Mismatch repair proteins and microsatellite instability in solid pseudopapillary neoplasm of the pancreas

作     者：Claudia Covelli Paola Parente Francesco Pepe Pasquale Pisapia Fabiola Fiordelisi Umberto Malapelle 

作者机构：UOC di Anatomia PatologicaFondazione Casa Sollievo della SofferenzaViale Cappuccini 171013 San Giovanni RotondoFGItaly Department of Public HealthUniversity of Naples Federico ⅡVia Pansini 580131 NapoliItaly 

出 版 物：《Hepatobiliary & Pancreatic Diseases International》 (国际肝胆胰疾病杂志（英文版）)

年 卷 期：2019年第18卷第5期

页      面：491-492页

核心收录：

学科分类：10[医学] 

主　　题：Solid pseudopapillary neoplasms (SPNs) Mismatch repair proteins microsatellite instability 

摘      要：Solid pseudopapillary neoplasms (SPNs) are rare solid pancreatic tumors mainly affecting young women. Despite the high percentage of favorable prognosis, they are considered as low grade malignant neoplasms, and metastases occur in 5%-15% of patients. Almost all SPNs (95%) have somatic activating mutations in the β-catenin gene [1].