Topical application of silk fibroin-based hydrogel in preventing hypertrophic scars
作者单位：State Key Laboratory of Silkworm Genome BiologyKey Laboratory for Sericulture Biology and Genetic BreedingMinistry of Agriculture and Rural AffairsCollege of BiotechnologySouthwest University
会议名称：《中国蚕学会2021年学术年会》
会议日期：2021年
学科分类：08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学]
关 键 词：Silk fibroin-based hydrogel hypertrophic scar collagen fibers α-Smooth muscle actin
摘 要：Current medications for the treatment of hypertrophic scars suffer from bottlenecks of limited therapeutic efficacy and a slow recovery *** fibroin（SF） has gained attention for its ability to promote wound healing in burns and cutaneous wounds,but its therapeutic effects against hypertrophic scar have not been thoroughly *** prepared SF-based hydrogels（SFHs） with various SF concentrations（1.5 %,3 %,and 6 %） and characterized their physicochemical *** experiments showed that these SFHs had favorable biocompatibility in *** animal experiments in rabbits revealed that the SFH（3 %）-treated group achieved scars on their ears that were thinner and significantly lighter in color compared with the negative control ***,treatment with SFHs reduced the density and led to the orderly arrangement of collagen *** was found that the therapeutic effects of SFHs were attributed to the reduced expression levels of α-smooth muscle *** results are the first to demonstrate that SFH can be exploited as an effective therapeutic agent for the treatment of hypertrophic scars.