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中国蚕学会第九届青年学术研讨会

作者： Xiaoling Tong Lei Chen Honglei Wang Lanlan Liu Mingyue Fu Peng Chen Minjin Han Hai Hu fangyin dai Cheng Lu Zhonghuai Xiang State Key Laboratory of Silkworm Genome Biology Key Laboratory of Sericultural Biology and Genetic BreedingMinistry of AgricultureCollege of BiotechnologySouthwest University

Hox gene clusters are one of the most ancient and highly conserved multigene loci in the animal *** conserved roles of the Hox genes encoding homeodomain-containing transcription factors were controlling morphogenesis and organogenesis in the evolution of *** proteins have remained enigmatic with regard to the molecular mechanisms that endow them with specific and diverse *** specific regional functions of individual Hox genes largely reflect their restricted expression patterns,the disruption of which can lead to developmental defects and *** silkworm,there are more than 30 mutants exhibiting profound morphological alterations during development,such as extra color markings,supernumerary or defective legs,abnormal silkgland,defective wings and embryonic ***,we identified the mutation region responsible for the E mutants by positional *** results showed that they are associated with the defect of Hox gene *** mutations in the gene coding region destroyed the encoded protein,while,mutations in the intergenic region affected the Hox gene expression *** long non-coding RNAs（lncRNAs） and miRNAs were also been identified in the Hox cluster,which supposed to regulate Hox gene expression as *** series of genome duplications associated with animal evolution have generated sets of paralogous genes within a *** silkworm,we identified five silkworm special homeobox（Shx） genes exhibiting tissues-specific expression pattern which suggesting that they are available to evolve new roles in regulation of different developmental processes compared to the ancestral functions in axial *** of the Hox genes expression and their roles in establishing the body structures in silkworm promise to shed light on the regulatory mechanisms of Hox genes during vertebrate evolution.

关键词： silkworm Hox gene development E mutants ncRNA

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QTL analysis of cocoon shell weight identifies BmRPL18 associated with silk protein synthesis in silkworm by pooling sequencing

QTL analysis of cocoon shell weight identifies BmRPL18 assoc...

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中国蚕学会第十届青年学术研讨会

作者： Chunlin Li Xiaoling Tong Weidong Zuo Yue Luan Rui Gao Minjin Han Gao Xiong Tingting Gai Hai Hu fangyin dai Cheng Lu State Key Laboratory of Silkworm Genome Biology Southwest University Key Laboratory of Sericulture biology and Genetic breeding Agricultural MinistryCollege of BiotechnologySouthwest University

Mechanisms that regulate silk protein synthesis provide the basis for silkworm variety breeding and silk gland bioreactor ***,using the pooling sequencing-based methodology,we deciphered the genetic basis for the varied silk production in different silkworm *** identified 8 SNPs,with 6 on chromosome 11 and 1 each on chromosomes 22 and 23,that were linked with silk *** conducting an association analysis between gene expression pattern,silk gland development and cocoon shell weight（CSW）,BMGN011620 was found to be regulating silk ***011620 encodes the 60S ribosomal protein,L18,which is an indispensable component of the 60S ribosomal subunit;therefore we named it ***,the clustering of linked SNPs on chromosome 11 and the analysis of differentially expressed genes reported in previous Omics studies indicated that the genes regulating silk protein synthesis may exhibit a clustering distribution in the silkworm *** results collectively advance our understanding of the regulation of silk production,including the role of ribosomal proteins and the clustered distribution of genes involved in silk protein synthesis.

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Topical application of silk fibroin-based hydrogel in preventing hypertrophic scars

Topical application of silk fibroin-based hydrogel in preven...

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中国蚕学会2021年学术年会

作者： Zheng Li Jiangbo Song Jianfei Zhang Kaige Hao Lian Liu Baiqing Wu Xinyue Zheng Bo Xiao Xiaoling Tong fangyin dai State Key Laboratory of Silkworm Genome Biology Key Laboratory for Sericulture Biology and Genetic BreedingMinistry of Agriculture and Rural AffairsCollege of BiotechnologySouthwest University

Current medications for the treatment of hypertrophic scars suffer from bottlenecks of limited therapeutic efficacy and a slow recovery *** fibroin（SF） has gained attention for its ability to promote wound healing in burns and cutaneous wounds,but its therapeutic effects against hypertrophic scar have not been thoroughly *** prepared SF-based hydrogels（SFHs） with various SF concentrations（1.5 %,3 %,and 6 %） and characterized their physicochemical *** experiments showed that these SFHs had favorable biocompatibility in *** animal experiments in rabbits revealed that the SFH（3 %）-treated group achieved scars on their ears that were thinner and significantly lighter in color compared with the negative control ***,treatment with SFHs reduced the density and led to the orderly arrangement of collagen *** was found that the therapeutic effects of SFHs were attributed to the reduced expression levels of α-smooth muscle *** results are the first to demonstrate that SFH can be exploited as an effective therapeutic agent for the treatment of hypertrophic scars.

关键词： Silk fibroin-based hydrogel hypertrophic scar collagen fibers α-Smooth muscle actin

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Identification of Genes that Control Silk Yield by RNA Sequencing Analysis of Silkworm（Bombyx mori） Strains of Variable Silk Yield

Identification of Genes that Control Silk Yield by RNA Seque...

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中国蚕学会第十届青年学术研讨会

作者： Yue Luan Weidong Zuo Chunlin Li Rui Gao Hao Zhang Xiaoling Tong Minjin Han Hai Hu Cheng Lu fangyin dai State Key Laboratory of Silkworm Genome Biology Key Laboratory of Sericultural Biology and Genetic BreedingMinistry of AgricultureCollege of BiotechnologySouthwest University

Silk is an important natural fiber of high economic value,and thus genetic study of the silkworm is a major area of *** analysis can provide guidance for genetic studies of silk yield *** this study,we performed a transcriptome comparison using multiple silkworms with different silk yields.A total of 22 common differentially expressed genes（DEGs） were identified in multiple strains and were mainly involved in metabolic *** these,seven significant common DEGs were verified by quantitative reverse transcription polymerase chain reaction,and the results coincided with the findings generated by RNA *** analysis showed that BGIBMGA003330 and BGIBMGA005780 are significantly associated with cocoon shell weight and encode uridine nucleosidase and small heat shock protein,*** annotation of these genes suggest that these play a role in silkworm silk gland development or silk protein *** addition,we performed principal component analysis（PCA） in combination with wild silkworm analysis,which indicates that modern breeding has a stronger selection effect on silk yield traits than domestication,and imply that silkworm breeding induces aggregation of genes related to silk yield.

关键词： silk yield RNA-seq multiple strains PCA

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家蚕着色模式相关的分子遗传学研究

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蚕业科学 2016年第3期42卷 373-385页

作者：彭晨星吴松原代方银家蚕基因组生物学国家重点实验室农业部蚕桑功能基因组与生物技术重点实验室西南大学生物技术学院重庆400715

体色与斑纹是昆虫重要的形态特征,对于昆虫捕食、避敌、寻偶、免疫和调节体温等具有重要的意义,其丰富着色模式形成的分子机制一直是昆虫学研究的热点。家蚕作为中国重要的农业经济昆虫,具有5 000多年的驯养历史,不仅成就了灿烂的丝绸文... 详细信息

体色与斑纹是昆虫重要的形态特征,对于昆虫捕食、避敌、寻偶、免疫和调节体温等具有重要的意义,其丰富着色模式形成的分子机制一直是昆虫学研究的热点。家蚕作为中国重要的农业经济昆虫,具有5 000多年的驯养历史,不仅成就了灿烂的丝绸文化,而且带来了巨大的经济效益。家蚕亦是鳞翅目的模式昆虫,拥有的超过200余个与着色相关的突变体是昆虫着色研究的重要实验材料。近年来,结合家蚕的经典遗传连锁图谱、家蚕基因组数据,运用高通量测序手段、定位克隆策略等分离鉴定家蚕着色相关突变体的关键基因,是探索着色模式形成的分子基础的主体。目前已在分子水平解析了家蚕30余种着色相关突变的产生机制,显著推动了家蚕着色机制的研究,对于丰富昆虫着色相关理论和基础知识具有重要贡献。本文总结了家蚕着色模式研究的最新成果,并结合其它昆虫着色相关研究的成果进行分析比较,这对于今后系统开展昆虫着色机制及其演化的研究,以及对着色相关基因的利用,均具有重要参考价值。

关键词：家蚕着色模式突变机制基因调控代谢通路

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后处理对静电纺丝素纤维膜性能的影响

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材料导报 2021年第14期35卷 14180-14184页

作者：徐梦婷马艳刘祖兰陈磊代方银李智西南大学家蚕基因组生物学国家重点实验室重庆400715 西南大学蚕桑纺织与生物质科学学院重庆市生物质纤维材料与现代纺织工程技术研究中心重庆400715 西南大学生物技术学院农业部蚕桑生物学与遗传育种重点实验室重庆400715

静电纺丝素纤维膜在载药、组织工程及多种电池的研究中具有广泛的应用。静电纺丝素纤维膜在制备过程中,需要后处理以保持纤维的形状及提升纤维膜的性能。本研究以乙醇和甘油对静电纺丝素纤维膜进行后处理,并通过SEM、FTIR、XRD、TGA等... 详细信息

静电纺丝素纤维膜在载药、组织工程及多种电池的研究中具有广泛的应用。静电纺丝素纤维膜在制备过程中,需要后处理以保持纤维的形状及提升纤维膜的性能。本研究以乙醇和甘油对静电纺丝素纤维膜进行后处理,并通过SEM、FTIR、XRD、TGA等表征手段系统研究了不同后处理条件对静电纺丝素纤维膜的结构及性能的影响,并分析及探讨了其影响机制。结果表明:仅用75%(体积分数)乙醇后处理可使丝素蛋白分子β折叠含量增大,纤维膜断裂强度显著增强;仅用甘油后处理可使丝素蛋白分子链无规卷曲度提高,纤维膜的断裂伸长率显著提高,亲水性大大增强;而用75%乙醇结合不同浓度的甘油对静电纺丝素纤维膜进行后处理可调控其力学性能,使其更能满足在不同领域的应用需求。

关键词：丝素蛋白静电纺丝膜乙醇甘油

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Comparative analysis of the integument transcriptomes of the black dilute mutant and the wild type silkworm Bombyx mori

Comparative analysis of the integument transcriptomes of the...

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中国蚕学会第九届青年学术研讨会

作者： Songyuan Wu Xiaoling Tong Chenxing Peng Gao Xiong Kunpeng Lu Hai hu Duan Tan Chunlin Li Minjin Han Cheng Lu fangyin dai State Key Laboratory of Silkworm Genome Biology Key Laboratory for Sericulture Functional Genomics and Biotechnology of Agricultural MinistrySouthwest University

The insect cuticle is a critical protective shell that is composed predominantly of chitin and various cuticular proteins and ***,insects often change their surface pigment patterns in response to selective pressures,such as threats from predators,sexual selection and environmental ***,the molecular mechanisms underlying the construction of the epidermis and its pigmentation patterns are not fully *** Lepidoptera,the silkworm is a favorable model for color pattern *** black dilute（bd） mutant of silkworm is the result of a spontaneous mutation;the larval body color is notably *** performed integument transcriptome sequencing of the wild-type strain Dazao and the mutant strains +/bd and bd/*** these experiments,during an early stage of the fourth molt,a stage at which approximately 51% of genes were expressed genome wide（RPKM ≥1） in each strain.A total of 254 novel transcripts were characterized using Cuffompare and BLAST *** of the transcriptome data revealed 28 diffrentially expressed genes（DEGs） that may contribute to bd larval melanism,including 15 cuticular protein genes that were remarkably highly expressed in the bd/bd *** suggest that these signifiantly upregulated cuticular proteins may promote melanism in silkworm larvae.

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Impacts of external forcing and internal variability on the North Atlantic multidecadal variations since 1950

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Science China Earth Sciences 2024年第8期67卷 2699-2701页

作者： Wenjian HUA Aiguo dai Key Laboratory of Meteorological Disaster Ministry of Education/Collaborative Innovation Center on Forecast and Evaluation of Meteorological DisastersNanjing University of Information Science and TechnologyNanjing 210044China Department of Atmospheric and Environmental Sciences University at AlbanyState University of New YorkAlbany 12222USA

The physical formation mechanisms of the Atlantic Multidecadal Variability(AMV)in the context of global warming have been a key research topic(Vecchi et al.,2017).The conventional view is that the AMV is mainly driven by internal dynamics within the climate system,especially in the Atlantic Ocean(Zhang et al.,2019).However,some studies suggest that decadal to multidecadal variations in North Atlantic sea surface temperature(SST)since around 1950 are related to anthropogenic and natural aerosol emissions(Otter?et al.,2010;Booth et al.,2012;Hua et al.,2019).

关键词： Atlantic decadal forcing

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On-demand molecular design for efficient blue phosphorescence

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Science China Chemistry 2024年第7期67卷 2124-2126页

作者： Meiqi dai Dongpeng Yan Beijing Key Laboratory of Energy Conversion and Storage Materials Key Laboratory of RadiopharmaceuticalsMinistry of EducationCollege of ChemistryBeijing Normal UniversityBeijing 100875China

Blue luminescence(including both fluorescence and phosphorescence)is one of the core elements in solid-state lighting and full-color *** to now,ultralong room temperature phosphorescence(RTP)with a long lifetime over 0.1 s has been continuously *** ultralong phosphorescence emission bands are in the region of 500 to600 ***,high-energy blue phosphorescence remains an immense challenge[1].

关键词： blue lifetime bands

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Neighborhood predictors of short sleep duration and bedtime irregularity among children in the United States: results from the 2019-2020 National Surveyof Children's Health

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World Journal of Pediatrics 2024年第1期20卷 73-81页

作者： Ying dai Jianghong Liu School of Nursing University of Pennsylvania418 Curie Blvd.Room 426Claire M.Fagin HallPhiladelphiaPA19104-6096USA

Background Environmental factors may contribute to short sleep duration and irregular bedtime in *** factors and children's sleep duration and bedtime regularity remain a less investigated *** aim of this study was to investigate the national and state-level proportions of children with short sleep duration and irregular bedtime and their neighborhood *** A total of 67,598 children whose parents completed the National Survey of Children's Health in 2019-2020 were included in the ***-weighted Poisson regression was used to explore the neighborhood predictors of children's short sleep duration and irregular *** The prevalence of short sleep duration and irregular bedtime among children in the United States(US)was 34.6%[95%confidence interval(CI)=33.8%-35.4%]and 16.4%(95%CI=15.6%-17.2%)in 2019-2020,*** neighborhoods,supportive neighborhoods,and neighborhoods with amenities were found to be protective factors against children's short sleep duration,with risk ratios ranging between 0.92 and 0.94,P<*** with detracting elements were associated with an increased risk of short sleep duration[risk ratio(RR)=1.06,95%CI=1.00-1.12]and irregular bedtime(RR=1.15,95%CI=1.03-1.28).Child race/ethnicity moderated the relationship between neighborhood with amenities and short *** Insufficient sleep duration and irregular bedtime were highly prevalent among US children.A favorable neighborhood environment can decrease children's risk of short sleep duration and irregular *** the neighborhood environment has implications for children's sleep health,especially for children from minority racial/ethnic groups.

关键词： Child National Survey of Children's Health Neighborhood.Sleep Social determinants of health

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