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Nano Research 2024年第6期17卷 5399-5408页

作者： Xuxuan Gu Jinlong Shen Zhiwei Xu Wenqi Wang Ying Wu Wen Zhou Chen Xie quli fan State Key Laboratory of Organic Electronics and Information Displays&Institute of Advanced Materials(IAM) Nanjing University of Posts&Telecommunications9 Wenyuan RoadNanjing 210023China

Semiconducting polymer nanoparticles(SPNs)have shown great promise in second near-infrared window(NIR-II)phototheranostics.However,the issue of long metabolic time significantly restricts the clinical application of SPNs.In this study,we rationally designed a biodegradable SPN(BSPN50)for NIR-II fluorescence imaging-guided photodynamic therapy(PDT).BSPN50 is prepared by encapsulating a biodegradable SP(BSP50)with an amphiphilic copolymer F-127.BSP50 is composed of NIR-II fluorescent diketopyrrolopyrrole(DPP)segment and degradable poly(phenylenevinylene)(PPV)segment with the ratio of 50/50.BSPN50 has both satisfactory degradability under myeloperoxidase(MPO)/hydrogen peroxide(H_(2)O_(2))and NIR-II fluorescence emission upon 808 nm laser excitation.Furthermore,BSPN50 shows good photodynamic efficacy under 808 nm laser irradiation.BSPN50 shows a faster degradation rate than BSPN100 which has no PPV segment both in vitro and in vivo.In addition,BSPN50 can effectively diagnose tumor via NIR-II fluorescence imaging and inhibit the tumor growth by PDT.Thus,our study provides a rational approach to construct biodegradable nanoplatforms for efficient tumor NIR-II phototheranostics.

关键词： near-infrared(NIR)-II fluorescence imaging semiconducting polymer nanoparticles photodynamic therapy tumor imaging

Water-soluble light-emitting nanoparticles prepared by non-covalent bond self-assembly of a hydroxyl group functionalized oligo(p-phenyleneethynylene) with different water-soluble polymers

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Science China Chemistry 2010年第5期53卷 1121-1126页

作者： Lu XiaoMei fan quli Zhang GuangWei Pu KanYi Huang Wei Nanjing Univ Posts & Telecommun Jiangsu Key Lab Organ Elect & Informat Displays Nanjing 210046 Peoples R China Nanjing Univ Posts & Telecommun Inst Adv Mat Nanjing 210046 Peoples R China

Water-soluble light-emitting nanoparticles were prepared from hydroxyl group functionalized oligos(p-phenyleneethynylene) (OHOPEL) and water-soluble polymers(PEG,PAA,and PG) by non-covalent bond self-assembly.Their structure and optoelectronic properties were investigated through dynamic light scattering(DLS) ,UV and PL spectroscopy.The optical properties of OHOPEL-based water-soluble nanoparticles exhibited the same properties as that found in OHOPEL films,indicating the existence of interchain-aggregation of OHOPELs in the nanoparticles.OHOPEL-based nanoparticles prepared from conjugated oligomers show smaller size and lower dispersity than nanoparticles from conjugated polymers,which means that the structures of water-soluble nanoparticles are linked to the conjugated length.Furthermore,the OHOPEL/PG and OHOPEL/PAA systems produced smaller particles and lower polydispersity than the OHOPEL/PEG system,indicating that there may exist influence of the strength of non-covalent bonds on the size and degree of dispersity of the nanoparticles.

关键词： water-soluble oligo(p-phenyleneethynylene) fluorescence nanoparticles

Synthesis,characterization and applications of vinylsilafluorene copolymers:New host materials for electroluminescent devices

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Science China Chemistry 2010年第11期53卷 2329-2336页

作者： CHEN RunFeng ZHU Rui ZHENG Chao fan quli HUANG Wei Key Laboratory for Organic Electronics&Information Displays(KLOEID) Institute of Advanced Materials(IAM)Nanjing University of Posts and Telecommunications(NUPT)Nanjing 210046China

Vinylsilafluorene(VSiF) was successfully synthesized and copolymerized with vinylcarbazole and methyl methacrylate via free radical copolymerization for the first time.The synthesis,photophysical properties,computational modeling studies,and organic light-emitting devices of the VSiF copolymers were presented.The good coordinated photoluminescent(PL) spectra with the absorption of blue light-emitting materials and the high energy band-gap of the VSiF copolymers were observed.Higher triplet band gap(3Eg) to host the blue phosphorescent emitters and better HOMO and LUMO than PVK for electron and hole injection and transportation of the VSiF model compounds were revealed by density functional theory(DFT) calculations.The preliminary device results in applications of these copolymers as host materials for green phosphorescent emitters demonstrate the copolymers of VSiF and vinylcarbazole have comparable device performance of polyvinylcarazole(PVK),suggesting a bright future of VSiF as building blocks for host materials.

关键词： vinylsilafluorene host materials polyvinylsilafluorene

Rare-earth Doped Nanoparticles with Narrow NIR-II Emission for Optical Imaging with Reduced Autofluorescence

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Chemical Research in Chinese Universities 2021年第4期37卷 943-950页

作者： LU Feng ZHAO Ting SUN Xiaojun WANG Zuqiang fan quli HUANG Wei State Key Laboratory of Organic Electronics and Information Displays&Institute of Advanced Materials(IAM) Nanjing University of Posts&TelecommunicationsNanjing210023P.R.China Frontiers Science Center for Flexible Electronics(FSCFE) MIIT Key Laboratory of Flexible Electronics(KLoFE)Northwestern Polytechnical UniversityXi’an710072P.R.China

Fluorescence imaging in the second near-infrared region(900―1700 nm, NIR-II) with a high resolution and penetration depth due to the significantly reduced tissue scattering and autofluorescence has emerged as a useful tool in biomedical fields. Recently, many efforts have been devoted to the development of fluorophores with an emission band covering the long-wavelength end of NIR-II region(1500―1700 nm) to eliminate the autofluorescence. Alternatively, we believe imaging with a narrow bandwidth could also reduce the autofluorescence. As a proof of concept, NaYF4:Yb,Nd@NaYF4 downconversion nanoparticles(DCNPs) with sharp NIR-II emission were synthesized. The luminescence of DCNPs showed a half-peak width of 49 nm centered at 998 nm, which was perfectly matched with a (1000±25) nm bandpass filter. With this filter, we were able to retain most of the emissions from the nanoparticles, while the autofluorescence was largely reduced. After PEGylation, the DCNPs exhibited great performance for blood vessel and tumor imaging in living mice with significantly reduced autofluorescence and interference signals. This work provided an alternative way for the low-autofluorescence imaging and emphasized the importance of narrow emitting rare-earth doped nanoparticles for NIR-II imaging.

关键词： Second near-infrared Rare-earth Downconversion nanoparticle Autofluorescence Fluorescence imaging

Germafluorene conjugated copolymer——synthesis and applications in blue-light-emitting diodes and host materials

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Science China Chemistry 2009年第2期52卷 212-218页

作者： CHEN RunFeng ZHU Rui ZHENG Chao LIU ShuJuan fan quli HUANG Wei Jiangsu Key Laboratory for Organic Electronics and Information Displays Institute of Advanced MaterialsNanjing University of Posts and TelecommunicationsNanjing 210046China Institute of Advanced Materials Fudan UniversityShanghai 200433China

A germafluorene-fluorene copolymer was successfully obtained via Suzuki polymerization.The ger-manium containing copolymer has an efficient blue light emission under the ultraviolet irradiation and its single layer EL device showed the highest brightness of 2630 cd/m2 at 7.8 V and the highest effi-ciency of 0.301 lm/W at 6.2 V.The copolymer can also serve as the host material for phosphorescent metal complexes with the maximum brightness of 15600 cd/m2 and the quantum efficiency of 8.5%.The results are quite promising and promise that as its analogs of fluorene and silafluorene,germafluorene is an excellent building block for blue light-emitting polymers and host materials.

关键词： conjugated polymers germafluorene heteroatom-containing polymers host material light-emitting diodes(LEDs)

Nitrogen-doped carbon nanotube/polyaniline composite:Synthesis, characterization, and its application to the detection of dopamine

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Science China Chemistry 2011年第10期54卷 1615-1621页

作者： FENG XiaoMiao LI RuiMei MA YanWen CHEN RunFeng MEI QunBo fan quli HUANG Wei Key Laboratory for Organic Electronics & Information Displays (KLOEID) Institute of Advanced Materials (IAM) Nanjing University of Posts & Telecommunications (NUPT) Nanjing 210046 China

Nitrogen-doped carbon nanotubes (N-CNTs)/polyaniline (PANI) composites are developed as an electrode material for biosensors. The morphology, composition, and optical properties of the resulting products were characterized by transmission electron microscopy (TEM), thermogravimetric analysis (TGA), Fourier transform infrared spectroscopy (FT-IR), and ultraviolet-visible absorption spectra (UV-vis). Furthermore, N-CNTs/PANI composite was immobilized on the surface of a glassy carbon electrode (GCE) and applied to construct a sensor. The obtained N-CNTs/PANI-modified GCE showed one pair of redox peaks and high catalytic activity for the oxidation of dopamine (DA) in a neutral environment. Differential pulse voltam-mograms results illustrate that the fabricated DA biosensor has high anti-interference ability towards ascorbic acid (AA). In addition, the fabricated biosensor showed superior performances with two wide linear ranges from 1 to 80 μM and from 1.5 to 3.5 mM and a low detection limit of 0.01 μM.

关键词：聚苯胺复合材料碳纳米管氮掺杂多巴胺检测限表征傅立叶变换红外光谱生物传感器

Star-shaped conjugated oligoelectrolyte for bioimaging in living cells

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Chinese Science Bulletin 2013年第21期58卷 2570-2575页

作者： SONG WenLi JIANG RongCui YUAN Yan LU XiaoMei HU WenBo fan quli HUANG Wei Key Laboratory for Organic Electronics & Information Displays (KLOEID) and Institute of Advanced Materials (IAM) Nanjing University of Posts & Telecommunications (NJUPT)

A new star-shaped oligoelectrolyte (TEFCOONa) with triphenylamine as the core, acetylene as linkage and anionic fluorenes as arms was obtained and used for direct imaging in living PANC-1 cells. Because of the hydrophobic conjugated groups of the oli-goelectrolyte, TEFCOONa can form nanospheres with an average diameter of^75 nm in 10 mmol/L PBS. These nanospheres possess a relatively high absolute quantum yield (16.5% in PBS), low cytotoxicity and can penetrate into the nucleus through the cytoplasm, which is essential for living cellular imaging. Collectively, these results validate our rational design of conjugated oligoelectrolyte and even hyper branched polymers-copolyelectrolyte as effective nanovectors for bioimaging and other clinical applications.

关键词：活细胞成像生物成像共轭星形超支化聚合物直接成像平均直径纳米微球

A rectifying diode with hysteresis effect from an electroactive hybrid of carbazole-functionalized polystyrene with CdTe nanocrystals via electrostatic interaction

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Science China Chemistry 2010年第11期53卷 2324-2328页

作者： LIU JuQing QI XiaoYing JIANG Ting LIN ZongQiong CHEN ShuFen XIE LingHai fan quli LING QiDan ZHANG Hua HUANG Wei Key Laboratory for Organic Electronics&Information Displays(KLOEID)and Institute of Advanced Materials(IAM) Nanjing University of Posts and TelecommunicationsNanjing 210046China School of Materials Science and Engineering Nanyang Technological UniversitySingapore 639798Singapore

One of the strategies to tune current-voltage behaviors in organic diodes is to combine field-induced charge transfer processes with schottky barrier.According to this principle,a rectifying diode with hysteresis effect was fabricated utilizing a hybrid of electroactive polystyrene derivative covalently tethered with electron-donor carbazole moieties and electrostatic linked with electron-acceptor CdTe nanocrystals.Current-voltage characteristics show an electrical switching behavior with some hysteresis is only observed under a negative bias,with three orders of On/Off current ratio.The hybrid material based rectifier exhibits a rectification ratio of six and its maximum rectified output current is about 5 × 10-5 A.The asymmetric switching is interpreted as the result of both field induced charge transfer and schottky barrier,capable of reducing the misreading of cross-bar memory.Meanwhile,chemical doping of CdTe nanocrystals instead of physical blend favor their uniform dispersion in matrix and stable operation of device.

关键词： carbazole-functionalized polystyrene CdTe nanocrystal electrostatic hybrid hysteresis effect rectifying diode

Carbon-nitrogen/graphene composite as metal-free electrocatalyst for the oxygen reduction reaction

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Chinese Science Bulletin 2011年第33期56卷 3583-3589页

作者： MA YanWen ZHANG LingRong LIJuanJuan NI HaiTao LI Meng ZHANG JinLei FENG XiaoMiao fan quli HU Zheng HUANG Wei Jiangsu Key Laboratory for Organic Electronics ＆ Information Displays and Institute of Advanced Materials Nanjing University of Posts and Telecommunications Nanjing 210046 China Key Laboratory of Mesoscopic Chemistry of Ministry of Education Jiangsu Provincial Laboratory for Nanotechnology School of Chemistry and Chemical Engineering Nanjing University Nanjing 210093 China

Sheet-like carbon-nitrogen (CNx)/graphene composites with a high content of nitrogen (x≤0.15) was prepared by the carbonization of polypyrrole (PPy)/reduced-graphene-oxide (rGO) composite at 600-800°C. We used rGO instead of graphene oxide (GO) sheets as a template and a substrate to immobilize PPy since the PPy/GO composite agglomerates easily because of the dehydration of excess oxygen-containing groups on the GO sheets during the drying process. The dried PPy/rGO intermediate and its derived CNx/graphene products retain their high dispersion and loose-powder features. The as-prepared CNx/graphene composites have a total nitrogen content of about 10 at% and their nitrogen state is mainly of pyridinic and graphitic type. CNx/graphene composites exhibit excellent performance for the oxygen reduction reaction (ORR) in terms of electrocatalytic activity, stability and immunity towards methanol crossover and CO poisoning, suggesting their potential as metal-free electrocatalysts for the ORR.

关键词：氧还原反应复合金属电催化剂石墨复合材料一氧化碳中毒石墨氧化物总氮含量干燥过程

Advanced technologies for single-cell in situ protein profiling

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Science China Chemistry 2022年第1期65卷 48-67页

作者： Wen Zhou Xiaoyue Ni Chen Xie quli fan Dingbin Liu State Key Laboratory of Organic Electronics and Information Displays and Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM)Institute of Advanced Materials(IAM)Nanjing University of Posts&TelecommunicationsNanjing 210023China State Key Laboratory of Medicinal Chemical Biology Research Center for Analytical SciencesTianjin Key Laboratory of Biosensing and Molecular RecognitionCollege of ChemistryNankai UniversityTianjin 300071China

Cells are inherently heterogeneous to achieve a diverse spectrum of biological functions.To understand the underlying protein machinery that achieves these fascinating functions,it is important to develop advanced analytical methods that can profile proteins in their native environment,as protein expression,aggregation,degradation,and regulation define both normal physiology as well as pathogenicity.Genome and transcriptome sequencing have seen major advances at the single-cell levels,but comprehensive proteomic profiling is still challenging.The conventional proteomic methods,such as enzyme-linked immunosorbent assay(ELISA),western blot,and protein chips,can characterize biomarkers of interest.Still,these ensemble techniques are unsuitable for single-cell studies.Increasing evidence has shown the significance of in situ,sensitive,quantitative,and multiplexed profiling of biomarkers in single cells for diagnosis and treatment guidance.Here,we review the recent development of advanced imaging and spectroscopy techniques,including mass cytometry,immunofluorescence,and surfaceenhanced Raman spectrometry(SERS)for single-cell proteomic imaging.We also provide our view on the challenges and the outlook.

关键词： proteomics single-cell CyTOF immunofluorescence SERS