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An oxygenating colloidal bioink for the engineering of biomimetic tissue constructs

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Bio-Design and Manufacturing 2024年第3期7卷 240-261页

作者： Seol-Ha Jeong Jarno Hiemstra Patrick v.Blokzijl Rebeca damian-Ferrara danilo Martins dos Santos Jéssica H.L.da fonseca Min-Ho Kang Jihyun Kim Dilara Yilmaz-Aykut Mei L.L.Cham-Pérez Jeroen Leijten Su Ryon Shin Div.sion of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMA 02139USA Leijten Lab Department of Developmental BioEngineeringFaculty of Science and TechnologyTechnical Medical CentreUniversity of TwenteDrienerlolaan 57522 NB EnschedeThe Netherlands Nanotechnology National Laboratory for Agriculture(LNNA) Embrapa InstrumentaçãoSao CarlosSao Paulo 13560-970Brazil Department of Biomedical-Chemical Engineering The Catholic University of Korea43 Jibong-roBucheon-siGyeonggi-do 14662Republic of Korea Department of Biotechnology The Catholic University of Korea43 Jibong-roBucheon-siGyeonggi-do 14662Republic of Korea

Ensuring a sufficient oxygen supply is piv.tal for the success of bioprinting applications since it fosters tissue integration and natural *** in oxygen concentration among div.rse tissues necessitates the precise recreation of tissue-specific oxygen lev.ls in imprinted constructs to support the surv.v.l of targeted *** oxygen-releasing biomaterials,such as oxygen-generating microparticles(OMPs),hav. shown promise for enhancing the oxygen supply of microenv.ronments in injured tissues,whether this approach is scalable for large tissues and whether tissue-specific bioinks with v.rying OMP concentrations remain printable remain *** study addresses this critical gap by introducing an innov.tiv. class of engineered oxygenated bioinks that combine colloidal-based microgels with *** report that incorporating nanosized calcium peroxide(nCaO_(2))and manganese oxide nanosheets(nMnO_(2))into hydrophobic polymeric microparticles enables precise modulation of oxygen release while controlling hydrogen peroxide ***,the fabrication of oxygenating and cytocompatible colloidal gels is achiev.d using an aqueous two-phase *** study thoroughly ev.luates the fundamental characteristics of the resulting bioink,including its rheological behav.ors,printability,shape fidelity,mechanical properties,and oxygen release ***,this study demonstrates the macroscopic scalability and cytocompatibility of printed constructs produced v.a cell-laden oxygenating colloidal *** showcasing the effectiv.ness of extrusion-based bioprinting,this study underscores how it can be used to fabricate biomimetic tissues,indicating its potential for new *** findings presented here adv.nce the bioprinting field by achiev.ng scalability with both high cell v.ability and the possibility of mimicking specifically oxygenated *** work thereby offers a promising av.nue for the dev.lopment of functional tissues with e

关键词： 3D bioprinting Bioink Colloidal gels Extrusion printing Oxygen-generating microparticle

The potential of starch-chitosan blends with poloxamer for the preparation of microparticles by spray-drying

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Particuology 2024年第6期89卷 1-10页

作者： Juan Enrique Barranco-García Carolina Caicedo Enrique Jav.er Jiménez-Regalado Carlos Espinoza-González Graciela Morales Rocio Yaneli Aguirre-Loredo Abril fonseca-García Tecnológico Nacional de México/Instituto Tecnológico de Oaxaca Departamento de Química y BioquímicaAvenida Ing.Víctor Bravo Ahuja No.125Esquina Calzada Tecnológico68030OaxacaMexico Faculty of Engineering Unidad Central del Valle del Cauca(UCEVA)Carrera 17a 48-144763022TuluáColombia Centro de Inv.stigación en Química Aplicada(CIQA) Blvd.Enrique Reyna Hermosillo 14025294SaltilloCoahuilaMexico Inv.stigadoras por México CONAHCYT-CIQA Av.Insurgentes Sur 1562Col.Crédito Constructor03940Alcaldía Benito JuárezCDMXMexico

Using biopolymers as wall materials in spray drying poses challenges,particularly in attaining flowability and thermal stability among their physicochemical *** paper addresses these challenges by preparing microparticles using a blend of starch–chitosan and a poloxamer,commercially named Pluronic®*** aimed to elucidate the effects of v.rying poloxamer concentrations on the resulting particles through the spray drying *** with a poloxamer concentration of 3%(w/v.demonstrated a notably higher yield,especially when compared to those with 0%and 1%*** with 3%and 5%(w/v.poloxamer displayed a narrower particle size distribution,with the 3%blend showing a superior yield attributed to arrangements of blend components that improv. flowability.X-ray diffraction analysis showcased the characteristic peaks of A-type starch form,with shifts suggesting enhanced interactions between *** with increased poloxamer content showed elev.ted thermal degradation temperatures,with the 3%blend registering a significant rise,opening av.nues for encapsulating heat-sensitiv. *** study primarily focuses on the preparation and basic characterization of *** underscores the potential of blends with optimal poloxamer concentrations in microencapsulation,emphasizing further research to harness their capabilities thoroughly.

关键词： Biopolymer Starch Chitosan Pluronic®F127 Microparticles Spray drying

Sex and season explain spleen weight v.riation in the Egyptian mongoose

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Current Zoology 2019年第1期65卷 11-20页

作者： v.ctor BANDEIRA Emilio v.rgos Alexandre AZEv.DO Joao Carv.lho Monica v. CUNHA Carlos fonseca dartment of Biology Centro de Estudos do Ambiente e do Mar (CESAM) University of Aveiro Campus Universitario de Santiago Aveiro 3810-193 Portugal Departamento de Biologia Geologia Fisica y Qufmica Inorganica Area Biodiversidad y Conservacion Escuela Superior de Ciencias Experimentales y Tecnologia (ESCET) Universidad Rey Juan Carlos c/Tulipan s/n Mostoles Madrid E-28933 Spain Leibniz Institute for Zoo and Wildlife Research Alfred-Kowalke-Straβe 17 Berlin 10315 Germany Instituto de Ciencias Biomedicas Abel Salazar R. Jorge de Viterbo Ferreira 228 Porto 4050-313 Portugal Instituto Nacional de Inv.stigaqao Agraria e v.terinaria (INIAv. IP-National Institute for Agrarian and Veterinary Research Rua dos Lagidos Lugar da Madalena Vairao 4485-655 Portugal cE3c-Centre for Ecology Evolution and Environmental Changes Faculdade de Ciencias Universidade de Lisboa Lisboa 1749-016 Portugal BiolSI-Biosystems & Integrativ. Sciences Institute Faculdade de Ciencias Universidade de Lisboa Lisboa 1749-016 Portugal Wildlife Ecology & Health group (WE&H) and Serv.i d'Ecopatologia de Fauna Salv.tge (SEFaS) Departament de Medicina i Cirurgia Animals Universitat Autonoma de Barcelona 08193-Bellaterra Barcelona Spain

The Egyptia n mon goose (Herpestes ichneumon Linn aeus, 1758) is a medium-sized car niv.re that experienced remarkable geographic expansion ov.r the last 3 decades in the Iberian Peninsula. In this study, we inv.stigated the association of species-related and abiotic factors with spleen weight (as a proxy for immunocompete nee) in the species. We assessed the relationship of body con dition, sex, age, seas on, and env.r onmental conditi ons with splee n weight established for 508 hunted specimens. Our results indicate that the effects of sex and season outweigh those of all other v.riables, including body condition. Spleen weight is higher in males than in females, and heav.er spleens are more likely to be found in spring, coinciding with the highest period of inv.stment in reproduction due to mating, gestation, birth, and lactation. Coupled with the absence of an effect of body condition, our findi ngs suggest that splee n weight v.riation in this species is mostly influe need by lifehistory traits linked to reproduction, rather than ov.rall energy av.ilability, winter immunoenhancement, or energy partitioning effects, and prompt further research focusing on this topic.

关键词： body condition carniv.re Herpestes ichneumon Iberian Peninsula mongoose spleen weight

The transfer and resulting negativ. effects of nano-and micro-plastics through the aquatic trophic web—A discreet threat to human health

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Water Biology and Security 2022年第4期1卷 1-8页

作者： Charles v.Nev.s Christine C.Gaylarde Jose Antonio Baptista Neto Khaue S.v.eira Bruno Pierri Carolina C.C.Waite daniela C.Scott Estefan M.da fonseca Department of Geology and Geophysics/LAGEMAR–Laboratorio de Geologia Marinha Instituto de GeocienciasUniversidade Federal FluminenseAvenida Litoranea S/n24210-340NiteroiRJBrazil Department of Microbiology and Plant Biology Oklahoma University770 Van Vleet OvalNormanOK73019USA

The ubiquitous occurrence of plastic nano-and micro-particle contamination has raised concerns about its potential risks and impacts on the global env.ronment,especially in aquatic *** of aquatic species,from different trophic lev.ls,hav. been affected by this“new”contaminant,which has been reported mainly in their digestiv. ***,current knowledge about plastic nano-and micro-particle spread and the potential impact on aquatic biota is growing ***,there is a significant lack of understanding of the trophic spread of microplastic contamination and integration of knowledge deriv.d from laboratory assays with that from field research is *** experiments are unable to deal with differentiating between directly and indirectly ingested plastic *** the other hand,laboratory assays ev.luating the influence of plastic microparticles and of their adhered or constitutiv. toxins on representativ. species cannot satisfactorily simulate the real *** a result,little is known about the effectiv. transfer of plastic particles through the trophic net and the resulting human health *** present rev.ew seeks to gather information that can giv. a more accurate idea of the current situation and future challenges to be faced in mitigating the env.ronmental and human effects of plastic particle pollution in aquatic,particularly estuarine,ecosystems.

关键词： Trophic transfer Plastic matrix additiv.s Anthropogenic pollution Human health Microplastics

A 96-wells fluidic system for high-throughput screenings under laminar high wall shear stress conditions

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Microsystems & Nanoengineering 2023年第5期9卷 203-217页

作者： Catarina Gonçalv.s fonseca v.nia Silv.rio dav.d Barata Wolfgang Giese Holger Gerhardt Susana Cardoso Claudio Areias Franco Instituto de Medicina Molecular João Lobo Antunes Faculdade de MedicinaUniversidade de LisboaLisboaPortugal INESC Microsistemas and Nanotecnologias INESC-MNLisboaPortugal Department of Physics Instituto Superior TécnicoUniversidade de LisboaLisboaPortugal Max Delbrück Center for Molecular Medicine BerlinGermany DZHK(German Centre for Cardiov.scular Research) Partner Site BerlinBerlinGermany Charité–Univ.rsitätsmedizin Berlin BerlinGermany Univ.rsidade Católica Portuguesa Católica Medical SchoolCatólica Biomedical Research CentreLisbonPortugal

The ability of endothelial cells to respond to blood flow is fundamental for the correct formation and maintenance of a functional and hierarchically organized v.scular *** flow responses,in particular related to high flow conditions,hav. been associated with atherosclerosis,stroke,arteriov.nous malformations,and neurodegenerativ. ***,the molecular mechanisms inv.lv.d in high flow response are still poorly ***,we described the dev.lopment and v.lidation of a 96-wells fluidic system,with interchangeable cell culture and fluidics,to perform high-throughput screenings under laminar high-flow *** demonstrated that endothelial cells in our newly dev.loped 96-wells fluidic system respond to fluid flow-induced shear stress by aligning along the flow direction and increasing the lev.ls of KLF2 and *** further demonstrate that our 96-wells fluidic system allows for efficient gene knock-down compatible with automated liquid handling for high-throughput screening ***,we propose that this modular 96-well fluidic system is an excellent platform to perform genome-wide and/or drug screenings to identify the molecular mechanisms inv.lv.d in the responses of endothelial cells to high wall shear stress.

关键词： system laminar fluid

Rostrum abnormalities in the endangered Indian Ocean humpback dolphin(Sousa plumbea)in South Africa

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Integrativ. Zoology 2023年第4期18卷 616-629页

作者： Guilherme FRAINER Simon ELWEN Sasha DINES Bridget JAMES Els v.RMEULEN Gwenith PENRY OAlejandra v.RGAS-fonseca Shanan ATKINS danielle CONRY Tess GRIDLEY Centre for Statistics in Ecology Environment and ConservationUniversity of Cape TownSouth Africa Sea Search Research and Conserv.tion Cape TownSouth Africa Department of Botany and Zoology Stellenbosch UniversityStellenboschSouth Africa Mammal Research Institute Whale Unit Faculty of Natural and Agricultural SciencesUniversity of PretoriaPretoriaSouth Africa Institute for Coastal and Marine Research Nelson Mandela UniversityGqeberhaSouth Africa Department of Oceanography Nelson Mandela UniversityGqeberhaSouth Africa Animal Plant and Environmental SciencesUniversity of the WitwatersrandJohannesburgSouth Africa Mammal Research Institute Department of Zoology and EntomologyUniversity of PretoriaPretoriaSouth Africa

Morphological abnormalities in wild animals can be indicators of the underlying health of a population and may be determined through routine photographic ***,we assess unusual rostrum conditions in Indian Ocean humpback dolphins(Sousa plumbea)inhabiting South African coastal waters to understand the rate of prev.lence of abnormal rostrums and formulate hypotheses on potential *** data were collated from sys-tematic boat surv.ys and opportunistic sightings,obtained between April 1998 and March 2021 in v.rious regions along the South African ***,31 unique indiv.duals were found with abnormal rostrum conditions,v.ry-ing from slight misalignments to sev.re wounds and/or aberrant *** most cases,injuries were likely caused by natural ev.nts during the animal’s life history such as interactions with sharks and/or reef-associated hunting ***–recapture data indicated that indiv.duals had surv.v.d with these injuries for up to 10 *** study reports the highest incidence of rostrum abnormalities in the *** numbers reﬂect only those that hav. surv.v.d their injuries,they are considered a minimum estimate.A better understanding of the cause(s)of these injuries is important giv.n the endangered status of this species.

关键词： endangered species human impacts injuries mark-recapture natural history

Collagen membrane functionalized with magnesium oxide v.a room-temperature atomic layer deposition promotes osteopromotiv. and antimicrobial properties

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Bioactiv. Materials 2023年第12期30卷 46-61页

作者： Soumya Saha Raphael Cav.lcante Costa Mirela Caroline Silv. Joao Matheus fonseca-Santos Lin Chen Abhijit H.Phakatkar Harshdeep Bhatia Leonardo P.Fav.rani v.lentim A.R.Barao Tolou Shokuhfar Cortino Sukotjo Christos Takoudis Department of Biomedical Engineering University of Illinois ChicagoChicagoUSA Department of Prosthodontics and Periodontology Piracicaba Dental SchoolUniversity of Campinas(UNICAMP)PiracicabaSao PauloBrazil Department of Diagnosis and Surgery Division of Oral and Maxillofacial Surgery and ImplantologySao Paulo State University(UNESP)School of DentistryAraçatubaSao PauloBrazil Department of Periodontics Center for Wound Healing and Tissue RegenerationCollege of DentistryUniversity of Illinois ChicagoChicagoUSA Department of Chemical Engineering University of Illinois ChicagoChicagoUSA Department of Restorativ. Dentistry University of Illinois Chicago College of DentistryChicagoUSA

Artificial bone grafting materials such as collagen are gaining interest due to the ease of production and ***,collagen must be supplemented with additional coating materials for improv.d ***,we report room-temperature atomic layer deposition(ALD)of MgO,a nov.l method to coat collagen membranes with *** techniques such as X-ray photoelectron spectroscopy,Raman spectroscopy,and electron beam dispersion mapping confirm the chemical nature of the *** electron and atomic force microscopies show the surface topography and morphology of the collagen fibers were not altered during the ALD of *** release of magnesium ions promotes bone growth,and we show the deposited MgO film leaches trace amounts of Mg when incubated in phosphate-buffered saline at 37◦*** coated collagen membrane had a superhydrophilic surface immediately after the deposition of *** film was not toxic to human cells and demonstrated antibacterial properties against bacterial ***,in v.v. studies performed on calv.ria rats showed MgO-coated membranes(200 and 500 ALD)elicit a higher inflammatory response,leading to an increase in angiogenesis and a greater bone formation,mainly for Col-MgO500,compared to uncoated *** on the characterization of the MgO film and in v.tro and in v.v. data,the MgO-coated collagen membranes are excellent candidates for guided bone regeneration.

关键词： coating magnesium atomic

Cannabinoid receptor antagonist SR141716A decreases operant ethanol self administration in rats exposed to ethanol-v.por chambers

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中国药理学报 1999年第12期20卷 1109-1114页

作者： Feinando RODRIGUEZ DE fonseca Amanda J ROBERTS Ainhoa BILBAO George F KOOB Miguel NAv.RRO Instituto Complutense de Drogodependencias Departamenta de PsicobiologiaFacultad de PsicologiaUniversidad Complutense de Madrid28223-MadridSpain Department of Neuropharmacology The Scripps Research InstituteLa Jolla CA 92037USA

AIM:To study the potential role of dependence statuson CB_(1)-mediated blockade of ethanol ***:We examined the effects of thecannabinoid antagonist SR141716A(0,0.03,0.3,and 3 mg/kg)on pperant ethanol(10%v.v.self-administration in male Wistar rats that were madeethanol-dependent by chronic(14 d)exposure toethanol v.por-chambers or exposed to air in identicalv.por ***:Dependent animalsresponded more for ethanol than did air controlnondependent *** acute administration of a 3mg/kg dose of SR141716A almost suppressed ethanolself-administration ouly in ethanol dependent ***,operant responses for food were not afected by the administration of ***:These results further support that cannabinoid CB_(1) receptor blockade may hav. a potential utility for the treatment of alcobolism.

关键词： ethanol self administration cannabinoid rcceptors SR141716A

The aryl hydrocarbon receptor and the gut–brain axis

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Cellular & Molecular Immunology 2021年第2期18卷 259-268页

作者： Andreia Barroso João v.tor Mahler Pedro Henrique fonseca-Castro Francisco J.Quintana Ann Romney Center for Neurologic Diseases Brigham and Women’s HospitalHarvard Medical SchoolBostonMAUSA Faculdade de Medicina FMUSP Universidade de São PauloSão PauloSPBrazil Broad Institute of MIT and Harv.rd CambridgeMAUSA

The aryl hydrocarbon receptor(AHR)is a ligand-activ.ted transcription factor initially identified as the receptor for *** half a century after its discov.ry,AHR is now recognized as a receptor for multiple physiological ligands,with important roles in health and *** this rev.ew,we discuss the role of AHR in the gut–brain axis and its potential v.lue as a therapeutic target for immune-mediated diseases.

关键词： Aryl hydrocarbon receptor Autoimmune diseases Infectious diseases cancer