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Efficacy and safety of Shexiang Baoxin pill(MUSKARDIA)in patients with stable coronary artery disease:a multicenter,double-blind,placebo-controlled phase IV randomized clinical trial

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Chinese Medical Journal 2021年第2期134卷 185-192页

作者： Jun-Bo Ge Wei-Hu Fan Jing-Min Zhou Hai-Ming Shi fu-Sui Ji yang wu Yu-Lan Zhao Jun Qian Yuan-Zhe Jin Ying-wu Liu Sheng-Huang Wang Sheng-Hu He Ping yang Jie wu feng Lu Zi-Shan Hou department of Cardiology Zhongshan HospitalFudan UniversityShanghai 200032China department of Cardiology Huashan HospitalFudan UniversityShanghai 200040China department of Cardiology Beijing Hospital of the Ministry of HealthBeijing 100730China department of Cardiology Dongfang Hospital Affiliated to Beijing University of Chinese MedicineBeijing 100078China department of Cardiology The Second Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450000China department of Cardiology The Center Hospital of Ma'anshanMa'anshanAnhui 243000China department of Cardiology The Fourth Affiliated Hospital of China Medical UniversityShenyangLiaoning 110032China department of Cardiology Tianjin Third Central HospitalTianjin 300170China department of Cardiology Ningbo First HospitalNingboZhejiang 315010China department of Cardiology Northern Jiangsu People’s HospitalYangzhouJiangsu 210036China department of Cardiology China-Japan Union Hospital of Jilin UniversityChangchunJilin 130031China department of Cardiology The First Affiliated Hospital of University of South ChinaHengyangHunan 421000China department of Cardiology The Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinanShandong 250355China Ddepartment of Cardiology Linyi People's HospitalLinyiShandong 276000China

Background:The Shexiang Baoxin Pill(MUSKARDIA)has been used for treating coronary artery disease(CAD)and angina for more than 30 years in ***,methodologically sound trials on the use of MUSKARDIA in CAD patients are *** aim of the study is to determine the effects of MUSKARDIA as an add-on to optimal medical therapy(OMT)in patients with stable ***:A total of 2.74 participants with stable CAD from 97 hospitals in china were randomized 1:1 to a MUSKARDIA or placebo group for 2. *** groups received OMT according to local tertiary hospital *** primary outcome was the occurrence of a major adverse cardiovascular event(MACE),defined as a composite of cardiovascular death,non-fatal myocardial infarction(MI),or non-fatal *** outcomes included all-cause mortality,non-fatal MI,non-fatal stroke,hospitalization for unstable angina or heart failure,peripheral revascularization,angina stability and angina ***:In all,99.7%of the patients were treated with aspirin and 93.0%with *** 2.years of treatment,the occurrence of MACEs was reduced by 2..9%in the MUSKARDIA group(MUSKARDIA:1.9%***:2.6%;odds ratio=0.80;95%confidence interval:0.45-1.07;P=0.2.69).Angina frequency was significantly reduced in the MUSKARDIA group at 18 months(P=0.0362..Other secondary endpoints were similar between the two *** rates of adverse events were also similar between the two groups(MUSKARDIA:17.7%***:17.4%,P=0.8785).Conclusions:As an add-on to OMT,MUSKARDIA is safe and significantly reduces angina frequency in patients with stable ***,the use of MUSKARDIA is associated with a trend toward reduced MACEs in patients with stable *** results suggest that MUSKARDIA can be used to manage patients with *** registration:***,***-TRC-12.03.1..

关键词： MUSKARDIA Stable coronary artery disease Angina Major adverse cardiovascular event

CD147 contributes to SARS-CoV-2.induced pulmonary fibrosis

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Signal Transduction and Targeted Therapy 2022年第12期7卷 4422-4434页

作者： Jiao wu Liang Chen Chuan Qin Fei Huo Xue Liang Xu yang Kui Zhang Peng Lin Jiangning Liu Zhuan feng Jiansheng Zhou Zhuo Pei Yatao Wang Xiu-Xuan Sun Ke Wang Jiejie Geng Zhaohui Zheng Xianghui {2. Man Liu Qingyi Wang Zheng Zhang Huijie Bian Ping Zhu Zhi-Nan Chen department of Cell Biology of National Translational Science Center for Molecular Medicine and department of Clinical Immunology of Xijing Hospital Fourth Military Medical UniversityXi’an710032China Shanghai Engineering Research Center of Organ Repair School of MedicineShanghai UniversityShanghai200444China Institute of Laboratory Animals Science Chinese Academy of Medical SciencesBeijing100071China

COVID‐19 patients can develop clinical and histopathological features associated with fibrosis,but the pathogenesis of fibrosis remains poorly ***147 has been identified as a universal receptor for SARS-CoV-2.and its variants,which could initiate COVID-19-related cytokine ***,we systemically analyzed lung pathogenesis in SARS-CoV-2.and its delta variant-infected humanized CD147 transgenic *** and Transmission Electron Microscopy revealed inflammation,fibroblast expansion and pronounced fibrotic remodeling in SARS-CoV-2.infected ***,RNA-sequencing identified a set of fibrosis signature ***,we identified CD147 as a crucial regulator for fibroblast activation induced by *** found conditional knockout of CD147 in fibroblast suppressed activation of fibroblasts,decreasing susceptibility to bleomycin-induced pulmonary ***,a CD147 antibody,was able to inhibit the accumulation of activated fibroblasts and the production of ECM proteins,thus alleviating the progression of pulmonary fibrosis caused by *** conclusion,we demonstrated that CD147 contributed to SARS-CoV-2.triggered progressive pulmonary fibrosis and identified CD147 as a potential therapeutic target for treating patients with post-COVID-19 pulmonary fibrosis.

关键词： CD147 inflammation fibrosis

Application of retroperitoneoscopy in urologic operation (report of 2.3 cases)

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Application of retroperitoneoscopy in urologic operation (re...

The experience of mini-percutaneous nephrolithotomy (Report of 961 cases)

第十三届全国泌尿外科学术会议暨第八届全球华人泌尿外科学术会议

作者： ZOU Xiao-feng, YUAN Yuan-hu, XIAO Ri-hai, HUANG Ming, wu Geng-qing, WANG Xiao-nin, wu Yu-ting, LONG Da-zhi, LIU fu-lin, LIU min, XU Hui, {2. Jun department of Urology, First Affiliated Hospital of Gannan Medical university, Jiangxi Provincial Modern Treatment Center of Urolithiasis, Ganzhou, Jiangxi, 3.1.00, china

Objective: To investigate the clinical value of retroperitoneoscopic surgery in the treatment of urological diseases. Methods: Review the data of 2.3 patients underwent retroperitoneoscopic surgery. Of them 148 cases ...

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The experience of mini-percutaneous nephrolithotomy (Report ...

Chemotherapy for patients with gastric cancer after complete resection: A network meta-analysis

第十三届全国泌尿外科学术会议暨第八届全球华人泌尿外科学术会议

作者： ZOU Xiao-feng, YUAN Yuan-hu, XIAO Ri-hai, HUANG Ming, wu Geng-qing, WANG Xiao-ning, wu Yu-ting, LONG Da-zhi, LIU fu-lin, LIU Min, XU Hui, {2. Jun department of Urology, First Affiliated Hospital of Gannan Medical university, Jiangxi Provincial Modern Treatment Center of Urolithiasis, Ganzhou, Jiangxi, 3.1.00, china

Objective: To evaluate the value of mini-percutaneous nephrolithotomy (MPCNL) for treating upper urinary calculus. Methods: Review the clinical data of 961 patients (1016 sides) underwent one-stage MPCNL (546 men and ...

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World Journal of Gastroenterology 2014年第2期20卷 584-592页

作者： Ya-wu Zhang Yu-Long Zhang Hui Pan feng-Xian Wei You-Cheng Zhang Yuan Shao Wei Han Hai-Peng Liu Zhe-Yuan Wang Sun-Hu yang department of General Surgery Lanzhou University Second Hospital

AIM: To conduct a network meta-analysis to evaluate the effectiveness of different chemotherapy regimens for patients with gastric cancer.

关键词： Gastric cancer Chemotherapy Randomized controlled trials Indirect treatment comparison Network meta-analysis

CT guided ^12.iodine seed implantation for portal vein tumor thrombus in primary hepatocellular carcinoma

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Chinese Medical Journal 2008年第23期121卷 2410-2414页

作者： ZHANG fu-jun LI Chuan-xing JIAO De-chao ZHANG Nian-hua wu Pei-hong DUAN Guang-feng wu Yue-xia State Key Laboratory of Oncology in South china Department of Imaging and Interventional Radiology Cancer Centre Sun Yat-sen University Guangzhou Guangdong 510060 China department of Oncology Guangdong Second Provincial Traditional Chinese Medicine Hospital Guangzhou Guangdong 510095 China

Background This study evaluated the clinical application of CT guided ^12.iodine implantation in patients with portal vein tumor thrombus in primary hepatocellular carcinoma. Methods The ten patients （9 males and 1 female, aged from 36 to 72.years） with portal vein tumor thrombus accompanying hepatocellular carcinoma had been treated with comprehensive therapy including surgery, transcatheter arterial chemoembolization, radiotherapy ablation, microwave ablation or percutaneous ethanol injection. The average diameter of each tumor thrombus was 2..5 mm × 30.5 mm. Seeds of 30 MBq ^12.I were implanted 5 mm apart within the portal vein tumor thrombus. The follow-up after 4 months included enhanced spiral CT. Results CT screening of the tumours indicated that 4 out of 10 patients showed complete response to the therapy, 5 partial response and 1 stable disease. Adverse effects included aggravated abdominal dropsy and temporarily increased transaminase, which were controlled by medical management. Severe complications such as haemorrhage, biliary fistula hepatic abscess, pancreatic fistula and hepatic function failure were not observed. Implanted seeds migrated to lung and left hepatic lobe in 1 case. Conclusion CT guided implantation of ^12.iodine seeds, can effectively treat portal vein tumor thrombus accompanying hepatocellular carcinoma with minimal damage and few complications.

关键词： ^12.I iodine seed implantation portal vein tumor thrombus brachytherapy primary hepatocellular carcinoma

Effects of high flux hemodialysis on cardiac function and levels of IL-6, IL-8 and TNF-alpha in end-stage renal disease patients

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Journal of Hainan Medical university 2020年第5期26卷 17-20页

作者： Xiao-Yan Xuan Jie-feng Li Zi-An Liang Xiao-Ling Chen Sai Zhou Fang Chen Ai-Cheng yang Guang-{2. wu Jiangmen wuyi Middle School Hospital 529000

Objective:To observe the therapeutic effect of high-flux hemodialysis on patients with end-stage renal disease,and to evaluate cardiac function and interleukin-6(IL-6),interleukin-8(IL-8)and tumor necrosis factor-α(TNF).-αeffects such as cytokine ***:Eighty patients with end-stage renal disease who underwent hemodialysis in the department of Nephrology,wuyi Hospital of Jiangmen City from June 2.16 to June 2.18 were *** to their dialysis methods,they were divided into high-flux dialysis group(40 cases).Low-throughput dialysis group(40 cases).The differences of cardiac function,renal function and IL-6,IL-8 and TNF-αlevels between the two groups before and after dialysis were ***:After treatment,LAD,RAD and LVEF in both groups were lower than those before treatment,and LVEF in high throughput dialysis group was lower than that in low throughput dialysis group(t=9.191,6.559,P2.hSBP SD and 2.hDBP SD in both groups were lower than those before treatment,and those in high throughput dialysis group were lower than those in low flux dialysis group(t=6.2.7,10.611,12.082.6.564,P2.5、4.595、6.458,P2.819,Pfunction of patients and reduce the levels of I

关键词： Hemodialysis Nephropathy Cardiac function Cytokine

Newborn emergency transport based on the fifth-generation wireless networks and blockchain

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World Journal of Pediatrics 2022年第7期18卷 520-524页

作者： Jin-wu Fang Wei-Jia fu Rui feng Hong-Tao Ni Yun Cao Cheng-Jie Ye Ying Gu Xiao-Ling Ge Fan Zhang Long-Quan Jiang Juan-Wei Xing Liang-feng Tang Ying-Ying Zhang Jian-Guo Zhou Ru-Yi Zheng Hong Xu Xiao-Bo Zhang department of Epidemiology School of Public HealthFudan UniversityShanghaiChina Children's Hospital of fudan university ShanghaiChina Shanghai Key Laboratory of Intelligent Information.Processing School of Computer ScienceFudan UniversityShanghaiChina china Telecom(Shanghai)Co. LidShanghaiChina department of Respiratory Children's Hospital of Fudan UniversityNo.399 Wanyuan RoadShanghai 201102China department of Nephrology Children's Hospital of Fudan UniversityNo.399 Wanyuan RoadShanghai 201102China

Neonatal care is of great significance to health *** neonatal intensive care units(NICUs)started to be established in the late 1980s in china,neonatal mortal-ity has decreased each year to reach 3.4‰in 2.2.[1,2..However,the improvement for neonatal care is still on the *** than three-fifths of deaths included critically ill neonates occur in their first 2. days[3].Critically ill neo-nates usually have lower gestational age and body weight,leading to high mortality or requiring specific treatment and monitoring[4].It is a common practice to transfer a critically ill newborn patient to a tertiary children's hospi-tal with an excellent ***,it is crucial to pro-mote patients'safety by improving the neonatal transport network services[5].Owing to the complexity and rapid changes in neonatal conditions,especially for those requir-ing multi-disciplinary treatment,there is a high reliance on a specialized newborn transport team[6,7].

关键词： mortality transport treatment

Reposition of coronary sinus lead dislocation only using pre-shaped stylet and guidewire： a case report

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Chinese Medical Journal 2011年第6期124卷 954-955页

作者： YI fu SHEN Min wu feng WANG Hai-chang GUO Wen-yi LI Wei-jie LIU Bing department of Cardiovascular Medicine Xijing Hospital Fourth Military Medical University Xi'an Shaanxi 710032 China

Technologies associated with cardiac resynchronization therapy （CRT） devices and lead systems have ***, dislocation after coronary sinus （CS） lead placement continues to be a problem. We reported on the patient treated with CRT, in whom dislocation of CS lead occurred. In the case, we tried to reposition the CS lead without the left heart delivery system only using pre-shaped stylet and guidewire, and the dislocated CS lead could be successfully repositioned by the method. The method of only using a pre-shaped stylet and guidewire is easier than the conventional way, and it can shorten procedure duration and fluoroscopy time, as well as reduce the cost of treatment, but it is not always feasible.

关键词： cardiac resynchronization therapy coronary sinus lead dislocation reposition