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白介素-33至白介素-13信号级联调节小鼠胃组织上皮化生

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英国医学杂志中文版 2018年第7期21卷 418-418页

作者： Christine P Petersen Anne R Meyer Carlo De Salvo Eunyoung Choi cameron Schlegel Alec Petersen Amy C Engevik Nripesh Prasad Shawn E Levy R Stokes Peebles Theresa T Pizarro James R Goldenring 李佳宁(译) 吴东(校) 不详北京协和医院消化科

目的选择性活化巨噬细胞（Alternativelyactivated macrophages, M2）与胃部解痉多肽表达性化生（spasmolytic polypeptide-expressingmetaplasia, SPEM）过程相关。然而，诱导SPEM的确切机制及关键介质尚不明确。研究设计为确定这一... 详细信息

目的选择性活化巨噬细胞（Alternativelyactivated macrophages, M2）与胃部解痉多肽表达性化生（spasmolytic polypeptide-expressingmetaplasia, SPEM）过程相关。然而，诱导SPEM的确切机制及关键介质尚不明确。研究设计为确定这一过程中的关键基因，分离胃部SPEM小鼠（DMP-777处理）及高级胃部SPEM小鼠（L635处理）胃体的巨噬细胞进行RNA测序。评估白介素．33、白介素-33受体（ST2）及白介素-13基因敲除小鼠，经L635处理急性壁细胞缺失后对上皮细胞化生过程的影响。结果胃部上皮化生相关性巨噬细胞中可鉴定出M2极化亚群。高级胃部SPEM小鼠巨噬细胞中自介素-33的表达显著上调。L635可在野生型小鼠胃组织中诱导上皮化生，但在白介素-33及白介素．33受体敲除鼠中未观察到这一现象。尽管在诱导上皮化生过程中不需白介素．5及白介素-9，白介素-13基因敲除小鼠无法在L635诱导下发生上皮化生。对白介素-33受体基因敲除小鼠应用白介素-13，可重新诱导急性壁细胞缺失后的上皮化生。结论壁细胞缺失后上皮化生及巨噬细胞极化过程通过白介素．33及白介素-13的细胞信号网络协调进行，将损伤应答过程中固有黏膜机制及M2浸润联系起来。

关键词： IL-13 组织变形调整老鼠串联信号胃

Apple whole genome sequences:recent advances and new prospects

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Horticulture Research 2019年第1期6卷 1247-1270页

作者： cameron P.Peace Luca Bianco Michela Troggio Eric van de Weg Nicholas P.Howard Amandine Cornille Charles-Eric Durel Sean Myles ZoëMigicovsky Robert J.Schaffer Evelyne Costes Gennaro Fazio Hisayo Yamane Steve van Nocker Chris Gottschalk Fabrizio Costa David Chagné Xinzhong Zhang Andrea Patocchi Susan E.Gardiner Craig Hardner Satish Kumar Francois Laurens Etienne Bucher Dorrie Main Sook Jung Stijn Vanderzande Department of Horticulture Washington State UniversityPullmanWA 99164USA Computational Biology Fondazione Edmund MachSan Michele all’AdigeTN 38010Italy Department of Genomics and Biology of Fruit Crops Fondazione Edmund MachSan Michele all’AdigeTN 38010Italy Plant Breeding Wageningen University and ResearchWageningen 6708PBThe Netherlands Department of Horticultural Science University of MinnesotaSt.PaulMN 55108USA Institut für Biologie und Umweltwissenschaften Carl von Ossietzky Universität26129 OldenburgGermany GQE-Le Moulon Institut National de la Recherche AgronomiqueUniversity of Paris-SudCNRSAgroParisTechUniversitéParis-Saclay91190 Gif-sur-YvetteFrance Institut National de la Recherche Agronomique Institut de Recherche en Horticulture et SemencesUMR 134549071 BeaucouzéFrance Department of Plant Food and Environmental SciencesFaculty of AgricultureDalhousie UniversityTruroNS B2N 5E3Canada The New Zealand Institute for Plant and Food Research Ltd Motueka 7198New Zealand School of Biological Sciences University of AucklandAuckland 1142New Zealand AGAP INRACIRADMontpellier SupAgroUniversity of MontpellierMontpellierFrance Plant Genetic Resources Unit USDA ARSGenevaNY 14456USA Laboratory of Pomology Graduate School of AgricultureKyoto UniversityKyoto 606-8502Japan Department of Horticulture Michigan State UniversityEast LansingMI 48824USA The New Zealand Institute for Plant and Food Research Ltd(Plant&Food Research) Palmerston North Research CentrePalmerston North 4474New Zealand College of Horticulture China Agricultural University100193 BeijingChina Agroscope 8820 WädenswilSwitzerland Queensland Alliance of Agriculture and Food Innovation University of QueenslandSt Lucia 4072Australia New Cultivar Innovation Plant and Food ResearchHavelock North 4130New Zealand Agroscope 1260 ChanginsSwitzerland

In 2010,a major scientific milestone was achieved for tree fruit crops:publication of the first draft whole genome sequence(WGS)for apple(Malus domestica).This WGS,v1.0,was valuable as the initial reference for sequence information,fine mapping,gene discovery,variant discovery,and tool development.A new,high quality apple WGS,GDDH13 v1.1,was released in 2017 and now serves as the reference genome for *** the past decade,these apple WGSs have had an enormous impact on our understanding of apple biological functioning,trait physiology and inheritance,leading to practical applications for improving this highly valued *** gene identities for phenotypes of fundamental and practical interest can today be discovered much more ***-wide polymorphisms at high genetic resolution are screened efficiently over hundreds to thousands of individuals with new insights into genetic relationships and ***-density genetic maps are constructed efficiently and quantitative trait loci for valuable traits are readily associated with positional candidate genes and/or converted into diagnostic tests for *** understand the species,geographical,and genomic origins of domesticated apple more precisely,as well as its relationship to wild *** WGS has turbo-charged application of these classical research steps to crop improvement and drives innovative methods to achieve more durable,environmentally sound,productive,and consumer-desirable apple *** review includes examples of basic and practical breakthroughs and challenges in using the apple *** for“what’s next”focus on necessary upgrades to the genome sequence data pool,as well as for use of the data,to reach new frontiers in genomics-based scientific understanding of apple.

关键词： breakthrough hundreds frontier

A Case Report of Lemierre’s Syndrome with Multisystem Dysfunction in the Setting of COVID-19 Exposure in a Pediatric Patient

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2000～2015年非洲疟疾防治措施对恶性疟原虫的影响

Case Reports in Clinical Medicine（临床医学病理报告） 2021年第9期

作者： Kathleen McMahon Odiraa Nwankwor Christina Palladino Laura Czulada cameron Jacobs

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安徽预防医学杂志 2016年第5期22卷 355-355页

作者： S.Bhatt E.cameron 邓舒刘永孝

自2000年以来，在撒哈拉以南非洲地区的抗疟行动干预覆盖率达到前所未有的水平，了解其控制效果对指导下一步控制措施的制定至关重要。然而由于监测方法较为简单和缺乏可靠的监测数据，非洲不同流行模式下疟疾干预措施对疾病发病水平的... 详细信息

自2000年以来，在撒哈拉以南非洲地区的抗疟行动干预覆盖率达到前所未有的水平，了解其控制效果对指导下一步控制措施的制定至关重要。然而由于监测方法较为简单和缺乏可靠的监测数据，非洲不同流行模式下疟疾干预措施对疾病发病水平的影响仍然知之甚少。本研究根据疟疾现场调查的大量数据，重建从2000年至2015年的干预措施覆盖率变化趋势，并量化疟疾防控工作对其影响。研究结果显示从2000年至2015年，非洲恶性疟原虫带虫率减半，发病率下降了40％，自2000年以来干预措施已经避免了6．63（5．42—7．53可信区间）亿的临床病例。经杀虫剂处理过的蚊帐作为最广泛的干预措施，为降低疾病发病做出最大的贡献率（避免了68％的发病）。尽管干预措施的效果仍然低于预期水平，目前的疟疾干预措施已明显降低了整个非洲大陆的疟疾发病率。2015年之后的控制策略应以继续加强目前的干预措施，并保持杀虫剂有效性为基础。

关键词：疟疾防治非洲地区恶性疟原虫干预措施监测数据撒哈拉以南发病率控制效果

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资本主义、种族主义与特朗普主义

国外理论动态 2020年第6期 49-58页

作者：大卫·G.恩比克 J.斯科特·卡特卡梅隆·利帕德布米·K.塔科尔刘曙辉(译) 美国康涅狄格大学美国中佛罗里达大学美国阿帕拉契州立大学中国社会科学院马克思主义研究院

在美国,法西斯主义、新自由主义及种族主义的持续存在都是制度性、系统性的,是各种不同群体长期受压迫的历史的一部分。特朗普主义的兴起在于它有能力助长白人对抗。白人对抗是一种个体性的、制度性的或结构性的对抗手段,它反对的是对... 详细信息

在美国,法西斯主义、新自由主义及种族主义的持续存在都是制度性、系统性的,是各种不同群体长期受压迫的历史的一部分。特朗普主义的兴起在于它有能力助长白人对抗。白人对抗是一种个体性的、制度性的或结构性的对抗手段,它反对的是对白人至上地位的威胁或矫正种族不平等的行动。白人对抗是对挑战白人地位以及日益增长的多样性和渐进式变化的反应,同时也与资本主义、阶级和性别有着千丝万缕的联系。要理解当代政治中复杂而又看似矛盾的细微差别,我们就必须超越单一的阶级、种族或性别解释,并考虑到这些制度性、系统性的支配体系有着紧密联系这一事实。

关键词：资本主义种族主义特朗普主义白人对抗

Pollen morphology of the family Smilacaceae and its phylogenetic and taxonomic significance

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Pollen morphology of the family Smilacaceae and its phylogen...

死海盐光浴疗法与窄波紫外线B单一疗法治疗慢性斑块型银屑病的随机对照研究

浙江省第二届生物多样性保护与可持续发展研讨会

作者： SHI-CHAO CHEN, CHEN-XIN FU , XIAO-PING ZHANG , SHI-FENG NI and KENNETH M. cameron Laboratory of Systematic and Evolutionary Botany & Biodiversity, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, P. R. China. College of Life Sciences. Anhui Normal University, Wuhu, Anhui. P. R. China. The New York Botanical Garden, Bronx, NY, USA

The pollen morphology of 125 species belonging to 3 genera of the Smilacaceae was investigated with light and scanning electron microscopy, of which 10 species were also examined by transmission electron microscopy, in order to find additional taxonomic informations for phylogenetic analysis of the family. The variations of pollen morphology in Smilacaceae are sufficient to permit two pollen classes and four pollen types to be distinguished. The pollen grains of all Smilax and Heterosmilax species are spheroidal, inaperturate and spinulate or microspinulate, with thin and fragile exine of varied sculperturing, which is remarkably distinct from Ripogonum that are prolate, monosulcate, and reticulate. Ripogonum was recognized as a separate pollen class and type of its own, whereas Smilax and Heterosmilax were grouped into another pollen class with three pollen types. It can be concluded that Ripogonum should be separated as a single family as its pollen type is incompatible with those in most of species of Smilacaceae. Heterosmilax can be incorprated into the Smilax based on the fact that the successive variation series of pollen morphology occur in these two genera. A key for the identification of these pollen types as well as the possible phylogenetic trends of pollen types are presented.

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世界核心医学期刊文摘（皮肤病学分册） 2005年第12期1卷 50-50页

作者： Dawe R.S. Yule S. cameron H. 王琼 Department of Dermatology University of Dundee Ninewells Hospital and Medical School Dundee DD1 9SY United Kingdom

Background: Dead Sea (DS) salt solution soaks are used in combination with narrowband ultraviolet B (NB- UVB) to treat psoriasis in many centres, particularly in continental Europe. No previously published controlled study has assessed DS salt + NB- UVB balneophototherapy. Objectives: To compareDS salt balneophototherapy with NB- UVB monotherapy for chronic plaque psoriasis. Methods: Sixty patients with chronic plaque psoriasis participated in this paired, controlled study, with pretreatment DS salt soaks randomly allocated to each participant’ s right or left study limb. Psoriasis severity was assessed with a Scaling, Erythema and Induration score by a blinded observer. Assessments were weekly during the therapy course, and thereafter 8- weekly until relapse or for up to 1 year after clearance. Results: The mean area under the psoriasis severity- time curves during treatment was not detectably lower with DS salt balneophototherapy than with NB- UVB monotherapy (P=0.099). The psoriasis severity score fell slightly more from beginning to end of courses with DS salt balneophototherapy than with NB- UVB monotherapy (P=0.019). There was no detectable difference in times to relapse. Conclusions: In this population the addition of pretreatment DS salt soaks to NB- UVB did not result in a clinically important improvement in clearance of psoriasis.

关键词：斑块型银屑病浴疗法严重度复发时间盐浸配对设计研究人群盐溶液时间曲线

65岁及以上早期乳腺癌患者保乳术后辅助放疗的随机对照研究

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中国肿瘤外科杂志 2015年第3期7卷 153-153页

作者： Kunkler IH Williams LJ Jack WJ cameron DA Dixon JM 刘嘉

背景对于绝大多数老年早期乳腺癌患者来说,保乳术后的标准治疗手段为辅助全乳腺放疗及辅助内分泌治疗。Kunkler项目组开展的随机对照前瞻性研究,目的在于评估5年局部复发风险较低的老年女性乳腺癌患者在保乳术后如不行全乳腺放疗是否... 详细信息

背景对于绝大多数老年早期乳腺癌患者来说,保乳术后的标准治疗手段为辅助全乳腺放疗及辅助内分泌治疗。Kunkler项目组开展的随机对照前瞻性研究,目的在于评估5年局部复发风险较低的老年女性乳腺癌患者在保乳术后如不行全乳腺放疗是否也能够产生良好的局部控制效果。方法2003年4月16日至2009年12月22日,在4个国家的76个机构共招募1 326例65周岁以上的女性患者,均确定为低危早期乳腺癌（通过激素受体、腋下淋巴结、瘤体最长直径、切缘情况、肿瘤组织学、淋巴血管侵袭等判定）。

关键词：术后辅助放疗乳腺癌患者随机对照研究早期乳腺癌保乳术后辅助内分泌治疗腋下淋巴结老年女性

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吞噬作用能促进线虫的程序性细胞死亡

四川解剖学杂志 2002年第2期10卷 94-94页

作者： Peter W.Reddien Scott cameron H.Robert Horvit 魏星第三军医大学学员旅5队