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Preoperative albumin-bilirubin score and liver resection percentage determine postoperative liver regeneration after partial hepatectomy

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World Journal of Gastroenterology 2024年第14期30卷 2006-2017页

作者： Kazuhiro Takahashi Masahiko Gosho Yoshihiro Miyazaki Hiromitsu Nakahashi Osamu Shimomura Kinji Furuya Manami Doi Yohei Owada koichi Ogawa Yusuke Ohara Yoshimasa Akashi Tsuyoshi Enomoto Shinji Hashimoto Tatsuya Oda Department of Gastrointestinal and Hepatobiliary-Pancreatic Surgery University of TsukubaTsukuba 3058-575IbarakiJapan Department of Biostatistics University of TsukubaTsukuba 3058-575IbarakiJapan

BACKGROUND The success of liver resection relies on the ability of the remnant liver to *** of the knowledge regarding the pathophysiological basis of liver regeneration comes from rodent studies,and data on humans are ***,there is limited knowledge about the preoperative factors that influence postoperative *** To quantify postoperative remnant liver volume by the latest volumetric software and investigate perioperative factors that affect posthepatectomy liver *** A total of 268 patients who received partial hepatectomy were *** were grouped into right hepatectomy/trisegmentectomy(RH/Tri),left hepa-tectomy(LH),segmentectomy(Seg),and subsegmentectomy/nonanatomical hepatectomy(Sub/Non)*** regeneration index(RI)and late rege-neration rate were defined as(postoperative liver volume)/[total functional liver volume(TFLV)]×100 and(RI at 6-months-RI at 3-months)/RI at 6-months,*** lower 25th percentile of RI and the higher 25th percentile of late regeneration rate in each group were defined as“low regeneration”and“delayed regeneration”.“Restoration to the original size”was defined as regeneration of the liver volume by more than 90%of the TFLV at 12 months *** The numbers of patients in the RH/Tri,LH,Seg,and Sub/Non groups were 41,53,99 and 75,*** RI plateaued at 3 months in the LH,Seg,and Sub/Non groups,whereas the RI increased until 12 months in the RH/Tri *** to our multivariate analysis,the preoperative albumin-bilirubin(ALBI)score was an independent factor for low regeneration at 3 months[odds ratio(OR)95%CI=2.80(1.17-6.69),P=0.02;per 1.0 up]and 12 months[OR=2.27(1.01-5.09),P=0.04;per 1.0 up].Multivariate analysis revealed that only liver resection percentage[OR=1.03(1.00-1.05),P=0.04]was associated with delayed ***,multivariate analysis demonstrated that the preoperative ALBI score[OR=2.63(1.00-1.05),P=0.02;per 1.

关键词： Liver regeneration Albumin-bilirubin score Liver resection percentage Partial hepatectomy Human Regeneration index

Subloading-friction model with saturation of tangential contact stress

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Friction 2023年第6期11卷 1107-1120页

作者： koichi HASHIGUCHI Masami UENO Kyushu University Fukuoka 819-0395Japan MSC Software Ltd. Tokyo 101-0054Japan University of the Ryukyus Okinawa 903-0213Japan

The incorporation of the saturation of the tangential contact stress with the increase of the normal contact stress is required for the analysis of the friction phenomenon of solids and structures subjected to a high normal contact stress,which cannot be described by the Coulomb friction condition,in which the tangential contact stress increases linearly with the increase of the normal contact *** this article,the subloading-friction model,which is capable of describing the smooth elastic-plastic transition,the static-kinetic transition,and the recovery of the static friction during the cease of sliding,is extended to describe this ***,some numerical examples are shown,and the validity of the present model will be verified by the simulation of the test data on the linear sliding of metals.

关键词： high contact stress monotonic/reciprocal sliding static/kinetic friction subloading-friction model

Potential significance of CX3CR1 dynamics in stress resilience against neuronal disorders

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Neural Regeneration Research 2022年第10期17卷 2153-2156页

作者： koichi Inoue Department of Integrative Anatomy Nagoya City University Graduate School of Medical SciencesNagoyaJapan

Recent findings have implicated inflammatory responses in the central nervous system in a variety of neuropsychiatric and neurodegenerative diseases,and the understanding and control of immunological responses could be a major factor of future therapeutic strategies for neurological ***,derived from myelogenous cells,respond to a number of stimuli and make immune responses,resulting in a prominent role as cells that act on inflammation in the central nervous ***(FKN or CX3CL1)signaling is an important factor that influences the inflammatory response of *** receptor for FKN,CX3CR1,is usually expressed in microglia in the brain,and therefore the inflammatory response of microglia is modified by ***,FKN often suppresses inflammatory responses in microglia and activation of its receptor may be effective in the treatment of inflammatory neurological ***,it has also been suggested that inflammatory responses facilitated by FKN signaling aggravate neurological ***,further studies are still required to resolve the conflicting interpretation of the protective or deleterious contribution of microglial FKN *** notably,regulation of FKN signaling has recently been shown to be beneficial in the treatment of human diseases,although not neurological *** addition,a CX3CR1 inhibitor has been developed and successfully tested in animal models,and it is expected to be in human clinical trials in the *** this review,I describe the potential therapeutic consideration of microglial CX3CR1 dynamics through altered FKN signaling.

关键词： Alzheimer’s disease CX3CR1 fractalkine inflammation knockout mice microglia resilience SARS-CoV-2 stress stroke

Capillary method for measuring near-infrared spectra of microlitre volume liquids

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第2期8卷 171-175页

作者： YUAN Bo MURAYAMA koichi Department of Information Science and Optoelectronic Engineering State Key Laboratory of Modern Optical Instrumentation CNERC for Optical Instrument Zhejiang University Hangzhou 310027 China Department of Biochemistry and Biophysics Gifu University School of Medicine Gifu 500-8705 Japan

The present study theoretically explored the feasibility of the capillary method for measuring near-infrared (NIR) spectra of liquid or solution samples with microlitre volume, which was proposed in our previous studies. Lambert-Beer absorb- ance rule was applied to establish a model for the integral absorbance of capillary, which was then implemented in numerical analyses of the effects of capillary on various spectral features and dynamic range of absorption measurement. The theoretical speculations indicated that the capillary method might be used in NIR spectroscopy, which was further supported by the empirical data collected from our experiments by comparison between capillary NIR spectra of several organic solvents and cuvette cell NIR spectra.

关键词： Near-infrared (NIR) spectroscopy Capillary Cuvette cell Numerical analysis

Compelling Challenges in Antenna Technologies for Future Medical Applications

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Engineering 2022年第4期8卷 15-17页

作者： koichi Ito Center for Frontier Medical Engineering Chiba UniversityChiba 263-8522Japan

*** Numerous types of antennas have been developed,tested,and utilized for medical applications such as diagnosis,treatment,data transmission,and wireless power transfer(WPT).Recently,compact and robust antennas are needed to realize implantable and wearable wireless devices for medical applications such as delivering drugs from implanted capsules,stimulating nerve systems,and monitoring physiological data[1].Because antennas for medical applications are used close to or in a human body,their effects on the human body should be included in their development and evaluation[2].However,it is rather difficult due to ethical and practical reasons to employ a real human body when experimentally evaluating the characteristics of antennas or wireless devices for medical ***,numerical simulations are generally conducted as an alternative,using elaborate digital human models[3].Many different types of software are now commercially available for this purpose,along with digital human-body models.

关键词： antennas utilized diagnosis

Microstructure and properties of alumina-silicon carbide nanocomposites fabricated by pressureless sintering and post hot-isostatic pressing

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Transactions of Nonferrous Metals Society of China 2011年第A1期21卷 1-6页

作者： Young-Keun JEONG koichi NIIHARA National Core Research Center for Hybrid Materials Solution Pusan National University Nagaoka University of Technology

A1203/5%SIC nanocomposites were fabricated by pressureless sintering using MgO as a sintering aid and then post hot-isostatic pressed （HIP）, which can subsequently break through the disadvantage of hot-pressing process. The MgO additive was able to promote the densification of the composites, but could not induce the grain growth of A1203 matrix due to the grain growth inhibition by nano-sized SiC particles. After HIP treatment, A12OJSiC nanocomposites achieved full densification and homogeneous distribution of nano-sized SiC particles. Moreover, the fracture morphology of HIP treated specimens was identical with that of the hot-pressed A1203/SiC nanocomposites showing complete transgranular fracture. Consequently, high fracture strength of 1 GPa was achieved for the A1203/5%SIC nanocomposites by pressureless sintering and post HIP process.

关键词： nanocomposite pressureless sintering fracture strength

Novel quantum phenomena induced by strong magnetic fields in heavy-ion collisions

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Nuclear Science and Techniques 2017年第2期28卷 70-98页

作者： koichi Hattori Xu-Guang Huang Physics Department and Center for Particle Physics and Field Theory Fudan University Shanghai 200433 China RIKEN-BNL Research Center Brookhaven National Laboratory Upton NY 11973-5000 USA Department of Physics Brookhaven National LaboratoryUpton NY 11973-5000 USA

The relativistic heavy-ion collisions create both hot quark–gluon matter and strong magnetic fields, and provide an arena to study the interplay between quantum chromodynamics and quantum electrodynamics. In recent years, it has been shown that such an interplay can generate a number of interesting quantum phenomena in hadronic and quark–gluon matter. In this short review, we first discuss some properties of the magnetic fields in heavy-ion collisions and then give an overview of the magnetic fieldinduced novel quantum effects. In particular, we focus on the magnetic effect on the heavy flavor mesons, the heavyquark transports, and the phenomena closely related to chiral anomaly.

关键词： Relativistic heavy-ion collisions Strong magnetic fields Anomalous transports Quarkonium Heavy quark diffusion dynamics

Intraoperative glycemic control procedures and the use of an artificial pancreas

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World Journal of Gastroenterology 2009年第33期15卷 4126-4131页

作者： koichi Yamashita Tomoaki Yatabe Department of Anesthesiology and Critical Care Medicine Kochi Medical School

Strict intraoperative glycemic control can significantly decrease the incidence of postoperative infection; however, anesthesiologists must carefully control blood glucose levels as well as properly manage the respiratory and cardiovascular systems. However, standard blood glucose measurement systems and insulin dosing algorithms, which are necessary for achieving strict glycemic control, have not yet been developed. An artificial pancreas (STG-22TM; Nikkiso Co., Tokyo, Japan) is considered a highly accurate blood glucose monitoring system capable of closed-loop control of blood glucose. The device has, however, many problems to be addressed since it is a large and expensive system with little versatility, and it requires a large amount of blood to be collected. Therefore, the development of less invasive and inexpensive systems with future technological progress is greatly anticipated.

关键词： Strict glycemic control Artificial pancreas Anesthesiologist Sliding scale

Possible divergence of serum-and glucocorticoid-inducible kinase function in ischemic brain injury

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Neural Regeneration Research 2016年第9期11卷 1396-1397页

作者： koichi Inoue Department of Integrative Anatomy Nagoya City University Graduate School of Medical Sciences

As recent medical progress decreases the incidence of certain diseases, ischemic brain injury remains one of the major dis- eases that threaten human lives, especially in western countries. Ischemic brain injury occurs as a result of lack of oxygen and nutrients due to obstruction of blood flow in the brain, and often leads to neurological disorders such as cerebral palsy, depression, and ultimately, death. Around 800,000 Americans suffer a new or recurrent stroke, and more than 130,000 people die annually in the United States （Goldstein et al., 2011）. Despite much effort in searching for an effective treatment, at most a few reagents are approved for therapeutic medication in many countries.

关键词： SGK Possible divergence of serum-and glucocorticoid-inducible kinase function in ischemic brain injury