Rational design of biodegradable semiconducting polymer nanoparticles for NIR-II fluorescence imaging-guided photodynamic therapy
作者机构：State Key Laboratory of Organic Electronics and Information Displays&Institute of Advanced Materials(IAM)Nanjing University of Posts&Telecommunications9 Wenyuan RoadNanjing 210023China
出 版 物：《Nano Research》 (纳米研究（英文版）)
年 卷 期：2024年第17卷第6期
页 面：5399-5408页
核心收录：
学科分类：1002[医学-临床医学] 07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 100214[医学-肿瘤学] 10[医学] 0702[理学-物理学]
基 金：the National Natural Science Foundation of China(Nos.22174070 and 22205115) Natural Science Foundation of Jiangsu Province(No.BK20230060) Natural Science Foundation of Jiangsu University(No.21KJB150022) the Research startup fund of NJUPT(No.NY220149) Natural Science Foundation of NJUPT(No.NY221088) the Project of State Key Laboratory of Organic Electronics and Information Displays,Nanjing University of Posts and Telecommunications(Nos.GZR2022010012 and GZR2023010022) the Synergetic Innovation Center for Organic Electronics and Information Displays for the financial support
主 题：near-infrared(NIR)-II fluorescence imaging semiconducting polymer nanoparticles photodynamic therapy tumor imaging
摘 要：Semiconducting polymer nanoparticles(SPNs)have shown great promise in second near-infrared window(NIR-II)***,the issue of long metabolic time significantly restricts the clinical application of *** this study,we rationally designed a biodegradable SPN(BSPN50)for NIR-II fluorescence imaging-guided photodynamic therapy(PDT).BSPN50 is prepared by encapsulating a biodegradable SP(BSP50)with an amphiphilic copolymer ***50 is composed of NIR-II fluorescent diketopyrrolopyrrole(DPP)segment and degradable poly(phenylenevinylene)(PPV)segment with the ratio of 50/***50 has both satisfactory degradability under myeloperoxidase(MPO)/hydrogen peroxide(H_(2)O_(2))and NIR-II fluorescence emission upon 808 nm laser ***,BSPN50 shows good photodynamic efficacy under 808 nm laser ***50 shows a faster degradation rate than BSPN100 which has no PPV segment both in vitro and in *** addition,BSPN50 can effectively diagnose tumor via NIR-II fluorescence imaging and inhibit the tumor growth by ***,our study provides a rational approach to construct biodegradable nanoplatforms for efficient tumor NIR-II phototheranostics.
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