关生活质量及双眼视功能。

关键词：急性共同性内斜视复视融合功能立体视功能视觉相关生活质量