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Anti-MMP-2 and MMP-9 activity of Salsola komarovii Iljin extract and its solvent fractions

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Asian Pacific Journal of Tropical Biomedicine 2020年第10期10卷 460-469页

作者： Jung-Ha Kil fatih karadeniz Ga Hyun Yu Hojun Kim Junse Kim Jung Hwan Oh Jung Im Lee Chang-SukKong Youngwan Seo Marine Biotechnology Center for Pharmaceuticals and Foods Silla UniversityBaegyang-daero 700 beon-gil 140Sasang-guBusan 46958Korea Department of Food and Nutrition College of Medical and Life SciencesSilla UniversityBaegyang-daero 700 beon-gil 140Sasang-guBusan 46958Korea Division of Marine Bioscience Korea Maritime and Ocean UniversityBusan 49112Korea

Objective: To investigate matrix metalloproteinases(MMP)-2 and MMP-9 inhibitory effect of Salsola komarovii Iljin, an edible halophyte with health beneficial ***: Salsola komarovii crude extracts(SKI), and solvent(n-hexane, 85% aq. MeOH, n-BuOH, and H2O) fractionated extracts of SKI were prepared. Gelatin zymography was carried out to observe MMP enzymatic activity. The release of the MMP enzymes was measured by enzyme-linked immunosorbent assay. Expression of MMPs in m RNA and protein level were investigated by polymerase chain reaction analysis and immunoblotting, ***: SKI and SKI fractions inhibited active MMP-2 and MMP-9 amount in the treated cell culture medium. Also, SKI suppressed the release of MMP-2 and MMP-9 from stimulated HT1080 human fibrosarcoma cells. Furthermore, SKI suppressed the m RNA and protein expression of MMP-2 and MMP-9. SKI fractions showed parallel effects except for H2O fraction which did not yield any significant MMP inhibitory effect. Among fractions, 85% aq. Me OH was the most active fraction to inhibit both the enzymatic effect and expression of MMP-2 and ***: SKI may contain potential MMP release inhibitory compounds. Salsola komarovii is a promising source of compounds against MMP and could be utilized in the development of antitumor agents.

关键词： release utilized effect

Lentinula edodes extract inhibits matrix metalloproteinase expression and increases typeⅠprocollagen expression via the p38 MAPK/c-Fos signaling pathway in ultraviolet A and B-irradiated HaCaT keratinocytes

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Asian Pacific Journal of Tropical Biomedicine 2021年第4期11卷 164-173页

作者： Jung Im Lee Jung Hwan Oh fatih karadeniz So Young Park Hye Ran Kim Hyun Jin Jo Kyung Im Jung Byung-Jin Jeon Chang-Suk Kong Marine Biotechnology Center for Pharmaceuticals and Foods Silla UniversityBusan 46958Korea Department of Food and Nutrition College of Medical and Life SciencesSilla UniversityBusan 46958Korea Ocean Fisheries and Bio Center Busan technoparkBusan 46048Korea

Objective:To determine the effect of Lentinula edodes extract on ultraviolet(UV)A and UVB-induced changes in matrix metalloproteinase(MMP)and type I procollagen expression using human immortalized HaCaT ***:Lentinula edodes ethanol extract(LEE)was obtained by extraction with 80%ethanol for 4 h at 80℃.Effect of LEE on UVinduced alteration on the expression and production of MMPs and type I procollagen in keratinocytes was investigated using ELISA,RT-PCR,and Western blotting *** determine the underlying mechanism of LEE-mediated effects,mitogen-activated protein kinase(MAPK)and activator protein 1 signaling pathways were analysed by Western blotting ***:LEE significantly inhibited the expression of MMP-1 and MMP-9 and increased the expression of type I procollagen in UVA and UVB-irradiated HaCaT *** phosphorylation levels of p38 were significantly inhibited by LEE whereas it did not affect c-Jun N-terminal kinase and extracellular signal-regulated kinase *** of p38 phosphorylation was also accompanied by downregulation of UVA and UVB-induced increase in ***:LEE effectively inhibits the expression of MMP-1 and MMP-9 and increases type I procollagen production through the p38 MAPK/c-Fos signaling pathway in UVA and UVB-irradiated HaCaT *** findings suggest that Lentinula edodes may be developed as a cosmetic material to suppress UV exposuremediated skin aging.

关键词： Lentinula edodes Ultraviolet Matrix metalloproteinases TypeⅠprocollagen Ha Ca T

Single-station microtremor surveys for site characterization:A case study in Erzurum city,eastern Turkey

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Earthquake Engineering and Engineering Vibration 2024年第3期23卷 563-576页

作者： fatih Karsli Erdem Bayrak The Higher Education Credit and Hostels Institution Ministry of Youth and SportsErzurum 25240Turkey Earthquake Research Centre Ataturk UniversityErzurum 25240Turkey Department of Civil Engineering Ataturk UniversityErzurum 25240Turkey

The single-station microtremor method is one of the fastest,most reliable,and cheapest methods used to identify dynamic soil *** study utilizes 49 single-station microtremor measurements to identify the dynamic soil properties of the Hilalkent quarter of the Yakutiye district in *** dominant frequency and the amplification factor were calculated by using the Nakamura horizontal/vertical spectral ratio(H/V)*** the soil dominant frequency values varied between 0.4 Hz and 10 Hz,the soil amplification factor changed between 1 and *** H/V values were acquired with lower frequency *** vulnerability index(K_(g))and shear strain parameters that are utilized to estimate the damage that may be caused by an earthquake were *** in the west side of the study area,higher K_(g) values were *** shear strain map was created with 0.25 g,0.50 g and 0.75 g bedrock accelerations,and soil types that lost elasticity during an earthquake were *** average shear wave velocity for the first 30 m(V_(s30))was ***,it was observed that the western part of the study area,which resulted in a higher period and higher H/V,higher K_(g) and lower V_(s30) values,presents a higher risk of damage during an earthquake.

关键词： Nakamura horizontal/vertical spectral ratio single-station microtremor predominant frequency vulnerability index Erzurum

A robust optimization method for label noisy datasets based on adaptive threshold: Adaptive-k

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Frontiers of Computer Science 2024年第4期18卷 49-60页

作者： Enes DEDEOGLU Himmet Toprak KESGIN Mehmet fatih AMASYALI Department of Computer Engineering Yildiz Technical UniversityIstanbul 34220Turkey

The use of all samples in the optimization process does not produce robust results in datasets with label *** the gradients calculated according to the losses of the noisy samples cause the optimization process to go in the wrong *** this paper,we recommend using samples with loss less than a threshold determined during the optimization,instead of using all samples in the *** proposed method,Adaptive-k,aims to exclude label noise samples from the optimization process and make the process *** noisy datasets,we found that using a threshold-based approach,such as Adaptive-k,produces better results than using all samples or a fixed number of low-loss samples in the *** the basis of our theoretical analysis and experimental results,we show that the Adaptive-k method is closest to the performance of the Oracle,in which noisy samples are entirely removed from the ***-k is a simple but effective *** does not require prior knowledge of the noise ratio of the dataset,does not require additional model training,and does not increase training time *** the experiments,we also show that Adaptive-k is compatible with different optimizers such as SGD,SGDM,and *** code for Adaptive-k is available at GitHub.

关键词： robust optimization label noise noisy label deep learning noisy datasets noise ratio estimation robust training

Prediction of the undrained shear strength of remolded soil with non-linear regression,fuzzy logic,and artificial neural network

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Journal of Mountain Science 2024年第9期21卷 3108-3122页

作者： YÜNKÜL Kaan KARAÇOR fatih GÜRBÜZ Ayhan BUDAK TahsinÖmür Department of Civil Engineering Faculty of Engineering and ArchitectureTokat Gaziosmanpaşa UniversityTokat 60100Türkiye Department of Civil Engineering Faculty of Engineering and ArchitectureKafkas UniversityKars 36000Türkiye Department of Civil Engineering Faculty of EngineeringGazi UniversityAnkara 06570Türkiye Ministry of Youth and Sports Ankara 06090Türkiye

This study aims to predict the undrained shear strength of remolded soil samples using non-linear regression analyses,fuzzy logic,and artificial neural network modeling.A total of 1306 undrained shear strength results from 230 different remolded soil test settings reported in 21 publications were collected,utilizing six different measurement *** water content,plastic limit,and liquid limit were used as input parameters for fuzzy logic and artificial neural network modeling,liquidity index or water content ratio was considered as an input parameter for non-linear regression *** non-linear regression analyses,12 different regression equations were derived for the prediction of undrained shear strength of remolded ***-Forward backpropagation and the TANSIG transfer function were used for artificial neural network modeling,while the Mamdani inference system was preferred with trapezoidal and triangular membership functions for fuzzy logic *** experimental results of 914 tests were used for training of the artificial neural network models,196 for validation and 196 for *** was observed that the accuracy of the artificial neural network and fuzzy logic modeling was higher than that of the non-linear regression ***,a simple and reliable regression equation was proposed for assessments of undrained shear strength values with higher coefficients of determination.

关键词： Undrained shear strength Liquidity index Water content ratio Non-linear regression Artificial neural networks Fuzzy logic

Effects of using sinusoidal porous object(SPO)and perforated porous object(PPO)on the cooling performance of nano-enhanced multiple slot jet impingement for a conductive panel system

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Propulsion and Power Research 2024年第2期13卷 166-177页

作者： fatih Selimefendigil Faiza Benabdallah Kaouther Ghachem Hind Albalawi Badr MAlshammari Lioua Kolsi Department of Mechanical Engineering College of EngineeringKing Faisal UniversityAl Ahsa 31982Saudi Arabia Department of Mechanical Engineering Celal Bayar UniversityManisa 45140Turkey Department of Industrial Engineering and Systems College of EngineeringPrincess Nourah Bint Abdulrahman UniversityP.O.Box 84428Riyadh 11671Saudi Arabia Department of Physics College of SciencesPrincess Nourah Bint Abdulrahman UniversityP.O.Box 84428Riyadh 11671Saudi Arabia Department of Electrical Engineering College of EngineeringUniversity of Ha’ilHa’il City 81451Saudi Arabia Department of Mechanical Engineering College of EngineeringUniversity of Ha’ilHa’il City 81451Saudi Arabia

Cooling system design for thermal management of electronic equipment,batteries and photovoltaic(PV)modules is important for increasing the efﬁciency,safety operation,and long life span the *** the present study,two different cooling systems are proposed with nano-enhanced multiple impinging jets for a conductive *** present cooling systems can be used in electronic cooling and PV *** porous object(PPO)and sinusoidal porous object(SPO)are used in the jet cooling system.2D numerical analysis usingﬁnite volume method is conducted considering different values of permeability of the objects(Darcy number(Da)between 10^(-6) and 10^(-1)).When PPO is used in the cooling system,num-ber of cylinders(between 1 and 6),and size of the cylinders(between 0.015 and 0.075)are *** the case of using SPO,amplitude(between 0.1 and 2)and wave number(be-tween 1 and 12)are ***-water nanoﬂuid with cylindrical shaped nanoparticles is used as the heat transferﬂ*** permeability is changed for PPO,the average temper-ature increases by roughly 3.89℃ for a single cylinder and drops by roughly 0.57℃ for a six-cylinder *** the size of the cylinder in the PPO case at highest permeability results in temperature drop of 5.3℃.When changing the number of cylinders,cooling rate varies by about 3.6%.Wave number of SPO is more inﬂuential on the cooling performance enhancement as compared to amplitude and permeability of the *** average surface temperature drops by 12.4℃ when the wave number is increased to *** compared to reference case of jet impingement cooling without porous object,using PPO and SPO along with the nanoﬂuid result in temperature drop of 12.3℃ and 14.4℃.

关键词： Thermal management Jet impingement Perforated porous

Red cell distribution width-to-albumin ratio is a simple promising prognostic marker in acute cholangitis requiring biliary drainage

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Hepatobiliary & Pancreatic Diseases International 2024年第5期23卷 487-494页

作者： fatih Acehan Hüseyin Camli Cagdas Kalkan Mesut Tez Burak Furkan Demir Emin Altiparmak Ihsan Ates Department of Internal Medicine Ankara City HospitalAnkara 06800Türkiye Department of Gastroenterology Ankara City HospitalAnkara 06800Türkiye Department of General Surgery Ankara City HospitalAnkara 06800Türkiye

Background: It is crucial to assess the severity of acute cholangitis(AC). There are currently several prognostic markers. However, the accuracies of these markers are not satisfied. The present study aimed to investigate the predictive value of the red cell distribution width(RDW)-to-albumin ratio(RAR) for the prognosis of AC. Methods: We retrospectively evaluated consecutive patients diagnosed with AC between May 2019 and March 2022. RAR was calculated, and its predictive ability for in-hospital mortality, intensive care unit(ICU) admission, bacteremia, and the length of hospitalization were analyzed. Results: Out of 438 patients, 34(7.8%) died. Multivariate analysis showed that malignant etiology [odds ratio(OR) = 4.816, 95% confidence interval(CI): 1.936-11.980], creatinine(OR = 1.649, 95% CI: 1.095-2.484), and RAR(OR = 2.064, 95% CI: 1.494-2.851) were independent risk factors for mortality. When adjusted for relevant covariates, including age, sex, malignant etiology, Tokyo severity grading(TSG), Charlson comorbidity index, and creatinine, RAR significantly predicted mortality(adjusted OR = 1.833, 95% CI: 1.280-2.624). When the cut-off of RAR was set to 3.8, its sensitivity and specificity for mortality were 94.1% and 56.7%, respectively. Patients with an RAR of > 3.8 had a 20.9-fold(OR = 20.9, 95% CI: 4.9-88.6) greater risk of mortality than the remaining patients. The area under the curve value of RAR for mortality was 0.835(95% CI: 0.770-0.901), which was significantly higher than that of TSG and the other prognostic markers, such as C-reactive protein-to-albumin ratio, and procalcitonin-to-albumin ratio. Lastly, RAR was not inferior to TSG in predicting ICU admission, bacteremia, and the length of hospitalization. Conclusions: RAR successfully predicted the in-hospital mortality, ICU admission, bacteremia, and the length of hospitalization of patients with AC, especially in-hospital mortality. RAR is a promising marker that is more convenient than TSG and o

关键词： Acute cholangitis Albumin Biliary drainage Mortality Red blood cell distribution width-to-albumin ratio

Epithelioid malignant peripheral nerve sheath tumor of the bladder and concomitant urothelial carcinoma: A case report

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World Journal of Clinical Cases 2024年第3期12卷 551-559页

作者： Sami Berk Ozden Muhammed fatih Simsekoglu Ipek Sertbudak Cetin Demirdag Iclal Gurses Istanbul University-Cerrahpasa Cerrahpasa School of Medicine Department of UrologyIstanbul 34100FatihTurkey Istanbul University-Cerrahpasa Cerrahpasa School of Medicine Department of PathologyIstanbul 34100FatihTurkey

BACKGROUND Epithelioid malignant peripheral nerve sheath tumor(EMPNST)of the bladder is a rare entity with devastating *** tumors are thought to originate from malignant transformation of pre-existing schwannomas of pelvic autonomic nerve plexuses,and unlike the conventional malignant peripheral nerve sheath tumor(MPNST),are not associated with *** tumor has dis-tinctive morphological,immunohistochemical and molecular ***-tionally,it tends to be more aggressive and have a higher *** is the first case that presents with a synchronous urothelial carcinoma of the bladder and the epithelioid variant of MPNST in the ***’s also the second re-ported case of EMPNST originating from the bladder *** SUMMARY In this case report,we present the detailed clinical course of a 71-year-old patient with EMPNST of the bladder alongside a literature *** During the management of EMPNST cases,offering aggressive treatment moda-lities to the patient,such as radical cystectomy,is appropriate for the best chance to contain the disease,regardless of the tumor stage and the extent of local disease at initial diagnosis.

关键词： Epithelioid Peripheral nerve sheath tumor Bladder Case report Urothelial Cystoprostatectomy

Late corneal ectasia after penetrating and deep anterior lamellar keratoplasty for keratoconus

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International Journal of Ophthalmology(English edition) 2024年第10期17卷 1828-1836页

作者： Bora Yüksel Arife Esra Kocakaya Tuncay Küsbeci fatih Gümüş Department of Ophthalmology University of Health SciencesIzmir Bozyaka Education and Research HospitalIzmir 35110Türkiye

AIM:To investigate tomographic features of late corneal ectasia after keratoplasty for keratoconus and compare penetrating keratoplasty(PK)and deep anterior lamellar keratoplasty(DALK)in terms of incidence,time of onset and risk factors of corneal ***:Sixty eyes with PK and 30 eyes with DALK operated between 1999 and 2021 were *** Pentacam scans were evaluated together with vision and previous *** outcome measures were vision,K values,apparent thinning on graft-host cornea and the difference between opposing quadrants in the thinnest point *** segment optic coherence tomography was performed for further ***:Mean follow-up was 127.2mo(24–282mo)in PK,and 64.3mo(24–144mo)in DALK.K max was higher in DALK(60.6 vs 56.7 D,P=0.012).Inferior recipient was thinner(595.9μm)in PK than DALK(662.2μm,P=0.021),due to longer *** corneal ectasia rate was 20.0%within *** rate was the same(6.7%)in DALK 2/30 and in PK 4/60 in 10y and 13.3%in 12y(4/30 and 8/60,respectively).It increased to 23.3%(14/60)in PK over *** ectasia was not seen before 7y in PK,it could be seen in DALK starting from the 5^(th) *** intervals between keratoplasty and ectasia were 144.5mo in PK and 99mo in *** recipient was significantly thinner in 18 eyes with ectasia(502.7μm)compared to 76 non-ectasia(649.1μm,P=0.000).Inferior graft was thinner(561.0 vs 620.4μm,P=0.006),K max(63.3 vs 56.5 D,P=0.000),and anterior elevation was higher in ectasia(89.1 vs 48.6μm,P=0.002).Accelerated crosslinking was performed on 5 ***:Inferior-superior recipient and inferior graft thinning on tomography,with high K max and anterior elevation emerge as the most reliable criteria for the diagnosis of late *** incidence of corneal ectasia increases with the time.

关键词： keratoconus penetrating keratoplasty deep anterior lamellar keratoplasty corneal ectasia