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Mismatch repair proteins and microsatellite instability in solid pseudopapillary neoplasm of the pancreas

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Hepatobiliary & Pancreatic Diseases International 2019年第5期18卷 491-492页

作者： Claudia Covelli Paola Parente Francesco Pepe Pasquale Pisapia fabiola Fiordelisi Umberto Malapelle UOC di Anatomia Patologica Fondazione Casa Sollievo della SofferenzaViale Cappuccini 171013 San Giovanni RotondoFGItaly Department of Public Health University of Naples Federico ⅡVia Pansini 580131 NapoliItaly

Solid pseudopapillary neoplasms (SPNs) are rare solid pancreatic tumors mainly affecting young women. Despite the high percentage of favorable prognosis, they are considered as low grade malignant neoplasms, and metastases occur in 5%-15% of patients. Almost all SPNs (95%) have somatic activating mutations in the β-catenin gene [1].

关键词： Solid pseudopapillary neoplasms (SPNs) Mismatch repair proteins microsatellite instability

Catalytic feasibility of Ce-doped LaCoO_(3) systems for chlorobenzene oxidation:An analysis of synthesis method

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Journal of Rare Earths 2022年第6期40卷 897-905,I0002页

作者： Héctor Acosta Pérez Carlos A.López Luis E.Cadús fabiola N.Agüero Chemical Technology Research Institute(INTEQUI) UNSL-CONICETFaculty of Biochemical Chemistry and Pharmacy(UNSL)Almirante Brown 14555700San LuisArgentina

A family of Ce-doped LaCoO_(3) perovskites are presented as possible catalysts for Cl-VOCs *** materials with different contents of Ce were obtained through the citrate and the reactive grinding *** insertion of Ce in the original perovskite structure favours the presence of Co^(2+)/Co^(3+) and Ce^(3+)/Ce^(4+) redox pairs and a higher content of oxygen vacancies that enhances the catalytic performance in chlorobenzene combustion based on differential kinetics *** family obtained by the grinding method presents a performance as high as that synthesized by citrate ***,the reactive grinding is a feasible green chemistry alternative to obtain a catalyst with the same performance as that obtained from traditional ***,the stability of samples was evaluated under total combustion reaction conditions showing an excellent activity during 45 h time on stream.

关键词： Cl-VOCs Perovskites Chlorobenzene Cerium Cobalt Rare earths

Cystic fibrosis and Crohn’s disease:Successful treatment and long term remission with infliximab

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World Journal of Gastroenterology 2010年第15期16卷 1924-1927页

作者： Francesca Vincenzi Barbara Bizzarri Alessia Ghiselli Nicola de' Angelis fabiola Fornaroli Gian Luigi de' Angelis Gastroenterology and Endoscopy Unit University of Parma Digestive Surgery University of Pisa

The association of cystic fibrosis and Crohn's disease (CD) is well known, but to date, there are very few cas-es in the literature of patients suffering from mucovisci-dosis who have required treatment with infliximab. We report the case of a 23-year-old patient suffering from cystic fibrosis and severe CD treated successfully with infliximab without any infective complications or wors-ening of the pulmonary disease and with a long term (2 years) complete remission.

关键词： Cystic fibrosis Crohn’ s disease Infliximab

Beneficial effects of nutritional supplements on intestinal epithelial barrier functions in experimental colitis models in vivo

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World Journal of Gastroenterology 2019年第30期25卷 4181-4198页

作者： Hilda Vargas-Robles Karla fabiola castr.-Ochoa Alí Francisco Citalán-Madrid Michael Schnoor Department for Molecular Biomedicine Cinvestav-IPN

Acute and chronic colitis affect a huge proportion of the population *** etiology of colitis cases can be manifold,and diet can significantly affect onset and outcome of *** many forms of acute colitis are easily treatable,chronic forms of colitis such as ulcerative colitis and Crohn’s disease(summarized as inflammatory bowel diseases)are multifactorial with poorly understood *** bowel diseases are characterized by exacerbated immune responses causing epithelial dysfunction and bacterial *** is no cure and therapies aim at reducing inflammation and restoring intestinal barrier ***,most drugs can have severe side *** in diet and inclusion of nutritional supplements have been extensively studied in cell culture and animal models,and some supplements have shown promising results in clinical *** of these nutritional supplements including vitamins,fatty acids and phytochemicals reduce oxidative stress and inflammation and have shown beneficial effects during experimental colitis in rodents induced by dextran sulphate sodium or 2,4,6-trinitrobenzene sulfonic acid,which remain the gold standard in pre-clinical colitis ***,we summarize the mechanisms through which such nutritional supplements contribute to epithelial barrier stabilization.

关键词： Colitis Dextran sulphate sodium 2,4,6-trinitrobenzene sulfonic acid Tight junction Adherens junction Phytochemicals Butyrate Vitamins Short chain fatty acids Micronutrients

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数字游民:自由、责任与新自由主义秩序

学术探索 2024年第9期 67-78页

作者：法比奥拉·曼奇内利姚建华(编译) 徐偲騄(编译) 巴塞罗那大学社会人类学系西班牙巴萨罗那08001 复旦大学新闻学院上海200433 上海大学新闻传播学院上海200444

数字游民是这样一群人,他们运用便携式计算技术和广泛的互联网接入,能在任何地方远程工作,并利用这种自由来探索世界。本文使用民族志和网络民族志研究方法概述了这一最新现象,将其置于生活方式流动性和个体化理论的视角中,通过关注个... 详细信息

数字游民是这样一群人,他们运用便携式计算技术和广泛的互联网接入,能在任何地方远程工作,并利用这种自由来探索世界。本文使用民族志和网络民族志研究方法概述了这一最新现象,将其置于生活方式流动性和个体化理论的视角中,通过关注个体化过程所带来的一系列新的责任和承诺,丰富了现有的研究。在研究参与者的解释中,脱离定居主义的生活使他们能够表达一种自由的精神,在这种精神中,极简主义、不确定性和风险取代了物质积累、稳定性和舒适性。不过,这种精神在哪些结构性约束中运作,也是必须予以关注的。本文的目的是双重的:一方面,它将数字游民的社会文化想象——流动性/非流动性,与他们为维持流动性所采取的特定经济策略(包括地理套利和网络资本商品化)进行对比;另一方面,它提供了新的民族志证据,阐明数字游民的自我实现计划如何与企业家精神的意识形态相吻合,使他们得以成为“特权一族”,畅行在资本主义制度的全球不平等中。由此可见,数字游牧主义是一种适应新自由主义意识形态的生活方式,而非是对既有制度的挑战。

关键词：数字游民生活方式流动性地理套利网络资本商品化

Molecular mechanisms underlying the neuroprotection of environmental enrichment in Parkinson’s disease

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Neural Regeneration Research 2023年第7期18卷 1450-1456页

作者： Tamara Andrea Alarcón Sarah Martins Presti-Silva Ana Paula Toniato Simões fabiola Mara Ribeiro Rita Gomes Wanderley Pires Department of Physiological Sciences Health Science CenterUniversidade Federal do Espirito SantoVitoriaBrazil Laboratory of Molecular and Behavioral Neurobiology Health Science CenterUniversidade Federal do Espirito SantoVitoriaBrazil Department of Biochemistry and Immunology Institute o Biological SciencesUniversidade Federal de Minas GeraisAvenida Antônio CarlosBelo HorizonteBrazil

Parkinson’s disease is the most common movement disorder,affecting about 1%of the population over the age of 60 ***’s disease is characterized clinically by resting tremor,bradykinesia,rigidity and postural instability,as a result of the progressive loss of nigrostriatal dopaminergic *** addition to this neuronal cell loss,Parkinson’s disease is characterized by the accumulation of intracellular protein aggregates,Lewy bodies and Lewy neurites,composed primarily of the proteinα-*** it was first described almost 200 years ago,there are no disease-modifying drugs to treat patients with Parkinson’s *** addition to conventional therapies,non-pharmacological treatment strategies are under investigation in patients and animal models of neurodegenerative *** such strategies,environmental enrichment,comprising physical exercise,cognitive stimulus,and social interactions,has been assessed in preclinical models of Parkinson’s *** enrichment can cause structural and functional changes in the brain and promote neurogenesis and dendritic growth by modifying gene expression,enhancing the expression of neurotrophic factors and modulating *** this review article,we focus on the current knowledge about the molecular mechanisms underlying environmental enrichment neuroprotection in Parkinson’s disease,highlighting its influence on the dopaminergic,cholinergic,glutamatergic and GABAergic systems,as well as the involvement of neurotrophic *** describe experimental pre-clinical data showing how environmental enrichment can act as a modulator in a neurochemical and behavioral context in different animal models of Parkinson’s disease,highlighting the potential of environmental enrichment as an additional strategy in the management and prevention of this complex disease.

关键词： acetylcholine brain-derived neurotrophic factor dopamine environment enrichment gamma-aminobutyric acid glial cell line-derived neurotrophic factor glutamate molecular mechanisms Parkinson’s disease

RESPIRATORY STUDIES IN CHRONIC MOUNTAIN SICKNESS:THE PERUVIAN EXPERIENCE

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青海医学院学报 2005年第4期26卷 217-222,239页

作者： fabiola León-Velarde Department of Biological and Physiological Sciences Faculty of Sciences and Philosophy/ IIA Cayetano Heredia University Lima-Perú

Chronic Mountain Sickness (CMS) is a multifactorial disease caused by a limited capacity to achieve complete adaptation to life under chronic hypoxic conditions. It is accompanied by excessive erythrocitosis (levels of erythrocytes above the normal value set for each altitude), and in advances cases also by pulmonary hypertension. The hypoxemia, caused by central or peripheral respiratory disorders and/or associated to diverse risk factors, produces the excessive erythrocytosis. The most common symptoms are headaches, dizziness, breathlessness, sleep disturbances, tinnitus, physical and mental fatigue, anorexia, and bone and muscle pain. The most common signs are an intermittent or permanent cyanosis, hyperemia and venous dilatation in hands or feet (Monge-M et al., 1928; Winslow and Monge-C, 1987). Aging, respiratory diseases, sleep, menopause, and overweight has proved to be additional risk factors in the development of CMS (Kryger et al., 1978; León-Velarde et al., 1993; Sime et al., 1975; León-Velarde et al., 1997; León-Velarde et al., 2001; Monge-C et al., 1992; Normand et al., 1992)

关键词： Figure RESPIRATORY STUDIES IN CHRONIC MOUNTAIN SICKNESS body

Obese zebrafish: A small fish for a major human health condition

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Animal Models and Experimental Medicine 2018年第4期1卷 255-265页

作者： Francesca Faillaci fabiola Milosa Rosina Maria Critelli Elena Turola Filippo Schepis Erica Villa Department of Internal Medicine Gastroenterology Unit University of Modena and Reggio Emilia Women in Hepatology Group National Institute of Gastroenterology "S.de Bellis" Research Hospital Department of Internal Medicine Endocrinology UnitAOU of Parma

Obesity is becoming a silent worldwide epidemic, with a steady increase in both adults and children. To date, even though several drugs have been licensed for long-term obesity treatment, none of them are yet used in routine clinical practice. So far the only successful intervention has been behavioral therapy. A suitable and economic experimental model mimicking the human condition would therefore be extremely useful to evaluate preventive measures and novel treatments. Zebrafish are emerging as an important model system to study obesity and related metabolic disease. Remarkable similarities have been reported in lipid metabolism and the adipogenic pathway between zebrafish and mammals. Moreover, the zebrafish possesses a number of features—the relative inexpensiveness of animal husbandry, its optical transparency and the ability to produce a large number of offspring at low cost—that make it ideal for large-scale screening and for testing drugs and intervention. In this review, we summarize recent progress in using zebrafish as a model system to study obesity and obesity-related metabolic disorders. We describe several zebrafish models(in both larvae and adult animals) that develop obesity and non-alcoholic fatty liver disease(NAFLD) using different approaches, including gene manipulation, diet manipulation and modification of microbiota composition. For these models, we have outlined the specific aspects related to obesity and its development and we have summarized their advantages and limitations.

关键词： inflammation metabolic diseases NAFLD obesity zebrafish

Hepatobiliar manifestations in inflammatory bowel disease: A practical approach

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World Journal of Hepatology 2022年第2期14卷 319-337页

作者： Paulina Núñez F fabiola castr. Gabriel Mezzano Rodrigo Quera Diego Diaz Lorena castr. Universidad de los Andes Inflammatory Bowel Disease ProgramDigestive Disease CenterSantiago 7600976RMChile Inflammatory Bowel Disease Program Hospital San Juan de DiosUniversidad de ChileSantiago 7701230RMChile Universidad de los Andes Hepatology ProgramDigestive Disease CenterSantiago 7600976RMChile Department of Gastroenterology Hospital del Salvador/Universidad de ChileSantiago 7600976RMChile Universidad de los Andes Santiago 770976RMChile

Inflammatory bowel diseases(IBD)are associated with various hepatobiliary *** can occur at any moment in the course of the disease or associated with the *** prevalence of liver dysfunction can reach up to 50%in different *** fatty liver disease is considered the most common hepatobiliary complication in IBD,while primary sclerosing cholangitis is the most *** of hepatic manifestations in IBD involves a multidisciplinary approach that includes a high index of suspicion and joint management with *** medical confrontation with abnormal liver tests must include an exhaustive study to determine if these patterns can be related to IBD,associated diseases or to the therapies used.

关键词： Extraintestinal manifestations Inflammatory bowel disease Sclerosing primary cholangitis Hepatic steatosis Liver toxicity