Apoptosis,antimicrobial and antioxidant activities of phytochemicals from Garcinia malaccensis Hk.f

作     者：Muhammad Taher Deny Susanti Mohamad Fazlin Rezali Farah Syahidah Ahmad Zohri Solachuddin Jauhari Arief Ichwan Suhaib Ibrahim Alkhamaiseh Farediah Ahmad 

作者机构：Department of Pharmaceutical TechnologyKulliyyah of PharmacyInternational Islamic University MalaysiaJalan IstanaBandar Indera Mahkota25200 KuantanPahangMalaysia Department of Biomedical ScienceKulliyyah of ScienceInternational Islamic University MalaysiaJalan IstanaBandar Indera Mahkota25200 KuantanPahangMalaysia SIRIM Rerhad(National Metrology Laboratory)Lot PT 4803Bandar Baru Salak Tinggi43900 SepangSelangorMalaysia Kulliyyah of DentistryInternational Islamic University MalaysiaJalan IstanaBandar Indera Mahkota25200 KuantanPahangMalaysia Department of ChemistryFaculty of ScienceUniversity Teknologi Malaysia81310 UTMJohorMalaysia 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)

年 卷 期：2012年第5卷第2期

页      面：136-141页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：partially supported by the Intermtional Islamic University Malaysia(HUM)through EDWB1002-350 

主　　题：Garcinia malaccensis Guttiferae Apoptosis Antibacterial Antioxidant 

摘      要：Objective:To study the chemical constituents of stembark of Garcinia malaccenm（***） together with *** and antioxidant ***:Purification and structure elucidation were carried out by chromatographic and spectroscopic techniques, *** and trypan blue exclusion methods were performed to study the cytotoxic *** activity was conducted by dise diffusion and microdilulion methods, whereas antioxidant activities were done by ferric thiocyanate method and DPPH radical ***:The phylochemical study led lo the isolation ofα,β-mangostin and cycloarl-24-en-3β-ol.α-Mangostin exhibited cytotoxic activity against HSC-3 cells with an IC50 of 0.33μM.β- andα-mangostin showed activity against K562 cells with IC50 of 0.40μM and 0.48μM,respectively,α-Mangostin was active against Gram-positive bacteria, Staphylococcus aureus（***） and Bacilus anthracis（***） with inhibition zone and MIC value of（19 mm;0.02S mg/mL） and（20 mm;0.013 mg/mL）,*** antioxidant assay,α-mangostin exhibited activity as an inhibitor of lipid ***:*** presenceα- andβ-mangostin and cycloart-24-en-3β-ol.β-Mangostin was found very active against ***-3 cells and *** results suggest that mangoslins derivatives have the potential to inhibit the growth of cancer cells by inducing *** addition,α-andβ-mangostin was found inhibit the growth of Cram-positive pathogenic bacteria and also showed the activity as an inhibitor of lipid peroxidation.