Beneficial effects of nutritional supplements on intestinal epithelial barrier functions in experimental colitis models in vivo

作     者：Hilda Vargas-Robles Karla Fabiola Castro-Ochoa Alí Francisco Citalán-Madrid Michael Schnoor 

作者机构：Department for Molecular BiomedicineCinvestav-IPN 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2019年第25卷第30期

页      面：4181-4198页

核心收录：

学科分类：10[医学] 

基　　金：funded by the fund SEP-Cinvestav (Project 108) by Conacyt (284292) the Royal Society (NAF/R1/180017) 

主　　题：Colitis Dextran sulphate sodium 2,4,6-trinitrobenzene sulfonic acid Tight junction Adherens junction Phytochemicals Butyrate Vitamins Short chain fatty acids Micronutrients 

摘      要：Acute and chronic colitis affect a huge proportion of the population *** etiology of colitis cases can be manifold,and diet can significantly affect onset and outcome of *** many forms of acute colitis are easily treatable,chronic forms of colitis such as ulcerative colitis and Crohn’s disease(summarized as inflammatory bowel diseases)are multifactorial with poorly understood *** bowel diseases are characterized by exacerbated immune responses causing epithelial dysfunction and bacterial *** is no cure and therapies aim at reducing inflammation and restoring intestinal barrier ***,most drugs can have severe side *** in diet and inclusion of nutritional supplements have been extensively studied in cell culture and animal models,and some supplements have shown promising results in clinical *** of these nutritional supplements including vitamins,fatty acids and phytochemicals reduce oxidative stress and inflammation and have shown beneficial effects during experimental colitis in rodents induced by dextran sulphate sodium or 2,4,6-trinitrobenzene sulfonic acid,which remain the gold standard in pre-clinical colitis ***,we summarize the mechanisms through which such nutritional supplements contribute to epithelial barrier stabilization.