How to overcome ATP-binding cassette drug efflux transporter-mediated drug resistance?
作者机构：Department of HematologyVU University Medical CenterCancer Center AmsterdamAmsterdam 1007 MBThe Netherlands Department of Medical OncologyVU University Medical CenterCancer Center AmsterdamAmsterdam 1007 MBThe Netherlands Amsterdam Rheumatology and Immunology CenterVU University Medical CenterAmsterdam 1007 MBThe Netherlands
出 版 物：《Cancer Drug Resistance》 (癌症耐药（英文）)
年 卷 期：2018年第1卷第1期
页 面：6-29页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Breast cancer resistance protein ATP-binding cassette transporters multidrug resistance multidrug resistance protein
摘 要：P-glycoprotein(ABCB1),multidrug resistance protein-1(ABCC1)and breast cancer resistance protein(ABCG2)belong to the ATP-binding cassette(ABC)superfamily of proteins that play an important physiological role in protection of the body from toxic xenobiotics and endogenous *** this,these transporters determine the toxicity profile of many drugs,and confer multidrug resistance(MDR)in cancer cells associated with a poor treatment outcome of cancer *** has long been hypothesized that inhibition of ABC drug efflux transporters will increase drug accumulation and thereby overcome MDR,but until now no approved inhibitor of these transporters is available in the *** this review we present molecular strategies to overcome this type of drug resistance and discuss for each of these strategies their promising value or indicate underlying reasons for their limited success.
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