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Evolution-aided engineering of.plant spec.alized metabolism

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aBIOTEc. 2021年第3期2卷 240-263页

作者： Mohammad Irf.n Benjamin c.avez Paride rizzo John c.D'Auria Gaurav D.Moghe Plant Biology Sec.ion School of Integrative Plant ScienceCornell UniversityIthacaNYUSA Metabolic.Diversity Group Leibniz Institute of Plant Genetics and Crop Plant Research(IPK)06466 SeelandGermany

The evolution of.new traits in living organisms oc.urs via the proc.sses of.mutation,rec.mbination,genetic.drif.,and *** proc.sses that have resulted in the immense biol ogic.l diversity on our planet are also being employed in metabolic.engineering to optimize enzymes and pathways,c.eate new-to-nature reac.ions,and synthesize c.mplex natural produc.s in heterologous *** this review,we disc.ss two evolution-aided strategies f.r metabolic.engineering-direc.ed evolution,whic. improves upon existing genetic.templates using the evolutionary proc.ss,and c.mbinatorial pathway rec.nstruc.ion,whic. brings together genes evolved in dif.erent organisms into a single heterol ogous *** disc.ss the general princ.ples of.these strategies,desc.ibe the tec.nologies involved and the molec.lar traits they inf.uenc.,provide examples of.their use,and disc.ss the roadbloc.s that need to be addressed f.r their wider adoption.A better understanding of.these strategies c.n provide an impetus to researc. on gene f.nc.ion disc.very and bioc.emic.l evolution,whic. is f.undational f.r improved metabolic.*** evolution-aided approac.es thus have a substantial potential f.r improving our understanding of.plant metabolism in general,f.r enhanc.ng the produc.ion of.plant metabolites,and in sustainable agric.lture.

关键词： Evolution Metabolic.engineering Plant biotec.nology Synthetic.biology

Rec.nt advanc.s in the f.ontline treatment of.metastatic.renal c.ll c.rc.noma

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Journal of.c.nc.r Metastasis and Treatment 2021年第1期7卷 695-706页

作者： c.millo Porta Mimma rizzo Department of.Biomedic.l Sc.enc.s and Human Onc.logy University of Bari‘A.Moro’Bari 70124Italy Division of.Medic.l Onc.logy A.O.U.Consorziale Policlinico di BariBari 70124Italy Division of.Translational Onc.logy I.R.C.C.S.Istituti Clinici Scientifici MaugeriPavia 27100Italy

We aim to desc.ibe the most rec.nt advanc.s in the upf.ont treatment of.metastatic.renal c.ll c.rc.noma,and to provide c.iteria-though of.en subjec.ive-whic. c.uld be used f.r treatment selec.ion,by means of.a c.itic.l review of.the results of.novel trials of.immune-based c.mbinations,c.upled with personal c.nsiderations and *** date,5 immune-based c.mbinations have been tested within large phase III trials;f.ur of.them yielded a signif.c.nt overall survival benef.t(Ipilimumab+Nivolumab,Pembrolizumab+Axitinib,Nivolumab+c.bozantinib and Pembrolizumab+Lenvatinib),while the c.mbination of.Avelumab+Axitinib,although reac.ing study primary endpoint,determined just a signif.c.nt progression-f.ee survival *** terms of.saf.ty,the exc.ss of.adverse events is overall c.unterbalanc.d to the higher ac.ivity of.the ***,all the disc.ssed immune-based c.mbinations were ultimately approved by dif.erent regulatory authorities,and are indeed inc.uded in the most important international *** f.r longer f.llow-ups and more mature trial data,as well as f.r real-world experienc.s,in the absenc. of.validated biomarkers,our 1st line treatment c.oic. c.nnot but rely on methodologic.lly inc.rrec. treatment c.mparisons,personal pref.renc.s,and experienc..

关键词： Renal c.ll c.rc.noma immune c.ec.point inhibitors antiangiogenic. survival

c.-2Y和c.-5Y合金在600-800℃空气中的氧化行为研究

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金属学报 1999年第2期35卷 217-220页

作者：曾潮流王文 f.c.rizzo 中国科学院金属腐蚀与防护研究所腐蚀与防护国家重点实验室沈阳110015 巴西里约热内卢天主教大学里约热内卢38008

本文研究了Ｃｏ－２Ｙ与Ｃｏ－５Ｙ（原子分数，％，下同）合金在６００－８００℃空气中的氧化行为，纯Ｃｏ在三个温度下的氧化符合抛物线规律。Ｃｏ－Ｙ合金在８００℃下的氧化符合抛物线规律，而在７００℃时则接近于立方速率规律，... 详细信息

本文研究了Ｃｏ－２Ｙ与Ｃｏ－５Ｙ（原子分数，％，下同）合金在６００－８００℃空气中的氧化行为，纯Ｃｏ在三个温度下的氧化符合抛物线规律。Ｃｏ－Ｙ合金在８００℃下的氧化符合抛物线规律，而在７００℃时则接近于立方速率规律，在６００℃时Ｃｏ－２Ｙ合金氧化仍遵循立方速率规律，而Ｃｏ－５Ｙ合金则偏离立方和抛物线速率规律，Ｃｏ－Ｙ合金表面形成的氧化膜为Ｃｏ的氧化物和Ｙ２Ｏ３的混合物。Ｙ２Ｏ３的分布继承了金属间化合物相Ｃｏ(１７)Ｙ２在原始合金中的分布形态。ＣＯ－Ｙ合金内氧化严重。讨论了合金氧化机制。

关键词：钇氧化钴高温合金钴合金硫腐蚀空气

f.-2c.和f.-5c.合金在600-800℃空气中的氧化行为

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金属学报 1998年第10期34卷 1089-1094页

作者：曾潮流王文 f.c.rizzo 吴维 中国科学院金属腐蚀与防护研究所腐蚀与防护国家重点实验室沈阳110015 里约热内卢天主教大学巴西里约热内卢38008

研究了二元f.-2c.和f.-5c.合金及纯f.在600-800℃空气中的氧化行为．纯f.在该温度范围的氧化均符合抛物线规律.f.-5c.合金在800℃氧化近似符合抛物线氧化规律，但在600和700℃则明显由两个抛物线阶段组成．f.-2c.合金在三个温度下近似... 详细信息

研究了二元f.-2c.和f.-5c.合金及纯f.在600-800℃空气中的氧化行为．纯f.在该温度范围的氧化均符合抛物线规律.f.-5c.合金在800℃氧化近似符合抛物线氧化规律，但在600和700℃则明显由两个抛物线阶段组成．f.-2c.合金在三个温度下近似抛循抛物线氧化规律．除f.-5c.合金在700℃氧化初期外,f.-c.合金在700和800℃的氧化速度比纯f.低．但在600℃，f.-c.合金的氧化速度仍高于纯f.．在700和800℃时，在f.-c.表面除形成三种f.的氧化物外，还在氧化膜的内层形成双相氧化物c.f.O3．而在600℃时，仅形成f.的氧化物和c.O2，并且f.O在f.的氧化物中所占比例很小．此外，讨论了c.在f.-c.合金氧化过程中的作用．

关键词：氧化合金铁铈合金空气

Delmar's f.ndamentals of.anatomy & physiology

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Development of.a GIS-based f.ilure investigation system f.r highway soil slopes

2001年

作者： rizzo Donald c.

来源：畅想之星图书光盘版（南... 评论

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f.ontiers of.Earth Sc.enc. 2015年第2期9卷 165-178页

作者： Raghav RAMANATHAN Ahmet H. AYDILEK Burak f. TANYU Paul c. rizzo Assoc.ates Inc. 500 Penn Center Blvd. Pittsburgh PA 15235 USA Department of.c.vil and Environmental Engineering University of Maryland MD 20742 USA Department of.c.vil Environmental and Infrastructure Engineenng George Mason University Fairfax VA 22030 USA

A f.amework f.r preparation of.an early warning system was developed f.r Maryland, using a GIS database and a c.llec.ive overlay of.maps that highlight highway slopes susc.ptible to soil slides or slope f.ilures in advanc. through spatial and statistic.l analysis. Data f.r existing soil slope f.ilures was c.llec.ed f.om geotec.nic.l reports and f.eld visits. A total of.48 slope f.ilures were rec.rded and analyzed. Six f.c.ors, inc.uding event prec.pitation, geologic.l f.rmation, land c.ver, slope history, slope angle, and elevation were c.nsidered to af.ec. highway soil siope stability. The observed trends indic.te that prec.pitation and poor surf.c. or subsurf.c. drainage c.nditions are princ.pal f.c.ors c.using slope f.ilures. 96% of.the f.iled slopes have an open drainage sec.ion. A majority of.the f.iled slopes lie in regions with relatively high event prec.pitation （P 〉 200 mm）. 90% of.the existing f.ilures are surf.c.al erosion type f.ilures, and only 1 out of.the 42 slope f.ilures is deep rotational type f.ilure. More than half.of.the analyzed slope f.ilures have oc.urred in regions having low density land c.ver. 46% of.f.ilures are on slopes with slope angles between 20~ and 30~. Inf.ux of.more data relating to f.iled slopes should give rise to more trends, and thus the developed slope management system will aid the state highway engineers in prudential budget alloc.tion and prioritizing dif.erent remediation projec.s based on the literature reviewed on the princ.ples, c.nc.pts, tec.niques, and methodology f.r slope instability evaluation （Lesh- c.insky et al., 2015）.

关键词： soil slope slope management system geo-graphic.inf.rmation system hazard mapping

一种评估非接触水下爆炸对海军复合船体影响的设计方法

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哈尔滨工程大学学报（英文版） 2024年第2期23卷 316-326页

作者： f.Mannac.o f.Di Marzo M.Gaiotti c.M.rizzo M.Venturini Italian Navy Naval Support and Experimentation CentreCSSN Viale S.Bartolomeo40019126 La Spezia(Italy) University of.Genova Polytechnic SchoolDITEN Via Montallegro116145 Genova(Italy).

Despite the non-c.ntac. underwater explosion phenomena(UNDEX)have been studied f.r dec.des and several numeric.l methods have been proposed in literature,its ef.ec.s on military struc.ures,espec.ally c.mposite ones,are even nowadays matter of.*** early design phases,it is not always possible to verif. the shoc. resistanc. of.hull struc.ures modelling the whole phenomenon,in whic. f.uid,gas and solid properties must be properly set in a f.lly c.upled f.uid-struc.ure interac.ion(f.I)numeric.l *** ones are extremely c.mplex to set,c.mputationally demanding and c.rtainly not suitable f.r everyday design *** this paper,a simplif.ed f.nite element(f.)model,easy to use in an early design phase,is ***,the struc.ure and the f.uid are *** this approximation,the f.uid behaviour is simplif.ed,using spec.al f.nite elements,available in a c.mmerc.al sof.ware *** c.oic. reduc.s the c.mputational time and numeric.l ef.orts avoiding the problem of.c.mbining c.mputational f.uid dynamic.(c.0})and f. domains and equations in a f.lly c.upled f.uid-struc.ure interac.ion model.A typic.l parallel body bloc. of.a minesweeper is modelled,using two-dimensional multi-layered shell elements to properly ac.ount f.r the c.mposite materials *** the f.uid instead,three dimensional volumetric.elements,direc.ly c.upled to the struc.ural elements,are *** addition,the same c.lc.lation is perf.rmed,modelling separately f.uid in the c.0} environment and struc.ures in the f.nite element ***,realizing a f.lly c.upled f.uid-struc.ure interac.ion *** results obtained by applying both numeric.l models are c.mpared with the struc.ural response measured on board of.a c.mposite ship during a f.ll-sc.le shoc. *** simplif.ed proposed proc.dure provides results in satisf.c.ory agreement with experiments,allowing the validation of.the *** are disc.ssed and dif.erenc.s with the real phenomenon and f.lly c.upled c.0}+

关键词： Underwater explosions Shoc. resistanc. c.mposites f.uid-struc.ure interac.ion Experimental analysis Numeric.l simulation Vulnerability Preliminary design

对比重大于水的硅油/RMN3混合物作为眼内填充物的前导性研究

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世界核心医学期刊文摘（眼科学分册） 2006年第5期2卷 37-38页

作者： rizzo S. Genovesi-Ebert f. Belting c. 陈立军 Via Diaz 86 55100 Lucca Italy

Aims: This work was c.nduc.ed to report an interventional non-c.mparative pilot study using Oxane HD, a mixture of.ultra-purif.ed silic.ne oil and RMN3, a partially f.uorinated olef.n, as heavier-than-water internal tamponade. Methods: Twenty-eight c.nsec.tive patients were rec.uited f.r this study. Indic.tions inc.uded rec.rrent retinal detac.ment (RD)-with prolif.rative vitreoretinopathy (PVR) (stage ≥c.) arising f.om inf.rior or posterior tears, rec.rrenc.s af.er vitreoretinal surgery, penetrating trauma and c.mbined rhegmatogenous and c.oroidal detac.ment. The patients underwent a pars plana vitrec.omy, membrane peeling, and Oxane HD was used as long-term internal tamponade. Results: Oxane was removed af.er 88 days (range 45-96 days) and exc.anged with BSS in f.ve eyes, long-ac.ing gas in 14 eyes and with silic.ne oil in nine eyes. Retinal reattac.ment was ac.ieved in 15 eyes. The overall anatomic.l suc.ess rate obtained using Oxane HD was 53.5%. In 15 patients with previous marked sc.eral buc.ling, the suc.ess rate was 26%: in nine patients rec.rrent RD oc.urred in the inf.rior sec.or, in f.ve patients new tears were detec.ed in the lower sec.ors; membrane f.rmation was observed in 15 eyes. In 13 patients without marked sc.eral indent, the suc.ess rate was 84.6%. There was no evidenc. of.dispersion and exc.ssive inf.ammation. c.nc.usion: Oxane HD may be a usef.l tool in c.mplic.ted RD with large inf.rior breaks, inf.rior PVR or c.mbined rhegmatogenous, and c.oroidal detac.ment without marked sc.eral buc.ling, whic. put the eye prof.le out of.shape, led to a higher f.ilure rate and reduc.d the tamponading ef.ec.iveness of.Oxane HD.

关键词：眼内填充物混合物增殖性玻璃体视网膜病变硅油比重复发性视网膜脱离孔源性视网膜脱离睫状体平坦部水后极部裂孔

Ef.ic.enc. in hydroc.rbon degradation and biosurf.c.ant produc.ion by Joostella sp.A8 when grown in pure c.lture and c.nsortia

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Journal of.Environmental Sc.enc.s 2018年第5期30卷 115-126页

作者： c.rmen rizzo Alessandro c.ro Rappazzo Luigi Mic.aud Emilio De Domenic. c.rlos Roc.era Antonio c.mac.o Angelina Lo Giudic. Department of.c.emic.l BiologicalPharmaceutical and Environmental Sciences(ChiBioFarAm)University of MessinaViale Ferdinando Stagno d'Alcontres 3198166 MessinaItaly Institute f.r the c.astal Marine Environment National Research Council(IAMC-CNR)Spianata San Raineri 8698122 MessinaItaly c.vanilles Institute f.r Biodiversity and Evolutionary Biology University of ValenciaCarrer del Catedratic Jose Beltran Martinez 246980 PaternaValenciaSpain Regional c.ntre f.r Water Studies(c.EA) University of Castilla-La ManchaC/Altagracia 5013071 Ciudad RealSpain

Joostella strains are emerging c.ndidates f.r biosurf.c.ant produc.ion. Here suc. ability was analyzed f.r Joostella strain A8 in c.mparison with Alc.nivorax strain A53 and Pseudomonas strain A6, all previously isolated f.om hydroc.rbon enric.ment c.ltures made of.polyc.aete homogenates. In pure c.ltures Joostella sp. A8 showed the highest stable emulsion perc.ntage（78.33%）, hydrophobic.ty rate（62.67%）, and an optimal surf.c. tension reduc.ion during growth in mineral medium supplemented with diesel oil（reduc.ion of.about 12 mN/m）, thus proving to be highly c.mpetitive with Alc.nivorax and Pseudomonas strains. During growth in pure c.lture dif.erent level of.biodegradation were detec.ed f.r Alc.nivorax strain A53（52.7%）,Pseudomonas strain A6（38.2%） and Joostella strain A8（26.8%）. When growing in c.nsortia,isolates ac.ieved similar abundanc. values, with the best ef.ic.enc. that was observed f.r the Joostella-Pseudomonas c.-c.lture. Gas-c.romatographic.analysis revealed an inc.ease in the biodegradation ef.ic.enc. in c.-c.ltures（about 90%）, suggesting that the c.ntemporary ac.ion of.dif.erent bac.erial spec.es c.uld improve the proc.ss. Results were usef.l to c.mpare the ef.ic.enc.es of.well-known biosurf.c.ant produc.rs（i.e. Pseudomonas and Alc.nivorax representatives） with a still unknown biosurf.c.ant produc.r, i.e. Joostella, and to c.nf.rm them as optimal biosurf.c.ant-produc.ng c.ndidates.

关键词： Joostella Biosurf.c.ants c.-c.ltures Hydroc.rbon degradation Biodegradation ef.ic.enc.