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The reservoir characteristics and their controlling factors of the sublacustrine fan in the Paleogene Dongying Formation, Bohai Sea,China

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Journal of Palaeogeography 2024年第1期13卷 127-148页

作者： Xiao-Jun Pang Guan-Min Wang Meng Zhao Qing-Bin Wang xue-fang Zhang School of Geosciences China University of Petroleum(East China)QingdaoShandong 266580China Tianjin Branch of China National Offshore Oil Corporation Limited Tianjin 300459China

Sublacustrine fan is an important element in continental lacustrine basins and is significant for reservoir exploration. Oil and gas resources have been found in the sublacustrine fan sandstone reservoirs of the Paleogene Dongying Formation in the Bohai Sea. In this study, the characteristics of the sublacustrine fan reservoirs and the controlling factors are studied using information from logging, cores, physical properties,casting thin sections, X-ray diffraction of clay minerals, vitrinite reflectance, rock pyrolysis, manometry data,and 3D seismic data. The sublacustrine fans of the Dongying Formation in the LD10, QHD34, and BZ21 structures show high-quality reservoirs with porosity >15 % and permeability >5 m D. The main controlling factors of the high-quality reservoirs are attributed to the favorable sedimentary facies type and negligible compaction,and cementation, substantial dissolution of K-feldspar, overpressure, and the development of faults and fractures. A high-quality sublacustrine fan reservoir model has been established to explain how these factors affected the physical properties. The favorable targets for oil and gas exploration in the Dongying Formation of Bohai Sea include undercompacted sandy debris flow reservoirs showing the dissolution of K-feldspar, and the reservoirs which are connected to the source rocks by faults. This study provides insights to establish the relationship between sedimentology, diagenesis and reservoir quality. The results of this study are significant for the exploration and development of the sublacustrine fan sandstone reservoirs in the Bohai Sea and analogous sandstone reservoirs elsewhere.

关键词： Sublacustrine fan High-quality reservoir Dissolution Overpressure Fault Bohai Sea

The Regulatory Role and Mechanism of Circadian Rhythm in Hemoglobin Co-cultured Neurovascular Unit

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Biomedical and Environmental Sciences 2024年第7期37卷 726-738页

作者： fang xue Wenchao Chen Xia Lian Guanghui He Jingyuan Tian Yinghong Liu Gaiqing Wang Department of Neurology The Second Clinical School of MedicineShanxi Medical UniversityTaiyuan 030002ShanxiChina The Second Clinical School of Medicine Shanxi Medical UniversityTaiyuan 030002ShanxiChina Department of Clinical lab The First People’s Hospital of ZhaotongZhaotong 657000YunnanChina Department of Neurology Sanya Central Hospital(Hainan Third People’s Hospital)Hainan Medical UniversitySanya 57200HainanChina

disruption of the blood-brain barrier(BBB),leading to vasogenic edema,plasma protein extravasation,and infiltration of neurotoxic *** clearance capacity of the brain plays a crucial role in maintaining BBB homeostasis and facilitating patient recovery after *** study aimed to investigate the effect of circadian rhythms on BBB function,neuronal damage,and clearance *** The transwell model and hemoglobin were co-cultured to simulate the BBB environment after *** intervention with different light groups,neuronal apoptosis was determined,glial phagocytosis was analyzed,the expression of endogenous clearing-related proteins aquaporin 4(AQP4)and low-density lipoprotein receptor-related protein 1(LRP1)was detected by western blotting and immunofluorescence dual standard method,and the expression of the tight junction protein occludin and melatonin receptor 1A(MTNR1A)was quantitatively *** Circadian rhythms play a key role in maintaining the integrity of the BBB,reducing oxidative stress-induced neuronal damage,and improving microglial ***,the expression of occludin and MTNR1A in neurovascular unit(NVU)co-cultured with hemoglobin improved the expression of AQP4 and LRP1,the key proteins in the NVU’s endogenous brain clearance *** Circadian rhythm(alternating black and white light)protects the NVU BBB function after ICH,promotes the expression of proteins related to the clearance of the hematoma,provides new evidence for the clinical treatment of patients recovering from ICH,and improves the circadian rhythm to promote brain metabolism and hematoma clearance.

关键词： Blood-brain barrier Circadian rhythm Neurovascular unit Melatonin receptor 1A Aquaporin-4

Rational design of superior catalysts from topological semimetals with nontrivial energy window

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Rare Metals 2024年第5期43卷 1956-1964页

作者： Min Zhao Li-Rong Wang Wei Liu Ming-Hang Li Ying Liu xue-fang Dai Guo-Dong Liu Xiao-Ming Zhang Key Laboratory of Reliability and Intelligence of Electrical Equipment School of Materials Science and Engineering ManufacturingHebei University of TechnologyTianjin 300130China

Materials featuring topological energy bands and nontrivial surface states hold significant promise in unlocking unprecedented opportunities for innovating electrocatalytic ***,it remains a challenge to realize superior topological catalysts which can carry both high catalytic activity and excellent catalytic ***,we propose that a family of Ni-based binary materials hosting fantasying topological conjunct-nodalpoint state and a large nontrivial energy window(NEWD)represents an ideal choice for such superior topological catalysts in hydrogen evolution *** presence of conjunct-nodal-points ensures long Fermi arcs on the surface,thereby enabling an extremely high catalytic *** NEWD plays a crucial role in stabilizing the high catalytic activity against external perturbations,such as strain and electron/hole *** roles for conjunctnodal-points and NEWD are substantiated by the observable weakening of catalytic performance during topological phase transitions,which result in the removal of the conjunct-nodal-points,NEWD and their corresponding long Fermi *** work unveils a hidden mechanism and opens a feasible route for developing superior quantum catalysts from novel topology point of view.

关键词： First-principles modeling Topological semimetal Nontrivial surface states Hydrogen evolution reaction

Electroacupuncture at Sensitized Acupoints Relieves Somatic Referred Pain in Colitis Rats by Inhibiting Sympathetic-Sensory Coupling to Interferewith 5-HT Signaling Pathway

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Chinese Journal of Integrative Medicine 2024年第2期30卷 152-162页

作者： YANG Ying QU Jin-yu GUO Hua ZHOU Hai-ying RUAN Xia PENG Ying-chun SHEN xue-fang XIONG Jin WANG Yi-li School of Clinical Medicine Chengdu Medical CollegeChengdu(610500)China Department of Rehabilitation Medicine the First Affliated Hospital of Chengdu Medical CollegeChengdu(610500)China Department of Rehabilitation Medicine West China HospitalSichuan University/West China School of NursingSichuan UniversityChengdu(610041)China Department of Neurology the First Affiliated Hospital of Chengdu Medical CollegeChengdu(610500)China

Objective:To investigate whether electroacupuncture(EA) at sensitized acupoints could reduce sympathetic-sensory coupling(SSC) and neurogenic inflammatory response by interfering with 5-hydroxytryptamine(5-HT)ergic neural pathways to relieve colitis and somatic referred pain,and explore the underlying ***:Rats were treated with 5% dextran sodium sulfate(DSS) solution for 7 days to establish a colitis *** rats were randomly divided into the control and model groups according to a random number table(n=6).According to the Research on Rat Acupoint Atlas",sensitized acupoints and non-sensitized acupoints were *** were randomly divided into the control,model,Zusanli-EA(ST 36),Dachangshu-EA(BL 25),and Xinshu(BL 15) groups(n=6),as well as the control,model,EA,and EA+GR113808(a 5-HT inhibitor)groups(n=6).The rats in the control group received no *** was administered on 2 days after modeling using the stimulation pavameters:1 mA,2 Hz,for 30 min,with sparse and dense waves,for 14 consecutive ***113808 was injected into the tail vein at 5 mg/kg before EA for 10 min for 7 consecutive *** sensitivity was assessed with von Frey *** weight and disease activity index(DAI) scores of rats were *** and eosin staining was performed to observe colon *** was analyzed by immunofluorescence *** staining was performed to detect 5-HT and substance P(SP) *** calcitonin gene-related peptide(CGRP) in skin tissue and tyrosine hydroxylase(TH) protein levels in DRG were detected by Western *** levels of hyaluronic acid(HA),bradykinin(BK),prostaglandin I2(PGI2) in skin tissue,5-HT,tryptophan hydroxylase 1(TPH1),serotonin transporters(SERT),5-HT 3 receptor(5-HT3R),and 5-HT 4 receptor(5-HT4R) in colon tissue were measured by enzyme-linked immunosorbent assay(ELISA).Results:BL 25 and ST 36 acupoints were determined as sensitized acupoints,and BL 1

关键词： electroacupuncture sensitized acupoints sympathetic-sensory coupling 5-hydroxytryptamine neurogenic inflammation somaticreferredpain

Serum urate is associated with an increased risk of inflammatory bowel disease: A bidirectional Mendelian randomization study

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World Journal of Clinical Cases 2024年第5期12卷 891-902页

作者： Song Zhang xue fang Le Kang Xiang-Yu Sui Miao Liu Yu-Jia Luo Shuo Fu Zhao-Shen Li Sheng-BingZhao Yu Bai Department of Gastroenterology Changhai HospitalShanghai 200433China Department of Gastroenterology Changhai HospitalSecond Military Medical University/Naval Medical UniversityShanghai 200433China Digestive Endoscopy Center Changhai HospitalNaval/Second Military Medical UniversityShanghai 200433China National Clinical Research Center for Digestive Diseases Shanghai 200433China

BACKGROUND Previous studies have indicated bidirectional associations between urate levels and inflammatory bowel disease(IBD),including ulcerative colitis(UC)and Crohn’s disease(CD).However,it remains unclear whether the observations are causal because of confounding *** To investigate the causal associations between urate levels and IBD using bidirec-tional Mendelian randomization(MR).METHODS Independent genetic variants for urate levels and IBD were selected as instru-mental variables from published genome-wide association studies(GWASs).Summary statistics for instrument-outcome associations were retrieved from three separate databases for IBD(the UK Biobank,the FinnGen database and a large GWAS meta-analysis)and one for urate levels(a large GWAS meta-analysis).MR analyses included the inverse-variance-weighted method,weighted-median estimator,MR-Egger and sensitivity analyses(MR-PRESSO).A meta-analysis was also conducted to merge the data from separate outcome databases using a fixed-effects *** Genetically higher serum urate levels were strongly associated with an increased risk of UC[odds ratio(OR):1.95,95%confidence interval(CI):1.86-2.05]after outlier correction,and the ORs(95%CIs)for IBD and CD were 0.94(95%CI:0.86-1.03)and 0.91(95%CI:0.80-1.04),*** studies have confirmed the positive association between urate levels and ***,genetically predicted IBD was inversely related to urate levels(OR:0.97,95%CI:0.94-0.99).However,no association was observed between genetically influenced UC or CD and urate *** Urate levels might be risk factors for UC,whereas genetically predicted IBD was inversely associated with urate *** findings provide essential new insight for treating and preventing IBD.

关键词： Inflammatory bowel disease Urate levels Antioxidant Mendelian randomization Single nucleotide polymorphism

The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

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Neural Regeneration Research 2025年第1期20卷 209-223页

作者： Shi-Yan Sun Lingyun Nie Jing Zhang xue fang Hongmei Luo Chuanhai Fu Zhiyi Wei Ai-Hui Tang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

价值对齐:AIGC时代的人工智能文化科技伦理风险与精准共治路径研究

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兰州大学学报（社会科学版） 2024年第3期52卷 147-156页

作者：解学芳曲晨同济大学人文学院上海200092

随着生成式人工智能技术的兴起,AIGC时代来临,人工智能技术在打造文化新质生产力方面取得显著进步,同时也带来了科技伦理风险和治理挑战。从理论建构来看,人工智能文化科技伦理涉及透明度、监管、责任、道德,以及与计算机伦理、机器伦... 详细信息

随着生成式人工智能技术的兴起,AIGC时代来临,人工智能技术在打造文化新质生产力方面取得显著进步,同时也带来了科技伦理风险和治理挑战。从理论建构来看,人工智能文化科技伦理涉及透明度、监管、责任、道德,以及与计算机伦理、机器伦理和计算伦理等关系的处理。从发展隐忧来看,算法作为非人类网络行动者,面临在隐私与道德交汇中的游离问题,数字化时代的数智鸿沟与伦理边缘不清问题,以及深度合成与深度伪造带来的多维安全风险。基于此,旨在立足人工智能技术遵守价值对齐,提出构建共创共建共治的AIGC文化科技伦理治理体系,即包括人工智能文化科技伦理治理制度创新、治理技术创新、治理主体创新的协同善治框架,推进AI文化新质生产力高质量发展并应对伦理风险,确保文化科技创新与文化科技伦理之间的可持续平衡。

关键词： AIGC 人工智能文化科技伦理价值对齐

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大气污染物暴露对健康迁徙大学生肺功能和鼻腔炎症因子的影响

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中国热带医学 2024年第4期24卷 417-421页

作者：方雪张倩也肖莎薛萍沈阳医学院公共卫生学院辽宁沈阳110034 海南医学院公共卫生与全健康国际学院Heinz Mehlhorn院士工作站海南海口571199

目的了解不同生源地学生肺功能及鼻腔炎性现况,探索大气污染物对健康大学生的肺功能及炎症因子水平可能存在的影响。方法采用自编问卷对253名在校健康大学生进行调查,内容包括个人基本信息、生源地及居住环境情况等,检测用力肺活量(FVC... 详细信息

目的了解不同生源地学生肺功能及鼻腔炎性现况,探索大气污染物对健康大学生的肺功能及炎症因子水平可能存在的影响。方法采用自编问卷对253名在校健康大学生进行调查,内容包括个人基本信息、生源地及居住环境情况等,检测用力肺活量(FVC)、第一秒用力呼气容积(FEV1)和呼气峰值流量(PEF),并依照生源地空气质量分别选取等级为优良的大学生60名,等级为差的大学生30名。分别于暑假前(2019年7月12日)和暑假后(2019年8月27日)检测鼻腔炎症因子IL-6和TNF-α水平,分析健康大学生肺功能的影响因素及短期差异大气污染物暴露后的鼻腔炎症因子水平。结果问卷调查单因素分析结果显示健康大学生的肺功能受城乡分布、生源地空气质量等影响。多因素分析结果发现,与城市健康大学生相比,乡镇学生FVC和FEV1分别升高0.346 L和0.322 L(P<0.05);生源地空气质量每下降一个等级,FEV1和PEF分别随之降低0.193 L和0.687 L/s(P<0.05);经过假期差异大气污染物暴露,生源地空气质量差的健康大学生鼻腔黏膜炎症因子TNF-α值高于空气质量优良的学生(P<0.05)。结论健康大学生肺功能受城乡分布、生源地的空气质量影响,短期大气污染物的差异暴露导致青年健康个体鼻腔炎症因子发生变化。

关键词：肺功能炎症因子空气质量健康大学生

基于深度合成技术的文化科技伦理风险识别与善治机制

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南昌大学学报（人文社会科学版） 2024年第4期55卷 53-65页

作者：解学芳陈思函同济大学人文学院上海200082

生成式人工智能技术的应用使人工智能直接参与数字文化的生产环节,既成为新质生产力,也增加了文化科技伦理风险。生成式人工智能在内容生成上导致的“幻觉”叠加深度合成在内容传播过程中的虚假效应,进一步扩展了人工智能在数字文化领... 详细信息

生成式人工智能技术的应用使人工智能直接参与数字文化的生产环节,既成为新质生产力,也增加了文化科技伦理风险。生成式人工智能在内容生成上导致的“幻觉”叠加深度合成在内容传播过程中的虚假效应,进一步扩展了人工智能在数字文化领域的潜在风险;即在核心内容生产层面涉及新型文化意识形态安全风险、文化内容安全风险、文化版权安全风险,在外围传播层面涉及文化数据安全风险和新型文化信息安全风险。生成式人工智能带来的文化科技伦理风险根源于智能时代文化资本的数字化、人机关系倒置化和认知方式的变化。文化科技伦理风险的善治机制亟须在全球治理体系框架下,整合核心技术研发、预见性制度规范与多元主体协同联动,形成政府、企业、公共三方的“组合拳”效应,以人机协同、善治向上的治理机制回应生成式人工智能时代数字文化新质生产力变革。

关键词：生成式人工智能深度合成伦理风险善治机制