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ZMYM3:a new candidate gene in nonobstructive azoospermia?

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Asian Journal of Andrology 2023年第5期25卷 648-649页

作者： Morgane Le Beulze Nelly Swierkowski-Blanchardl farah Ghieh Joanne Fortemps Carole Gerault Valerie Scrazin Anne Louboutin-Sanchez Marc Bailly Francois Vialard Paris-Saclay University UVSQINRAEBREEDJouy-en-Josas F-78350France Alfort National Veterinary Scholl BREEDMaisons Alfort F-94700France Department of Gynecology and Obstetric CHI de Poissy/Saint-Germain-en-LayePoissy F-78300France Unit of Anatomo-Pathology CHI de Poissy/Saint-Germain-en-LayePoissy F-78300France Department of Genetic CHI de Poissy/Saint-Germain-en-LayePoissy F-78300France

Dear Editor,Infertility affects about 15%of couples of childbearing age.i About half of these cases can be attributed predominantly to a male factor,such as a quantitative or qualitative impairment in *** etiology of male infertility is related to anatomic,genetic,and environmental causes,being sometimes multifactorial and of unknown or idiopathic *** present,genetic screening for nonobstructive azoospermia(NOA)is generally limited to karyotyping for the identification of chromosome abnormalities such as 47,XXY,46,X,der(X)t(X;Y)(p22.3;p11.2),chromosome rearrangements,and Y chromosome ***-genome analyses have shown that over 100 gene variants are associated with a male infertility phenotype,and the list continues to grow;hence,a large number of genes are involved in *** continuing identification of genes responsible for male infertility in general and azoospermia,in particular,is a major challenge in both research and the diagnosis ofmale infertility.

关键词： azoospermia obstructive diagnosis

Rare Aggressive Form of Multiple Myeloma with Diffuse Osteosclerosis and Elevated CA 15-3 Levels

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Open Journal of Internal Medicine 2016年第1期6卷 11-14页

作者： Dally Najib Daniel Talmud Saher Srour Rola Khamisy-farah Raymond farah Department of Hematology Ziv Medical Center Zefat Israel Faculty of Medicine in the Galilee Bar-Ilan University Safed Israel Department of Internal Medicine Ziv Medical Center Zefat Israel Department of Radiology Ziv Medical Center Zefat Israel Clalit Health Service Akko Israel

We report the case of a 56-year-old female who had recently been examined for back and epigastric pain, and was diagnosed in the internal medicine ward as having an aggressive rare form of multiple myeloma with diffuse osteoblastic bone lesions. She also had high levels of breast tumor marker (CA 15-3), severe tumor lysis syndrome, and pleural and central nervous system involvement. A few cases of multiple myeloma with diffuse osteosclerosis that are not part of POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, skin changeshave) have been described. None of these cases were as aggressive as our case. To our knowledge it is the first report describing an elevation in CA 15-3 in conjunction with multiple myeloma.

关键词： Multiple Myeloma Osteosclerosis CA 15-3 Pleural Effusion

Time-Dependent Nonplanar Dust-Ion-Acoustic Gardner Double Layers

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Open Journal of Acoustics 2011年第3期1卷 70-75页

作者： farah Deeba A. A. Mamun 不详

A theoretical investigation has been made on the nonplanar (cylindrical and spherical) dust-ion-acoustic (DIA) double layers (DLs) in a dusty plasma system, containing inertial ions, Boltzmann electrons, and negatively charged stationary dust. In this investigation, in order to analyze the time dependent nonplanar DIA DLs, we have used the modified Gardner equation, which has been obtained by employing the reductive perturbation method. It has been found that the behaviors of DIA DLs have been significantly modified by the time period and the nonplanar geometry. The nonplanar DIA DLs has been found to be similar with planar DIA DLs only at large time scale and the cylindrical DIA DLs have been found to be smaller than the spherical DLs, but larger than the planar DLs.

关键词： Dust-Ion-Acoustic Double Layers Nonplanar

Apoptosis,antimicrobial and antioxidant activities of phytochemicals from Garcinia malaccensis Hk.f

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Asian Pacific Journal of Tropical Medicine 2012年第2期5卷 136-141页

作者： Muhammad Taher Deny Susanti Mohamad Fazlin Rezali farah Syahidah Ahmad Zohri Solachuddin Jauhari Arief Ichwan Suhaib Ibrahim Alkhamaiseh Farediah Ahmad Department of Pharmaceutical Technology Kulliyyah of PharmacyInternational Islamic University MalaysiaJalan IstanaBandar Indera Mahkota25200 KuantanPahangMalaysia Department of Biomedical Science Kulliyyah of ScienceInternational Islamic University MalaysiaJalan IstanaBandar Indera Mahkota25200 KuantanPahangMalaysia SIRIM Rerhad(National Metrology Laboratory) Lot PT 4803Bandar Baru Salak Tinggi43900 SepangSelangorMalaysia Kulliyyah of Dentistry International Islamic University MalaysiaJalan IstanaBandar Indera Mahkota25200 KuantanPahangMalaysia Department of Chemistry Faculty of ScienceUniversity Teknologi Malaysia81310 UTMJohorMalaysia

Objective:To study the chemical constituents of stembark of Garcinia malaccenm（***） together with *** and antioxidant ***:Purification and structure elucidation were carried out by chromatographic and spectroscopic techniques, *** and trypan blue exclusion methods were performed to study the cytotoxic *** activity was conducted by dise diffusion and microdilulion methods, whereas antioxidant activities were done by ferric thiocyanate method and DPPH radical ***:The phylochemical study led lo the isolation ofα,β-mangostin and cycloarl-24-en-3β-ol.α-Mangostin exhibited cytotoxic activity against HSC-3 cells with an IC50 of 0.33μM.β- andα-mangostin showed activity against K562 cells with IC50 of 0.40μM and 0.48μM,respectively,α-Mangostin was active against Gram-positive bacteria, Staphylococcus aureus（***） and Bacilus anthracis（***） with inhibition zone and MIC value of（19 mm;0.02S mg/mL） and（20 mm;0.013 mg/mL）,*** antioxidant assay,α-mangostin exhibited activity as an inhibitor of lipid ***:*** presenceα- andβ-mangostin and cycloart-24-en-3β-ol.β-Mangostin was found very active against ***-3 cells and *** results suggest that mangoslins derivatives have the potential to inhibit the growth of cancer cells by inducing *** addition,α-andβ-mangostin was found inhibit the growth of Cram-positive pathogenic bacteria and also showed the activity as an inhibitor of lipid peroxidation.

关键词： Garcinia malaccensis Guttiferae Apoptosis Antibacterial Antioxidant

Utilizing the Vector Autoregression Model (VAR) for Short-Term Solar Irradiance Forecasting

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Energy and Power Engineering 2023年第11期15卷 353-362页

作者： farah Z. Najdawi Ruben Villarreal Department of Material Science Engineering and Commercialization Texas State University San Marcos USA

Forecasting solar irradiance is a critical task in the renewable energy sector, as it provides essential information regarding the potential energy production from solar panels. This study aims to utilize the Vector Autoregression (VAR) model to forecast solar irradiance levels and weather characteristics in the San Francisco Bay Area. The results demonstrate a correlation between predicted and actual solar irradiance, indicating the effectiveness of the VAR model for this task. However, the model may not be sufficient for this region due to the requirement of additional weather features to reduce disparities between predictions and actual observations. Additionally, the current lag order in the model is relatively low, limiting its ability to capture all relevant information from past observations. As a result, the model’s forecasting capability is limited to short-term horizons, with a maximum horizon of four hours.

关键词： Vector Autoregression Model Hyperparameter Parameters Augmented Dickey Fuller Durbin Watson’s Statistics

水介质中药物-AOT混合物的温度依赖的混合胶束化行为(英文)

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物理化学学报 2014年第4期30卷 699-707页

作者： RUB Malik Abdul ASIRI Abdullah M KUMAR Dileep AZUM Naved KHAN farah Chemistry Department King Abdulaziz University Center of Excellence for Advanced Materials Research King Abdulaziz University Department of Chemistry Aligarh Muslim University

The mixed micellization behavior of an amphiphilic antidepressant drug amitriptyline hydrochloride(AMT)in the presence of the conventional anionic surfactant sodium bis(2-ethylhexyl)sulfosuccinate(AOT)was studied at five different temperatures and compositions by the conductometric *** critical micelle concentration(cmc)and critical micelle concentration at the ideal state(cmcid)values show mixed micelle formation between the components(i.e.,drug and AOT).The micellar mole fractions of the AOT(X1)values calculated using the Rubingh,Motomura,and Rodenas models show a higher contribution of AOT in the mixed *** interaction parameter(β)is negative at all temperatures and the compositions show attractive interactions between the *** activity coefficients(f1and f2)calculated using the different proposed models are always less than unity indicating non-ideality in the ***ΔGmΘ values were found to be negative for all the binary mixed ***,ΔHmΘ values for the pure drug as well as the drug-AOT mixed systems are negative at lower temperatures(293.15-303.15 K)and positive at higher temperatures(308.15 K and above).TheΔSmΘ values are positive at all temperatures but their magnitude was higher at T=308.15 K and *** excess free energy of mixing(ΔGex)determined using the different proposed models also explains the stability of the mixed micelles compared to the pure drug(AMT)and surfactant micelles.

关键词：抗抑郁药物临床分析药物治疗浓度

How to overcome ATP-binding cassette drug efflux transporter-mediated drug resistance?

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Cancer Drug Resistance 2018年第1期1卷 6-29页

作者： Adrian C.Jaramillo farah Al Saig Jacqueline Cloos Gerrit Jansen Godefridus J.Peters Department of Hematology VU University Medical CenterCancer Center AmsterdamAmsterdam 1007 MBThe Netherlands Department of Medical Oncology VU University Medical CenterCancer Center AmsterdamAmsterdam 1007 MBThe Netherlands Amsterdam Rheumatology and Immunology Center VU University Medical CenterAmsterdam 1007 MBThe Netherlands

P-glycoprotein(ABCB1),multidrug resistance protein-1(ABCC1)and breast cancer resistance protein(ABCG2)belong to the ATP-binding cassette(ABC)superfamily of proteins that play an important physiological role in protection of the body from toxic xenobiotics and endogenous *** this,these transporters determine the toxicity profile of many drugs,and confer multidrug resistance(MDR)in cancer cells associated with a poor treatment outcome of cancer *** has long been hypothesized that inhibition of ABC drug efflux transporters will increase drug accumulation and thereby overcome MDR,but until now no approved inhibitor of these transporters is available in the *** this review we present molecular strategies to overcome this type of drug resistance and discuss for each of these strategies their promising value or indicate underlying reasons for their limited success.

关键词： Breast cancer resistance protein ATP-binding cassette transporters multidrug resistance multidrug resistance protein

Gestational Diabetes Mellitus and Folic Acid Supplementation in Pregnant Women: A Systematic Review

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Journal of Diabetes Mellitus 2021年第1期11卷 26-39页

作者： Stephanie farah Obey Albaini Karl Jallad Lebanese American University Medical Center Beirut Lebanon Obstetrics and Gynecology and Urology Lebanese American University Medical Center Beirut Lebanon

Background: Gestational diabetes mellitus (GDM) is a common pregnancy disorder screened for between the 24th and 28th weeks of gestation using oral glucose tolerance test. GDM has maternal and fetal health implications. Objective: To assess the relation between folic acid supplementation in pregnant women and the risk of developing GDM. Search Strategy: The search employed topic-based strategies designed for each database in June 2020. Databases searched were Pubmed, Cochrane Library, Embase and Lebanese American University online database. Selection Criteria: Studies eligible were those targeting the association of GDM development and folic acid supplementation, including pregnant women who have developed GDM and pregnant women who were on folic acid supplementation and developed GDM. Both interventional and observational studies were included. Data Collection and Analysis: Two reviewers extracted the data independently. A third reviewer checked the data for consistency and clarity. Data extracted included the sample characteristics, sample size and outcomes. Cohen’s κ was used to assess agreement between reviewers. All tools and processes were piloted prior to use. Risk of bias was assessed using the Newcastle-Ottawa Scale. Data was presented in a tabulated form. Main Results: Six studies showed a proportional relation between folic acid intake and GDM, two reported a protective effect, and one cohort found no association. Conclusion: The inconsistent results made the formulation of a definitive conclusion difficult. Hence, larger studies are needed.

关键词： Folic Acid Gestational Diabetes

Formation Cycle of Creative Region

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Open Journal of Geology 2016年第7期6卷 553-560页

作者： Ehsan Dorostkar farah Habib Hamid Majedi Faculty of Art & Architecture Science and Research Branch Islamic Azad University Tehran Iran

Creative regions and their formation in a region depend on several factors. These factors are effective when placed side by side and have a positive impact on the establishment of the physical system of area. In fact, continuous and chained activity of these factors will play an important map. The connection between the key factors of creative region is named creative ecosystem that starts from a point, and after a few steps becomes a creative idea. Finding this ecosystem is particularly important in formation of the creative region. With proper understanding, apropos analysis, and timely use of this chain, actual and virtual potentials of region will be stimulated and pleasant result will come out. This paper explores the creative region factors and components that can be involved in the creative ecosystem. These factors are sometimes fundamental and sometimes minor considered compared to the current situation in the region. The used research method is grounded theory and in fundamental extent, it is seeking to achieve an underlying or grounded theory. After investigations and the results of this study, a creative region cycle theory has been reached and is presented as a fundamental theory that is a basis for formation of future researches. In the cycle of creative region, innovation, social capital, creative human capital and living quality are discussed that as the criteria for the formation of a creative region have numerous separated indicators.

关键词： Creative Region Regional Planning Formation Creative Region