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Effects of length alteration of OpE-containing mono- and dinuclear alkynylplatinum(II) terpyridine complexes on photophysical, structural and morphological properties

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Nano Research 2024年第10期17卷 8893-8903页

作者： jason Koon-Lam poon Sammual Yu-Lut Leung Eric Ka-Ho Wong Vivian Wing-Wah Yam Institute of Molecular Functional Materials State Key Laboratory of Synthetic Chemistry and Department of ChemistryThe University of Hong KongHong Kong 999077China

A series of mononuclear complexes and unsymmetric dinuclear alkynylplatinum(II)terpyridine complexes with oligo(paraphenylene ethynylene)(OpE)-derived backbone with a variation of the lengths of alkoxy chains and OpE backbones was *** morphological properties,packing lattice and gelation behaviors of the mononuclear complexes were systematically studied,and the thermodynamic parameters and packing lattices of the dinuclear complexes were also investigated,providing further insights into the roles of the non-covalent interactions and their delicate balance in constructing sophisticated supramolecular *** and nanotube formation have been observed upon a delicate control of the intermolecular interactions by altering the lengths and structural dimensions of the complexes.

关键词： supramolecular chemistry self-assembled nanostructures platinum(II)complexes metallogel

performance of generative pre-trained transformers (GpTs) in Certification Examination of the College of Family physicians of Canada

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Family Medicine and Community Health 2024年第S1期12卷 12-19页

作者： Mehdi Mousavi Shabnam Shafiee jason M Harley Jackie Chi Kit Cheung Samira Abbasgholizadeh Rahimi Department of Family Medicine Faculty of MedicineUniversity of SaskatchewanNipawinSaskatchewanCanada Department of Family Medicine Saskatchewan Health AuthorityRiverside Health ComplexTurtlefordSaskatchewanCanada Department of Surgery Faculty of Medicine and Health SciencesMcGill UniversityMontrealQuebecCanada Research Institute of the McGill University Health Centre MontrealQuebecCanada Institute for Health Sciences Education Faculty of Medicine and Health SciencesMcGill UniversityMontrealQuebecCanada McGill University School of Computer Science MontrealQuebecCanada CIFAR AI Chair Mila-Quebec AI InstituteMontrealQuebecCanada Department of Family Medicine McGill UniversityMontrealQuebecCanada Mila Quebec AI-Institute MontrealQuebecCanada Faculty of Dentistry Medicine and Oral Health Sciences McGill UniversityMontrealQuebecCanada Lady Davis Institute for Medical Research Jewish General HospitalMontrealQuebecCanada

Introduction The application of large language models such as generative pre-trained transformers(GpTs)has been promising in medical education,and its performance has been tested for different medical *** study aims to assess the performance of GpTs in responding to a set of sample questions of short-answer management problems(SAMps)from the certification exam of the College of Family physicians of Canada(CFpC).Method Between August 8th and 25th,2023,we used GpT-3.5 and GpT-4 in five rounds to answer a sample of 77 SAMps questions from the CFpC *** independent certified family physician reviewers scored AI-generated responses twice:first,according to the CFpC answer key(ie,CFpC score),and second,based on their knowledge and other references(ie,Reviews’score).An ordinal logistic generalised estimating equations(GEE)model was applied to analyse repeated measures across the five *** According to the CFpC answer key,607(73.6%)lines of answers by GpT-3.5 and 691(81%)by GpT-4 were deemed ***’s scoring suggested that about 84%of the lines of answers provided by GpT-3.5 and 93%of GpT-4 were *** GEE analysis confirmed that over five rounds,the likelihood of achieving a higher CFpC Score percentage for GpT-4 was 2.31 times more than GpT-3.5(OR:2.31;95%CI:1.53 to 3.47;ppercentage for responses provided by GpT-4 over 5 rounds were 2.23 times more likely to exceed those of GpT-3.5(OR:2.23;95%CI:1.22 to 4.06;p=0.009).Running the GpTs after a one week interval,regeneration of the prompt or using or not using the prompt did not significantly change the CFpC score *** In our study,we used GpT-3.5 and GpT-4 to answer complex,open-ended sample questions of the CFpC exam and showed that more than 70%of the answers were accurate,and GpT-4 outperformed GpT-3.5 in responding to the *** language models such as GpTs seem promising for assisting candidates of the CFpC exam by pr

关键词： Canada prompt education

Dynamics of self-hybridized exciton–polaritons in 2D halide perovskites

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Light(Science & Applications) 2024年第1期13卷 13-22页

作者： Surendra B.Anantharaman jason Lynch Christopher E.Stevens Christopher Munley Chentao Li Jin Hou Hao Zhang Andrew Torma Thomas Darlington Francis Coen Kevin Li Arka Majumdar pJames Schuck Aditya Mohite Hayk Harutyunyan Joshua R.Hendrickson Deep Jariwala Department of Electrical and Systems Engineering University of PennsylvaniaPhiladelphiaPA19104USA KBR Inc. BeavercreekOH45431USA Air Force Research Laboratory Sensors DirectorateWright-Patterson Air Force BaseOH45433USA Department of physics University of WashingtonSeattleWA98195USA Department of physics Emory UniversityAtlantaGA30322USA Department of Chemical and Biomolecular Engineering Rice UniversityHoustonTX77005USA Department of Materials Science and Nanoengineering Rice UniversityHoustonTX77005USA Applied physics program Smalley‐Curl InstituteRice UniversityHoustonTX77005USA Department of Mechanical Engineering Columbia UniversityNew YorkNY10027USA Department of Electrical and Computer Engineering University of WashingtonSeattleWA98195USA

Excitons,bound electron–hole pairs,in two-dimensional hybrid organic inorganic perovskites(2D HOIps)are capable of forming hybrid light-matter states known as exciton-polaritons(E–ps)when the excitonic medium is confined in an optical *** the case of 2D HOIps,they can self-hybridize into E–ps at specific thicknesses of the HOIp crystals that form a resonant optical cavity with the ***,the fundamental properties of these self-hybridized E–ps in 2D HOIps,including their role in ultrafast energy and/or charge transfer at interfaces,remain ***,we demonstrate that>0.5µm thick 2D HOIp crystals on Au substrates are capable of supporting multiple-orders of self-hybridized E–p *** E–ps have high Q factors(>100)and modulate the optical dispersion for the crystal to enhance sub-gap absorption and *** varying excitation energy and ultrafast measurements,we also confirm energy transfer from higher energy E–ps to lower energy E–***,we also demonstrate that E–ps are capable of charge transport and transfer at *** findings provide new insights into charge and energy transfer in E–ps opening new opportunities towards their manipulation for polaritonic devices.

关键词： charge polar excitation

Multi-category diagnostic accuracy based on logistic regression

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Statistical Theory and Related Fields 2017年第2期1卷 143-158页

作者： Jialiang Li jason p.fine Michael Jpencina Department of Statistics and Applied probability Duke-NUS Graduate Medical SchoolSingapore Eye Research InstituteNational University of SingaporeSingapore Department of Biostatistics University of North CarolinaChapel HillNCUSA Department of Biostatistics Duke UniversityDurhamNCUSA

We provide a detailed review for the statistical analysis of diagnostic accuracy in a multi-category classification *** qualitative response variables with more than two categories,many traditional accuracy measures such as sensitivity,specificity and area under the ROC curve are no longer *** recent literature,new diagnostic accuracy measures are introduced in medical research *** this paper,important statistical concepts for multi-category classification accuracy are reviewed and their utilities are demonstrated with real medical *** offer problem-based R code to illustrate how to perform these statistical computations step by *** expect such analysis tools will become more familiar to practitioners and receive broader applications in *** program can be adapted to many classifiers among which logistic regression may be the most popular *** thus base our discussion and illustration completely on the logistic regression in this paper.

关键词： Hypervolume under the ROC manifold multi-category classification correct classification probability net reclassification improvement integrated discrimination improvement marker evaluation R software

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单孔腹腔镜胃袖状切除术265例临床分析

中国实用外科杂志 2024年第8期44卷 906-910页

作者：杨建军董文培 jason Wadjaja 顾岩复旦大学附属华东医院普外科上海200040

目的分析单孔腹腔镜胃袖状切除术(SpSG)在单中心临床应用的初步经验与结果,探讨SpSG在高BMI病人中应用的安全性和有效性。方法回顾性分析2023年2月至2024年6月复旦大学附属华东医院行SpSG的265例病人的临床资料。所有纳入病人分为BMI≥5... 详细信息

目的分析单孔腹腔镜胃袖状切除术(SpSG)在单中心临床应用的初步经验与结果,探讨SpSG在高BMI病人中应用的安全性和有效性。方法回顾性分析2023年2月至2024年6月复旦大学附属华东医院行SpSG的265例病人的临床资料。所有纳入病人分为BMI≥50组(21例)、40≤BMIpSG,无中转开腹。BMI≥50组手术时间为(118.48±33.25)min,长于40≤BMIppp>0.05)。结论高BMI并不是SpSG的绝对禁忌证,充分的术前评估、准备及恰当的术中处置对于SpSG的规范开展具有重要意义。

关键词：腹腔镜胃袖状切除术单孔疗效并发症

CD8+T cell metabolic flexibility elicited by CD28-ARS2 axisdriven alternative splicing of pKM supports antitumor immunity

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Cellular & Molecular Immunology 2024年第3期21卷 260-274页

作者： G.Aaron Holling Colin A.Chavel Anand p.Sharda Mackenzie M.Lieberman Caitlin M.James Shivana M.Lightman jason H.Tong Guanxi Qiao Tiffany R.Emmons Thejaswini Giridharan Shengqi Hou Andrew M.Intlekofer Richard M.Higashi Teresa W.M.Fan Andrew N.Lane Kevin H.Eng Brahm H.Segal Elizabeth A.Repasky Kelvin p.Lee Scott H.Olejniczak Department of Immunology Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Department of Medicine Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Human Oncology and pathogenesis program Memorial Sloan Kettering Cancer CenterNew YorkNY 10065USA Center for Environmental Systems Biochemistry Department of Toxicology and Cancer Biology and Markey Cancer CenterLexingtonKY 40536USA Department of Cancer Genetics and Genomics Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA present address:University of Colorado Boulder BoulderCO 80309USA present address:Dana Farber Cancer Institute BostonMA 02215USA present address:Massachusetts Institute of Technology BostonMA 02139USA present address:Melvin and Bren Simon Comprehensive Cancer Center Indiana University School of MedicineIndianapolisIN 46202USA

Metabolic flexibility has emerged as a critical determinant of CD8+T-cell antitumor activity,yet the mechanisms driving the metabolic flexibility of T cells have not been *** this study,we investigated the influence of the nuclear cap-binding complex(CBC)adaptor protein ARS2 on mature T *** doing so,we discovered a novel signaling axis that endows activated CD8+T cells with flexibility of glucose ***2 upregulation driven by CD28 signaling reinforced splicing factor recruitment to pre-mRNAs and affected approximately one-third of T-cell activation-induced alternative splicing *** these effects,the CD28-ARS2 axis suppressed the expression of the M1 isoform of pyruvate kinase in favor of pKM2,a key determinant of CD8+T-cell glucose utilization,interferon gamma production,and antitumor effector ***,pKM alternative splicing occurred independently of CD28-driven pI3K pathway activation,revealing a novel means by which costimulation reprograms glucose metabolism in CD8+T cells.

关键词： Immunometabolism mRNA splicing CD8 T cells ARS2 pKM2

Capturing CO2 Emissions in the George C. Wallace Tunnel: A Case Study

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Intelligent Control and Automation 2024年第3期15卷 83-94页

作者： Gabe Canitz Cole Ciesta Klint Green Justin Sanders jason Valencia Jeremy Willingham Daniel Fonseca Department of Mechanical Engineering The University of Alabama Tuscaloosa AL USA

This paper describes the design of a ventilation system to be paired with a carbon capture system. The ventilation system utilizes the geometry of the George C. Wallace tunnel, located in the City of Mobile, Alabama, USA to capture and redirect emissions to a direct air capture (DAC) device to sequester 25% of the total CO2 mass generated from inside the tunnel. The total CO2 mass rate for the westbound traffic between the week-day hours of 7 a.m. and 6 p.m. has been estimated between 2,300 to 3,000 lbs./hr. By sequestering these emissions, the overall surrounding air quality was shown to be improved to a level that mirrors that from the pre-US industrial era of 270 ppm.

关键词： CO2 Capture Tunnel Ventilation Air Flow Analysis Jet Fan Sizing

The evolving roles of Wnt signaling in stem cell proliferation and differentiation, the development of human diseases, and therapeutic opportunities

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Genes & Diseases 2024年第3期11卷 155-187页

作者： Michael Yu Kevin Qin Jiaming Fan Guozhi Zhao piao Zhao Wei Zeng Connie Chen Annie Wang Yonghui Wang jiamin Zhong Yi Zhu William Wagstaff Rex C.Haydon Hue H.Luu Sherwin Ho Michael J.Lee jason Strelzow Russell R.Reid Tong-Chuan He School of Medicine Rosalind Franklin University of Medicine and ScienceNorth ChicagoIL 60064USA Molecular Oncology Laboratory Department of Orthopedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Ministry of Education Key Laboratory of Diagnostic Medicine and Department of Clinical BiochemistryThe School of Laboratory MedicineChongqing Medical UniversityChongqing 400016China Department of Orthopedic Surgery The First Affliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Urology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Clinical Laboratory Medicine Shanghai Jiaotong University School of MedicineShanghai 200000China Department of Orthopaedic Surgery Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Laboratory of Craniofacial Suture Biology and Development Department of Surgery Section of Plastic SurgeryThe University of Chicago Medical CenterChicagoIL 60637USA Department of Neurology The First Dongguan Affiliated HospitalGuangdong Medical UniversityDongguanGuangdong 523475China

The evolutionarily conserved Wnt signaling pathway plays a central role in develop-ment and adult tissue homeostasis across *** proteins are secreted,lipid-modified signaling molecules that activate the canonical(β-catenin dependent)and non-canonical(β-catenin independent)Wnt signaling *** behaviors such as proliferation,differ-entiation,maturation,and proper body-axis specification are carried out by the canonical pathway,which is the best characterized of the known Wnt signaling *** signaling has emerged as an important factor in stem cell biology and is known to affect the self-renewal of stem cells in various *** includes but is not limited to embryonic,hematopoietic,mesenchymal,gut,neural,and epidermal stem *** signaling has also been implicated in tumor cells that exhibit stem cell-like *** signaling is crucial for bone formation and presents a potential target for the development of therapeutics for bone *** surprisingly,aberrant Wnt signaling is also associated with a wide variety of diseases,including *** of Wnt pathway members in cancer can lead to unchecked cell proliferation,epithelial-mesenchymal transition,and ***,advances in the understand-ing of dysregulated Wnt signaling in disease have paved the way for the development of novel therapeutics that target components of the Wnt *** with a brief overview of the mechanisms of canonical and non-canonical Wnt,this review aims to summarize the cur-rent knowledge of Wnt signaling in stem cells,aberrations to the Wnt pathway associated with diseases,and novel therapeutics targeting the Wnt pathway in preclinical and clinical studies.

关键词： β-Catenin Cancer Canonical Wnt Disease Non-canonical Wnt Stem cells Targeted therapy Wnt signaling

Canonical and noncanonical Wnt signaling: Multilayered mediators, signaling mechanisms and major signaling crosstalk

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Genes & Diseases 2024年第1期11卷 103-134页

作者： Kevin Qin Michael Yu Jiaming Fan Hongwei Wang piao Zhao Guozhi Zhaoo Wei Zeng Connie Chen Yonghui Wang Annie Wang Zander Schwartz Jeffrey Hong Lily Song William Wagstaff Rex C.Haydon Hue H.Luu Sherwin H.Ho jason Strelzow Russell R.Reid Tong-Chuan He Lewis L.Shi Chicago Medical School Rosalind Franklin University of Medicine and ScienceNorth ChicagoIL 60064USA Molecular Oncology Laboratory Department of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Ministry of Education Key Laboratory of Diagnostic Medicine and Department of Clinical BiochemistryThe School of Laboratory MedicineChongqing Medical UniversityChongqing 400016China Departments of Orthopaedic Surgery and Urology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Interventional Neurology The First Dongguan Affiliated HospitalGuangdong Medical UniversityDongguanGuangdong 523475China Department of Clinical Laboratory Medicine Shanghai Jiaotong University School of MedicineShanghai 200000China School of Biomedical Engineering Vanderbilt UniversityNashvilleTN 37235USA Laboratory of Craniofacial Biology and Development Department of Surgery Section of Plastic SurgeryThe University of Chicago Medical CenterChicagoIL 60637USA

Wnt signaling plays a major role in regulating cell proliferation and *** Wnt ligands are a family of 19 secreted glycoproteins that mediate their signaling effects via binding to Frizzled receptors and LRp5/6 coreceptors and transducing the signal either throughβ-catenin in the canonical pathway or through a series of other proteins in the nonca-nonical *** of the individual components of both canonical and noncanonical Wnt signaling have additional functions throughout the body,establishing the complex interplay between Wnt signaling and other signaling *** crosstalk between Wnt signaling and other pathways gives Wnt signaling a vital role in many cellular and organ ***-regulation of this system has been implicated in many diseases affecting a wide array of organ systems,including cancer and embryological defects,and can even cause embryonic *** complexity of this system and its interacting proteins have made Wnt signaling a target for many therapeutic ***,both stimulatory and inhibitory treatments come with potential risks that need to be *** review synthesized much of the current knowl-edge on the Wnt signaling pathway,beginning with the history of Wnt *** thoroughly described the different variants of Wnt signaling,including canonical,noncanonical Wnt/pCp,and the noncanonical Wnt/Ca2+*** description involved each of its components and their involvement in other cellular ***,this review explained the various other pathways and processes that crosstalk with Wnt signaling.

关键词： β-catenin Canonical Wnt Noncanonical Wnt Signal transduction Signaling crosstalk