Effects of high flux hemodialysis on cardiac function and levels of IL-6, IL-8 and TNF-alpha in end-stage renal disease patients

作     者：Xiao-Yan Xuan Jie-Feng Li Zi-An Liang Xiao-Ling Chen Sai Zhou Fang Chen Ai-Cheng Yang Guang-Fu Wu Xiao-Yan Xuan;Jie-Feng Li;Zi-An Liang;Xiao-Ling Chen;Sai Zhou;Fang Chen;Ai-Cheng Yang;Guang-Fu Wu

作者机构：Jiangmen Wuyi Middle School Hospital529000 

出 版 物：《Journal of Hainan Medical University》 (海南医学院学报（英文版）)

年 卷 期：2020年第26卷第5期

页      面：17-20页

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：Science and technology planning project of Jiangmen city  Guangdong province (2016-100-8) 

主　　题：Hemodialysis Nephropathy Cardiac function Cytokine 

摘      要：Objective:To observe the therapeutic effect of high-flux hemodialysis on patients with end-stage renal disease,and to evaluate cardiac function and interleukin-6(IL-6),interleukin-8(IL-8)and tumor necrosis factor-α(TNF).-αeffects such as cytokine ***:Eighty patients with end-stage renal disease who underwent hemodialysis in the Department of Nephrology,Wuyi Hospital of Jiangmen City from June 2016 to June 2018 were *** to their dialysis methods,they were divided into high-flux dialysis group(40 cases).Low-throughput dialysis group(40 cases).The differences of cardiac function,renal function and IL-6,IL-8 and TNF-αlevels between the two groups before and after dialysis were ***:After treatment,LAD,RAD and LVEF in both groups were lower than those before treatment,and LVEF in high throughput dialysis group was lower than that in low throughput dialysis group(t=9.191,6.559,P0.01).After treatment,SBP,DBP,24hSBP SD and 24hDBP SD in both groups were lower than those before treatment,and those in high throughput dialysis group were lower than those in low flux dialysis group(t=6.217,10.611,12.082,6.564,P0.01).There was no difference in cytokine levels between the two groups before *** treatment,I of the two groups of patients was not different from that of the two *** levels of IL 6 and TNF-αin high throughput dialysis group were lower than those before treatment,and the levels of IL 6 and GFRαin high throughput dialysis group were lower than those in low flux dialysis group(t=14.245、4.595、6.458,P0.01).After treatment,BUN,SCr and GFR in high throughput dialysis group were higher than those before treatment,and those in high throughput dialysis group were lower than those in low flux dialysis group(t=7.805,12.819,P0.01).Conclusion:High-flux hemodialysis has a better therapeutic effect on patients with end-stage renal disease,which can significantly improve the heart function of patients and reduce the levels of I