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Inhibitory effect of Tong Xie-Yao fang formula on colonic contraction in rats

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World Journal of Gastroenterology 2015年第10期21卷 2912-2917页

作者： Cheng Yang Sheng-Sheng Zhang Xiao-Ling Li Zheng-fang Wang Lu-Qing Zhao Digestive Disease Diagnosis and Treatment Center Beijing Chinese Medicine HospitalCapital Medical University Basic Medicine College Beijing University of Chinese Medicine

AIM:To investigate the pharmacological effect ofTong Xie-Yao fang(TXYF)formula and its underlying ***:A neonatal maternal separation plus restraint stress(NMS+RS)model of diarrheapredominant irritable bowel syndrome was developed by subjecting male Sprague-Dawley rats to daily maternal separation from postnatal days 2 to 21 plus restraint stress from days 50 to *** were randomly divided into two groups(NMS+RS and TXYF formula),and rats with no handling or separation were used as normal *** from postnatal day 60,rats were administered TXYF formula(9.84 g/100 g body weight)orally twice daily for 14 consecutive days,while the normal and NMS+RS groups were given distilled *** distinctions of movement index(MI,area under the curve of contraction intensity/min,mg/min)and contraction frequency(CF,number of contractions/min,times/min)of isolated colonic longitudinal smooth muscle strips(CLSMs)in the three groups before and after treatment were observed with a Power Lab *** inhibitors were applied,and then 10-4mol/L acetylcholine chloride(Ach)was added to CLSMs to induce muscle ***:Before treatment,the MI of CLSMs in the NMS+RS and TXYF formula groups was similar and both higher than that in the normal group(545.49±73.66 mg/min vs 245.76±34.44 mg/min and551.09±54.29 mg/min vs 245.76±34.44 mg/min,P<0.01,respectively).After treatment,the MI in the TXYF formula group was lower than that in the NMS+RS group(261.39±38.59 mg/min vs 533.9±61.63 mg/min,P<0.01).In the same way,the CF of CLSMs in the NMS+RS and TXYF formula groups was similar and both higher than that in the normal group(3.42±0.25 times/min and 3.31±0.21 vs1.1±0.17 times/min,P<0.01)before *** treatment,the CF in the TXYF formula group was lower than that in the NMS+RS group(1.42±0.87 times/min vs 3.11±0.82 times/min,P<0.01)and similar to that in the normal group(1.42±0.87 times/min vs 1.09±0.13 times/min).When8-(N,N-diethylamino)octyl 3,4,

关键词： Irritable bowel syndrome Neonatal maternal separat

Regulating effect of Tong Xie-Yao fang on colonic epithelial secretion via Cl- and HCO3- channel

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World Journal of Gastroenterology 2016年第48期22卷 10584-10591页

作者： Cheng Yang Ying Xiong Sheng-Sheng Zhang fang-Mei An Jing Sun Qing-Lin Zhang Qiang Zhan Department of Gastroenterology Wuxi People’s HospitalNanjing Medical UniversityWuxi 214023Jiangsu ProvinceChina Community Health Service Center of Jinkui Street Wuxi 214023Jiangsu ProvinceChina Digestive Disease Diagnosis and Treatment Center Beijing Chinese Medicine HospitalCapital Medical UniversityBeijing 100010China

AIM To investigate the pharmacological effect of Tong XieYao fang(TXYF) formula, a Chinese herbal formula, on Diarrhea-predominant irritable bowel syndrome(D-IBS) *** In a neonatal maternal separation plus restraint stress(NMS + RS) model of D-IBS, male Sprague Dawley rats were randomly divided into two groups(NMS + RS group and TXYF-formula group) with no handlings were used as controls(NH group). Starting from postnatalday 60, rats in TXYF-formula group were administered TXYF-formula(4.92 g/100 g bodyweight) orally twice a day for 14 consecutive days while NH group and NMS + RS group were given distilled water. Using short-circuit current technology, we observed 5-HT-induced changes of current across ion channels, such as cystic fibrosis transmembrane conductance regulator(CFTR) Clchannel, epithelial Na+ channel(ENaC), Ca2+-dependent Cl- channel(CACC), Na+-K+-2Cl- co-transporter(NKCC), and Na+-HCO-3 co-transporter(NBC), in the colonic epithelium of three groups after exposure to drugs and specific blockers with a Power Lab System(AD Instruments International).RESULTS Under basal conditions, the changes of short-circuit current(?Isc, μA/cm2) induced by 5-HT were similar in NH group and TXYF-formula group, and both higher than NMS + RS group(70.86 μA/cm2 ± 12.32 μA/cm2, 67.67 μA/cm2 ± 11.68 μA/cm2 vs 38.8 μA/cm2 ± 7.25 μA/cm2, P < 0.01, respectively). When CACC was blocked by 4,4′-diisothiocyanato-stilbene-2,2′-disulfonic acid, 5-HT-induced ?Isc was smaller in NMS + RS group than in NH group and TXYF-formula group, respectively(48.41 μA/cm2 ± 13.15 μA/cm2 vs 74.62 μA/cm2 ± 10.73 μA/cm2, 69.22 μA/cm2 ± 11.7 μA/cm2, P < 0.05, respectively). The similar result could be obtained when ENaC was blocked by Amiloride(44.69 μA/cm2 ± 12.58 μA/cm2 vs 62.05 μA/cm2 ± 11.26 μA/cm2, 62.11 μA/cm2 ± 12.01 μA/cm2, P < 0.05, respectively). However, when CFTR Cl- channel was blocked by 1,1-dimethyl piperidinium chloride(DPC), 5-HT-induced ?Isc did not significantly differ in t

关键词： Ion channel Diarrhea-predominant irritable bowel syndrome Colonic mucosa Short-circuit current TongX ie-YaoF ang formula

News:***-fang Li receives Environment Research and Development Award from the Chemical Institute of Canada

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Journal of Environmental Sciences 2017年第3期29卷 326-326页

作者： Xing-fang Li the Journal of Environmental Sciences

Dr. Xing-fang Li, an Editorial Board mem- ber of the Journal of Environmental Sdences, is the recipient of the 2017 Environment Division Research and Development Award, from the Chemical Institute of Canada. This Award ＂is presented for distinguished contributions to research and/or development in the fields of envi- ronmental chemistry or environmental chemical engineering...＂（CIC, 2017）.

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Ge Hong and Zhou Hou Jiu Zu fang (A Handbook of Formulas for Emergencies)

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Journal of Traditional Chinese Medical Sciences 2016年第1期3卷 1-2页

作者： Min Li Yongxuan Liang Tingyu fang(Translated) School of Basic Medical Science Beijing University of Chinese MedicineBeijing100029China

Ge Hong(283e363),also known as Ge Yachuan and Bao Po Zi from Danyang(present Jurong,Jiangsu Province)was a famous Taoism theorist,herbalist and *** was of good stock,clever and keen to *** later he suffered a fall in his family *** he had to cut firewood as a career and bought pen,ink and paper after the firewood was *** the evening,he threw himself into readings and copying out *** was well-read because he could even travel thousands of miles to look for ancient books and records.1 Since his youth,he began to be interested in eternal life,so he started to learn alchemy from Zheng Yin,a *** 303,he was appointed a general with the title of marquis by the imperial court because he had successfully put down a peasant *** emperor wanted to favor him with high position and salary for several times which was turned down by *** the sake of easy study of alchemy,he finally volunteered to be a county magistrate in Guangdong Province abounded in raw materials for *** he was proceeding to his post,he formerly took Bao Liang,Prefecture Chief of Nanhai as his master and learned skills of health preservation and *** highly appreciated his talent and *** decided to betroth his daughter Bao Gu to him.

关键词： travel daughter interested

Effect of Zhuang Yi Liu fang Teng fang on the Expression of TNF-αand NF-κB in Chronic Pelvic Inflammatory Disease(CPID)Model Rats

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Journal of Clinical and Nursing Research 2020年第4期4卷 95-98页

作者： Gang Li Zhiyong Cao Jingqin Chen Gang fang Guangxi Zhuang Yao Medicine Center of Engineering and Technology GuangxiUniversity of Chinese MedicineNanning 530200China Medical Department of Hubei University for Nationalities EnshiChina

Objecrive:To investigate the expression of TNF-αand NF-κB in the uterus of chronic pelvic inflammatory disease(CPID)model ***:40 female rats that adaptive fed for 5 days were randomly divided into normal group,model group,high dose group,medium dose group and low *** addition to the normal group:the rats in each group were made chronic pelvic inflammatory model by mechanical injuuy combined with implantation of *** rats in each group were administrated by gavage for *** the last administration,the level of TNF-αand NF-κB in serum was measured by ELASA ***:(1)after the establishment of the model,the uterus of the chronic pelvic inflammatory model rats showed the pathological damage of chroic infilammation;the levels of lNF-αand NF-κB inserum were higher than those in the normal group,the difference was statistically significant(Pfang Teng fang Group was basically restored to normal,with only a small amount of inflammatory cell infiltration and other pathological changes;compared with the rats in the model group,the TNF-αin serum of the rats in each treatment group was lower,the difference was statistically significant(Pfang can efectively improve the endometrial histomorphology of CPID model rats,and regulate the levels of TNF-αand NF-κB in the uterus of chronic pelvic inflammatory model rats.

关键词： Zhuang Yi Liu fang Teng fang,Chronic pelvic inflammatory disease TNF-α NF-κB

The analysis and countermeasures about developing the low carbon economy for Lang fang

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The analysis and countermeasures about developing the low ca...

Characteristics of the anti-dementia drug system of Zisu fang preparations based on pharmacokinetic and pharmacodynamic analysis

The Sixth Forum of Collaborative Development among Bohai-Rim,Circum-Capital and Beijing-Tianjin-Hebei

作者： Zhang Songping,teacher in HeBei University of Technology Lang fang Department Zhang Haixia,vice-professor in HeBei University of Technology Lang fang Department Li Zhongqin,leader in HeBei University of Technology Lang fang Department,Senior Administration Engineer Zhang Jinxia,Graduate Student in Hebei University of Technology

Developing low carbon economy and coping with global climate change are the major issue of the countries all over the *** fang is located in the pearl of Jing-jin *** fang is not only a city which is adjacent to the capital,but must be one of models about the planning and construction of low carbon economy around the capital *** the low carbon economy for Lang fang contributes to breakthrough current resources environment bottleneck,meanwhile,it has an important significance to eliminate around Beijing-Tianjin poor regions,to lead the adjustment and promotion of industry and promote the transformation of economic development *** order to insure the low emission and energy consumption in the future development of Lang fang,positive strategy plan and countermeasures are needed,especially,support and guarantee in the policy and legally are prerequisite.

关键词： Low carbon economy Industry adjustment Ecological industry

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Journal of Traditional Chinese Medical Sciences 2017年第2期4卷 207-215页

作者： Jianye Quan Shujuan Yang fang Zhang Li Tan Jing Kong Yanyan Jiang Rendi Sun Renbing Shi School of Chinese Pharmacy Key Unit of Exploring Effective Substances of Classical and Famous Formulas of State Administration of Traditional Chinese MedicineBeijing University of Chinese MedicineBeijing 100102China Quality Control Technology and Engineering Center of Chinese Medicine Beijing Municipal Commission of EducationBeijing 100102China Shanghai Green Valley Pharmaceutical Life Park Shanghai 201707China

Objectives:To investigate the pharmacokinetics (PK) and pharmacodynamics (PD)of index components of Zisu fang preparations and additionally analysis the anti-dementia drug system ***:A PK-PD-drug interaction (DI) method was applied to determine the characteristics of index components of Zisu Fong preparations in ***:In the PK study,maximum plasma concentration,area under the plasma concentration-time curve,and mean residence time of index components of Zisu fang preparations were higher in the memory-deficit model group than in the control *** suggested that the index components of Zisu fang preparations had an affinity for the state of dementia in this *** the PD study,at the peak time points of anti-dementia efficacy (0.17 h and 1 h),the plasma concentrations of index components of Zisu fang preparations reached the first or second largest plasma concentration peak or were close to the plasma concentration peak,and showed positive correlation between these two peaks,indicating that the index components of Zisu fang synergistically exerted an anti-dementia *** to the association analysis of PK-PD-DI,baicalin,rosmarinic acid,salvianolic acid B,matrine,and tanshinone ⅡA were the main active ingredients of the anti-dementia drug system of Zisu fang preparations in vivo,but were only efficacious against dementia when all five components were present at a specific concentration and ***:Based on the PK and PD correlation analysis,baicalin,rosmarinic acid,salvianolic acid B,matrine,and tanshinone ⅡA are the main active ingredients of Zisu fang preparations with regard to its anti-dementia effects,and represent the basic characteristics of drug system:natures,synergy,and affinity.

关键词： Index components Pharmacokinetics Pharmacodynamics Characteristics of anti-dementia drug system

Strengthening the city marketing way of Lang fang is based on the coordinated development of Beijing-Tianjin-Hebei

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Strengthening the city marketing way of Lang fang is based o...

The research on industrial structure coordination development of Lang fang city

The Sixth Forum of Collaborative Development among Bohai-Rim,Circum-Capital and Beijing-Tianjin-Hebei

作者： Deng Meihong,Hebei University of Technology Lang fang Department Zhang Yalan,Graduate Student in Hebei University of Technology

The coordinated development of the Beijing-Tianjin-Hebei region is the new strategy of regional economy in the development of the bohai *** coordinated development of the strategy planning in the Beijing-Tianjin-Hebei region,urban marketing is the main task of Lang fang into the next *** city marketing of Lang fang exists many problems for example,the construction of urban brand is weak,industrial cluster is lack of competitiveness and weak,public participation is not *** the Lang fang city marketing,we should give full play to the government’s guidance,the development of industry cluster and enhance competitiveness,strengthen the construction of urban brand,realize the docking of Lang fang and the Beijing-Tianjin.

关键词： The collaborative development of Beijing Tianjin and Hebei City marketing City brand

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The research on industrial structure coordination developmen...