Inhibitory effect of Cyrtomium falcatum on melanogenesis in α-MSH-stimulated B16F10 murine melanoma cells
作者机构：Department of BioscienceSilla UniversityBusan 46958Korea Collaborative Innovation Center for Child Nutrition and Health DevelopmentChongqing University of EducationChongqing 400067China Marine Biotechnology Center for Pharmaceuticals and FoodsSilla UniversityBusan 46958Korea Nutritional EducationGraduate School of EducationSilla UniversityBusan 46958Korea Department of Food and NutritionSilla UniversityBusan 46958Korea Division of Convergence on Marine ScienceKorea Maritime and Ocean UniversityBusan 49112Korea
出 版 物：《亚太热带生物医学杂志:英文版》 (Asian Pacific Journal of Tropical Biomedicine)
年 卷 期：2023年第13卷第9期
页 面：403-410页
核心收录：
学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学]
主 题：Cyrtomium falcatum Melanogenesis α-MSH B16F10 melanoma cells
摘 要：Objective:To explore the anti-melanogenic potential of Cyrtomium ***:The effects of Cyrtomium falcatum crude extract and its solvent fractions on tyrosinase activity,melanin content,and the expressions of melanogenesis-related genes and proteins were analyzed inα-melanocyte-stimulating hormone(α-MSH)-stimulated B16F10 ***:α-MSH treatment significantly increased tyrosinase activity,and extracellular and intracellular melanin content,as well as the expression levels of tyrosinase,microphthalmia-associated transcription factor(MITF),tyrosinase-related protein(TRP)-1,and TRP-2 in B16F10 *** with Cyrtomium falcatum crude extract and its solvent fractions reduced tyrosinase activity and extracellular and intracellular melanin content and downregulated the expression levels of tyrosinase,MITF,TRP-1,and TRP-2 in a dose-dependent ***:Cyrtomium falcatum has potential anti-melanogenesis effects and can be used as a potential source material in cosmeceutical industry for the research and development of novel lead molecules with whitening properties.
维普期刊数据库